28 results on '"Chue, Colin D."'
Search Results
2. Pathophysiology of severe primary graft dysfunction in orthotopic heart transplantation.
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Lim, Hoong Sern, Ranasinghe, Aaron, Quinn, David, Chue, Colin D., and Mascaro, Jorge
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HEART transplantation ,ARTIFICIAL blood circulation ,CARDIOGENIC shock ,HEART failure ,PATHOLOGICAL physiology - Abstract
Background: A series of insults on the donor heart result in pathophysiological changes that manifest as primary graft dysfunction (PGD) post‐orthotopic heart transplantation. The objectives of this study were: (i) describe the pathophysiology of severe PGD using an established cardiovascular model; and (ii) the evolution of the pathophysiology during recovery from severe PGD. Methods: Hemodynamic data from 20 consecutive patients with severe PGD (need for mechanical circulatory support, MCS) at baseline (T0), 6 h (T6) and "recovery" (explant of support), and 20 consecutive patients without severe PGD were used to model the pathophysiology using the cardiovascular model described by Burkhoff and Dickstein. Results: There was a progressive (from T0 to T6) up‐ and leftward shift in the diastolic pressure‐volume relationship, especially of the right ventricle (RV), resulting in reduced capacitance. RV end‐systolic elastance (Ees) was significantly elevated in severe PGD but preload‐recruitable stroke work (PRSW) was significantly lower compared to patients without severe PGD. "Recovery" (after liberation from MCS) was associated with improvement in RV Ees, chamber capacitance and PRSW, although they remained significantly lower than patients without severe PGD. Conclusion: Severe PGD of the dominant right heart failure phenotype is characterized by reduced chamber capacitance, increased "stiffness" and impaired contractility. Complete normalization was not required for successful weaning of MCS. [ABSTRACT FROM AUTHOR]
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- 2021
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3. Mechanical circulatory support in the heart failure population.
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Nazzari, Hamed, Chue, Colin D., and Toma, Mustafa
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- 2019
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4. Caveolin-1 single-nucleotide polymorphism and arterial stiffness in non-dialysis chronic kidney disease.
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Chand, Sourabh, Edwards, Nicola C., Chue, Colin D., Jesky, Mark, Stringer, Stephanie, Simmonds, Matthew J., Duff, Claire E., Cockwell, Paul, Harper, Lorraine, Steeds, Richard P., Townend, Jonathan N., Ferro, Charles J., and Borrows, Richard
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KIDNEY diseases ,CAVEOLINS ,SINGLE nucleotide polymorphisms ,ARTERIOSCLEROSIS ,CARDIOVASCULAR disease related mortality ,ARTERIAL diseases - Abstract
Background. Arteriosclerosis is an independent predictor of increased cardiovascular mortality in chronic kidney disease (CKD). Histologically it is characterized by hypertrophy and fibrosis of the arterial media wall leading to increased arterial stiffness and end-organ damage. Caveolin-1 acts as an intracellular signalling pathway chaperone in human fibrotic and vascular diseases. The purpose of this study was to assess the association between caveolin-1 (CAV1) single-nucleotide polymorphism (SNP) rs4730751 and arterial stiffness as measured by arterial pulse wave velocity (PWV) in an early-stage CKD cohort and in a cohort with more severe CKD. Methods. Two prospectively maintained patient cohorts with non-dialysis CKD were studied: 144 patients in the Chronic Renal Impairment in Birmingham (CRIB) cohort and 147 patients in the Renal Impairment in Secondary Care (RIISC) cohort, with matched exclusion criteria and DNA sampling availability. At entry to each cohort database, each patient's initial arterial PWV was measured, as well as their anthropomorphic and biochemical data. CAV1 rs4730751 SNP genotyping was performed using Taqman technology. Results. The CAV1 rs4730751 SNP CC genotype was associated with lower arterial PWV in both CRIB early stage CKD patients [8.1 versus 8.6 m/s; coefficient -0.780 (-1.412, -0.149); P = 0.016] and RIISC more advanced stage CKD patients [8.7 versus 9.4 m/s; coefficient -0.695 (-1.288, -0.102); P = 0.022]; these relationships held following adjustment for other important confounders. Conclusions. This replicated study suggests potential utility of the studied CAV1 SNP as a genetic biomarker in CKD and a role for CAV1 in the development of arteriosclerosis in this setting. Further studies are warranted to further explore the basic science driving these clinical observations. [ABSTRACT FROM AUTHOR]
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- 2016
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5. Cardiovascular Effects of Unilateral Nephrectomy in Living Kidney Donors.
