Search

Objective: To determine the tolerability, effectiveness and outcomes of percutaneous image-guided cryoablation on inoperable extra-abdominal desmoid tumors. Methods: Between 2011 and 2012, 13 patients (mean age 39.3 years, range 15-74) with inoperable extra-abdominal desmoid tumors were consecutively treated with cryoablation (17 tumors treated in 17 procedures), including two patients with Gardner syndrome and nine recurrences after surgery. Disease-free survival (DFS) and local control based on RECIST criteria were calculated on prospective clinical and imaging follow-up until 2013. Results: Cryoablation was performed under ultrasound ( n = 8), computed tomography ( n = 1), or combined ( n = 8) guidance, and under general ( n = 15) or local ( n = 2) anesthesia. A major complication was observed in one session (5.8 %). Mean follow-up was 11.3 months (6-27 months). Among all the patients treated, eight patients (47 %) presented residual tumors on the first magnetic resonance follow-up, which were asymptomatic. The DFS rate was stable at 82.3 % (95 % confidence interval 0.55-0.94) at 6, 12, and 24 months. The local tumor progression rate was 0 % at 6, 12, and 24 months. Two patients (12 %) presented an in situ recurrence. Conclusions: Despite high rates of partial ablation, percutaneous image-guided cryoablation appears to be safe and effective for local control for patients with inoperable extra-abdominal desmoid tumors. [ABSTRACT FROM AUTHOR]

Presents a modified barrier-augmented Lagrangian (MBAL)-based nonlinear optimal power-flow method for the optimum selections of the transformer tap positions and the voltage set points of the generators. Features of the MBAL method; Formulation of the optimal transformers tap selection; Outline of the MBAL algorithm.