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Five novel macrocyclic monoterpene O-glycosides, parkinsenes A-E ( 1- 5), and eleven known phenolic metabolites including three 3- O-glycosylflavonols ( 6- 8), five C-glycosylflavones ( 9- 13), p-hydroxybenzoic acid ( 14), esculetin ( 15), and diosmetin ( 16) were isolated from the leaves and small twigs of Parkinsonia aculeata L. (Fabaceae). Their structures were established by chemical and spectroscopic analyses (UV, ESI-MS, and 1D/2D NMR). The investigated 80 % aqueous methanol extract (AME) showed significant analgesic, antipyretic, anti-inflammatory, hepatoprotective, hypoglycemic, hypocholesterolemic, and antioxidant activities in a dose-dependent manner using two different doses 250 and 500 mg/kg b. wt. [ABSTRACT FROM AUTHOR]