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Background: The ratio between non-high-density lipoprotein cholesterol and high-density lipoprotein cholesterol (NHHR) is a reliable marker for assessing the risk linked to lipid metabolism disorders. Sarcopenia, characterized by age-related loss of muscle mass and strength/function, includes the assessment of muscle mass, muscle strength, and muscle-specific strength. However, research into NHHR's relationship with low muscle mass risk remains unexplored. Methods: Our study utilized a cross-sectional approach, examining data derived from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. Through multivariable linear and logistic regression, we investigated the relationships of the NHHR with muscle mass and low muscle mass. We visualized the results using smoothing curves and assessed threshold effects. We also performed various subgroup and sensitivity analyses. Results: This research encompassed 9,012 participants and demonstrated significant nonlinear associations between NHHR and ALMBMI or low muscle mass risk in a generalized additive model (GAM), pinpointing critical NHHR values (3.328 and 3.367) where changes in NHHR significantly impacted ALMBMI and low muscle mass risk. Conclusions: The NHHR demonstrates a significant association with an increased risk of low muscle mass among middle-aged Americans. This ratio has potential as a predictive marker for low muscle mass. Further exploration of NHHR is expected to aid in advancing preventive and therapeutic measures for this condition. [ABSTRACT FROM AUTHOR]

Soil erosion and extensive management, as key factors limiting the sustainability of the agroecosystem in the Loess Plateau, severely hamper the high-quality development of regional agriculture. Soil fertility and element synergy can be enhanced by applying mulching measures properly. However, there is a lack of systematic research into how soil stoichiometric characteristics under mulching affect crop productivity. This study focused on the agroecosystem of the Loess Plateau. Based on the 11-year field positioning experiment, the management measures of straw mulching (SM), plastic mulching (PM) and ridge-film mulching (RM) were selected to investigate the effects of long-term mulching measures on the stoichiometric characteristics of topsoil and the impact of crop productivity under the ecological stoichiometry theory. The findings revealed a significant increase in soil carbon, nitrogen and phosphorus contents and microbial biomass under mulching. SM and RM significantly decreased the stoichiometric ratio of soil available nutrients, whereas PM and RM had effective alleviating effects on C:N and C:P imbalance. The yield components of long-term SM and RM greatly increased and responded favorably to the synergy of soil carbon and phosphorus. This study provides theoretical guidance and technical support for the assessment of the effective and sustainable use of agricultural resources on the Loess Plateau. [ABSTRACT FROM AUTHOR]

Objective: We want to investigate the effect of aquaporin-4 (AQP4) on cerebral edema induced by ischemic stroke in rats and explore whether inhibiting the expression of AQP4 through acetazolamide (AZA) could attenuate brain edema and protect cerebral function. Methods: The Sprague Dawley (SD) rats were randomly divided into four groups: sham + saline group, sham + AZA group, AZA intervention group, and nonintervention group. Each group was divided into five subgroups according to the time of cerebral ischemia (6 h, 1 day, 3 days, 5 days, and 7 days). The model of cerebral infarction in rats was adopted by means of the bilateral carotid arteries ligation (2-VO) method. The rats in intervention group were given intraperitoneal injection of AZA (35 mg/kg/day). Hematoxylin–eosin staining was performed for pathological analysis of the infarcted area. The brain water content was calculated to evaluate the degree of brain edema. The messenger RNA (mRNA) and protein expressions of AQP4 in the brain were measured by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. Results: Significant cerebral pathological damages were found in ischemic stroke rats. The brain water content, protein, and mRNA expression of AQP4 of the intervention and nonintervention groups were markedly higher than those of the sham groups. By contrast, AZA administration reduced the brain water content, whereas improved cerebral dysfunction was induced by ischemic stroke. Moreover, AZA obviously reduced the protein and mRNA expression of AQP4 after ischemic stroke in rats' brains. Conclusions: The expression of AQP4 was closely related to cerebral edema induced by ischemic stroke. Decreasing the expression of AQP4 mRNA by AZA administration can effectively relieve cerebral edema and decrease cerebral pathological damage. [ABSTRACT FROM AUTHOR]

In the pulsed electroacoustic (PEA) space charge measurement system used for coaxial cables, the waveform of a coupled pulse will directly affect space charge profiles in cable insulation. In this paper, on the basis of the PEA measurement system with pulse injection from a measuring electrode, the original charge acoustic signals in a 35 kV cross-linked polyethylene (XLPE) cable were collected directly from the oscilloscope under different ground distances between the measuring point and the ground point along a cable's semiconductive (SC) layer. At the same time, the effects of ground distance, cable specification, and cable length on the waveform of a coupled pulse were studied through a series of experiments and simulations. The results show that the amplitude of the coupled pulse is directly proportional to the ground distance but inversely proportional to the cable cross section or voltage class. Furthermore, the pulse coupling efficiency is almost the same only if the cables have the same diameter of the outer SC layer. Therefore, a constant pulse coupling efficiency can be obtained by adjusting the ground distance according to the diameter of the cable's outer SC layer. [ABSTRACT FROM AUTHOR]