1. Tenosynovitis caused by Scedosporium apiospermum infection misdiagnosed as an Alternaria species: a case report.
- Author
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Choon-Mee Kim, Sung-Chul Lim, Joa Kim, Hoe-Soo Jang, Jong-Hun Chung, Na-Ra Yun, Dong-Min Kim, Piyush Jha, Babita Jha, Seok Won Kim, Sook Jin Jang, Jong Hee Shin, Kim, Choon-Mee, Lim, Sung-Chul, Kim, Joa, Jang, Hoe-Soo, Chung, Jong-Hun, Yun, Na-Ra, Kim, Dong-Min, and Jha, Piyush
- Subjects
ALTERNARIA ,TENOSYNOVITIS ,HOST plants ,MYCETOMA ,NUCLEOTIDE sequencing ,DIAGNOSIS ,COMMUNICABLE disease treatment ,ANTIFUNGAL agents ,TYPE 2 diabetes complications ,FLUCONAZOLE ,DEBRIDEMENT ,DIAGNOSTIC errors ,DNA ,FUNGI ,HAND ,JOINTS (Anatomy) ,MAGNETIC resonance imaging ,MYCOSES ,TYPE 2 diabetes ,IMMUNOCOMPROMISED patients ,SEQUENCE analysis ,DISEASE complications ,THERAPEUTICS - Abstract
Background: Scedosporium apiospermum, which can usually be isolated from soil, polluted stream water and decaying vegetation, is increasingly recognized as an opportunistic dematiaceous fungus. The mortality rate of infection in immunocompromised hosts is over 50%. S. apiospermum is commonly responsible for dermal and epidermal infections (i.e., mycetoma) after traumatic penetration.Case Presentation: A 73-year-old woman was admitted to our hospital complaining of painful swelling and tenderness on the dorsum of the proximal left wrist and hand. The symptoms had persisted for approximately 2 months. A physical examination revealed a 4 x 3 cm, poorly defined, erythematous papule, which was fluctuant, with pustules and crusts on the dorsum of the left hand.Conclusions: We report a very rare case of tenosynovitis caused by S. apiospermum infection. We identified the infectious agent via molecular DNA sequencing. The infectious agent was initially misidentified as an Alternaria species by microscopic examination with lactophenol cotton blue (LPCB) staining. The infection was successfully treated with debridement and adjuvant fluconazole therapy. [ABSTRACT FROM AUTHOR]- Published
- 2017
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