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Recent years have seen a tremendous increase of digital Earth Observation (EO) infrastructures, which provide web-based environments for accessing and processing data in a highly automated and scalable way. However, the current landscape of EO infrastructures and initiatives is fragmented, with various levels of user on-boarding and uptake success. The current work aims to make sense of this complex landscape by providing two main contributions. First, it offers a classification scheme used to review and analyse more than 150 EO infrastructures and initiatives. Then, adopting a user-centric perspective, the main limitations and obstacles currently faced by users when working with the existing EO platforms are identified. For each of these limitations, we propose a number of good practices that could benefit, from a user point of view, the design and functioning of EO platforms. Some technological enablers, i.e. specific resources (such as software components, standards and data encodings) that emerged from the analysis as holding a great potential for improving the usability of existing EO platforms, are finally listed. The work aims to provide a first scientific insight on how to best design and operate EO platforms to maximise the benefits of their user communities. [ABSTRACT FROM AUTHOR]

Structural elements, transversal to the Apennine chain, display various problematic aspects connected, above all, with their origin tectonogenetic role. From a seismic point of view, they may act as a structural barrier to the propagation of the Apennine normal faults or behave as transfer zones, thus activating neighboring segments belonging to the same fault system; the largest ones can also host significant earthquakes with the hypocenters located in the basement, below the Apennine thrust belt. This paper describes a case of recurrent surface faulting that reactivates a sector of a relevant transverse feature, the "." (FV-VE), near the city of Fabriano (Marche, Italy). Detailed geomorphological observations connect it with past earthquakes, including the disastrous event (I0 = IX MCS, about 6.2 Mw) of 24 April 1741 that struck the area with a wide distribution of damages extending along the Esino River Valley to the Adriatic coast over a distance of more than 50 km. Furthermore, paleoseismological analysis and radiocarbon datings of faulted river terraces and slope deposits, ranging in age from the end of the Middle Pleistocene to the recent Holocene, allowed us to define the evolutionary steps of the fault and estimate a slip rate of about 0.3 mm/year. [ABSTRACT FROM AUTHOR]

Improvement of metabolic control has been confirmed at follow-up visit, after 3 months, when patient presented 69% of TIR in the 14 days before the visit and HbA1c level was 7.2% (55 mmol/mol). At the discharge, insulin therapy with multiple daily injections, supported by advanced educational therapeutic plan about carbohydrates counting, was started, but, after a severe hypoglycemic event, she developed an important fear of hypoglycemia with a consequent wrong approach to the insulin therapy, preferring to maintain glycemic values higher than 200 mg/dL in order to avoid hypoglycemia. Patient reported improvement of quality of life and the reduction in diabetes burden. [Extracted from the article]

Rare truncating BRCA2 K3326X (rs11571833) and pathogenic CHEK2 I157T (rs17879961) variants have previously been implicated in familial pancreatic ductal adenocarcinoma (PDAC), but not in sporadic cases. The effect of both mutations in important DNA repair genes on sporadic PDAC risk may shed light on the genetic architecture of this disease. Both mutations were genotyped in germline DNA from 2,935 sporadic PDAC cases and 5,626 control subjects within the PANcreatic Disease ReseArch (PANDoRA) consortium. Risk estimates were evaluated using multivariate unconditional logistic regression with adjustment for possible confounders such as sex, age and country of origin. Statistical analyses were two‐sided with p values <0.05 considered significant. K3326X and I157T were associated with increased risk of developing sporadic PDAC (odds ratio (ORdom) = 1.78, 95% confidence interval (CI) = 1.26–2.52, p = 1.19 × 10−3 and ORdom = 1.74, 95% CI = 1.15–2.63, p = 8.57 × 10−3, respectively). Neither mutation was significantly associated with risk of developing early‐onset PDAC. This retrospective study demonstrates novel risk estimates of K3326X and I157T in sporadic PDAC which suggest that upon validation and in combination with other established genetic and non‐genetic risk factors, these mutations may be used to improve pancreatic cancer risk assessment in European populations. Identification of carriers of these risk alleles as high‐risk groups may also facilitate screening or prevention strategies for such individuals, regardless of family history. What's new? Mutations in BRCA2 and CHEK2 are associated with susceptibility to many cancers, including pancreatic. The survival rate for pancreatic cancer remains abysmal, and early diagnostic markers are urgently needed. Here, the authors investigated the effect of a truncating BRCA2 variant (rs11571833) and a missense CHEK2 variant (rs17879961) on sporadic pancreatic ductal adenocarcinoma risk. Using data from the PANDoRA consortium, they tested a large number of samples, making this the first high‐power study to investigate these variants. Both variants, they found, increased the risk of non‐familial PDAC, and these variants may contribute to polygenic risk scores that help identify at‐risk individuals. [ABSTRACT FROM AUTHOR]

