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Purpose: The exact nature of sex and gender differences in knee osteoarthritis (OA) among patient candidates for total knee arthroplasty (TKA) remains unclear and requires better elucidation to guide clinical practice. The purpose of this investigation was to survey physician practices and perceptions about the influence of sex and gender on knee OA presentation, care, and outcomes after TKA. Methods: The survey questions were elaborated by a multidisciplinary scientific board composed of 1 pain specialist, 4 orthopedic specialists, 2 physiatrists, and 1 expert in gender medicine. The survey included 5 demographic questions and 20 topic questions. Eligible physician respondents were those who treat patients during all phases of care (pain specialists, orthopedic specialists, and physiatrists). All survey responses were anonymized and handled via remote dispersed geographic participation. Results: Fifty-six physicians (71% male) accepted the invitation to complete the survey. In general, healthcare professionals expressed that women presented worse symptomology, higher pain intensity, and lower pain tolerance and necessitated a different pharmacological approach compared to men. Pain and orthopedic specialists were more likely to indicate sex and gender differences in knee OA than physiatrists. Physicians expressed that the absence of sex and gender-specific instruments and indications is an important limitation on available studies. Conclusions: Healthcare professionals perceive multiple sex and gender-related differences in patients with knee OA, especially in the pre- and perioperative phases of TKA. Sex and gender bias sensitivity training for physicians can potentially improve the objectivity of care for knee OA among TKA candidates. [ABSTRACT FROM AUTHOR]

This paper investigates the performance of flax textile–reinforced mortars (FTRM) as a retrofitting solution for unreinforced masonry. Six medium-scale walls were subjected to in-plane cyclic shear tests. Four of the specimens were retrofitted on both sides with one or two layers of flax textiles embedded in lime-based mortar. One bare wall and one wall strengthened only with lime-based mortar were examined as reference samples. FTRM provided up to 118% higher shear load and ultimate drift and promoted the development of energy dissipation mechanisms, while ensuring structural integrity. Based on the experimental evidence, the contribution of individual shear resisting mechanisms was assessed and existing design models were found to overestimate the stress that can be developed in the flax textile when two layers were applied. A new design model that adopts a more rational limiting strain value and accounts for the contribution of the mortar and the unique mechanical performance of FTRM systems was proposed and validated against an experimental database, including natural and advanced textile-reinforced mortar systems. [ABSTRACT FROM AUTHOR]

Due to the COVID-19 pandemic, universities across the world have curtailed face to face teaching. Associated with this is the halt to the delivery of the practical experience required of engineering students. The Multidisciplinary Engineering Education (MEE) team at The University of Sheffield have responded to this problem in an efficient and effective way by recording laboratory experiences and putting videos, quizzes and data online for students to engage with. The focus of this work was on ensuring all Learning Outcomes (LOs) for modules and courses were preserved. Naturally, practical skills cannot be easily provided using this approach, but it is an effective way of getting students to interact with real data, uncertainty and equipment which they cannot access directly. A number of short case studies from across the range of engineering disciplines are provided to inspire and guide other educators in how they can move experiments on line in an efficient and effective manner. No student feedback is available at the time of writing, but anecdotal evidence is that this approach is at least acceptable for students and a way of collecting future feedback is suggested. The effort expended on this approach and the artefacts produced will support student learning after the initial disruption of the lockdown has passed. [ABSTRACT FROM AUTHOR]

Purpose: Single-limb stance is a demanding postural task featuring a high number of daily living and sporting activities. Thus, it is widely used for training and rehabilitation, as well as for balance assessment. Muscle activations around single joints have been previously described, however, it is not known which are the muscle synergies used to control posture and how they change between conditions of normal and lack of visual information. Methods: Twenty-two healthy young participants were asked to perform a 30 s single-limb stance task in open-eyes and closed-eyes condition while standing on a force platform with the dominant limb. Muscle synergies were extracted from the electromyographical recordings of 13 muscles of the lower limb, hip, and back. The optimal number of synergies, together with the average recruitment level and balance control strategies were analyzed and compared between the open- and the closed-eyes condition. Results: Four major muscle synergies, two ankle-dominant synergies, one knee-dominant synergy, and one hip/back-dominant synergy were found. No differences between open- and closed-eyes conditions were found for the recruitment level, except for the hip/back synergy, which significantly decreased (p = 0.02) in the closed-eyes compared to the open-eyes condition. A significant increase (p = 0.03) of the ankle balance strategy was found in the closed-eyes compared to the open-eyes condition. Conclusion: In healthy young individuals, single-limb stance is featured by four major synergies, both in open- and closed-eyes condition. Future studies should investigate muscle synergies in participants with other age groups, as well as pathological conditions. [ABSTRACT FROM AUTHOR]

