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In this article, we discuss and reflect on the essential components of our concurrent session presentation at the American College of Lifestyle Medicine (ACLM) annual conference LM2023, "Implementing Lifestyle Medicine Competencies in Didactic and Clinical Settings for Allied Health Professionals." We illustrate the necessity of interdisciplinary lifestyle medicine approaches through a conscious fusion of analysis and storytelling. This review concludes with a call to action empowering the medical community to embrace interdisciplinary lifestyle medicine approaches in effort to increase access to equitable healthcare. [ABSTRACT FROM AUTHOR]

Background: Previous observational studies have linked circulating cytokines to sarcopenia, but their causal relationship remains unclear. This study employed Mendelian Randomization (MR) to investigate the causal links between circulating cytokines and sarcopenia‐related traits using genetic data. Methods: A two‐sample bidirectional MR analysis was conducted using data from individuals of European ancestry, utilizing genome‐wide association studies (GWAS) statistics. The study selected instrumental single nucleotide polymorphisms (SNPs) significantly associated with circulating cytokines and applied multiple MR methods, including inverse variance weighted (IVW), Weighted Median, MR‐Egger, Weighted Mode, Simple Mode, and MR‐PRESSO. The traits analyzed were appendicular lean mass (ALM) and grip strength. Heterogeneity, robustness, and consistency of results were assessed using Cochran's Q statistic, MR‐Egger regression, and "leave‐one‐out" sensitivity analyses. Results: The IVM‐MR analysis showed a casual association between genetically predicted circulating levels of interleukin‐16 and both ALM and grip strength (ALM: OR = 0.990, 95% CI: 0.980–1.000, p =.049; grip strength: OR = 0.971, 95% CI: 0.948–0.995, p =.020). Additionally, interferon‐gamma‐induced protein 10 (IP‐10), interleukin‐1‐beta (IL‐1β), and hepatocyte growth factor (HGF) were correlated with ALM and vascular endothelial growth factor (VEGF), interleukin‐12 (IL‐12), and interleukin‐5 (IL‐5) with grip strength. Comparable results were confirmed via the MR‐Egger, Weighted Median, Weighted Mode, and Simple Mode methods. Sensitivity analysis showed no horizontal pleiotropy to bias the causal estimates. Conclusion: The results suggest a significant causal effect of inflammatory cytokines on sarcopenia, offering new avenues for therapeutic target development. However, the study's focus on a European ancestry cohort limits its generalizability to other populations. Future research should aim to include diverse ethnic groups to validate and broaden these findings, thereby enhancing our understanding of sarcopenia's mechanisms in a global context. [ABSTRACT FROM AUTHOR]

This article explores the relationship between solar UV radiation, climate change, and plastic pollution. It highlights the role of UV-driven weathering in the degradation of plastics and the formation of harmful micro- and nanoplastic particles. The article emphasizes the need for global assessments of plastic dispersal, persistence, and weathering to consider these linkages. It also discusses the impact of the Montreal Protocol on plastic degradation and the potential effects of UV radiation and climate change on plastic pollution in the future. The article concludes by calling for further research and the development of new plastics with durability matching the functional life of products. [Extracted from the article]

This Assessment Update by the Environmental Effects Assessment Panel (EEAP) of the United Nations Environment Programme (UNEP) considers the interactive effects of solar UV radiation, global warming, and other weathering factors on plastics. The Assessment illustrates the significance of solar UV radiation in decreasing the durability of plastic materials, degradation of plastic debris, formation of micro- and nanoplastic particles and accompanying leaching of potential toxic compounds. Micro- and nanoplastics have been found in all ecosystems, the atmosphere, and in humans. While the potential biological risks are not yet well-established, the widespread and increasing occurrence of plastic pollution is reason for continuing research and monitoring. Plastic debris persists after its intended life in soils, water bodies and the atmosphere as well as in living organisms. To counteract accumulation of plastics in the environment, the lifetime of novel plastics or plastic alternatives should better match the functional life of products, with eventual breakdown releasing harmless substances to the environment. [ABSTRACT FROM AUTHOR]

The present communication introduces a modified high-performance supercapacitor electrode with chemically exfoliated MoS2@PANI nanocomposite as a solution for the upcoming energy needs. We put forward a chemical exfoliation route for increasing the effective surface area of hydrothermally synthesized MoS2, and effective encapsulation of a conducting polymer, polyaniline (PANI), was introduced via in-situ chemical oxidative polymerization of aniline monomer. The structural behaviors were systematically explored by X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR), and the surface characteristics were analyzed by Field emission scanning electron microscopy (FE-SEM), and Brunauer–Emmett–Teller (BET) surface area measurements. The effect of exfoliation on capacitive performance was analyzed by the electrochemical study of two material platforms, MoS2@PANI and MoS2 ex@PANI, in a weakly acidic medium of 1 M H3PO4. The unique structure of MoS2 ex@PANI nanocomposite maximizes the ionic contact between the exfoliated MoS2 and PANI with electrolyte, which synergistically combines the double-layer and pseudocapacitive behavior of the individual compounds, thereby improving the conductivity and energy storage performance. The binary exfoliated composite electrodes revealed an excellent specific capacitance of 277 F g−1 at a scan rate of 5 mV s−1 superior to that of the MoS2@PANI electrode. A symmetric supercapacitor device was successfully developed and achieved improved capacitance of 128 F g−1 with impressive cyclic stability (98%) even after 15,000 cycles. The MoS2 ex@PANI nanocomposite becomes a future solution for existing supercapacitor electrodes for energy storage in lightweight wearable electronics. [ABSTRACT FROM AUTHOR]

