1. The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis.
- Author
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Conforti, Alessandro, Esteves, Sandro C., Di Rella, Francesca, Strina, Ida, De Rosa, Pasquale, Fiorenza, Alessia, Zullo, Fulvio, De Placido, Giuseppe, and Alviggi, Carlo
- Subjects
META-analysis ,OVUM ,GONADOTROPIN ,ODDS ratio ,WOMEN ,INDUCED ovulation ,MISCARRIAGE - Abstract
Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results: Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion: In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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