Background: Microalgae are coming to the spotlight due to their potential applications in a wide number of fields ranging from the biofuel to the pharmaceutical sector. However, several factors such as low productivity, expensive harvesting procedures and difficult metabolite extractability limit their full utilization at industrial scale. Similarly to the successful employment of enzymatic arsenals from lignocellulolytic fungi to convert lignocellulose into fermentable sugars for bioethanol production, specific algalytic formulations could be used to improve the extractability of lipids from microalgae to produce biodiesel. Currently, the research areas related to algivorous organisms, algal saprophytes and the enzymes responsible for the hydrolysis of algal cell wall are still little explored. Results: Here, an algal trap method for capturing actively growing microorganisms was successfully used to isolate a filamentous fungus, that was identified by whole-genome sequencing, assembly and annotation as a novel Penicilliumsumatraense isolate. The fungus, classified as P.sumatraense AQ67100, was able to assimilate heat-killed Chlorellavulgaris cells by an enzymatic arsenal composed of proteases such as dipeptidyl- and amino-peptidases, β-1,3-glucanases and glycosidases including α- and β-glucosidases, β-glucuronidase, α-mannosidases and β-galactosidases. The treatment of C.vulgaris with the filtrate from P.sumatraense AQ67100 increased the release of chlorophylls and lipids from the algal cells by 42.6 and 48.9%, respectively. Conclusions: The improved lipid extractability from C.vulgaris biomass treated with the fungal filtrate highlighted the potential of algal saprophytes in the bioprocessing of microalgae, posing the basis for the sustainable transformation of algal metabolites into biofuel-related compounds. [ABSTRACT FROM AUTHOR]

Background: Considerable attention has been paid to the role of kinesiophobia with respect to knee prosthesis but it has not yet been studied as a prognostic factor of short-term functional performance following total hip replacement. The main purpose of the present study is to examine the possible predictors of early functional performance of patients undergoing total primary hip arthroplasty, including demographics as age, sex and body mass index, preoperative functional ability, type of anaesthesia, level of haemoglobin, pain and level of kinesiophobia before surgery. Secondly, we want to describe the main characteristics of the population with the highest levels of kinesiophobia.Methods: A prospective, prognostic cohort study was carried out. Patients undergoing primary hip replacement were recruited consecutively. The main outcome is the early functional performance achieved by patients after surgery and measured using the Iowa Level of Assistance (ILOA) scale on the fifth postoperative day. Preoperative kinesiophobia was measured by the Tampa Scale and the preoperative functional ability by the Western Ontario and McMaster Osteoarthritis Index (WOMAC). The multivariate analysis was performed by the General Linear Model. The analysis of the population with high levels of kinesiophobia was conducted by identifying a cut-off of 40 compared to the Tampa Scale.Results: Statistical analysis was performed on 269 patients. The average ILOA score recorded was 19.5 (DS 8.3). The levels of kinesiophobia, showed an average score of 35.1 (7.8) and it was not associated with early functional performance. The independent predictive factors include age, sex and body mass index. Kinesiophobia high levels were recorded in 30% of the population and this population had a higher level of pre-operative WOMAC score.Conclusions: Early functional performance after hip replacement surgery was not correlated with the level of kinesiophobia. Three significant factors that describe a population most at risk of not achieving optimal functional performance are increased age, being female and increase in body mass index. In the preoperative phase, high levels of kinesiophobia were associated with more impaired preoperative functional ability.Trial Registration: Current Controlled Trials NCT02786121 , May 2016. Retrospectively registered. [ABSTRACT FROM AUTHOR]