The consequences of warming-induced 'shrubification' on Arctic soil carbon storage are receiving increased attention, as the majority of ecosystem carbon in these systems is stored in soils. Soil carbon cycles in these ecosystems are usually tightly coupled with nitrogen availability. Soil microbial responses to 'shrubification' may depend on the traits of the shrub species that increase in response to warming. Increase in deciduous shrubs such as Betula nana likely promotes a loss of soil carbon, whereas the opposite may be true if evergreen shrubs such as Empetrum hermaphroditum increase. We analyzed soil organic matter stocks and 13C NMR fractions, microbial CO2 respiration, biomass, extracellular enzyme activities (EEAs), and their association with shrub density in northern Sweden after 20 years of experimental warming using open top chambers (OTCs). Our study sites were located in a tundra heath that stores high soil carbon quantities and where the OTCs had increased deciduous shrubs, and in a mountain birch forest that stores lower soil carbon quantities and where the OTCs had increased evergreen shrubs. We predicted that organic matter stocks should be lower and respiration and EEAs higher inside the OTCs than untreated plots in the tundra, whereas no effect should be detected in the forest. Soil organic matter stocks and 13C NMR fractions remained unaffected at both sites. When expressed as per gram microbial biomass, respiration and EEAs for carbohydrate and chitin degradation were higher inside the OTCs, and contrasting our prediction, this effect was stronger in the forest. Unexpectedly, the OTCs also led to a substantially lower microbial biomass carbon and nitrogen irrespective of habitat. The decline in the microbial biomass counteracted increased activities resulting in no effect of the OTCs on respiration and a lower phenol oxidase activity per gram soil. Microbial biomass nitrogen correlated negatively with evergreen shrub density at both sites, indicating that 'shrubification' may have intensified nutrient competition between plants and soil microorganisms. Nutrient limitation could also underlie increased respiration per gram microbial biomass through limiting C assimilation into biomass. We hypothesize that increasing nutrient immobilization into long-lived evergreen shrubs could over time induce microbial nutrient limitation that contributes to a stability of accumulated soil organic matter stocks under climate warming. [ABSTRACT FROM AUTHOR]

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Introduction: Sarcopenia is common in people 70+ years of age, and its prevalence increases with further aging. Insufficient energy and protein intake accelerates muscle loss, whereas sufficient protein intake and milk fat globule membrane (MFGM) may suppress age-associated deterioration of muscle mass and strength. Our objective was to test whether a snack product high in MFGM and protein would improve physical performance in older women. Methods: In this 12-week randomized controlled trial, women ≥ 70 years, with protein intake < 1.2 g/body weight (BW) kg/day (d), were randomized into intervention (n = 51) and control (n = 50) groups. The intervention group received a daily snack product containing ≥ 23 g of milk protein and 3.6–3.9 g of MFGM. Both groups were advised to perform a five-movement exercise routine. The primary outcome was the change in the five-time-sit-to-stand test between the groups. Secondary outcomes included changes in physical performance, cognition, hand grip strength, and health-related quality of life. Results: The change in the five-time-sit-to-stand test did not differ between the intervention and the control groups. The change in the total Short Physical Performance Battery score differed significantly, favoring the intervention group (p = 0.020), and the balance test showed the largest difference. Protein intake increased significantly in the intervention group (+14 g) compared to the control group (+2 g). No other significant changes were observed. Conclusions: Our results indicate that the combination of MFGM and protein may improve the physical performance-related balance of older women. [ABSTRACT FROM AUTHOR]

Background: Locally advanced oesophageal cancer can be treated with definitive chemoradiation (dCRT) or with neoadjuvant chemoradiation followed by surgery (nCRT + S), but treatment modality choice is not always clear. The aim of this study was to investigate the factors associated with the choice of treatment modality in locally advanced oesophageal cancer. Methods: This was a retrospective cohort study of 149 patients treated with dCRT(n = 85) or nCRT + S (n = 64) for oesophageal cancer in Helsinki University Hospital in 2008–2018. Logistic regression was used to analyse factors associated with choice of treatment modality and to compare dosimetric factors with postoperative complications. Multivariate analyses identified factors associated with survival. Results: Surgery was performed after chemoradiation as planned on 64/91 patients (70%). 28/64 had pathological complete response (44%). Probability of nCRT + S was higher in stages I-III versus IV (OR 3.62, 95% CI 1.53–8.53; P =.003), ECOG 0–1 versus 2 (OR 6.99, 95% CI 1.81–26.96; P =.005) or in the middle/lower vs upper oesophageal tumours (OR 5.61, 95% CI 1.83–17.16, P =.003). Probability for surgery was lower, if patient had lost > 10% of body weight (OR 0.46, 95% CI 0.21–0.98, P = 0.043). Patients in the nCRT + S group had significantly better median overall survival (mOS) and local control than the dCRT group (60 vs. 10 months, P <.001 and 53 vs. 6 months, P < 0.0001, respectively). 10/85 (12%) patients died within three months after dCRT. In multivariate analysis, nCRT + S was associated with improved mOS (HR 0.28, 95% CI 0.17–0.44, P <.001). Current smokers had worse mOS (HR 2.02, 95% CI 1.04–3.92, P =.037) compared to never-smokers. No significant dosimetric factor associated with postoperative complications was found. Conclusion: The overall clinical status of the patients and the stage of the cancer guide the choice of treatment modalities, leading to overtreatment. Patients with better prognoses were more likely operated after chemoradiation, although there is no evidence of OS benefit in previous randomized trials. On the other hand, the prognosis was poor for patients with poor general health and advanced cancers, despite the chemoradiation. Thus, there are signs of overtreatment. MDT practice should be recommended to optimise the choice of treatment modalities. Smoking status is an independent factor associated with survival. [ABSTRACT FROM AUTHOR]

