1. A retrospective study on the liver toxicity of oral retinoids in Chanarin–Dorfman syndrome.
- Author
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Valette, C., Jonca, N., Fischer, J., Pernin‐Grandjean, J., Granier Tournier, C., Diociaiuti, A., Neri, I., Dreyfus, I., Furman, M., Giehl, K., Wollenberg, A., Mallet, S., Martin, L., Martin‐Santiago, A., Onnis, G., Broue, P., Leclerc‐Mercier, S., Schmuth, M., Sprecher, E., and Gruber, R.
- Subjects
HEPATOTOXICOLOGY ,ICHTHYOSIS ,RETINOIDS ,LIPIDOSES ,HEPATIC fibrosis - Abstract
Patient (F5-1) had a cirrhosis at the age of 34 years (after 12 years of OR), but liver blood parameters remained stable during the 31 years of follow-up. Before introducing OR, all also had liver anomalies, that consisted in either increased liver enzymes, hyper echogenic liver, hepatosplenomaly or cirrhosis for one patient (F6-1). In conclusion, awaiting future targeted therapy for DCS or prospective monitoring studies, there is no safety signal to contraindicate OR in CDS patients with disabling skin anomalies, on condition that a close monitoring is performed. [Extracted from the article]
- Published
- 2023
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