Background: During routine check-ups of long-term surviving knee rotationplasty patients referred to our institute, we noted that the operated limb radiograph showed signs of hip osteoarthritis in some patients, and that one patient reported hip pain. We wondered whether radiographic changes and symptoms are common in patients undergoing rotationplasty due to mechanical or overloading problems during gait. Based on these considerations, we wished to determine how frequently arthrosis or arthritis would arise in the ipsilateral hip to a knee rotationplasty at long-term follow-up. To our knowledge, this issue has not been explored. Clinicians and patients should be aware of any problems that may affect the hip over time that could result in treatment.Questions/purposes: At a minimum of 10 years after rotationplasty, in a single-center series, we therefore asked: (1) What proportion of patients reported hip pain at rest and with activity? (2) What proportion have radiographically visible arthritic changes in the ipsilateral or contralateral hip? (3) What proportion of patients have changes in the hip morphology (femoral rotation, cervicodiaphyseal angle, acetabular angle, osteopenia)?Methods: Between 1986 to 2009, 42 patients underwent rotationplasty in our institute. They represent the 16.5% of a series of 254 children (age 3 to 14 years) affected by high-grade bone sarcomas located in the distal half of the femur. Three more patients were adolescents older than 15 years and were treated with rotationplasty because of the tumor volume and extracompartmental involvement. Of these 45 patients, 14 died of disease at a mean of 37 months; 31 patients were survivors at the time the study was done. Three of these long-term survivors were known to be alive but did not come for a clinic visit in the last 5 years. The remaining 28 patients were invited to participate in a research study on the long-term assessment of rotationplasty, and all agreed to participate. Unfortunately, 10 patients living far from our Institute could not come in the 2 days established for the assessment due to family or work constraints. AP plain radiographs of the pelvis were taken in 17 patients with long-term survival after knee rotationplasty. Patients were positioned in a standard weightbearing position, wearing their own prosthesis. Hip osteoarthritis was assessed using the Croft grading system. The presence of hip pain was assessed with the self-reported Numeric Rating Scale (NRS), with scores ranging from 0 to 10, at rest and during daily life activities. Femoral rotation, osteopenia, the cervicodiaphyseal and the acetabular angles were measured on radiographs. The median (range) age at follow-up was 32 years (22 to 45), the median age at the time of the intervention was 9 years (6 to 17), and the median follow-up duration after surgery was 25 years (11 to 30).Results: One of the 17 patients complained of mild pain (NRS score of 2) in the ipsilateral hip during walking. No other patient claimed to have hip pain at rest or during walking or other daily life activities. Eleven of 17 patients had signs of OA according to the Croft grading system: one had Grade 1 OA, seven had Grade 2, and three had Grade 3. Six patients did not show any sign of OA in the ipsilateral hip. Two patients had Grade 1 OA and one had Grade 2 OA of the contralateral hip. Sixteen patients had femoral external rotation. An increased valgus cervicodiaphyseal angle and acetabular angle were present in 10 and 9 patients, respectively. Osteopenia at the ipsilateral hip when compared with the contralateral, was present in all patients but one, with varying degrees of severity.Conclusions: In this small series, signs of osteoarthritis of the hip ipsilateral to the rotationplasty were present in a high proportion of patients at a minimum follow-up interval of 10 years after surgery, although only one participant reported hip pain. The finding of arthrosis in the hip above a rotationplasty is potentially important because it may be related to gait abnormalities that may modify the hip's morphology over time. It is encouraging that symptomatic hip pain was uncommon in our patients, but this could become more of a clinical problem with longer follow-up and result in therapeutic intervention. Patients (or the parents of patients) undergoing this procedure should be informed that they might develop hip arthritis during young adulthood.Level Of Evidence: Level IV, therapeutic study. [ABSTRACT FROM AUTHOR]

Owing to the unique mechanical characteristics and lack of plasticity of fiber-reinforced polymers (FRPs), relatively large strains can develop in FRP reinforced concrete (RC) elements at ultimate limit states and this can lead to different relative contributions of concrete and shear reinforcement to the total element's shear capacity. This paper examines the development and relative contribution of the main shear resisting mechanisms in concrete beams with different overall depths and reinforced with longitudinal and transversal FRP reinforcement. Complementary strain measurements obtained from digital image correlation (DIC) and strain gauges are presented and discussed thoroughly. Although current FRP shear design approaches rely on the assumption that the contributions of concrete and shear reinforcement are constant up to failure, their relative magnitude is found to vary with increasing crack width. The experimental results indicate that, when minimum shear reinforcement is provided, current shear models based on a fixed truss angle approach tend to overestimate the contribution of concrete and underestimate the contribution of shear reinforcement. The use of a variable angle truss model, along with an appropriate reduction in the contribution of concrete, would lead to a more reliable estimate of the main shear resisting mechanisms and optimal design of the required amount of shear reinforcement. [ABSTRACT FROM AUTHOR]

Tubular structures find wide application in the automotive context. In particular, rectangular cross-section tubes are used to fabricate structural frames via different techniques, such as Three-Roll-Push-Bending with the addition of twisting component (TRPBT) and the Rotary Draw Bending (RDB). However, whether the accumulated plastic strains, hardening and residual stresses influence the load capacity of the tubular component is still unclear. This paper is intended to shed light on this issue. The load capacity of a tubular mock-up obtained by sequential combination of TRPBT and RDB has been empirically assessed by a destructive compression test. A finite element (FE) model has been devised and validated to analyse the manufacturing processes. This work puts in light the need to correctly model the compliance of the tool set-up for Roll Bending in the numerical calculations. The final shape of the mock-up obtained by FE analysis is the input of the numerical simulation of the compression test. The present modelling has shown clearly that the global resistance of a tubular component is sensitive to plastic strains, hardening and residual stresses resulting from the previous forming processes. Taking into account these three factors greatly improves the capability of the FE to model the mechanical response of the structural part. [ABSTRACT FROM AUTHOR]