T1r is an NMR relaxation mode that is sensitive to low frequency molecular motions, making it an especially valuable tool in biomolecular research. Here, we introduce a new method, SPICY, for measuring T1r relaxation times. In contrast to conventional T1r experiments, in which the sequence is repeated many times to determine the T1r time, the SPICY sequence allows determination of T1r within a single scan, shortening the experiment time remarkably. We demonstrate the method using 1H T1r relaxation dispersion experiments. Additionally, we combine the sequence with spatial encoding to produce 1D images in a single scan. We show that T1r relaxation times obtained using the single scan approach are in good agreement with those obtained using the traditional experiments. [ABSTRACT FROM AUTHOR]

Background and Objective: India, a highly heterogeneous country, has no common reference standards for predicting spirometry values, with very few recent studies from south India. This study aimed to create reference equations for rural south Indian adults, based on a population‑based survey in Vellore, south India and compare it with other equations from India. Methods: The data from 583 non‑smoking, asymptomatic participants (30 years and older) from a spirometry‑based survey for airflow obstruction (rural Vellore, 2018), were used to develop equations for FEV1, FEV1/FVC, and FVC. The dataset was divided for development (70%) and validation (30%), by gender. Differences between observed and predicted values were assessed using the new equations and comparisons made with other equations from India. Results: Predictions with Vellore rural equations were closest to the previous south Indian equations from urban Bangalore. However, the Bangalore equations led to overestimation of FVC values in males, and of both FEV1 and FVC values in females. Using the rural Vellore equations also led to a higher percent of males being classified as having airflow obstruction, compared to the Bangalore equations which underestimated airflow obstruction in this rural population. Comparison with previously derived Indian equations from other parts of the country showed pronounced variations. Conclusions: Our study reiterates the need for representative rural and urban studies of adults from various parts of India, to obtain region specific reference equations, given the wide variations in spirometry values in “normal” individuals, due to social heterogeneities of the Indian population and resulting complexities in defining normal. [ABSTRACT FROM AUTHOR]

Background: Health benefits of physical activity are very well acknowledged but the role of both occupational physical activity (OPA) and leisure time physical activity (LTPA) in recovery after work is not thoroughly understood. The purpose of this study was to investigate the association between accelerometer-measured OPA and LTPA and the need for recovery after work (NFR) in early childhood education and care (ECEC) professionals. Methods: The study participants were 217 female ECEC professionals aged 17–64. Physical activity was recorded with a three-axis accelerometer (ActiGraph GT9X Link, ActiGraph, USA) for seven consecutive days. Separate analyses were conducted for both OPA and LTPA and reported as hours/day based on different intensity levels (light, moderate, vigorous, very vigorous). The NFR was measured with the Need For Recovery (NFR) scale (0%–100%). Results: Participants' average physical activity for both OPA and LTPA was about 4 h/day, and the mean NFR score was 38.4%. OPA was significantly associated with the NFR but not with LTPA. The relationship remained significant after adjustments for age, body mass index, work ability, mental health status, and sleep difficulties (p < 0.024). Conclusion: According to this study, the OPA level is related to the level of the NFR in female ECEC professionals. Based on the results, it seems that LTPA has no relevance to the NFR. Results suggest that long-lasting OPA, even without strenuous physical activity at work, may predispose individuals to a high NFR. [ABSTRACT FROM AUTHOR]

tOBJECTIVES: To identify factors associated with nonresponse to neuromuscular training (NMT) warm-up programs among youth exposed to NMT warm-ups. tMETHODS: This is a secondary analysis of youth (aged 11-18 years) in the intervention groups of 4 randomized controlled trials in high school basketball, youth community soccer, and junior high school physical education. Youth who were exposed to NMT and who sustained an injury during the study were considered nonresponders. Odds ratios (ORs) were based on generalized estimating equations logistic regression controlling for clus- tering by team/class and adjusted for age, weight, height, balance performance, injury history, sex, and sport (soccer/basketball/physical education). tRESULTS: A total of 1793 youth were included. Youth with a history of injury in the previous year had higher odds (OR = 1.64; 95% CI: 1.14, 2.37) of injury during the study, and females were more likely (OR = 1.67; 95% CI: 1.21, 2.31) to sustain an injury than males who were participating in NMT. Age was not associated with the odds of sustaining an injury (OR = 1.10; 95% CI: 0.93, 1.30). Soccer players benefited most from greater adherence, with 81% lower odds of injury (OR = 0.19; 95% CI: 0.06, 0.57) when completing 3 NMT sessions a week compared with 1 session per week. tCONCLUSION: Factors associated with nonresponse to an NMT warm-up program were female sex, history of injury during the previous 12 months, and lower weekly NMT session adherence in some sports (soccer). [ABSTRACT FROM AUTHOR]

Eutectic mixtures and deep eutectic solvents (DESs) are promising green media for the pre-treatment of lignocellulose materials. They can be harnessed for the swelling of cellulose and further facilitate cellulose hydrolysis, derivatization, and production of cellulose-based (nano) materials. Several studies indicated that water can take part in the formation of the nanostructure of DES; however, it is still unclear how additional water influences many important properties and functioning of DES, especially when the molar ratio of compounds differs from the eutectic point composition. Here, viscosity, pH, conductivity, solvatochromic and solvatomagnetic solvent parameters, and fiber swelling capacity of choline chloride and urea mixtures demonstrating different molar ratios were investigated in the presence and absence of added water. The participation of water in the formation of molecular clusters with choline chloride and urea was indicated by viscosity, pH, and conductivity measurements. Hydrogen bond acceptor values of aqueous mixtures increased as a function of water content, and the results obtained using both methods were in line, indicating their suitability for the determination of hydrogen bond acidity of aqueous choline chloride–urea mixtures. However, hydrogen bond basicity determined by solvatochromic and magnetic methods exhibited almost opposite trends. The close investigation of the chemical shift of solvatomagnetic probes indicated that the chemical environment of the choline chloride–urea (1 : 2) mixture remained constant until the water content of 30 wt% was in line with previous molecular simulations. When cellulose fibers were treated with mixtures under mixing, the non-ideality of the choline chloride–urea mixture and the absence of water were found to be advantageous; however, aqueous mixtures efficiently increased the diameters of cellulose fibers in the absence of mixing, and water-containing mixtures appeared to be appealing systems for cellulose pretreatments. [ABSTRACT FROM AUTHOR]