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Moody, William E., Ferro, Charles J., Edwards, Nicola C., Chue, Colin D., Lai Sze Lin, Erica, Taylor, Robin J., Cockwell, Paul, Steeds, Richard P., Townend, Jonathan N., Lin, Erica Lai Sze, and CRIB-Donor Study Investigators
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- 2016
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6. Comparison of magnetic resonance feature tracking for systolic and diastolic strain and strain rate calculation with spatial modulation of magnetization imaging analysis.
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Moody, William E., Taylor, Robin J., Edwards, Nicola C., Chue, Colin D., Umar, Fraz, Taylor, Tiffany J., Ferro, Charles J., Young, Alistair A., Townend, Jonathan N., Leyva, F., and Steeds, Richard P.
- Abstract
Purpose To compare cardiovascular magnetic resonance-feature tracking (CMR-FT) with spatial modulation of magnetization (SPAMM) tagged imaging for the calculation of short and long axis Lagrangian strain measures in systole and diastole. Materials and Methods Healthy controls ( n = 35) and patients with dilated cardiomyopathy ( n = 10) were identified prospectively and underwent steady-state free precession (SSFP) cine imaging and SPAMM imaging using a gradient-echo sequence. A timed offline analysis of images acquired at identical horizontal long and short axis slice positions was performed using CMR-FT and dynamic tissue-tagging (CIMTag2D). Agreement between strain and strain rate (SR) values calculated using these two different methods was assessed using the Bland-Altman technique. Results Across all participants, there was good agreement between CMR-FT and CIMTag for calculation of peak systolic global circumferential strain (−22.7 ± 6.2% vs. −22.5 ± 6.9%, bias 0.2 ± 4.0%) and SR (−1.35 ± 0.42 1/s vs. −1.22 ± 0.42 1/s, bias 0.13 ± 0.33 1/s) and early diastolic global circumferential SR (1.21 ± 0.44 1/s vs. 1.07 ± 0.30 1/s, bias −0.14 ± 0.34 1/s) at the subendocardium. There was satisfactory agreement for derivation of peak systolic global longitudinal strain (−18.1 ± 5.0% vs. −16.7 ± 4.8%, bias 1.3 ± 3.8%) and SR (−1.04 ± 0.29 1/s vs. −0.95 ± 0.32 1/s, bias 0.09 ± 0.26 1/s). The weakest agreement was for early diastolic global longitudinal SR (1.10 ± 0.40 1/s vs. 0.67 ± 0.32 1/s, bias −0.42 ± 0.40 1/s), although the correlation remained significant ( r = 0.42, P < 0.01). CMR-FT generated these data over four times quicker than CIMTag. Conclusion There is sufficient agreement between systolic and diastolic strain measures calculated using CMR-FT and myocardial tagging for CMR-FT to be considered as a potentially feasible and rapid alternative. J. Magn. Reson. Imaging 2015;41:1000-1012. © 2014 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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7. Impact of renal function on survival after transcatheter aortic valve implantation (TAVI): an analysis of the UK TAVI registry.
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Ferro, Charles J., Chue, Colin D., de Belder, Mark A., Moat, Neil, Wendler, Olaf, Trivedi, Uday, Ludman, Peter, and Townend, Jonathan N.
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AORTIC valve surgery ,HEART valve prosthesis implantation ,KIDNEY diseases ,PREOPERATIVE care ,HEMODIALYSIS ,CHRONIC kidney failure ,GLOMERULAR filtration rate - Abstract
Objective To determine the nature of the association between renal dysfunction and outcomes following transcatheter aortic valve implantation (TAVI) in all cases performed in the UK between 2007 and 2012. Methods The UK TAVI registry was established to report outcomes on all TAVI procedures performed within the UK. Data were collected prospectively on 3980 patients from 1 January 2007 until 31 December 2012. Results In total, 205 patients (5.5%) died during their admission. Moderate to advanced chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) <45 mL/min/1.73 m²) was significantly associated with increased mortality, even after adjustment for risk factors (OR 1.45, 95% CI 1.03 to 2.05; p=0.04). For every 10 mL/min/1.73 m² decrease in eGFR, in-hospital mortality increased by 8.2% (95% CI 1.1% to 14.7%; p=0.03). In total 1119 patients (30.2%) died during the follow-up period (median 543 days). Moderate to advanced CKD (eGFR <45 mL/min/1.73 m²) was significantly associated with increased mortality, even after adjustment for risk factors (OR 1.36, 95% CI 1.17 to 1.58; p<0.001). For every 10 mL/min/1.73 m² decrease in eGFR, cumulative mortality increased by 4.4% (95% CI 1.2% to 7.5%; p=0.007). Preoperative kidney function and the need for preoperative dialysis treatment discriminated between patients who died and survived. However, predictive power was poor with none of the c-statistics being >0.6. Conclusions Pre-procedural renal dysfunction is associated, in a graded fashion independently of dialysis status, with worse outcomes, including mortality in patients undergoing TAVI. [ABSTRACT FROM AUTHOR]
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- 2015
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8. Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphism and Left Ventricular Function in Early Chronic Kidney Disease.
