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Aims: To synthesize the evidence of interventions based on salutogenesis for older adults. Background: With the increasing tendency of global ageing and the progression of 'healthy ageing', salutogenesis has been adopted as a framework of health promotion for older adults. Design: An integrative review following PRISMA guidelines. Data Sources: Seven databases including PubMed, Cochrane Library, Web of Science, Embase, Scopus, PsycINFO and CINAHL Plus were systematically searched on 29 September 2022 and updated on 18 July 2023. Results: Eighteen eligible studies were included in this review. Salutogenic‐based interventions fell into three main categories: dialogue‐based, health education courses based, and goal setting and achievement based. The intervention doses: length ranged from 4 weeks to 2 years, with most (n = 12) within 12 weeks; the duration of each session ranged from 30 to 150 min, with the majority (n = 7) within 1 h; the frequency ranged from five times weekly to three times in 10 months, and in six studies was once a week. Intervention providers were mostly multidisciplinary teams, while in four studies were nurses only. Most of the studies reported that salutogenic‐based interventions could improve older adults' sense of coherence, quality of life, self‐efficacy, self‐management, meaning of life and mental health. Conclusions: This review synthesized the interventions based on salutogenesis for older adults, including salutogenesis application, intervention and its doses, intervention settings and providers, and intervention effects. Future research on the effectiveness of the intervention, the optimal dose of the intervention and the underlying mechanisms are still necessary to understand salutogenic‐based interventions. No Patient or Public Contribution: Not apply as it's a review paper. Relevance to Clinical Practice: Salutogenic‐based intervention is effective for older adults in different scenarios to improve their health outcomes. Nurses play a key role in salutogenic‐based interventional programs and thus should be essential personnel as the intervention provider. [ABSTRACT FROM AUTHOR]

It is challenging and expensive to manufacture composite cylindrical shells with characteristics such as large diameters and lengths and 0°‐fibers for applications such as bridge piers and wind power columns. In this study, a new type of cross section configuration of inner annular block and outer annular continuous fiber is proposed, and a low‐cost method is established First, the inner assembly block is pulled and extruded, and then, the outer continuous prestressed fiber is wound as the mold to apply annular compressive stress to the inner tube. Axial compression tests were carried out with Φ104 × 8 mm glass fiber‐reinforced polymer(GFRP) tubes made of pultruded standard blocks without integral forming, without external winding carbon fiber, and with an external winding layer. The results show that the mechanical properties of the pipe produced via piece‐assembling followed by winding are better than those produced via piece‐assembling without an external winding layer, which has mechanical properties similar to those of a one‐time forming member. Based on the obvious deterioration of mechanical properties, composite cylindrical shells with large diameters and lengths and 0°‐fibers can be produced at low costs. [ABSTRACT FROM AUTHOR]

The present study aimed to determine whether the expression of microRNA (miR)-10b was correlated with the molecular subtypes of early invasive ductal carcinoma of the breast. In situ hybridization was used to detect the expression of miR‑10b in 193 patients diagnosed with early invasive ductal carcinoma. Immunohistochemistry was performed to evaluate the expression of estrogen receptor (ER)‑α, progesterone receptor (PR) and human epidermal growth factor receptor‑2 (Her‑2). The positive expression rate of miR‑10b in patients with early invasive ductal carcinoma with ER‑α (+) or PR (+) was decreased compared with ER‑α (‑) or PR (‑) patients (P<0.05). Furthermore, the positive expression rate of miR‑10b in patients with Her‑2 (‑) was significantly increased compared with patients that were Her‑2 (+) (P=0.031). The positive expression rate of miR‑10b in the luminal B subtype was significantly decreased compared with that in the luminal A, Her‑2 and basal‑like subtypes (P=0.037). In patients that were identified as miR‑10b (+), the median disease‑free survival time was significantly increased in patients that were ER‑α (+)/PR (+)/Her‑2 (‑) compared with patients that were ER‑α (‑)/PR (‑)/Her‑2 (+) (P<0.05). In addition, the median disease‑free survival time was significantly decreased in Her‑2 overexpression and basal‑like subtypes when compared with luminal A and B subtypes (P<0.05). The molecular subtype was an independent prognostic factor for early invasive ductal carcinoma (odds ratios for luminal B, Basal‑like, and Her‑2 overexpression were 2.900, 5.232 and 4.214, respectively; all P<0.05). Positive expression of miR‑10b may also be a prognostic risk factor (odds ratio >1), though this was not statistically significant (P>0.05). The present findings indicated that miR‑10b‑positive expression was correlated with the expression of ER‑α, Her‑2 and the molecular subtypes of early invasive ductal carcinoma of the breast. [ABSTRACT FROM AUTHOR]