To expand, analyze and extend published behavioral phenotypes relevant to autism spectrum disorder (ASD), we present a study of three ASD genetic mouse models: Feng's Shank3tm2Gfng model, hereafter Shank3/F, Jiang's Shank3tm1Yhj model, hereafter Shank3/J and the Cacna1c deletion model. The Shank3 models mimick gene mutations associated with Phelan–McDermid Syndrome and the Cacna1c model recapitulates the deletion underlying Timothy syndrome. This study utilizes both standard and novel behavioral tests with the same methodology used in our previously published companion report on the Cntnap2 null and 16p11.2 deletion models. We found that some but not all behaviors replicated published findings and those that did replicate, such as social behavior and overgrooming in Shank3 models, tended to be milder than reported elsewhere. The Shank3/F model, and to a much lesser extent, the Shank3/J and Cacna1c models, showed hypoactivity and a general anxiety‐like behavior triggered by external stimuli which pervaded social interactions. We did not detect deficits in a cognitive procedural learning test nor did we observe perseverative behavior in these models. We did, however, find differences in exploratory patterns of Cacna1c mutant mice suggestive of a behavioral effect in a social setting. In addition, only Shank3/F showed differences in sensory‐gating. Both positive and negative results from this study will be useful in identifying the most robust and replicable behavioral signatures within and across mouse models of autism. Understanding these phenotypes may shed light of which features to study when screening compounds for potential therapeutic interventions. [ABSTRACT FROM AUTHOR]

The elbow, intermediate joint of the upper limb, frequently undergoes to pathological events and is especially prone to stiffness. Rehabilitation plays an important role in recovering functional activities. For the rehabilitation team, this goal always represents a challenge, as the treatment has to be continuously modeled and calibrated on the needs of the individual patient, even many times during the same rehabilitation cycle. Containing the effects of immobilization, avoiding to excessively stress the healing tissues, satisfying specific clinical criteria before moving to the next rehabilitation stage, basing the rehabilitation plan on up-to-date clinical and scientific data that can be adapted to each patient and to his/her needs are the basic principles of the rehabilitation plan, which can be chronologically grouped into four rehabilitation stages. After summarizing the general principles of elbow treatment, the specific principles of rehabilitation after elbow fractures and elbow instability are presented, and then the rehabilitative approach to the most frequent and feared pathological conditions of the elbow, namely stiffness, is described. [ABSTRACT FROM AUTHOR]

In the [ABrnIm] (A = C, Si, Ge, Sn; n + m = 4) compounds, with the heavier halides bonded to the central IV group elements, the experimental 13C, 29Si, 73Ge and 119Sn NMR chemical shifts of the central atoms were found to be strictly linearly proportional to the bonded halides ionic radii overall sum ∑(rh). Based on this, calibration lines relating the chemical shifts to ∑(rh) could be built for the considered subgroup of [ABrnIm] compounds. Using such calibration lines we could calculate the equivalent NMR radius, NMRrH–A, attributable to each of the bonded hydrogens in [AH4] species, according to the overall NMR shielding produced on the central A atom. Interestingly, the calculated NMRrH–A value resulted to be almost constant in all [AH4] examined systems (A = 13C, 29Si, 73Ge, 119Sn) with an average NMRr̅H–A value equal to 194.6 ± 1.6 pm. Based on this approach, we could calculate the 207Pb NMR chemical shift of the unstable [PbH4] complex using the value of 192.7 pm calculated for NMRrH–Sn in the stable closest hydride [SnH4]. The obtained unprecedented NMR value is in accord with the 207Pb NMR chemical shift estimation, independently calculated for [PbH4] from the [SnH4] data, using the Pb/Sn chemical shift correlation defined in the Mitchell equation. [ABSTRACT FROM AUTHOR]

The scope of this study is to characterize the mechanical properties of a novel Transformation-Induced Plasticity bainitic steel grade TBC700Y980T. For this purpose, tensile tests are carried out with loading direction 0, 45 and 90° with respect to the L rolling direction. Yield stress is found to be higher than 700 MPa, ultimate tensile strength larger than 1050 MPa and total elongation higher than 15%. Low-cycle fatigue (LCF) tests are carried out under fully reverse axial strain exploring fatigue lives comprised between 102 and 105 fatigue cycles. The data are used to determine the parameters of the Coffin-Manson as well as the cyclic stress-strain curve. No significant stress-induced austenite transformation is detected. The high-cycle fatigue (HCF) behaviour is investigated through load controlled axial tests exploring fatigue tests up to 5 × 106 fatigue cycles at two loading ratios, namely R = −1 and R = 0. At fatigue lives longer than 2 × 105 cycles, the strain life curve determined from LCF tests tends to greatly underestimate the HCF resistance of the material. Apparently, the HCF behaviour of this material cannot be extrapolated from LCF tests, as different damage, cyclic hardening mechanisms and microstructural conditions are involved. In particular, in the HCF regime, the predominant damage mechanism is nucleation of fatigue cracks in the vicinity of oxide inclusions, whereby mean value and scatter in fatigue limit are directly correlated to the dimension of these inclusions. [ABSTRACT FROM AUTHOR]

JarvSis is a distributed scheduler capable to automate the execution of multiple heterogeneous tasks on IoT and Robotics applications by means of a modular and adaptable software architecture. JarvSis is designed to accept pluggable modules that make it adaptable to any devices, from simple sensors to complex robots, that, in turn, expose remote interfaces, i.e. Web-API, MQTT or ROS message bus. Through JarvSis, the developer can easily configure and deploy hierarchies of control tasks running in the Cloud and in the Fog in order to interact and control IoT devices or robots that operate in the ground. Control tasks are organized in a hierarchical network on which Fog resources represent a bridge between the computational resources hosted in the Cloud, and IoT devices or robots operating in the 'ground'. In such a network, the highest layer provides control and coordination, and is typically hosted in the Cloud, while the last layer is distributed in the Fog. The advantages provided by JarvSis are discussed by a detailed example in the robotic domain. [ABSTRACT FROM AUTHOR]

The present paper is aimed at investigating the effect of the sinter-hardening treatment in improving the tooth root fatigue resistance of gears obtained by Powder Metallurgy. The gears were produced using two types of low-alloyed partially diffused steel powders, Distaloy DC and Distaloy DH (Höganäs AB, Sweden), that were conventionally sintered as well as sinter-hardened. A different microstructure was obtained after the two sintering processes that led to different fatigue response. As expected, the martensitic microstructure is responsible for good fatigue performances, slightly less than those of gears made with wrought low-alloyed quenched and tempered steels. [ABSTRACT FROM PUBLISHER]

An inverse linear relationship between 73Ge, 119Sn and 207Pb NMR chemical shifts and the overall sum of ionic radii of coordinated halido ligands has been discovered in tetrahedral [MXnY4−n] (M = Ge, Sn, Pb; 1 ≤n≤ 4; X, Y = Cl, Br, I) coordination compounds. This finding is consistent with a previously reported correlation found in octahedral, pentacoordinate and square planar platinum complexes. The effect of the coordinated halido ligands acting on the metal as shielding conducting rings is therefore confirmed also by 73Ge, 119Sn and 207Pb NMR spectroscopy. [ABSTRACT FROM AUTHOR]

Background: Although temporal lobe pathology may explain some of the symptoms of multiple sclerosis (MS), its role in the pathogenesis of seizures has not been clarified yet. Objectives: To investigate the role of temporal lobe damage in MS patients suffering from epilepsy, by the application of advanced multimodal 3T magnetic resonance imaging (MRI) analysis. Methods: A total of 23 relapsing remitting MS patients who had epileptic seizures (RRMS/E) and 23 disease duration matched RRMS patients without any history of seizures were enrolled. Each patient underwent advanced 3T MRI protocol specifically conceived to evaluate grey matter (GM) damage. This includes grey matter lesions (GMLs) identification, evaluation of regional cortical thickness and indices derived from the Neurite Orientation Dispersion and Density Imaging model. Results: Regional analysis revealed that in RRMS/E, the regions most affected by GMLs were the hippocampus (14.2%), the lateral temporal lobe (13.5%), the cingulate (10.0%) and the insula (8.4%). Cortical thinning and alteration of diffusion metrics were observed in several regions of temporal lobe, in insular cortex and in cingulate gyrus of RRMS/E compared to RRMS (p< 0.05 for all comparisons). Conclusions: Compared to RRMS, RRMS/E showed more severe damage of temporal lobe, which exceeds what would be expected on the basis of the global GM damage observed. [ABSTRACT FROM AUTHOR]

Aims: To investigate the association between occurrence of soft tissue sarcomas (STS) in Mantua and residence near an incinerator of industrial wastes.Methods: Cases were subjects with histologically confirmed primary malignant STS diagnosed 1989-98 in the population resident in Mantua and in the three neighbouring municipalities. Controls were randomly extracted from population registries, matched for age and sex. Residential history was reconstructed for all study subjects since 1960. Main residence was geographically positioned according to GPS standards.Results: The study included 37 STS cases (17 men and 20 women) and 171 controls. The incidence of STS in the area of study was estimated as 8.8 per 100 000 in men and 5.6 per 100 000 in women. The odds ratio associated with residence within 2 km, standardised by age and sex, was 31.4 (95% CI 5.6 to 176.1), based on five exposed cases. At greater distances, risk rapidly decreased, showing a fluctuation around the null value of 1.Conclusion: The study shows a significant increase in risk of STS associated with residence within 2 km of an industrial waste incinerator; an aetiological role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can be hypothesised. [ABSTRACT FROM AUTHOR]