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Chand, Sourabh, Chue, Colin D., Edwards, Nicola C., Hodson, James, Simmonds, Matthew J., Hamilton, Alexander, Gough, Stephen C. L., Harper, Lorraine, Steeds, Rick P., Townend, Jonathan N., Ferro, Charles J., and Borrows, Richard
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ENDOTHELIAL cells ,NITRIC-oxide synthases ,SINGLE nucleotide polymorphisms ,LEFT heart ventricle ,KIDNEY diseases ,HEART failure ,DISEASE progression - Abstract
Background: Chronic kidney disease (CKD) is associated with accelerated cardiovascular disease and heart failure. Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease. The association of a cardiac functional difference in non-dialysis CKD patients with no known previous heart failure, and eNOS gene variant is investigated. Methods: 140 non-dialysis CKD patients, who had cardiac magnetic resonance (CMR) imaging and tissue doppler echocardiography as part of two clinical trials, were genotyped for eNOS Glu298Asp SNP retrospectively. Results: The median estimated glomerular filtration rate (eGFR) was 50mls/min and left ventricular ejection fraction (LVEF) was 74% with no overt diastolic dysfunction in this cohort. There were significant differences in LVEF across eNOS genotypes with GG genotype being associated with a worse LVEF compared to other genotypes (LVEF: GG 71%, TG 76%, TT 73%, p = 0.006). After multivariate analysis, (adjusting for age, eGFR, baseline mean arterial pressure, contemporary CMR heart rate, total cholesterol, high sensitive C-reactive protein, body mass index and gender) GG genotype was associated with a worse LVEF, and increased LV end-diastolic and systolic index (p = 0.004, 0.049 and 0.009 respectively). Conclusions: eNOS Glu298Asp rs1799983 polymorphism in CKD patients is associated with relevant sub-clinical cardiac remodelling as detected by CMR. This gene variant may therefore represent an important genetic biomarker, and possibly highlight pathways for intervention, in these patients who are at particular risk of worsening cardiac disease as their renal dysfunction progresses. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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9. Characterization of a Resident Population of Adventitial Macrophage Progenitor Cells in Postnatal Vasculature.
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Psaltis, Peter J., Puranik, Amrutesh S., Spoon, Daniel B., Chue, Colin D., Hoffman, Scott J., Witt, Tyra A., Delacroix, Sinny, Kleppe, Laurel S., Mueske, Cheryl S., Pan, Shuchong, Gulati, Rajiv, and Simari, Robert D.
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- 2014
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10. Bleeding outcomes after routine transradial primary angioplasty for acute myocardial infarction using eptifibatide and unfractionated heparin: A single-center experience following the HORIZONS-AMI trial.
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Moody, William E., Chue, Colin D., Ludman, Peter F., Chan, Yik‐ki C., Narayan, Gautam, Millington, Jenna M., Townend, Jonathan N., and Doshi, Sagar N.
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- 2013
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11. Arterial disease in chronic kidney disease.
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Moody, William E., Edwards, Nicola C., Chue, Colin D., Ferro, Charles J., and Townend, Jonathan N.
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CHRONIC kidney failure ,ARTERIAL diseases ,CARDIOVASCULAR disease related mortality ,ARTERIOSCLEROSIS ,ATHEROSCLEROSIS ,MYOCARDIAL infarction - Abstract
End stage renal disease is associated with a very high risk of premature cardiovascular death and morbidity. Early stage chronic kidney disease (CKD) is also associated with an increased frequency of cardiovascular events and is a common but poorly recognised and undertreated risk factor. Cardiovascular disease in CKD can be attributed to two distinct but overlapping pathological processes, namely atherosclerosis and arteriosclerosis. While the risk of athero-thrombotic events such as myocardial infarction is elevated, arteriosclerosis is the predominant pathophysiological process involving fibrosis and thickening of the medial arterial layer. This results in increased arterial stiffness causing left ventricular hypertrophy and fibrosis and the exposure of vulnerable vascular beds such as the brain and kidney to high pressure fluctuations causing small vessel disease. These pathophysiological features are manifest by a high risk of lethal arrhythmia, congestive heart failure, myocardial infarction and stroke. Recent work has highlighted the importance of aldosterone and disordered bone mineral metabolism. [ABSTRACT FROM AUTHOR]
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- 2013
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12. Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease.
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Wall, Nadezhda A., Chue, Colin D., Edwards, Nicola C., Pankhurst, Tanya, Harper, Lorraine, Steeds, Richard P., Lauder, Sarah, Townend, Jonathan N., Moss, Paul, and Ferro, Charles J.
