6 results on '"Boeve, Koos"'
Search Results
2. Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy—Comparison to a Historic Elective Neck Dissection Cohort.
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Mahieu, Rutger, den Toom, Inne J., Boeve, Koos, Lobeek, Daphne, Bloemena, Elisabeth, Donswijk, Maarten L., de Keizer, Bart, Klop, W. Martin C., Leemans, C. René, Willems, Stefan M., Takes, Robert P., Witjes, Max J. H., and de Bree, Remco
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SENTINEL lymph node biopsy ,CANCER relapse ,NECK dissection ,ORAL cancer ,CANCER genetics ,SQUAMOUS cell carcinoma - Abstract
Introduction: Nowadays, two strategies are available for the management of the clinically negative neck in early-stage (cT1-2N0) oral squamous cell carcinoma (OSCC): elective neck dissection (END) and sentinel lymph node biopsy (SLNB). SLNB stages both the ipsilateral and the contralateral neck in early-stage OSCC patients, whereas the contralateral neck is generally not addressed by END in early-stage OSCC not involving the midline. This study compares both incidence and hazard of contralateral regional recurrences (CRR) in those patients who underwent END or SLNB. Materials and Methods: A retrospective multicenter cohort study, including 816 lateralized or paramedian early-stage OSCC patients, staged by either unilateral or bilateral END (n = 365) or SLNB (n = 451). Results: The overall rate of occult contralateral nodal metastasis was 3.7% (30/816); the incidence of CRR was 2.5% (20/816). Patients who underwent END developed CRR during follow-up more often than those who underwent SLNB (3.8 vs. 1.3%; p = 0.018). Moreover, END patients had a higher hazard for developing CRR than SLNB patients (HR = 2.585; p = 0.030). In addition, tumor depth of invasion was predictive for developing CRR (HR = 1.922; p = 0.009). Five-year disease-specific survival in patients with CRR was poor (42%) compared to patients in whom occult contralateral nodal metastases were detected by SLNB or bilateral END (88%), although not statistically different (p = 0.066). Conclusion: Our data suggest that SLNB allows for better control of the contralateral clinically negative neck in patients with lateralized or paramedian early-stage OSCC, compared to END as performed in a clinical setting. The prognosis of those in whom occult contralateral nodal metastases are detected at an earlier stage may be favorable compared to those who eventually develop CRR, which highlights the importance of adequate staging of the contralateral clinically negative neck. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early‐stage oral squamous cell carcinoma.
- Author
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Boeve, Koos, Melchers, Lieuwe J, Schuuring, Ed, Roodenburg, Jan L, Halmos, Gyorgy B, Dijk, Boukje A, Vegt, Bert, and Witjes, Max J
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SQUAMOUS cell carcinoma ,PROGRESSION-free survival ,TUMOR classification ,PROGNOSIS ,TUMORS ,NECK dissection ,HEAD & neck cancer - Abstract
Aims: In the 8th edition of the American Joint Committee on Cancer TNM staging manual, tumour infiltration depth and extranodal extension are added to the pathological classification for oral squamous cell carcinoma. The currently available 8th TNM validation studies lack patients with conservative neck treatment, and changes in the classification especially affect patients with small tumours. The aim of this study was to determine the potential impact of the changes in the 8th edition pTNM classification on the prognosis and treatment strategy for oral squamous cell carcinoma in a well‐defined series of pT1–T2 patients with long‐term follow‐up. Methods and results: Two hundred and eleven first primary pT1–T2 oral squamous cell carcinoma patients, with surgical resection as primary treatment, were analysed retrospectively. One hundred and seventy‐three patients underwent a neck dissection, and 38 patients had frequent clinical neck assessments. Long‐term follow‐up (median 64 months) and reassessed tumour infiltration depth were available. Classification according to the 8th edition criteria resulted in 36% total upstaging with the T classification and 16% total upstaging with the N classification. T3‐restaged patients (n = 30, 14%) had lower 5‐year disease‐specific survival rates than T2‐staged patients (81% versus 67%, P = 0.042). Postoperative (chemo)radiotherapy could have been considered in another seven (3%) patients on the basis of the 8th edition criteria. Conclusions: Addition of tumour infiltration depth and extranodal extension in the 8th TNM classification leads to the identification of oral squamous cell carcinoma patients with a worse prognosis who might benefit from an improved postoperative treatment strategy. [ABSTRACT FROM AUTHOR]
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- 2019
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4. Lymphatic drainage patterns of oral maxillary tumors: Approachable locations of sentinel lymph nodes mainly at the cervical neck level.