Objective: To study the prevalence of different NPSLE manifestations in our cohort and to compare clinical and immunological features and outcomes including mortality of patients with NPSLE and SLE controls without NP involvement. Methods: This was a retrospective study in a tertiary care referral centre. All patients of SLE seen in the last 10 years and fulfilling the SLICC criteria with neuropsychiatric manifestations as per the ACR definitions were included. Patients of SLE without NP involvement were sequentially assigned as controls in a ratio of 1:2. Results: Of the 769 patients diagnosed with SLE from Jan 2011 to December 2020, 128 (16.6%) had NPSLE manifestations as per the ACR definitions. The commonest NPSLE manifestation was seizures (6.5%) followed by cerebrovascular accident (3.9%). NPSLE manifestation occurred at the first presentation of SLE in 99/128 (77.3%) patients and 58 (45.3%) patients had more than one NPSLE manifestation. Lupus anticoagulant and anticardiolipin antibody were tested in 120 patients and were positive in 16 (13.3%) and 12 (10%), respectively. No difference was found in anti-ribosomal p, lupus anticoagulant and anticardiolipin antibodies between the cases and controls. Twenty-one (16.4%) deaths occurred in patients with NPSLE (median follow-up of 40 months) as compared to 13 (5%) in controls (median follow-up of 32 months) (p = <0.001). The cumulative survival of patients with NPSLE was lower as compared to controls (p < 0.001). Relapse of NPSLE was seen in 11(8.6%) patients and was associated with mortality (p = 0.017). Conclusions: Seizures and cerebrovascular accidents are the commonest NPSLE syndromes in our patients. The presence of NPSLE was associated with high mortality in Indian patients with lupus. [ABSTRACT FROM AUTHOR]

Overall survival (OS) with advanced esophageal or gastric cancer is poor. To avoid overly aggressive treatments at the end-of-life and assure adequate end-of-life quality, the decision to focus on symptom-centered palliative care (PC) and terminate anticancer treatments, i.e., the PC decision, should be made in time. We reviewed the charts of patients (N = 160) with esophageal or gastric cancer treated at the Department of Oncology at Helsinki University Central Hospital in 2013 and deceased by December 2014. The use of acute services (Emergency department (ED) visits and hospitalizations) and places of death were compared according to the timing of the PC decision. Reasons for ED visits and hospitalizations were collected. The median OS from diagnosis of advanced cancer was 6 months. Anti-cancer treatments were never started for 34% of the patients. The PC decision was made early (>30 days before death) for 54% of the patients and late (≤30 days before death) or not at all for 46%. Patients with late or no PC decision died more often in tertiary/secondary hospital (29 versus 7%, p = 0.001) and had more ED visits (49 versus 29%, p < 0.001) and hospitalizations (53 versus 28%, p = 0.001) in their last month, and visited the PC unit less often (18 versus 69%, p < 0.001), than the patients with early PC decision. The ED visits were most commonly related to cancer progression, and clinical deterioration (17%), fever (16%), and dysphagia (15%) were the most common symptoms. The decision to focus on PC and terminate anticancer treatments, i.e., the PC decision, was made late or not at all in every other patient, leading to increased tertiary/secondary hospital service use and deaths at tertiary/secondary hospital. Early decision-making increased end-of-life care at specialized PC services or at home, implying better end-of-life care. [ABSTRACT FROM AUTHOR]