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CYTOMEGALOVIRUS disease diagnosis ,ARTERIAL diseases ,CHRONIC kidney failure ,CARDIOVASCULAR diseases ,BLOOD serum analysis ,ENZYME-linked immunosorbent assay ,IMMUNOGLOBULIN G ,THORACIC aorta ,PATIENTS - Abstract
Background: Patients with chronic kidney disease have an increased cardiovascular risk that is not fully explained by traditional risk factors but appears to be related to increased arterial stiffness. Cytomegalovirus (CMV) infection is associated with increased cardiovascular risk although the mechanisms for this are unknown. We examined whether CMV seropositivity was associated with increased arterial stiffness in patients with chronic kidney disease. Methodology and Principal Findings: In 215 non-diabetic patients with chronic kidney disease, CMV seropositivity was determined using an anti-CMV IgG ELISA. Pulse wave velocity was measured and aortic distensibility assessed in the ascending, proximal descending and distal descending thoracic aorta. Patients seropositive for CMV had a higher pulse wave velocity and lower aortic distensibility at all 3 levels. These differences (except for ascending aortic distensibility) persisted in a subcohort matched for age, gender and renal function, and when the whole cohort was divided into quartiles of age. In multivariable analyses, CMV seropositivity was an independent determinant of pulse wave velocity and proximal and distal descending aortic distensibility. Conclusions: In patients with chronic kidney disease, CMV seropositivity is associated with increased arterial stiffness and decreased distensibility of the proximal descending and distal aorta. These findings suggest that further research is required to examine CMV as a possible cause of arterial disease and increased cardiovascular risk in patients with CKD and may be relevant more widely for CMV seropositive patients with normal renal function. [ABSTRACT FROM AUTHOR]
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- 2013
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13. An In Vivo Method to Quantify Lymphangiogenesis in Zebrafish.
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Hoffman, Scott J., Psaltis, Peter J., Clark, Karl J., Spoon, Daniel B., Chue, Colin D., Ekker, Stephen C., Simari, Robert D., and Riley, Bruce
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NEOVASCULARIZATION ,NEUROENDOCRINE tumors ,CYTOKINES ,LYMPHATIC cancer ,ZEBRA danio ,GROWTH factors - Abstract
Background: Lymphangiogenesis is a highly regulated process involved in the pathogenesis of disease. Current in vivo models to assess lymphangiogenesis are largely unphysiologic. The zebrafish is a powerful model system for studying development, due to its rapid growth and transparency during early stages of life. Identification of a network of trunk lymphatic capillaries in zebrafish provides an opportunity to quantify lymphatic growth in vivo. Methods and Results: Late-phase microangiography was used to detect trunk lymphatic capillaries in zebrafish 2- and 3- days post-fertilization. Using this approach, real-time changes in lymphatic capillary development were measured in response to modulators of lymphangiogenesis. Recombinant human vascular endothelial growth factor (VEGF)-C added directly to the zebrafish aqueous environment as well as human endothelial and mouse melanoma cell transplantation resulted in increased lymphatic capillary growth, while morpholino-based knockdown of vegfc and chemical inhibitors of lymphangiogenesis added to the aqueous environment resulted in decreased lymphatic capillary growth. Conclusion: Lymphatic capillaries in embryonic and larval zebrafish can be quantified using late-phase microangiography. Human activators and small molecule inhibitors of lymphangiogenesis, as well as transplanted human endothelial and mouse melanoma cells, alter lymphatic capillary development in zebrafish. The ability to rapidly quantify changes in lymphatic growth under physiologic conditions will allow for broad screening of lymphangiogenesis modulators, as well as help define cellular roles and elucidate pathways of lymphatic development. [ABSTRACT FROM AUTHOR]
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- 2012
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14. Aortic Calcification and Femoral Bone Density Are Independently Associated with Left Ventricular Mass in Patients with Chronic Kidney Disease.
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Chue, Colin D., Wall, Nadezhda A., Crabtree, Nicola J., Zehnder, Daniel, Moody, William E., Edwards, Nicola C., Steeds, Richard P., Townend, Jonathan N., and Ferro, Charles J.
