1. Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening.
- Author
-
Agarwal, Aniruddha, Corvi, Federico, Kumar Menia, Nitin, Aggarwal, Kanika, Erckens, Roel J., Berendschot, Tos T.J.M., Webers, Carroll A.B., Invernizzi, Alessandro, Gupta, Vishali, and Sadda, SriniVas
- Subjects
OPTICAL coherence tomography ,INDOCYANINE green ,ANGIOGRAPHY ,TOMOGRAPHY ,UVEITIS - Abstract
The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC). In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW). Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p =.77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p <.001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p <.001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p <.001). Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF