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Keywords: false positive; familial hCG syndrome; home pregnancy tests; human chorionic gonadotropin (hCG); pregnancy test EN false positive familial hCG syndrome home pregnancy tests human chorionic gonadotropin (hCG) pregnancy test e424 e425 2 10/18/21 20210915 NES 210915 To the Editor, A 41-year-old woman under contraceptive treatment with hormonal intrauterine device and without relevant medical history presented to the emergency department (ED) of the Cliniques Universitaires Saint-Luc in Brussels, Belgium, for abdominal pain and a one-month delay in menstruation. When the hCG test result was announced as negative, the patient was surprised because her previous HCG tests had always been positive in the other clinical laboratories without any medical explanation. [Extracted from the article]