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CALCIFICATION ,AORTIC valve ,BONE density ,KIDNEY diseases ,CARDIOVASCULAR diseases risk factors - Abstract
Background: Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a crosssectional observational study. Methodology and Principal Findings: A total of 120 patients were recruited (54% male, mean age 55±14 years, mean glomerular filtration rate 50613 ml/min/1.73 m
2 ). Abdominal aortic calcification was assessed using lateral lumbar spine radiography and was present in 48%. Mean femoral Z-score measured using dual energy x-ray absorptiometry was 0.60±1.06. Cardiovascular magnetic resonance imaging was used to determine left ventricular mass. One patient had left ventricular hypertrophy. Subjects with aortic calcification had higher left ventricular mass compared to those without (56±16 vs. 48612 g/m2 , P = 0.002), as did patients with femoral Z-scores below zero (56±15 vs. 49±13 g/m2 , P = 0.01). In univariate analysis presence of aortic calcification correlated with left ventricular mass (r = 0.32, P = 0.001); mean femoral Zscore inversely correlated with left ventricular mass (r =-0.28, P = 0.004). In a multivariate regression model that included presence of aortic calcification, mean femoral Z-score, gender and 24-hour systolic blood pressure, 46% of the variability in left ventricular mass was explained (P<0.001). Conclusions: In patients with stage 3 non-diabetic chronic kidney disease, lower mean femoral Z-score and presence of aortic calcification are independently associated with increased left ventricular mass. Further research exploring the pathophysiology that underlies these relationships is warranted [ABSTRACT FROM AUTHOR]- Published
- 2012
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15. Serum Phosphate Measured at 6 and 12 Months After Successful Kidney Transplant Is Independently Associated With Subsequent Graft Loss.
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Benavente, David, Chue, Colin D., Moore, Jason, Addison, Clara, Borrows, Richard, and Ferro, Charles J.
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- 2012
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16. The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease.
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Edwards, Nicola C., Steeds, Richard P., Chue, Colin D., Stewart, Paul M., Ferro, Charles J., and Townend, Jonathan N.
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SPIRONOLACTONE ,KIDNEY diseases ,BLOOD pressure ,ANGIOTENSIN converting enzyme ,BIOMARKERS - Abstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Spironolactone has recently been shown to exert beneficial effects on the cardiovascular and renal systems. To date, its use in patients with chronic kidney disease has been limited due to potential risks of hyperkalaemia and declining renal dysfunction. WHAT THIS STUDY ADDS • Non-diabetic patients with early stage chronic kidney disease (CKD) on concomitant therapy with angiotensin converting enzyme (ACE) inhibition or angiotensin II receptor blockade with a serum potassium of <5.5 mmol/L and no history of hyperkalaemia who were randomized in a trial to treatment with spironolactone for 40 weeks had low rates of serious hyperkalaemia (<1%) and worsening renal function (<3%). Frequent biochemical monitoring is required for the initial 4 weeks but only routine monitoring is needed thereafter. AIM Mineralocorticoid receptor blockade (MRBs) in combination with angiotensin converting enzyme (ACE) inhibitors and angiotensin-II receptor blockade (ARBs) improve prognostic markers of cardiovascular and renal disease in early stage chronic kidney disease (CKD). Concerns relating to the safety and tolerability of MRBs in CKD may limit their use in a non clinical trial setting. METHODS In the Chronic Renal Impairment in Birmingham II study, 115 patients with non-diabetic early stage CKD (eGFR 30-89 ml/min/1.73m
2 ) received 25 mg daily of spironolactone for 4 weeks before randomization to continuing treatment or placebo for a further 36 weeks. All patients were on ACE inhibitors and/or ARB therapy. Potassium and renal function were checked at weeks 1, 2, 4, 8, 16, 28 and 40. The incidence of hyperkalaemia, significant renal dysfunction (reduction eGFR ≥25%) and adverse effects was assessed. RESULTS After 40 weeks of treatment the incidence of serious hyperkalaemia (K+ ≥6.0 mmol/L) was <1%. A potassium 5.5-5.9 mmol/L occurred on ≥1 occasion over follow-up in 11 patients (nine on spironolactone) and was predicted by baseline potassium ≥5.0 mmol/L and eGFR ≤45 ml/min/1.73m2 . Over follow-up, three patients experienced significant renal dysfunction but no patients withdrew due to intolerance or side effects. Changes in potassium, eGFR and systolic blood pressure were most apparent in the first 4 eeks. CONCLUSION Spironolactone was well tolerated in selected patients with early stage CKD. Strict monitoring over the first month of treatment followed by standard surveillance as for ACE inhibitors and ARBs is suggested. [ABSTRACT FROM AUTHOR]- Published
- 2012
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17. Serum phosphate is associated with left ventricular mass in patients with chronic kidney disease: a cardiac magnetic resonance study.
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Chue, Colin D., Edwards, Nicola C., Moody, William E., Steeds, Richard P., Townend, Jonathan N., and Ferro, Charles J.