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Boeve, Koos, Schepman, Kees ‐ Pieter, Vegt, Bert van der, Schuuring, Ed, Roodenburg, Jan L., Brouwers, Adrienne H., and Witjes, Max J.
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LYMPHATIC diseases ,MAXILLARY sinus tumors ,SENTINEL lymph nodes ,LYMPHATIC massage ,BIOPSY ,CANCER - Abstract
Background There is debate if the lymphatic drainage pattern of oral maxillary cancer is to the retropharyngeal lymph nodes or to the cervical lymph nodes. Insight in drainage patterns is important for the indication for neck treatment. The purpose of this study was to identify the lymphatic drainage pattern of oral maxillary cancer via preoperative lymphoscintigraphy. Methods Eleven consecutive patients with oral maxillary cancer treated in our center between December 1, 2012, and April 22, 2016 were studied. Sentinel lymph nodes identified by preoperative lymphoscintigraphy after injection of
99m Tc-nanocolloid and by intraoperative detection using a γ-probe, were surgically removed and histopathologically examined. Results In 10 patients, sentinel lymph nodes were detected and harvested at cervical levels I, II, or III in the neck. In 2 patients, a parapharyngeal sentinel lymph node was detected. One of the harvested sentinel lymph nodes (1/19) was tumor positive. Conclusion This study suggests the likelihood of 73% of exclusively cervical level I to III sentinel lymph nodes in oral maxillary cancer. © 2016 Wiley Periodicals, Inc. Head Neck 39: 486-491, 2017 [ABSTRACT FROM AUTHOR]- Published
- 2017
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5. Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer.
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Noorlag, Rob, Boeve, Koos, Witjes, Max J. H., Koole, Ronald, Peeters, Ton L. M., Schuuring, Ed, Willems, Stefan M., and Es, Robert J. J.
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TREATMENT of oral cancer ,ORAL cancer ,RADIOTHERAPY treatment planning ,CANCER treatment ,PROTEIN expression ,METASTASIS ,CYCLINS ,DIAGNOSIS ,GENETICS - Abstract
Background Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain ( FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited. Methods In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases. Results CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers. Conclusion Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. © 2016 Wiley Periodicals, Inc. Head Neck 39: 326-333, 2017 [ABSTRACT FROM AUTHOR]
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- 2017
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6. Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience.
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den Toom, Inne J., Boeve, Koos, Lobeek, Daphne, Bloemena, Elisabeth, Donswijk, Maarten L., de Keizer, Bart, Klop, W. Martin C., Leemans, C. René, Willems, Stefan M., Takes, Robert P., Witjes, Max J.H., and de Bree, Remco
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CANCER patients ,LONGITUDINAL method ,MEDICAL cooperation ,METASTASIS ,MOUTH tumors ,MOUTH floor ,NECK surgery ,RESEARCH ,TUMOR classification ,RETROSPECTIVE studies ,SENTINEL lymph node biopsy - Abstract
Background: Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature. Methods: A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB. Results: The overall sensitivity (84% vs. 81%, p = 0.612) and negative predictive value (NPV) (93%, p = 1.000) were comparable between END and SLNB patients. The END cohort contained more pT2 tumours (51%) compared to the SLNB cohort (23%) (p < 0.001). No differences were found for sensitivity and NPV between SLNB and END divided by pT stage. In floor-of-mouth (FOM) tumours, SLNB had a lower sensitivity (63% vs. 92%, p = 0.006) and NPV (90% vs. 97%, p = 0.057) compared to END. Higher disease-specific survival (DSS) rates were found for pT1 SLNB patients compared to pT1 END patients (96% vs. 90%, p = 0.048). Conclusion: In the absence of randomized clinical trials, this study provides the highest available evidence that, in oral cancer, SLNB is as accurate as END in detecting occult lymph node metastases, except for floor-of-mouth tumours. [ABSTRACT FROM AUTHOR]
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- 2020
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