The Open Source Geospatial Foundation's (OSGeo) vision is to empower everyone, from pre-university students to professionals, with open source geospatial applications, tools and resources. In 2017, OSGeo decided to participate for the first time in the Code-in competition. Google Code-in (GCI) is an annual online competition aimed at introducing pre-university students (13-17 years) to open source projects, development and communities, through short 3-5 hour tasks. This is a unique opportunity to interact with pre-university students and to encourage them to become part of OSGeo. In this paper, we present OSGeo's involvement in GCI with the purpose of establishing lessons learned to improve our approach in the next editions of GCI. Over the 51 days of the competition, 279 students completed 649 OSGeo tasks. Students consistently communicated with the mentors to discuss submission and receive inputs from the wide community of developers too. During the GCI, the mentors reviewed the students' work and provided suggestions and feedback. Generally, the submissions were good and some of them are now part of the projects. As this was our first time participating in GCI these issues are seen as lessons learned and strategies to improve the process will be implemented based on the mentors' experience. It is key to encourage these students to continue contributing to the OSGeo community, as they will bring new energy and ideas into the organisation; for many of these young students, this competition is a way to introduce them to the geospatial industry. [ABSTRACT FROM AUTHOR]

Characterizing the dynamics of soil moisture fields is a key issue in hydrology, offering a strategy to improve our understanding of complex climate-soil-vegetation interactions. Besides in-situ measurements and hydrological models, soil moisture dynamics can be inferred by analyzing data acquired by sensors on board of airborne and/or satellite platforms. In this work, we investigated the use of the National Oceanic and Atmospheric Administration -- Advanced Microwave Sounding Unit-A (NOAA-AMSU-A) radiometer for the remote characterization of soil water content. To this aim, a field measurement campaign, lasted about three months (3 March 2010-18 May 2010), was carried out using a portable time-domain reflectometer (TDR) to get soil water content measures over five different locations within an experimental basin of 32.5 km², located in the South of Italy. In detail, soil moisture measurements were carried out systematically at the times of satellite overpasses, over two square areas of 400m², a triangular area of 200m² and two transects of 60 and 170m, respectively. Each monitored site is characterized by different land covers and soil textures, to account for spatial heterogeneity of land surface. Afterwards, a more extensive comparison (i.e. analyzing a 5 yr data time series) was made using soil moisture simulated by a hydrological model. Measured and modeled soil moisture data were compared with two AMSU-based indices: the Surface Wetness Index (SWI) and the Soil Wetness Variation Index (SWVI). Both time series of indices have been filtered by means of an exponential filter to account for the fact that microwave sensors only provide information at the skin surface. This allowed to understand the ability of each satellite-based index to account for soil moisture dynamics and to understand its performances under different conditions. As a general remark, the comparison shows a higher ability of the filtered SWI to describe the general trend of soil moisture, while the SWVI can capture soil moisture variations with a precision that increases at the higher values of SWVI. [ABSTRACT FROM AUTHOR]

