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5′-Deoxy-5′-S-allenylthioadenosine 1 and 5′-deoxy-5′-S-propnylthioadenosine 2, derived from adenosine, were prepared. 1 and 2 caused irreversible inactivation of AdoHcy hydrolase. ESI mass spectra analysis of the inactivated enzyme demonstrated that 1 and 2 were type II “mechanism-based” inhibitors. [ABSTRACT FROM AUTHOR]

Fluorinated analogs of 2′- and 3′-deoxy-5′-methylthioadenosine 1–4 caused irreversible inactivation of AdoHcy hydrolase. Based on the ESI-Mass spectra analysis of the inactivated enzyme with the fluorinated analog 1 a mechanism of inactivation is proposed. [ABSTRACT FROM AUTHOR]

The article discusses Mycobacterium szulgai infection. Mycobacterium szulgai is rare in nature and humans. To date, the organism has been isolated from a snail and a tropical fish and it accounts for less than 1% of all human isolates of non-tuberculous mycobacteria. When present, however, it is mostly considered as a true pathogen. Since the organism was first described in 1972, sporadic cases of infection have been reported regularly. Mycobacterium szulgai infection typically causes chronic lung disease, but it may present a variety of clinical manifestations such as bursitis, keratitis, synovitis, osteomyelitis and systemic infections in immunocompromised patients.