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Objective: To analyze the association of various factors in terms of pathological response among breast cancer patients. Study Design: Cross-sectional study. Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Jan 2019 to Jun 2020. Methodology: This study was conducted on 82 female patients with advanced breast cancer who required neo-adjuvant chemotherapy followed by surgical tumour resection. The pathological response was classed as complete, partial, and no response based on histological findings on resected tumour sample. In addition, the age of the patient, stage of disease at presentation, intrinsic (molecular) subtypes and pathological subtype were the factors correlated with response to treatment in the target population. Results: A total of 82 female patients were included in the final analysis. The mean age of the patients was 47.421±8.857 years. 27(32.9%) had a complete pathological response, 34(41.5%) had partial, and 21(25.6%) had no response to the neoadjuvant therapy. Intrinsic subtypes of the tumour were statistically significantly associated with pathological response to neoadjuva nt therapy (p-value<0.05) in our study participants. Conclusion: Considerable number of patients with advanced breast cancer showed pathological responses to neoadjuvant chemotherapy. In addition, intrinsic subtyping significantly predicted pathological response to therapy in our patients, with triple-negative patients having more chances of complete response to neoadjuvant chemotherapy. [ABSTRACT FROM AUTHOR]

Objectives: To study the anatomical and histomorphological pattern of extranodal non Hodgkin`s lymphoma (NHL). Study Design: Descriptive study Place and Duration of Study: The study was carried out at Oncology department Combined Military Hospital Rawalpindi during July 2012 to April 2013. Materials and Methods: All newly diagnosed patients of NHL with extranodal involvement were included in the study. They were categorized as primary extranodal or secondary extranodal lymphomas. Histological pattern and site of involvement were studied. Results: The male to female ratio was 2.2:1 (Male 31, Female 14), and the mean age was 48.16 years (SD=13.40). Primary extranodal involvement was seen in 55.6% of patients. Secondary extranodal involvement was seen in 44.4% of patients. Diffuse large B- cell lymphoma (DLBCL) was the most common type of NHL observed in both primary and secondary extranodal involvement. Gastrointestinal tract was the most common site for primary extranodal involvement and bone marrow was the most common site for secondary extranodal involvement. Conclusion: High frequency of primary extranodal involvement was noted in our study. DLBCL was the most common morphological type observed. Gastrointestinal tract and secondary bone marrow involvement were the most common anatomical sites for primary and secondary extranodal involvement respectively. [ABSTRACT FROM AUTHOR]