1. Long-term disease-free survival after nonmyeloablative cyclophosphamide/fludarabine conditioning and related/unrelated allotransplantation for acute myeloid leukemia/myelodysplasia.
- Author
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Nelson, R. P., Yu, M., Schwartz, J. E., Robertson, M. J., Hromas, R., Fausel, C. A., Vance, G. H., Dlouhy, S. R., Baute, J. A., Cox, E. A., Wood, L. L., Srivastava, S., Robertson, K. A., Haut, P. R., Farag, S. S., Abonour, R., Cornetta, K., and Cripe, L. D.
- Subjects
ACUTE myeloid leukemia ,CYCLOPHOSPHAMIDE ,FLUDARABINE ,TRANSPLANTATION of organs, tissues, etc. ,HEMATOPOIETIC stem cells ,IMMUNOSUPPRESSION ,PATIENTS - Abstract
A total of 50 consecutive patients (median age, 57.5 years) with AML (n=30) or myelodysplasia (MDS, n=20) underwent HLA matched related donor (MRD, n=27) or unrelated donor (MUD, n=23) peripheral blood hematopoietic cell transplantation after nonmyeloablative CY/fludarabine (Flu) conditioning. GVHD prophylaxis included CsA (n=19)±mycophenolate mofetil (n=31). At a median follow-up of 59 months, 21 patients (42%) were alive without evidence of disease. By Kaplan–Meier analysis, year 1–4 disease-free survival (DFS) and OS estimates were 0.50/0.58, 0.40/0.46, 0.37/0.43 and 0.37/0.41. MUD recipients were engrafted quickly (13.5 days) compared to MRD recipients (16 days) and relapsed/progressed less frequently (P=0.005). Overall grade 3/4 acute GVHD (aGVHD) occurred in 26% in the absence of antecedent mucositis and was associated with chronic GVHD (cGVHD) and poor OS. Extensive cGVHD developed in 51.2% of 100 day survivors. Rates of aGVHD, cGVHD and survival were similar between MRD and MUD recipients. Of 14 survivors with cGVHD, 5 (35.7%) experienced resolution off immunosuppression, suggesting that tolerance with HLA matched grafts is possible at an advanced age by this method. This study provides further evidence for prolonged DFS after CY/Flu MRD allotransplantation for AML/MDS, and extends the findings to older patients and those with unrelated donors. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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