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KIDNEY disease risk factors ,PHOSPHATES ,LEFT heart ventricle ,BLOOD serum analysis ,ARTERIAL diseases ,MAGNETIC resonance imaging - Abstract
Objective To explore the relationship between serum phosphate, arterial stiffness and left ventricular mass (LVM) in patients with early-stage chronic kidney disease (CKD). Design A cross-sectional observational study. Setting Single centre. Patients 208 patients with stage 2 to stage 4 non-diabetic CKD. Interventions Arterial stiffness was determined through measurement of aortic pulse wave velocity (PWV). Cardiac magnetic resonance was used to determine LVM. Main outcome measure Relationship between serum phosphate, aortic PWV and LVM. Results Mean age was 54±13 years, mean glomerular filtration rate was 50±15 ml/min/1.73 m², mean serum phosphate was 1.11±0.21 mmol/l and mean PWV was 8.6±2.1 m/s. When the cohort was divided into quartiles according to serum phosphate, LVM increased across quartiles (p=0.04), with no significant differences in age, kidney function, blood pressure or PWV. Serum phosphate correlated with LVM (r=0.173; p=0.01), but PWV did not (p=0.2). In a regression model containing gender, serum phosphate, office systolic blood pressure, albumin/creatinine ratio and haemoglobin, 30% of the variation in LVM was explained (p<0.0005), with serum phosphate accounting for 5% of the variance. Conclusion Serum phosphate is independently associated with LVM in patients with CKD. Interventional studies are required to determine whether this association is causative and whether reducing phosphate exposure reduces LVM in this population. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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18. Serum phosphate but not pulse wave velocity predicts decline in renal function in patients with early chronic kidney disease.
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Chue, Colin D., Edwards, Nicola C., Davis, Laura J., Steeds, Richard P., Townend, Jonathan N., and Ferro, Charles J.
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KIDNEY diseases ,KIDNEY function tests ,CARDIOVASCULAR diseases risk factors ,SERUM ,BIOMARKERS ,ARTERIAL diseases ,PHOSPHATES ,DIALYSIS (Chemistry) - Abstract
Background. The rate of decline in kidney function is a powerful predictor of cardiovascular risk in patients with chronic kidney disease (CKD). Serum phosphate and increased arterial stiffness are associated with elevated cardiovascular risk in CKD and the general population. We sought to determine whether serum phosphate and markers of arterial stiffness predict progression of renal dysfunction in patients with early CKD.Methods. Two hundred and twenty-five patients with Stage II–IV CKD were prospectively followed up at University Hospital Birmingham. Serum phosphate was measured at baseline and arterial stiffness was determined through measurement of aortic pulse wave velocity (PWV) and augmentation index (AIx). Progression of renal dysfunction was defined as the slope of estimated glomerular filtration rate (eGFR) against time. We determined the associations between possible predictors and rate of progression and also examined a combined end point of start of dialysis or ≥25% decline in eGFR.Results. Mean baseline eGFR was 43 ± 19 mL/min/1.73 m2 and serum phosphate 1.22 ± 0.27 mmol/L. Median follow-up was 924 days. Serum phosphate independently predicted a greater decline in eGFR; a 1 mmol/L increment in serum phosphate was associated with a 0.34 mL/min/month steeper decline (P = 0.02). Brachial and aortic systolic pressure independently predicted the rate of renal function decline but aortic PWV and AIx had no significant influence. Forty-one patients (18%) reached the combined end point; serum phosphate was significantly higher in this group (1.32 ± 0.36 versus 1.19 ± 0.24 mmol/L, P = 0.04) and was an independent predictor for the combined end point.Conclusions. Serum phosphate independently predicts decline in renal function in early CKD. Further studies are required to determine the mechanisms involved and to investigate the potential benefits of phosphate lowering on preserving kidney function. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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19. Evaluating the effects of sevelamer carbonate on cardiovascular structure and function in chronic renal impairment in Birmingham: the CRIB-PHOS randomised controlled trial.
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Chue, Colin D., Townend, Jonathan N., Steeds, Richard P., and Ferro, Charles J.
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SERUM ,CARDIOVASCULAR disease related mortality ,ECHOCARDIOGRAPHY ,MAGNETIC resonance imaging ,TONOMETRY - Abstract
Background: Serum phosphate is an independent predictor of cardiovascular morbidity and mortality in patients with chronic kidney disease and the general population. There is accumulating evidence that phosphate promotes arterial stiffening through structural vascular alterations such as medial calcification, which are already apparent in the early stages of chronic kidney disease. Aim: To determine the effects of phosphate binding with sevelamer carbonate on left ventricular mass and function together with arterial stiffness in patients with stage 3 chronic kidney disease. Methods/Design: A single-centre, prospective, randomised, double-blind, placebo-controlled trial of 120 subjects with stage 3 chronic kidney disease recruited from University Hospitals Birmingham NHS Foundation Trust. Baseline investigations include transthoracic echocardiography and cardiac magnetic resonance imaging to assess ventricular mass, volumes and function, applanation tonometry to determine pulse wave velocity and pulse wave analysis as surrogate measures of arterial stiffness and dual energy x-ray absorptiometry scanning to determine bone density. During an open-label run in phase, subjects will receive 1600 mg sevelamer carbonate with meals for four weeks. They will then be randomised to either continue sevelamer carbonate or receive an identical placebo (60 subjects per arm) for the remaining 36 weeks. Four-weekly monitoring of serum electrolytes and bone biochemistry will be performed. All baseline investigations will be repeated at the end of the treatment period. The primary endpoint of the study is a reduction in left ventricular mass after 40 weeks of treatment. Secondary endpoints are: i) change in aortic compliance; ii) change in arterial stiffness; iii) change in arterial elastance; iv) change in left ventricular systolic and diastolic elastance; v) change in left ventricular function; and vi) change in bone density. Trial Registration: This trial is registered at ClinicalTrials.gov: NCT00806481 and Current Controlled Trials: ISRCTN35254279. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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20. Arterial stiffness in chronic kidney disease: causes and consequences.
