1. The key roles of thrombin and fibrinogen in human infant and mice atopic dermatitis models.
- Author
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Filuta, Alyssa L., Amezcua, Peter, Ruff, Brandy P., Biagini, Jocelyn M., Kroner, John, He, Hua, Brandt, Eric B., Martin, Lisa J., Palumbo, Joseph S., Khurana Hershey, Gurjit K., and Sherenian, Michael G.
- Subjects
ATOPIC dermatitis ,THROMBIN ,FIBRINOGEN ,INFANTS ,MICE ,ECZEMA - Abstract
This article explores the role of thrombin and fibrinogen in atopic dermatitis (AD) in both human infants and mice models. The study found that children with AD under the age of 1 had increased thrombin generation and decreased time to peak thrombin compared to children without AD. Additionally, thrombin inhibition in mice resulted in decreased AD symptoms and fibrinogen deficiency in mice led to decreased disease development. These findings suggest that thrombin and fibrinogen may contribute to AD pathogenesis and could be potential targets for therapy. The study was funded by NIH and the American Academy of Allergy, Asthma, and Immunology Foundation. [Extracted from the article]
- Published
- 2024
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