The moderately high lateral RS gradients (on the order of tens of MPa/μm) near shot peened notches in conjunction with the shallow treatment depth (some hundreds of microns) limit the application of far-field and/or high resolution synchrotron diffraction residual stress measurement techniques. Recently proposed Focused Ion Beam - Scanning Elecron Microscope - Digital Image Correlation (FIB-SEM-DIC) based micro mechanical stress relaxation methods for the measurement of residual stress at the micron scale became suitable techniques for local evaluation of residual stresses and stress gradients in shot peened specimens. In this paper ultra-high resolution (~0.5-0.8 μm depth and 5-10 μm lateral resolution) mechanical relaxation stress measurements were used to evaluate the stress variation local to individual peening dimples in ceramic (60-120 μm diameter beads) shot peened Al-7075-T651 double notched samples having 0.15, 0.5 and 2.0 mm radii using Micro-Hole Drilling (μHD), Micro-Slot Cutting (μSC) and micro X-ray Diffraction (μXRD) methods. The micron-sized sampling volumes enabled the stress to be evaluated in individual impact craters (dimples) showing significant point-to-point variation (~ +/−150 MPa) (with certain dimples even recording tensile stresses). After around 30 μm of layer removal the heavily deformed region had largely been removed and the stress profile became much more homogeneous. At this depth the μHD and μSC results were in good accord with those from μXRD measurements which sample over a much larger volume (~40 μm depth × 50 μm laterally) showing an in-plane compressive stress of around 150 MPa far from the notches with the residual stress rising to about 200 MPa at a blunt (2 mm) notch and 500 MPa for a sharp (0.15 mm) one. Further, these recorded variations of residual stresses were correlated with microstructural features, e.g. grains, networks of sub-surface cracks, intermetallics and highly deformed sub-surface regions, revealed by large volume Serial Sectioning Tomography using Plasma Xe Focus Ion Beam - Scanning Electron Microscope (PFIB-SEM), EDS and EBSD maps. This allowed for the first time characterize large volume (100 × 66 × 30 μm) of shot peened regions with resolution of dozens of nanometers and correlate residual stress depth profiles with 3D microstructural features. Finally, in (Benedetti et al. 2016, Int. J. Fatigue) these RS measurements are used to reconstruct the RS field through finite element (FE) analyses. [ABSTRACT FROM AUTHOR]

Aims: Critical appraisal of secondary data made available by the OECD for the time frame 2000-2011. Methods: Comparison of trends and variation of amputations in people with diabetes across OECD countries. Generalized estimating equations to test the statistical significance of the annual change adjusting for major potential confounders. Results: A total of 26 OECD countries contributed to the OECD data collection for at least 1 year in the reference time frame, showing a decline in rates of over 40 %, from a mean of 13.2 (median 9.4, range 5.1-28.1) to 7.8 amputations per 100,000 in the general population (9.9, 1.0-18.4). The multivariate model showed an average decrease equal to −0.27 per 100,000 per year ( p = 0.015), adjusted by structural characteristics of health systems, showing lower amputation rates for health systems financed by public taxation (−4.55 per 100,000 compared to insurance based, p = 0.002) and non-ICD coding mechanisms (−7.04 per 100,000 compared to ICD-derived, p = 0.001). Twelve-year decrease was stronger among insurance-based financing systems (tax based: −0.16 per 100,000, p = 0.064; insurance based: −0.36 per 100,000; p = 0.046). Conclusions: In OECD countries, amputation rates in diabetes continuously decreased over 12 years. Still, in 2011, one amputation every 7 min could be directly attributed to diabetes. Although interesting, these results should be taken with extreme caution, until common definitions are improved and data quality issues, e.g., a different ability in capturing diabetes diagnoses, are fully resolved. [ABSTRACT FROM AUTHOR]

Aims To assess country- and individual-level correlates of psychological outcomes, and differences among countries in the associations of individual characteristics with psychological outcomes among adults with diabetes. Methods The second Diabetes Attitudes, Wishes and Needs ( DAWN2™) study assessed self-reported characteristics of people with diabetes in 17 countries, including 1368 adults with Type 1 diabetes and 7228 with Type 2 diabetes. In each country, a sample of 500 adults, stratified by diabetes type and treatment, completed a questionnaire incorporating the validated WHO-5 wellbeing index, the WHOQOL- BREF, and the five-item Problem Areas in Diabetes Scale, as well as the newly developed Diabetes Impact on Life Dimensions that assessed impact ranging from very positive to very negative, with no impact as the midpoint. Multilevel regression analyses identified significant ( P < 0.05) independent correlates of psychological outcomes. Results There were significant variations in all outcomes across countries before adjustment for individual-level factors; adjustment reduced between-country disparities. Worse psychological outcomes were associated with more complications, incidence of hypoglycaemia, hypoglycaemic medication, perceived burden of diabetes, family conflict and experience of discrimination. Better psychological outcomes were associated with higher self-rated health, greater access to diabetes education and healthcare, and more psychosocial support from others. The associations of many factors with the outcomes were mediated by modifiable factors. The association of all factors with the outcomes varied across (interacted with) countries, highlighting the need for country-specific analyses. Conclusions Improvements in modifiable risk factors (reductions in burden and increases in support) may lead to better psychological outcomes in adults with diabetes. [ABSTRACT FROM AUTHOR]

Assessing threats and causes of mortality is crucial for understanding the factors driving population dynamics and planning effective conservation actions. Investigating the causes for admission into wildlife rehabilitation centres can contribute to assessing the main threats affecting animal populations inhabiting urban and suburban habitats. After analysing 2367 raptors belonging to 28 species admitted at the LIPU/Bioparco wildlife rehabilitation centre of Rome during 12 years (2000–2011), we found that collisions with man-made structures were the most frequent cause for admission, with shooting the second most frequent cause of admission. However, for Falconiformes, excluding kestrels, shooting was the most common cause for admission (52% of all admissions). Comparing urban with suburban landscapes, we found that the occurrence of birds admitted with evidence of gunshot wounds was higher in the suburban landscape for both Strigiformes and Falconiformes. Considering only the 17 species listed in Annex I to Bird Directive 147/2009/EC, shooting was the most frequent cause of admission and accounted for more than 40% of cases. The high frequency of admissions of raptors due to shooting in urban and suburban Rome shows that persecution of raptors is not restricted to rural areas of Italy. [ABSTRACT FROM PUBLISHER]

Rotary draw bending is usually applied to round tubes, since their axisymmetric cross section helps reduce any type of distortion. In the present paper, we investigate rotary draw bending of rectangular tubes employing a novel elastic parallelepiped mandrel. For this purpose, tubes, manufactured by cold forming flat rolled sheets of steel S235JR into rectangular tubular shapes and electric resistance welded into solid wall tubing, were bent, both the 'hard way' and the 'easy way,' to form a nominal angle of 90°. A finite element (FE) model was developed to perform the process simulation based on an explicit dynamic time integration scheme using the commercial code ABAQUS. The FE outcomes have been validated by comparison with experimental results. Specifically, a coordinate measuring machine was used to determine the degree of bend as well as the radius, the profile, and the wall thickness of the bent sections. The obtained results showed the capability of the FE modeling to predict the material deformation process. Implementing the stiffness of the welding seam into the FE model of the tube dramatically increases the accuracy of the numerical simulations. The validated model is adopted for investigating the effect of mandrel position, clearance, and friction and how they can be set to minimize the tube distortions. [ABSTRACT FROM AUTHOR]

Aim: Italian national guidelines on pain management were published in 2010, but there is little information on how effective pain management is in paediatric emergency care, with other countries reporting poor levels. Using headache as an indicator, we described pain assessment in Italian emergency departments and identified predictors of algometric scale use.Methods: All Italian paediatric and maternal and child hospitals participated, plus four general hospitals. Data on all children aged 4-14 years admitted during a one-month period with headache as their chief complaint were abstracted from clinical records. Multivariable analyses identified predictors of algometric assessment, taking into account the cluster study design.Results: We studied 470 admissions. During triage, pain was assessed using a standardised scale (41.5%), informally (15.5%) or was not recorded (42.9%). Only 32.1% of the children received analgesia in the emergency department. The odds ratios for predictors of algometric assessment were non-Italian nationality (3.6), prehospital medication (1.8), admission to a research hospital (7.3) and a more favourable nurses-to-admissions ratio of 10.8 for the highest versus lowest tertile.Conclusion: Despite national guidelines, paediatric pain assessment in Italian emergency care was suboptimal. Hospital variables appeared to be stronger predictors of adequate assessment than patient characteristics. [ABSTRACT FROM AUTHOR]

Background Benign multiple sclerosis ( BMS) definitions rely on physical disability level but do not account sufficiently for cognitive impairment which, however, is not rare. Objective To study the evolution of physical disability and cognitive performance of a group of patients with BMS followed at an University Hospital Multiple Sclerosis Center. Methods A consecutive sample of 24 BMS cases (diagnosis according to 2005 McDonald's criteria, relapsing-remitting course, disease duration ≥10 years, and expanded disability status scale [ EDSS] score ≤2.0) and 13 sex- and age-matched non- BMS patients differing from BMS cases for having EDSS score 2.5-5.5 were included. Main outcome measures were as follows: (i) baseline and 5-year follow-up cognitive impairment defined as failure of at least two tests of the administered neuropsychological battery; (ii) EDSS score worsening defined as confirmed increase ≥1 point (or 0.5 point if baseline EDSS score = 5.5). Results At inclusion, BMS subjects were 41 ± 8 years old and had median EDSS score 1.5 (range 0-2), while non- BMS patients were 46 ± 8 years old and had median EDSS score 3.0 (2.5-5.5). At baseline 16% of patients in both groups were cognitively impaired. After 5 years, EDSS score worsened in 8% of BMS and 46% of non- BMS patients ( P = 0.008), while the proportion of cognitively impaired subjects increased to 25% in both groups. Conclusions Patients with BMS had better physical disability outcome at 5 years compared to non- BMS cases. However, cognitive impairment frequency and decline over time appeared similar. Neuropsychological assessment is essential in patients with BMS given the distinct pathways followed by disease progression in cognitive and physical domains. [ABSTRACT FROM AUTHOR]

