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Reptin/RUVBL2 is involved in the remodeling of chromatin, DNA damage repair, and regulation of the cell cycle, all of which help to play essential roles in cancer. However, relevant pan-cancer analysis of Reptin is lacking. This study first investigated the potential oncogenic roles of Reptin and revealed a relationship between Reptin with clinicopathological characteristics and immune infiltration based on big data. Here, we showed that Reptin is overexpressed in many cancers. A significant association exists between the expression of Reptin and the prognosis of cancer cases. Reptin had a meaningful interaction with the immune infiltration of CD4+ Th1 cells and immune modulator genes in multiple cancer types. And negative correlation exists between Reptin and cancer-associated fibroblasts in BRCA, PRAD, TGCT, and THYM. A significant negative association exists between Reptin and regulatory T cells in TGCT and THCA. Moreover, Reptin is significantly associated with genomic heterogeneity, DNA mismatch repair genes, methyltransferase, and RNA modification genes in specific cancer types. Spliceosome, Hippo signaling pathway, DNA replication pathway, and acetyltransferase activity-associated functions were observed in the effect of Reptin on the tumor. This systematic analysis highlights Reptin as a vital cancer regulator among numerous genes and proved its potential prognosticator value and therapeutic target role for specific tumor types. [ABSTRACT FROM AUTHOR]

This paper investigates the global synchronization problem of master-slave coupled multi-scroll saturated chaotic systems via single-state linear feedback control. An algebraic criterion for global synchronization is rigorously proven by means of the absolute stability theory. The obtained algebraic criterion is then optimized thereby deriving a less-conservative result, which is finally verified by numerical examples. [ABSTRACT FROM AUTHOR]

This paper investigates global robust synchronization of a class of nonautonomous chaotic systems with parameter mismatch under the master-slave variable substitution control. A criterion of linear matrix inequality (LMI) for the global robust synchronization is rigorously proven and the corresponding synchronization error bound is analytically estimated. The LMI criterion is then applied to the gyrostat systems, obtaining some simple and optimized algebraic criteria for global robust synchronization of the master-slave gyrostat systems with time-varying phase mismatch under single-variable substitution configurations, further verified in a numerical example. [ABSTRACT FROM AUTHOR]