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The conditions were developed and the optimal temperature regime was selected for a selective thionation of 5-aryl-3-[(dimethylamino)-methylidene]furan-2(3H)-ones with Lawesson's reagent. The stereochemistry of the synthesized 3-[(dimethylamino)methylidene]furan-2(3H)-thiones was established. Based on this, a number of 3-arylaminomethylidenefuran-2(3H)-thiones were synthesized via transamination reaction. [ABSTRACT FROM AUTHOR]

The publication presents a number of modifications based on electrophilic reactions of previously synthesized biologically active benzannulated pyrrolo[1,2-a]imidazolones and pyrrolo[2,1-b]quinazolinones, which make it possible to widely change the physicochemical properties of molecules. Quantitative assessments of the lipophilicity of all synthesized compounds were carried out, on the basis of which conclusions were made regarding the advisability of introducing alkyl and trifluoroacetyl groups to increase the bioavailability of compounds by increasing their lipophilicity to 40%. [ABSTRACT FROM AUTHOR]

The review summarizes the publications devoted to the synthesis of pyrrolo[2,1-b]thiazoles with a various degree of saturation and substitution over the last 10 years. The synthesis methods are conditionally divided into three groups depending on the starting compounds: modification of thiazole derivatives, modification of derivatives of other heterocycles, as well as synthesis from acyclic compounds. [ABSTRACT FROM AUTHOR]

This review provides generalized information on the synthesis of substituted pyrrolo[2,1-b]oxazoles, including derivatives fused with other rings, covering literature sources from mostly the last 10 years. We focus on the main methods for the synthesis of such compounds: tandem heterocyclization using 2-aminoethanols, the use of catalysts, α-C−H functionalization, as well as reactions with microwave activation. [ABSTRACT FROM AUTHOR]

Molecules of the title compound, C16H14N2O, a potential plant-growth regulator, are linked into chains by intermolecular C=O...H-N hydrogen bonds. These chains are weakly interconnected by π-π stacking interactions to form a three-dimensional framework. A comparison of the geometric parameters of the title molecule and several related benzimidazoles and pyrrolidones is presented. [ABSTRACT FROM AUTHOR]