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The development of gold(I)-catalyzed intermolecular carbo- and hetero-cycloadditions of alkynes and allenes has been more challenging than their intramolecular counterparts. Here we review, with a mechanistic perspective, the most fundamental intermolecular cycloadditions of alkynes and allenes with alkenes. [ABSTRACT FROM AUTHOR]

We disclose a protocol for the palladium-catalyzed ortho-selective CH deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho-deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination. [ABSTRACT FROM AUTHOR]

We disclose a protocol for the palladium-catalyzed ortho-selective CH deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho-deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination. [ABSTRACT FROM AUTHOR]

From a series of gold complexes of the type [ t-BuXPhosAu(MeCN)]X (X=anion), the best results in intermolecular gold(I)-catalyzed reactions are obtained with the complex with the bulky and soft anion BAr4F− [BAr4F−=3,5-bis(trifluoromethyl)phenylborate] improving the original protocols by 10-30% yield. A kinetic study on the [2+2] cycloaddition reaction of alkynes with alkenes is consistent with an scenario in which the rate-determining step is the ligand exchange to generate the (η2-phenylacetylene)gold(I) complex. We have studied in detail the subtle differences that can be attributed to the anion in this formation, which result in a substantial decrease in the formation of unproductive σ,π-(alkyne)digold(I) complexes by destabilizing the conjugated acid formed. [ABSTRACT FROM AUTHOR]

As the field of supramolecular catalysis develops, a sound fundamental understanding of the catalytic assemblies used will be essential. There is a lack of knowledge regarding systems based on transition-metal catalysts as guests of supramolecular capsules. We investigate the inclusion behavior of gold complexes based on well-known cationic Au(I) catalysts within a self-assembled hexameric resorcin[4]arene capsule. The results shed light on the nature of the encapsulated species and the way in which those species are encapsulated. We introduce an encapsulation methodology that functions through the transient introduction of an excess of water. Through small modifications in the encapsulation methodology, we show that the inclusion process can be controlled to give different encapsulated species stemming from the same gold(I) precursor. [ABSTRACT FROM AUTHOR]