Plantar pressure, ground reaction force and body-segment kinematics measurements are largely used in gait analysis to characterise normal and abnormal function of the human foot. The combination of all these data together provides a more exhaustive, detailed and accurate view of foot loading during activities than traditional measurement systems alone do. A prototype system is presented that integrates a pressure platform, a force platform and a 3D anatomical tracking system to acquire combined information about foot function and loading. A stereophotogrammetric system and an anatomically based protocol for foot segment kinematics is included in a previously devised piezo-dynamometric system that combines pressure and force measurements. Experimental validation tests are carried out to check for both spatial and time synchronisation. Misalignment of the three systems is found to be within 6.0, 5.0 and 1.5 mm for the stereophotogrammetric system, force platform and pressure platform, respectively. The combination of position and pressure data allows for a more accurate selection of plantar foot subareas on the footprint. Measurements are also taken on five healthy volunteers during level walking to verify the feasibility of the overall experimental protocol. Four main subareas are defined and identified, and the relevant vertical and shear force data are computed. The integrated system is effective when there is a need for loading measurements in specific plantar foot subareas. This is attractive both in clinical assessment and in biomechanics research. [ABSTRACT FROM AUTHOR]

Chemical extraction, multi-element stable isotopic dilution ( ID) and multi-surface modelling were used to investigate the lability of cadmium ( Cd) and copper ( Cu) in nine types of soil with different properties and contaminated or not with Cd and Cu. The chemical extraction and ID analyses both showed that Cd was more labile than Cu in all the soil types studied. From the ID results, 32.8-93.3% of total Cd and 14.7-71.8% of total Cu were isotopically exchangeable after 3 days of equilibration. A single extraction in 0.43 m HNO3 gave similar results to the 3-day ID assay for Cu in most of the soils and for Cd in the non-calcareous soils. However, an eight-step selective sequential extraction ( SSE) procedure gave different results from the ID assay for both metals. Predictions of the multi-surface model for the amounts of Cd and Cu adsorbed, based on measured metal ion activities in the soil solution and the concentrations of reactive surfaces in the soil, agreed with the ID results. The model predicted that soil organic matter was the predominant sorbent for Cd and Cu in the soils and that manganese oxide was the least important sorbent. The contributions of iron oxides to sorption were predicted to be small except in soil with a high pH and little organic matter. The predicted sorption on different soil components did not match SSE measurements. [ABSTRACT FROM AUTHOR]

An inverse linear relationship between the experimentally observed 195Pt NMR signals and the overall sum of coordinated halido ligands’ ionic radii was discovered in Pt(ii) and Pt(iv) complexes. The reduction of 195Pt NMR frequencies parallels the increase of coordinated halido ligands’ ionic radii sum. This suggests that each halido ligand may act as a conducting ring whose induced electric current shields the 195Pt NMR signals proportionally to the ionic radius of the coordinated halido ligand. [ABSTRACT FROM AUTHOR]

ABSTRACT We examine the Atlantic maritime vegetation history from Praia Rei Cortiço, Portugal, to understand natural vegetation patterns and infer climatic conditions during the transition from the last interglacial to early glacial periods. Optically stimulated luminescence dating of quartz grains from sediments surrounding the 1.3-m-thick organic deposit date the section to within 120-89 ka. Pollen data were used to reconstruct the vegetation history and determine a range of possible past climates using an ensemble of seven modern analogue approaches. A five-part environmental sequence transitioned from heath-pine-dominated communities, deciduous hardwood forests and pine forests to heathlands surrounded by steppe-like environments. Mixed temperate and Mediterranean forest elements existed during the last interglacial period at Praia Rei Cortiço, suggesting a proximal limit to these floras. Abundant Fagus pollen (>6%) suggests local beech populations existed within maritime forests of the Iberian Atlantic margin, representing a greater distribution of this genus during interglacial periods than has previously been recognized. Climate reconstructions indicate that variations in moisture availability may have been a major driver of the observed environmental changes. [ABSTRACT FROM AUTHOR]