Search

Copyright of Medicina UPB is the property of Universidad Pontificia Bolivariana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of HiSTOReLo: Revista de Historia Regional y Local is the property of Universidad Nacional de Colombia, Centro Editorial Facultad de Ciencias Humanas y Economicas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Latinoamericana de Ciencias Sociales, Niñez y Juventud is the property of Centro de Estudiso Avanzados en Ninez y Juventud alaianza Cinde, Universidad de Manizales and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Summary: In this paper we examine the structure of politically complex societies in the north‐east of the Iberian Peninsula during the first millennium BC, using the Lower Ebro region as an example. Drawing on data provided in recent years by archaeological research, we discuss the combination of territorially hierarchical and heterarchical phenomena. At the same time we reassess the chronological framework in which this sociopolitical process took place. To do so, we rely more on information about the evolution of the protohistoric societies in the region under study than on information about material culture. We present a model that may serve as a starting point for future research. [ABSTRACT FROM AUTHOR]

After two turbulent years in which different pathways for the future of the political and institutional framework of Portugal clashed, the country began a process of consolidation of the democratic institutions delineated between 1975/6. However, the role played by the military in the fall of the previous dictatorial regime and the fragility of the new democratic institutions did not allow their immediate withdrawal from political life. The President of the Republic was a military man and the political parties had agreed to maintain an unelected sovereign body, the Council of the Revolution, which only dissolved in 1982. Based on primary sources that only recently became available, this article presents some elements that help to understand the success of democratic consolidation in Portugal. This long process should not be interpreted as a confrontation between civilians, desirous to put an end to military tutelage, and the military, who at all costs sought to keep their privileges. The dividing line should be placed between those who defended the maintenance of the status quo, and the supporters of military subordination to the civil power. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Filosofía UIS is the property of Universidad Industrial de Santander and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Melo Antunes: Uma Biografia Política, Maria Inácia Rezola (2012) Lisbon: Âncora Editora, 791 pp., paperback, ISBN: 9789727803736 The Foreign Policy of the European Union - Assessing Europe's Role in the World, federiga bindi (ed.) (2010) Washington, DC: Brookings Institution Press, 367 pp., ISBN: 9780815701408 [ABSTRACT FROM AUTHOR]

In this article we will seek to analyse the development of international ties that enabled the channelling of international support to the Portuguese Socialist Party led by Mário Soares. The support directed to Portuguese socialists assumed particular relevance in the summer of 1975, during which the revolutionary dynamic questioned and challenged the democratic legitimacy. Coincidentally, during these months there were ongoing negotiations for the signing of the Final Act of the Conference on Security and Cooperation in Europe and the situation in Portugal was presented by several actors as a test of the climate of détente. [ABSTRACT FROM PUBLISHER]

Cardiotrophin-1 (CT-1/CTF1) is a member of the interleukin-6 (IL-6) family of cytokines that stimulates STAT-3 phosphorylation in cells bearing the cognate receptor. We report that Ctf1-/- mice (hereby referred to as CT-1-/- mice) are resistant to the hepatic engraftment of MC38 colon carcinoma cells, while these cells engraft normally in the mouse subcutaneous tissue. Tumor intake in the liver could be enhanced by the systemic delivery of a recombinant adenovirus encoding CT-1, which also partly rescued the resistance of CT-1-/- mice to the hepatic engraftment of MC38 cells. Moreover, systemic treatment of wild-type (WT) mice with a novel antibody-neutralizing mouse CT-1 also reduced engraftment of this model. Conversely, experiments with Panc02 pancreatic cancer and B16-OVA melanoma cells in CT-1-/- mice revealed rates of hepatic engraftment similar to those observed in WT mice. The mechanism whereby CT-1 renders the liver permissive for MC38 metastasis involves T lymphocytes and natural killer (NK) cells, as shown by selective depletion experiments and in genetically deficient mice. However, no obvious changes in the number or cell killing capacity of liver lymphocytes in CT-1-/- animals could be substantiated. These findings demonstrate that the seed and soil concept to understand metastasis can be locally influenced by cytokines as well as by the cellular immune system. [ABSTRACT FROM AUTHOR]

Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. In a recent study we examined the metabolic features of ct-1 null mice and the effects on body composition, glucose and lipid metabolism of acute and chronic administration of recombinant CT-1. Our data revealed that CT-1 is a key regulator of energy metabolism with potential applications in the treatment of obesity and the metabolic syndrome. This commentary discusses the significance of these findings in the context of other key studies in the field of obesity and insulin resistance. [ABSTRACT FROM AUTHOR]

d-allose binding protein (ALBP) belongs to the family of perisplamic receptors of the bacterial ABC transporter system. ALBP experiences a significant conformational rearrangement upon binding to the sugar. Here, we report the sequential backbone assignment for the ALBP from Escherichia coli in the free form (BMRB no. 16982) and in complex with d-allose (BMRB no. 16984). [ABSTRACT FROM AUTHOR]

Archaeological excavations carried out at Turó del Calvari (Tarragona, Spain) have revealed a protohistoric building interpreted as one of the earliest enclosures of power operating during the Early Iron Age in the northeast of the Iberian Peninsula. The structure is exceptional in several respects: the techniques of construction, the materials used, and the topographic situation. The building is perfectly integrated in the landscape and has an exquisite geometrical design, with measurement units based on the Iberian foot. The intended beauty in having used the golden ratio in its construction and an orientation that is both stellar and solar demonstrates the existence at that time of a complete series of mechanisms of representation and territorial control. This was based on the use of rituals and feasts as elements of political cohesion by an emergent elite within a process that reproduced a scaled-down Mediterranean cultural system in an indigenous space. [ABSTRACT FROM PUBLISHER]

Proteins from halophilic organisms, which live in extreme saline conditions, have evolved to remain folded at very high ionic strengths. The surfaces of halophilic proteins show a biased amino acid composition with a high prevalence of aspartic and glutamic acids, a low frequency of lysine, and a high occurrence of amino acids with a low hydrophobic character. Using extensive mutational studies on the protein surfaces, we show that it is possible to decrease the salt dependence of a typical halophilic protein to the level of a mesophilic form and engineer a protein from a mesophilic organism into an obligate halophilic form. NMR studies demonstrate complete preservation of the three-dimensional structure of extreme mutants and confirm that salt dependency is conferred exclusively by surface residues. In spite of the statistically established fact that most halophilic proteins are strongly acidic, analysis of a very large number of mutants showed that the effect of salt on protein stability is largely independent of the total protein charge. Conversely, we quantitatively demonstrate that halophilicity is directly related to a decrease in the accessible surface area. [ABSTRACT FROM AUTHOR]

The ability of three anionic cosolutes (sulfate, thiocyanate, and chloride) in modulating the 1H/2H exchange rates for backbone amide protons has been investigated using nuclear magnetic resonance (NMR) for two different proteins: the IGg-binding domain of protein L (ProtL) and the glucose-galactose-binding protein (GGBP). Our results show that moderate anion concentrations (0.2 M-1 M) regulate the exchange rate following the Hofmeister series: Addition of thiocyanate increases the exchange rates for both proteins, while sulfate and chloride (to a less extent) slow down the exchange reaction. In the presence of the salt, no alteration of the protein structure and minimal variations in the number of measurable peaks are observed. Experiments with model compounds revealed that the unfolded state is modulated in an equivalent way by these cosolutes. For ProtL, the estimated values for the local free energy change upon salt addition ( m3,Δ G) are consistent with the previously reported free energy contribution from the cosolute's preferential interaction/exclusion term indicating that nonspecific weak interactions between the anion and the amide groups constitute the dominant mechanism for the exchange-rate modulation. The same trend is also found for GGBP in the presence of thiocyanate, underlining the generality of the exchange-rate modulation mechanism, complementary to more investigated effects like the electrostatic interactions or specific anion binding to protein sites. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Filosofía UIS is the property of Universidad Industrial de Santander and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)