Neuromuscular training (NMT) warm-up programs effectively prevent injuries in youth, but monitoring exercise fidelity is challenging. The purpose of this study was to compare the exercise fidelity as measured via an inertial measurement unit (IMU) with direct observations of selected exercises. Youth basketball and soccer players performed single leg jumps, squat jumps, Nordic hamstring curls, and/or single leg balance exercises as part of an NMT warm-up. An IMU was placed on the lower back of each participant and the warm-up was video recorded. A physiotherapist evaluated the volume aspect of exercise fidelity (i.e., performing the prescribed number of repetitions) using the video recordings and a checklist. Algorithms were developed to count the number of repetitions from the IMU signal. The repetitions from the algorithms were compared with the physiotherapist's evaluation, and accuracy, precision, and recall were calculated for each exercise. A total of 91 (39 female, 52 male) athletes performed at least one of the four warm-up exercises. There was an accuracy, precision, and recall of greater than 88% for all exercises. The single leg jump algorithm classified all sets correctly. IMUs may be used to quantify exercise volume for exercises that involve both impact during landing and changes in orientation during rotations. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate sport-related injury rates, types, locations, and mechanisms in female youth team sports. This was a secondary analysis of a cross-sectional study. An anonymous online survey was administered to high school students (ages 14-19) in Alberta, Canada. The survey included questions regarding demographic information, sport participation and self-reported injuries sustained in the past year. Results were analyzed for girls who reported playing a top ten team sports for female participation. For girls participating in team sports, the overall injury rate was 55.5 injuries/100 participants/year. The rate of at least one concussion was 9.4 concussions/100 participants/year. Injury and concussion rates were highest in ringette (Injury rate=42.9 injuries/100 participants/year, Concussion rate=19.0 concussions/100 participants/year) and rugby (Injury rate=40.0, Concussion rate=15.3). The top three most serious injury locations were the knee (24.7%), ankle (21.6%) and head (16.1%). The most common injury types were joint/ligament sprain (26.71%), fracture (13.0%) and concussion (11.8%). Contact mechanisms accounted for 73.4% of all serious injuries reported in girls team sports. Team sport injury rates are high in female youth team sports. Specific consideration of sport-specific injury rates, types and mechanisms in girls' team sports will inform development and evaluation of targeted sport-specific prevention strategies. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To evaluate the effectiveness of a neuromuscular training warm-up prevention program, Surveillance in High school and community sport to Reduce (SHRed) Injuries Basketball, for reducing all-complaint ankle and knee injuries in youth basketball players. DESIGN: Quasi-experimental study. METHODS: High school/club basketball teams (male and female players aged 11-18 years) in Calgary, Canada participated in 2016-2017 (control; season 1) and 2017-2018 (intervention; season 2). The control season included a standard-of-practice warm-up. In season 2, a SHRed Injuries Basketball coach workshop was completed by participating team coaches. Teams were randomized by school/club to an unsupervised or a supervised (weekly supervision by study personnel) implementation of the coach-delivered SHRed Injuries Basketball program. The 10-minute SHRed Injuries Basketball program included 13 exercises (ie, aerobic, agility, strength, balance). All-complaint ankle and knee injuries were collected weekly using validated injury surveillance. Multilevel, multivariable Poisson regression analyses (considering important covariates, clustering by team and individual, and offset by exposure hours) estimated incidence rate ratios (IRRs) by intervention group (season 1 versus season 2) and secondarily considered the control versus completion of the SHRed Injuries Basketball program, unsupervised and supervised. RESULTS: Sixty-three teams (n = 502 players) participated in season 1 and 31 teams (n = 307 players: 143 unsupervised, 164 supervised) participated in season 2. The SHRed Injuries Basketball program was protective against all-complaint knee and ankle injuries (IRR = 0.64; 95% confidence interval [CI]: 0.51, 0.79). Unsupervised (IRR = 0.62; 95% CI: 0.47, 0.83) and supervised (IRR = 0.64; 95% CI: 0.49, 0.85) implementations of the SHRed Injuries Basketball program had similar protective effects. CONCLUSION: The SHRed Injuries Basketball program was associated with a 36% lower rate of ankle and knee injuries. Neuromuscular training warm-ups are recommended as the minimal standard of practice for injury prevention in youth basketball. [ABSTRACT FROM AUTHOR]

In this study, the effect of the deep eutectic solvent (DES) based on triethylmethylammonium chloride and imidazole on the mechanochemical succinylation of sawdust was investigated. The sawdust was ball milled in the presence of succinic anhydride and the effects of different amounts of the DES on the carboxylic acid content and particle size were studied with and without post-heating. The carboxylic acid content significantly increased with the addition of the DES and by using 1.5 mass excess of the DES compared to sawdust; milled sawdust with 3.5 mmol/g of carboxylic acid groups was obtained using 60 min post-heating at 100 °C. The particle size was found to depend strongly on DES-to-wood ratio and a change in size-reduction characteristics was observed related to fiber saturation point. After mechanochemical milling, three succinylated sawdust samples with different carboxylic acid contents were disintegrated into wood nanofibers and self-standing films were produced. Although the mechanical properties of the films were lower than the cellulose nanofibers, they were higher or in line with oil- and biobased polymers such as polypropene and polylactic acid, respectively. Because of their amphiphilic nature, wood nanofibers were found to be effective stabilizers of water–oil emulsions. [ABSTRACT FROM AUTHOR]

Background: Early detection of breast and cervical cancer by organized screening has been found to reduce mortality rates in trials, but documentation of programme results and challenges is rarely done from non-trial settings. This study reports results of a population-based cancer control programme in a rural block in Vellore, Tamil Nadu, population size (116,085), targeting a population of 18,490 women aged 25-60 years, between November 2014 and March 2018.Methods: Village-based health education sessions were conducted by social workers, using trained volunteers and health workers to motivate eligible women. Screening was done at a secondary level hospital, by trained general physicians using visual inspection with acetic acid and clinical breast examination, followed by colposcopy, radiological imaging (breast) and biopsy as required.Results: A total of 8 volunteers and 17 health workers motivated women for 93 health education and screening sessions, in 46 out of 82 villages. While 1,890/18,490 (10.2 per cent) were screened for breast cancer, 1,783 (9.6 per cent) were screened for cervical cancer, with a yield of 3.4/1,000 for cervical pre-cancer/cancer. The main challenges were creating time for screening activities in a busy secondary hospital and difficulty in ensuring treatment completion of screen-detected cases.Conclusions: Population-based cancer screening programs can be offered by secondary hospitals that also run primary care services, to increase screening rates. Clear referral systems need to be established, bearing in mind that social factors, especially poor family support, may pose a threat to treatment, in spite of easy availability of cure. [ABSTRACT FROM AUTHOR]

Background: Prevention of sports injuries is essential in youth, as injuries are associated with less future physical activity and thus greater all-cause morbidity. Purpose: To investigate whether a neuromuscular training warm-up operated by team coaches is effective in preventing acute lower extremity (LE) injuries in competitive U11-U14 soccer players. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Twenty top-level U11 to U14 soccer clubs in Finland were randomized into intervention and control groups and assessed for 20 weeks. Participants included 1403 players (280 female, 1123 male; age range, 9-14 years): 673 players (44 teams) in the intervention group and 730 players (48 teams) in the control group. The intervention group team coaches were introduced to a neuromuscular training warm-up to replace the standard warm-up 2 to 3 times per week. The control teams were asked to perform their standard warm-up. Injury data collection was done via weekly text messages. The primary outcome measure was a soccer-related acute LE injury, and the secondary outcome measure was an acute noncontact LE injury. Results: A total of 656 acute LE injuries occurred: 310 in the intervention group and 346 in the control group. The overall acute LE injury incidence was 4.4 per 1000 hours of exposure in the intervention group and 5.5 per 1000 hours of exposure in the control group, with no significant difference between groups (incidence rate ratio [IRR], 0.82 [95%CI, 0.64-1.04]). There were 302 acute noncontact LE injuries: 129 in the intervention group (incidence, 1.8 per 1000 hours) and 173 in the control group (2.7 per 1000 hours). A significant reduction in acute noncontact LE injuries of 32% (IRR, 0.68 [95% CI, 0.51-0.93]) was observed in the intervention group compared with the control group. Furthermore, significant reductions in injury incidence in favor of the intervention group were seen in the subanalyses of acute noncontact LE injuries, leading to 7 days of time loss and fewer ankle and joint/ligament injuries. Conclusion: A neuromuscular training warm-up operated by team coaches was found to be effective in preventing acute noncontact LE injuries in children's soccer, but this was not seen in all acute LE injuries. [ABSTRACT FROM AUTHOR]

Keywords: climate change; ecosystems; human health; Montreal Protocol; stratospheric ozone; sustainability; ultraviolet radiation; UV-B EN climate change ecosystems human health Montreal Protocol stratospheric ozone sustainability ultraviolet radiation UV-B 5681 5683 3 10/19/21 20211115 NES 211115 The Montreal Protocol and its Amendments have been highly effective in protecting the stratospheric ozone layer, preventing global increases in solar ultraviolet-B radiation (UV-B; 280-315 nm) at Earth's surface, and reducing global warming. Climate change, ecosystems, human health, Montreal Protocol, stratospheric ozone, sustainability, ultraviolet radiation, UV-B. [Extracted from the article]

OBJECTIVES: To (1) identify the wearable devices and associated metrics used to monitor workload and assess injury risk, (2) describe the situations in which workload was monitored using wearable technology (including sports, purpose of the analysis, location and duration of monitoring, and athlete characteristics), and (3) evaluate the quality of evidence that workload monitoring can inform injury prevention. DESIGN: Scoping review. LITERATURE SEARCH: We searched the CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Embase, HealthSTAR, MEDLINE, PsycINFO, SPORTDiscus, and Web of Science databases. STUDY SELECTION CRITERIA: We included all studies that used wearable devices (eg, heart rate monitor, inertial measurement units, global positioning system) to monitor athlete workload in a team sport setting. DATA SYNTHESIS: We provided visualizations that represented the workload metrics reported, sensors used, sports investigated, athlete characteristics, and the duration of monitoring. RESULTS: The 407 included studies focused on team ball sports (67% soccer, rugby, or Australian football), male athletes (81% of studies), elite or professional level of competition (74% of studies), and young adults (69% of studies included athletes aged between 20 and 28 years). Thirty-six studies of 7 sports investigated the association between workload measured with wearable devices and injury. CONCLUSION: Distance-based metrics derived from global positioning system units were common for monitoring workload and are frequently used to assess injury risk. Workload monitoring studies have focused on specific populations (eg, elite male soccer players in Europe and elite male rugby and Australian football players in Oceania). Different injury definitions and reported workload metrics and poor study quality impeded conclusions regarding the relationship between workload and injury. [ABSTRACT FROM AUTHOR]

Research indicates that nature offers many physical and mental health benefits, including restoration - or recovery from mental fatigue. However, questions remain about what exactly in one's environment is experienced as restorative and why. Bridging environmental aesthetics, environmental psychology and cultural studies, this study establishes a connection between landscape and mindscape as seen, for instance, in the ways in which an orderly environment is interpreted as an orderly state of mind and vice versa. Using data drawn from a qualitative survey targeting expatriate Finns, the article mobilises content analysis to interpret the results and concludes that a 'favourite place' is aesthetically appealing, enables actions that are experienced as restorative and is as much an interpretation of a space as a physical place. [ABSTRACT FROM AUTHOR]

Lignin modification opens the possibility of using it in polyol bio-based polymers, such as phenol–formaldehyde resins, polyurethanes, composites, and binders. Pine kraft lignin Indulin AT was partially depolymerized and the resulting products analyzed to determine their degree of valorization. Depolymerized lignin products were analyzed by GPC-SEC (molar mass), ∆ε-IDUS (phenolic hydroxyls), HACL (formaldehyde uptake), 13C-NMR (hydroxyl and methoxyl groups), and 1H-DOSY (molar mass distribution). The dominant parameter in lignin depolymerization by solvolysis was reaction temperature. According to the results, a higher reaction temperature decreases the average molar masses and PDI of lignin as well as the primary and secondary aliphatic hydroxyls, while simultaneously increasing the phenolic hydroxyls and formaldehyde uptake of lignin. Other variables (time, formic acid wt %, ethanol wt %, lignin load) had lesser effects. Partial depolymerization by solvolysis in mild conditions without catalyst is a viable valorization route for lignin, by which lignin properties can be significantly improved. [ABSTRACT FROM AUTHOR]

* OBJECTIVE: To investigate the association between lower extremity alignment during unilateral and bilateral drop jump tests and the risk of acute noncontact knee or ankle injuries in young team sport athletes, * DESIGN: Prospective cohort study. * METHODS: A 2-dimensional video analysis was used to measure the frontal plane knee projection angle in the single-leg vertical drop jump (VDJ) and the bilateral VDJ in young team sport athletes. Out of the 364 athletes (187 male, 177 female), 189 played basketball and 175 played floorball. * RESULTS: Six male athletes sustained knee injuries and 23 sustained ankle injuries. Frontal plane knee projection angle in the single-leg VDJ or the bilateral VDJ was not associated with ankle injuries among male athletes. No statistical analysis was performed for the knee injuries. Among female athletes, 28 sustained knee and 41 sustained ankle injuries. Frontal plane knee projection angle during the single-leg VDJ or the bilateral VDJ was not a risk factor for knee or ankle injuries. * CONCLUSION: Lower extremity alignment during unilateral and bilateral drop jump tests was not associated with future noncontact knee or ankle injuries among young team sport athletes. The findings should be interpreted cautiously due to the small number of injuries. [ABSTRACT FROM AUTHOR]