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Chue, Colin D., Townend, Jonathan N., Steeds, Richard P., and Ferro, Charles J.
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ARTERIAL diseases ,CHRONIC kidney failure ,ETIOLOGY of diseases ,DISEASE complications ,CARDIOVASCULAR diseases ,PATHOLOGICAL physiology ,COHORT analysis - Abstract
Chronic kidney disease is associated with elevated cardiovascular risk, and heart failure and arrhythmias are the biggest causes of cardiovascular death in this population. Increased arterial stiffness is a hallmark of chronic kidney disease and is associated with adverse alterations in cardiac structure and function that may predispose to an increased risk of cardiovascular death. These changes are already apparent in early kidney disease, which is highly prevalent in the developed world. The mechanisms underlying increased arterial stiffness in chronic kidney disease are undoubtedly complex, but an understanding is paramount to enable the development of novel therapeutic strategies to prevent or reverse this pathophysiology and therefore reduce the cardiovascular disease burden in this high-risk cohort. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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21. THE IMPORTANCE OF RENIN-ANGIOTENSIN BLOCKADE IN PATIENTS WITH CARDIO-RENAL DISEASE.
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Benavente, David, Chue, Colin D., and Ferro, Charles J.
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RENIN ,ANGIOTENSINS ,RENIN-angiotensin system ,KIDNEY diseases ,CARDIOVASCULAR diseases ,DRUG administration ,DISEASE complications ,THERAPEUTICS ,DISEASE risk factors - Abstract
The existence of the renin–angiotensin–aldosterone system was first postulated over 100 years ago. Following the identification of all the major components, came the discovery of their potential pathogenicity in cardiovascular and renal disease. The introduction of drugs that inhibit the synthesis or actions of this system has prompted a number of trials that have largely shaped how cardiovascular and renal disease is managed today. The continued discovery of yet more components of this system promises to further our understanding of its influence on disease processes and herald the development of more highly selective drugs, ensuring that the renin–angiotensin–aldosterone system will continue to be a key area of interest for many years to come. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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22. Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis.
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Toledo-Flores, Deborah, Williamson, Anna, Schwarz, Nisha, Fernando, Sanuja, Dimasi, Catherine, Witt, Tyra A., Nguyen, Thao M., Puranik, Amrutesh S., Chue, Colin D., Delacroix, Sinny, Spoon, Daniel B., Bonder, Claudine S., Bursill, Christina A., Di Bartolo, Belinda A., Nicholls, Stephen J., Simari, Robert D., and Psaltis, Peter J.
- Abstract
The cellular origins of vasa vasorum are ill-defined and may involve circulating or local progenitor cells. We previously discovered that murine aortic adventitia contains Sca-1
+ CD45+ progenitors that produce macrophages. Here we investigated whether they are also vasculogenic. In aortas of C57BL/6 mice, Sca-1+ CD45+ cells were localised to adventitia and lacked surface expression of endothelial markers (<1% for CD31, CD144, TIE-2). In contrast, they did show expression of CD31, CD144, TIE-2 and VEGFR2 in atherosclerotic ApoE−/− aortas. Although Sca-1+ CD45+ cells from C57BL/6 aorta did not express CD31, they formed CD31+ colonies in endothelial differentiation media and produced interconnecting vascular-like cords in Matrigel that contained both endothelial cells and a small population of macrophages, which were located at branch points. Transfer of aortic Sca-1+ CD45+ cells generated endothelial cells and neovessels de novo in a hindlimb model of ischaemia and resulted in a 50% increase in perfusion compared to cell-free control. Similarly, their injection into the carotid adventitia of ApoE−/− mice produced donor-derived adventitial and peri-adventitial microvessels after atherogenic diet, suggestive of newly formed vasa vasorum. These findings show that beyond its content of macrophage progenitors, adventitial Sca-1+ CD45+ cells are also vasculogenic and may be a source of vasa vasorum during atherogenesis. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
23. Impaired circumferential and longitudinal myocardial deformation in early stage chronic kidney disease: the earliest features of uremic cardiomyopathy.
