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Between January 2018 and June 2021, the Ezer Mizion recruited 223,960 donors. All donors were typed for their HLA class I and II alleles at high resolution by Next Generation Sequencing techniques. Comparison between the sequences obtained from these donors and those in the IPD‐IMGT/HLA Database, revealed 122 Novel HLA alleles that were found in 133 donors. Most of the alleles, 94 (77%) were identified in the HLA class I genes (30, 35, and 29 in HLA‐A, ‐B, and –C, respectively), and 28 (23%) were detected in the HLA class II genes (9 in HLA‐DRB1 and ‐DQB1 and 10 in ‐DPB1). Most of these novel alleles, 106 (86.9%) comprised single nucleotide variation (SNV), 9 (7.4%) present multiple amino acids variation, 4 and 3 were generated because of deletions and insertions, respectively. Ten of these novel alleles were seen to be null alleles. [ABSTRACT FROM AUTHOR]

Between 2008 and April 2018, we recruited more than 37 000 potential Arab donors to the Hadassah Bone Marrow Donor Registry, all of whom were typed for high resolution HLA‐A, ‐B, and ‐DRB1. In addition, more than 22% of them were also typed for their HLA‐C and ‐DQB1 alleles. A comparison of the sequences obtained from these donors with the IPD‐IMGT/HLA Database showed 33 novel alleles from five loci (HLA‐A, ‐B, ‐C, ‐DR, ‐DQ). All of these novel HLA alleles were detected in the local Arab communities; 79% of these alleles have not been described in other groups yet and remain unique to the local Arab communities. [ABSTRACT FROM AUTHOR]