Nuclear shielding and chemical shift are considered independent of the magnetic-field strength. Ramsey proposed on theoretical grounds in 1970 that this may not be valid for heavy nuclei. Here we present experimental evidence for the direct field dependence of shielding, using 59Co shielding in Co(acac)3 [tris(acetylacetonate)cobalt(III)] as an example. We carry out NMR experiments in four field strengths for this low-spin diamagnetic Co(III) complex, which features a very large and negative nuclear shielding constant of the central Co nucleus. This is due to a magnetically accessible, low-energy eg ← t2g orbital excitation of the d6 system. The experiments result in temperature-dependent magnetic-field dependence of −5.7 to −5.2 ppb T−2 of the 59Co shielding constant, arising from the direct modification of the electron cloud of the complex by the field. First-principles multiconfigurational non-linear response theory calculations verify the sign and order of magnitude of the experimental results. [ABSTRACT FROM AUTHOR]

Research supports that exposure to stressors (e.g., perceived stress and racism) during pregnancy can negatively impact the immune system, which may lead to infection and ultimately increases the risk for having a preterm or low‐birthweight infant. It is well known that Black women report higher levels of stressors at multiple timepoints across pregnancy compared with women of all other racial and ethnic groups. This study addresses gaps in the literature by describing pregnant and early post‐partum Black women's exposures to structural racism and self‐reported experiences of racial discrimination, and the extent to which these factors are related. We used a cross‐sectional study design to collect data related to exposures to racism from pregnant and early post‐partum Black women residing in Oakland, California, from January 2016 to December 2017. Comparative analysis revealed that living in highly deprived race + income neighborhoods was associated with experiencing racial discrimination in three or more situational domains (p =.01). Findings show that Black women are exposed to high levels of racism that may have negative impacts on maternal health outcomes. [ABSTRACT FROM AUTHOR]

Purpose: This study reviews the literature on business-school (b-school) competition and competitiveness to extend our understanding of b-schools' competitive strategies. Design/methodology/approach: Both content and network analysis were used in the examination of the scholarly discourse. Findings: The analyses distinguish three literature streams. The first concentrates on resources, capabilities and competencies; the second focuses on measures of competitiveness; and the third includes competitive dynamics and strategy discourse. The analysis shows that the conceptions of competitiveness are quite coherent concerning resources, capabilities and competencies. However, in the "measures of competitiveness" and "industry dynamics and strategy," discourses were more diverse, indicating greater ambiguity in how the core competencies, capabilities and resources are portrayed as competitiveness outside the institutions. The literature suggests that the measures and indicators of competitiveness are ambiguous to external stakeholders and, furthermore, reflect institutional goal ambiguity. Originality/value: The question of how, and to what extent, increasing competition in management education and research catalyzes unwelcome changes in the industry has been of great concern to management educators and scholars. This has given rise to a considerable body of literature referring to b-school competition. Despite its topicality, this discourse has remained theoretically fragmented and separate from the mainstream strategy literature. Therefore, this study provides a review and critical discussion of the current state of research on b-school competition, as well as proposes avenues for future research and tools for strategic management of b-schools. [ABSTRACT FROM AUTHOR]

Background: The purpose of this study was to investigate the prevalence of adolescent physical activity-related injuries in sports club activities, leisure time physical activity and school-based physical activity. The secondary aim was to investigate the differences in the prevalence of physical activity -related injuries between years 2014 and 2016. In addition, we set out to study the associations between age, sex and the frequency of physical activity and injury prevalence.Methods: This cross-sectional study is based on the National Physical Activity Behaviour Study for Children and Adolescents (LIITU in Finnish) conducted in years 2014 and 2016. The subjects completed an online questionnaire in the classroom during school hours. A total of 8406 subjects participated in the current study. Out of these, 49% were boys and 51% were girls. The proportions of 11-, 13-, and 15-year-olds were 35%, 34% and 31%, respectively.Results: In the combined data for 2014 and 2016, injury prevalence was higher in sports club activities (46%, 95% CI 44.8-47.8) than in leisure time PA (30%, 95% CI, 28.5-30.5) or school-based PA (18%, 95% CI, 17.4-19.1). In leisure time PA, the injury prevalence was higher than in school-based PA. In all the three settings, injury prevalence was higher in 2016 than in 2014. Frequency of PA was associated with a higher risk for PA-related injuries in sports clubs and leisure time.Conclusions: With half of the subjects reporting at least one PA-related injury during the past year, results indicate that adolescent PA-related injuries are a large-scale problem. There is a worrisome rise in injury prevalence in recent years. From a public health standpoint, there is an urgent need to invest in injury prevention to reverse this trend. [ABSTRACT FROM AUTHOR]

Premature contraction of the uterus is the very first sign of premature labour, which is followed by progressive changes in cervix such as effacement and dilatation. Four or more uterine contractions with or without pain per hour is a major biophysical predictor of preterm labour. According to the WHO statistics, every year, an estimated 15 million babies are born preterm and this number is rising. Although tocolytic agents are used to suppress premature contractions and prevent preterm labour, it is not proven to be efficacious in preventing preterm birth or reducing neonatal mortality or morbidity. As per Ayurveda, Akala Prasava (preterm labour) results due to the malfunctioning of Apana Vata (a type of Vata Dosha which is responsible for the excretory action). Basti (medicated enema therapy) is considered the best for managing the deranged Apana Vata. Basti is also indicated in Garbhini Paricharya (routine antenatal care) after completion of seven months of pregnancy. In this present case study, Shatavaryadi Ksheerapaka Basti (medicated enema prepared along with milk) was administered in a 28 year old second gravida patient of 33 weeks gestation with premature contractions, wherein isoxsuprine hydrochloride proved to be ineffective. Per-rectal Basti with 450 ml Shatavaryadi Ksheerapaka administered for 2 consecutive days was found to be effective in preventing the uterine contractions and further advancement to preterm labour. The drugs in Shatavaryadi Ksheerapaka Basti possess antioxytocic and vasodilating properties which may effectively curtailed the progress of premature contractions. [ABSTRACT FROM AUTHOR]