- Author
-
Edwards, Nicola C., Noori, Abdullah, Chue, Colin D., Moody, William E., Ferro, Charles J., Townend, Jonathan N., and Steeds, Richard
- Subjects
CHRONIC kidney failure ,CONFERENCES & conventions ,MAGNETIC resonance imaging ,CARDIOMYOPATHIES ,UREMIA ,DISEASE complications ,DIAGNOSIS - Abstract
An abstract of the article "Impaired circumferential and longitudinal myocardial deformation in early stage chronic kidney disease: the earliest features of uremic cardiomyopathy," by Nicola C. Edwards and colleagues is presented.
- Published
- 2013
- Full Text
- View/download PDF
24. Comparison of magnetic resonance feature tracking for longitudinal strain calculation with spatial modulation of magnetization imaging analysis.
- Author
-
Moody, William E., Taylor, Robin J., Edwards, Nicola C., Umar, Fraz, Chue, Colin D., Taylor, Tiffany J., Ferro, Charles J., Townend, Jonathan N., Leyva, Francisco, and Steeds, Richard
- Subjects
LEFT heart ventricle ,HEART physiology ,CONFERENCES & conventions ,MAGNETIC resonance imaging - Abstract
An abstract of the article "Comparison of magnetic resonance feature tracking for longitudinal strain calculation with spatial modulation of magnetization imaging analysis," by William E. Moody and colleagues is presented.
- Published
- 2013
- Full Text
- View/download PDF
25. DISEASE IN KIDNEY DONORS.
- Author
-
Moody, William E., Ferro, Charles J., Chue, Colin D., Edwards, Nicola C., Steeds, Richard P., Townsend, Jonathan N., Sammartino, Christine, Clark, Carolyn, and Gray, Nicholas
- Subjects
ORGAN donation ,BLOOD pressure measurement ,PATIENT aftercare ,KIDNEY transplantation ,ORGAN donors ,REPORT writing ,SAFETY ,DATA analysis - Abstract
Several letters to the editor are presented in response to articles in previous issues such as the understanding of the long term consequences of living kidney donation and the increased risk of cardiovascular disease compared with matched non-donors in the general population.
- Published
- 2012
26. Aortic dissection with left atrial compression: An unusual cause of breathlessness.
- Author
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Chue, Colin D., Routledge, Helen C., and Epstein, Andrew C.R.
- Subjects
CASE studies ,DYSPNEA ,AORTIC dissection ,CORONARY artery bypass ,HEART blood-vessels - Abstract
The article presents the case of a 71-year old male patient with the problem of breathlessness. The patient had undergone coronary artery bypass grafting nine years ago with an internal mammary graft to the left anterior descending artery and single saphenous vein graft to the diagonal. Radiography of the chest shown a widened mediastinum with small bilateral pleural effusions.
- Published
- 2009
- Full Text
- View/download PDF
27. An acrodermatitis enteropathica-like eruption secondary to acquired zinc deficiency in an exclusively breast-fed premature infant.
- Author
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Chue, Colin D., Rajpar, Sajjad F., and Bhat, Jaideep
- Subjects
ACRODERMATITIS ,PREMATURE infant diseases ,SKIN diseases ,ZINC deficiency diseases ,ATOMIC absorption spectroscopy ,BREASTFEEDING - Abstract
The article reports on a case of a 14-week-old female infant with a history of polymorphous rash affecting the diaper and facial areas. Observations show that the 8-weeks premature baby has a localization of lesions in a periorificial distribution. This leads to zinc deficiency, confirmed by flame atomic absorption spectroscopy. Moreover, this case illustrates that premature neonates are susceptible to acquired zinc deficiency if breast-fed by mothers with defective zinc transport.
- Published
- 2008
- Full Text
- View/download PDF
28. Thrombus straddling a patent foramen ovale.
- Author
-
Chue, Colin D., Qaisar, Sohail, and Ment, Jerome
- Subjects
THROMBOSIS ,DYSPNEA ,COMPUTED tomography ,ECHOCARDIOGRAPHY ,SURGICAL excision - Abstract
The article presents a case study of a 77-year old Caucasian woman with a history of progressive breathlessness who undergo computed tomography imaging. She was recommended for surgical excision but she refused and was advised to avoid straining. Topic discussed also include the use of anticoagulation with warfarin, the resolution of the disease, and used of repeat transthoracic echocardiography for the resolution of the thrombus.
- Published
- 2014
- Full Text
- View/download PDF
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