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The Bauhinia ungulata, also known by its common name "pata de vaca", is one of the species used in Brazil for medicinal purposes, and is commonly used for the treatment of diabetes. In this study, the authors studied the interaction between the chemical constituents which are present in the essential oil of Bauhinia ungulata (EOBU), collected in Boa Vista-RR, Legal Amazon, and their effects on the enzyme acetylcholinesterase (AChE) in the essential oil. The analysis that we perform includes proton magnetic resonance (¹H NMR), enzymatic inhibition, molecular docking, in silico toxicity prediction, enrichment analysis, and target prediction for biological interactions. According to the tests performed on the essential oil, it obtained 100% inhibition of the enzyme AChE. During ¹H NMR experiments, it was found that α-Bisabolol, one of the main components, had a significant alteration in its chemical shift. A molecular docking analysis confirmed that this compound binds to the AChE enzyme, which confirms the ¹H NMR analysis. The results of this work showed that the major component of EOBU acted as a possible inhibitor of AChE enzyme in vitro and in silico assays. These results show that EOBU could be potentially applied in Alzheimer's disease treatment. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to translate, culturally adapt, and validate the Mindful Self-Care Scale (MSCS, 33-item) in a Brazilian hospice and palliative care context. Method: This was a cross-sectional study with a sample of 336 Brazilian hospice and palliative care providers. The European Organisation for Research and Treatment of Cancer — Quality of Life Group Translation Procedure protocol was used for the translation and the cultural adaptation process. Psychometric properties supporting the use of the MSCS were examined through confirmatory factor analysis (CFA) and correlation analysis with other instruments to assess congruence to related constructs (resilience and self-compassion). The reliability of the Brazilian-Portuguese version of the MSCS was assessed using Cronbach's α and composite reliability coefficients. Results: The six-factor (33-item) model showed a good fit to the data, with satisfactory reliability indices and adequate representation of the scale's internal structure. Further validity is evidenced in the significant, positive correlations found between the MSCS, and similar well-being constructs, namely the Self-Compassion and Resilience scales. Significance of results: The findings reveal that the MSCS (33-item) is a valid, reliable, and culturally appropriate instrument to examine the practice of mindful self-care by hospice and palliative care providers in Brazil. More broadly, it represents a promising instrument for future research into self-care practices and well-being among Brazilian healthcare providers. [ABSTRACT FROM AUTHOR]

Psidium striatulum is a fruit popularly known as araçá or araçari in region from Brazilian Amazon. These fruits are widely used in folk medicine for the treatment of diarrhea and infections caused by microorganisms that cause harm to human health. Thus, this work aims to characterize the chemical profile and biological evaluation of the essential oil of the green fruits of Psidium striatulum DC. The plant material was collected in the municipality of Boa Vista-RR, on the margin of Rio Branco and submitted to hydrodestillation, in a Clevenger, Spell brand double - condenser type device for 2 hour interrupt period. Identification and quantification of twenty volatile constituents corresponding to 91.9% of its composition was provided through GC-MS and GC-FID, with 8.1% remaining unidentified, with the majority of a-pinene (11.9%), humulene (10.4%), a-copaene (7.1%), globulol (5.7%), d-cadinene (4.2%) and ß-pinene (4.2%). Microbiological tests of essential oil at 250 µg/mL were performed against Staphylococcus aureus, ATCC 29212 (67.03±4.06%); Bacillus cereus, ATCC 11778 (73.14±2.70%); Escherichia coli, ATCC 25922 (11.47±0.28%); Salmonella typhimurium, ATCC 14028 (78.43±2.12%) and C. albicans (13.18±1.69%) and showed moderate inhibitory activity for the AChE enzyme (44.42%). The results showed that the essential oil had an activity greater than 65% against Staphylococcus aureus, Bacillus cereus and Salmonella typhimurium, as well as having a moderate inhibitory effect on the enzyme acetylcholinesterase (AChE) in the conduction conditions of the bioassays of the present study. [ABSTRACT FROM AUTHOR]

One of the oldest plants known and considered a symbol of wisdom in antiquity especially in China is cinnamon (Cinnamomum zeylanicum Nees). The objective of this work was to study the fixed oil extracted from cinnamon (Cinnamomum zeylanicum Nees) seeds regarding its biological potential for inhibition of acetylcholinesterase. The inhibitory activity test of hexane extract studied on the enzyme acetylcholinesterase was conducted based on Ellman spectrophotometric method. The percentage of acetylcholinesterase enzyme inhibition was 65.5%, being considered a potent inhibitor according to the literature standarts. In conclusion, the results indicate that the oil can be used in the pharmaceutical industry as part or to develop drugs for treatment of certain neurodegenerative diseases, such as Alzheimer's disease. [ABSTRACT FROM AUTHOR]