Characterizing the dynamics of soil moisture fields is a key issue in hydrology, offering a strategy to improve our understanding of complex climate-soil-vegetation interactions. Apart from in-situ measurements and hydrological models, soil moisture dynamics can be inferred by analyzing data acquired by sensors aboard satellite platforms. In this work, we investigated the use of the National Oceanic and Atmospheric Administration -- Advanced Microwave Sounding Unit (NOAA-AMSU) radiometer for the remote characterization of soil water content. To this aim, a field measurement campaign, lasted about three months, was carried out using a portable time-domain reflectometer (TDR) to get soil water content measures over five different locations within an experimental basin of 32.5 kmm², located in the South of Italy. In detail, soil moisture measurements have been carried out systematically at the times of satellite overpasses, over two square areas of 400m², a triangular area of 200mm² and two transects of 60 and 170 m, respectively. Each monitored site is characterized by different land covers and soil textures, to account for spatial heterogeneity of land surface. Afterwards, a more extensive comparison (i.e. analyzing a 5-yr data time series) has been made using soil moisture simulated by a hydrological model. Achieved measured and modeled soil moisture data were compared with two AMSU-based indices: the Surface Wetness Index (SWI) and the SoilWetness Variation Index (SWVI). Both indices have been filtered to account for soil depth by means of an exponential filter. This allowed to understand the ability of each satellite-based index to account for soil moisture dynamics and to understand its performances under different conditions. As a general remark, the comparison shows a higher ability of the filtered SWI to describe the state of the soil, while the SWVI can capture soil moisture variations with a precision that increases at the higher values of SWVI and it may represent a useful and reliable tool to frequently monitor the soil moisture state for flood forecasting purposes. [ABSTRACT FROM AUTHOR]

This study evaluates the effect of 4 months supplementation with 2% and 5% taurine (w/w) on the retina of diabetic rats. In non-diabetic rats, taurine does not modify glycemia, body weight, retinal conjugated dienes (CD), lipid hydroperoxide (LP), and Na+K+ATPase activity. In diabetic rat, at 2, 4, 8, 16 weeks following the onset of diabetes, retinal CD and LP are significantly and progressively increased, while pump activity is gradually and significantly reduced. In taurine supplemented diabetic rats, glycemia is not affected but lipid peroxidation is significantly decreased. Finally, taurine preserves ATPase activity being 5% more effective than 2% taurine. We conclude that taurine supplementation ameliorates biochemical retinal abnormalities caused by diabetes, thereby suggesting that taurine may have a role in the prevention of retinal changes in diabetes. [ABSTRACT FROM AUTHOR]

Sixty consecutive patients who were symptom free 2-12 months after an uncomplicated acute myocardial infarction underwent maximal treadmill exercise testing, radionuclide angiography before and during submaximal bicycle stress test, and coronary angiography. The results of the non-invasive procedures were compared with those of coronary angiography. The sensitivity and specificity of electrocardiogram stress test for detection of multivessel disease were 40% and 77% respectively. Failure of left ventricular ejection fraction to increase at least 5% with exercise identified 20 of the 25 patients with multivessel disease (sensitivity 80%) and 23 of the 35 patients with no additional coronary artery stenosis (specificity 66%). In patients with anterior Q waves the sensitivity was 78% and the specificity 50%, whereas in the presence of inferior Q waves these values were 81% and 87% respectively. Loss of left ventricle synchronicity during effort, as indicated by failure of the standard deviation of the phases to decrease during exercise, demonstrated a radionuclide angiography sensitivity of 80% (77% for anterior myocardial infarction and 81% for inferior myocardial infarction) and a specificity of 50% (33% for anterior myocardial infarction and 64% for inferior myocardial infarction). When the test was considered to be positive if either the ejection fraction or the standard deviation of the phases criteria were positive, the sensitivity was 100% and specificity 46% (30% for anterior myocardial infarction and 65% for inferior myocardial infarction). It is concluded that in patients who are free from angina 2-12 months after an episode of uncomplicated myocardial infarction, a simple exercise electrocardiogram cannot be relied upon to detect residual ischaemia. An abnormal ejection fraction response or an increased standard deviation of the phases during exercise nuclear angiography or both identified all the patients with multivessel disease. None of the patients in whom radionuclide angiographic criteria were negative had multivessel disease. [ABSTRACT FROM PUBLISHER]