The amount of hydroxyl groups, particularly phenolic, is one of the most important parameters in lignins, as it is an indicator of lignin reactivity. Ultraviolet (UV) Spectrophotometry is a simple and inexpensive method for determining phenolic hydroxyls in lignin. Ionization Difference Ultraviolet Spectrophotometry (Δε-method) relies on the analysis of solubilized lignin at neutral and alkaline conditions with a UV spectrophotometer. We added a slope analysis to the ∆ε-method and dubbed the resulting method ∆ε-IDUS (Ionization Difference UV Spectrophotometry). We assessed the reliability of ∆ε-IDUS by studying the well-known Indulin AT lignin. Additionally, ∆ε-IDUS was applied to a previously uncharacterized milox lignin. When compared to 13C-NMR, ∆ε-IDUS underestimated the amount of phenolic hydroxyls for Indulin AT, possibly due to neglecting second phenolic hydroxyls in some lignin units, which resist ionization because of steric hindrance. Nevertheless, the results agreed with previously reported values and confirm that ∆ε-IDUS is useful to screen lignins based on their phenolic hydroxyl group content. [ABSTRACT FROM AUTHOR]

Understanding the consequences of extreme climatic events is a growing challenge in ecology. Climatic extremes may differentially affect varying elements of biodiversity, and may not always produce ecological effects exceeding those of 'normal' climatic variation in space and time. We asked how the extreme drought years of 2013-2014 affected the cover, species richness, functional trait means, functional diversity, and phylogenetic diversity of herbaceous plant communities across the California Floristic Province. We compared the directions and magnitudes of these drought effects with expectations from four 'pre-drought' studies of variation in water availability: (1) a watering experiment, (2) a long-term (15-yr) monitoring of interannual variability, (3) a resampling of historic (57-yr-old) plots within a warming and drying region, and (4) natural variation in communities over a broad geographic gradient in precipitation. We found that the drought was associated with consistent reductions in species richness and cover, especially for annual forbs and exotic annual grasses, but not with changes in functional or phylogenetic diversity. Except for total cover and cover of exotic annual grasses, most drought effects did not exceed quantitative expectations based on the four pre-drought studies. Qualitatively, plant community responses to the drought were most concordant with responses to pre-drought interannual rainfall variability in the 15-yr monitoring study, and least concordant with responses to the geographic gradient in precipitation. Our results suggest that, at least in the short term, extreme drought may cause only a subset of community metrics to respond in ways that exceed normal background variability. [ABSTRACT FROM AUTHOR]

We investigated the effects of fermented milk product containing isoleucine–proline–proline, valine–proline–proline and plant sterol esters (Pse) on plasma lipids, blood pressure (BP) and its determinants systemic vascular resistance and cardiac output. In a randomised, double-blind, placebo-controlled study, 104 subjects with the metabolic syndrome (MetS) were allocated to three groups in order to receive fermented milk product containing (1) 5 mg/d lactotripeptides (LTP) and 2 g/d plant sterols; (2) 25 mg/d LTP and 2 g/d plant sterols; (3) placebo for 12 weeks. Plasma lipids and home BP were monitored. Haemodynamics were examined in a laboratory using radial pulse wave analysis and whole-body impedance cardiography in the supine position and during orthostatic challenge. There were no differences between the effects of the two treatments and placebo on the measurements of BP at home or on BP, systemic vascular resistance index and cardiac index in the laboratory, neither in the supine nor in the upright position. The changes in plasma LDL-cholesterol concentration were − 0·1 (95 % CI − 0·3, 0·1 and − 0·3, 0·0) mmol/l in the 5 and 25 mg/d LTP groups, respectively, and +0·1 (95 % CI − 0·1, 0·3) mmol/l during placebo (P= 0·024). Both at baseline and at week 12, the increase in systemic vascular resistance during head-up tilt was lower in the 25 mg/d LTP group than in the 5 mg/d LTP group (P< 0·01), showing persistent differences in cardiovascular regulation between these groups. In subjects with the MetS, intake of LTP and Pse in fermented milk product showed a lipid-lowering effect of borderline significance, while no antihypertensive effect was observed at home or in the laboratory. [ABSTRACT FROM PUBLISHER]

It has previously been demonstrated that the advance of the Neolithic Revolution from the Near East through Europe was decelerated in the northernmost confines of the continent, possibly as a result of space and resource competition with lingering Mesolithic populations. Finland was among the last domains to adopt a farming lifestyle, and is characterized by substructuring in the form of a distinct genetic border dividing the northeastern and southwestern regions of the country. To explore the origins of this divergence, the geographical patterns of mitochondrial and Y-chromosomal haplogroups of Neolithic and Mesolithic ancestry were assessed in Finnish populations. The distribution of these uniparental markers revealed a northeastern bias for hunter-gatherer haplogroups, while haplogroups associated with the farming lifestyle clustered in the southwest. In addition, a correlation could be observed between more ancient mitochondrial haplogroup age and eastern concentration. These results coupled with prior archeological evidence suggest the genetic northeast/southwest division observed in contemporary Finland represents an ancient vestigial border between Mesolithic and Neolithic populations undetectable in most other regions of Europe. [ABSTRACT FROM AUTHOR]