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We showed that differences in learning capacity between DBA and C57Bl/6 mice correlates with differences in slow afterhyperpolarization amplitude in hippocampal CA1 pyramid neurons. In DBA mice learning capacity is lower, but the amplitude of slow afterhyperpolarizations higher than in C57Bl/6 mice. [ABSTRACT FROM AUTHOR]

Abstract Objective: This multi-center phase II trial was conducted by the Gynecologic Oncology Group to evaluate the activity and toxicity of irofulven in patients with previously treated adenocarcinoma of the endometrium. Methods: Eligible patients had documented recurrent or persistent endometrial carcinoma after receiving definitive locoregional therapy, and were required to have measurable disease, performance status of 02, and adequate bone marrow, hepatic and renal functions prior to study entry. Patients were allowed one prior chemotherapy regimen. The initial dose of irofulven was 11 mg/m2/day for four days administered intravenously. Cycles were repeated every 28 days. Doses were escalated or reduced based on previous cycle toxicity. Results: Twenty-five patients were enrolled onto the trial. There was one (4%) confirmed complete response. Seven (28%) patients had stable disease, with a median duration of 10.4 (range: 4.421.6) months. Patients received a median of one (range: 15) cycle of protocol treatment. There were three early treatment-related deaths due to renal failure and severe electrolyte disturbances. Two patients experienced grade 4 hematologic adverse effects. Conclusion: Irofulven administered at the dose and schedule used in this trial was minimally active and resulted in significant toxicity. [ABSTRACT FROM AUTHOR]

This paper provides an overview of the new and exciting opportunities that satellite creates for the delivery of true broadband Internet and multimedia content directly to the edge of the network or to the end user. A current snapshot of the different satellite delivery topologies is given, followed by an appraisal of the underlying protocol aspects on which these satellite topologies are built. This paper then reviews the various broadband applications that can be effectively delivered via satellite, exploiting satellite's natural broadcasting and ubiquitous coverage characteristics. These aspects are then expanded further by a discussion of the key security options that must be considered when designing such networks. [ABSTRACT FROM AUTHOR]