1. Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study.
- Author
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Lee, Melissa H., Vogrin, Sara, Paldus, Barbora, Jayawardene, Dilshani, Jones, Hannah M., McAuley, Sybil A., Obeyesekere, Varuni, Gooley, Judith, La Gerche, André, MacIsaac, Richard J., Sundararajan, Vijaya, Jenkins, Alicia J., Ward, Glenn M., and O'Neal, David N.
- Subjects
TYPE 1 diabetes ,HIGH-intensity interval training ,HYPOGLYCEMIA ,GLUCOSE ,INSULIN ,BLOOD sugar monitors ,BLOOD sugar analysis ,RESEARCH ,BLOOD sugar monitoring ,RESEARCH methodology ,COGNITION ,BLOOD sugar ,EVALUATION research ,MEDICAL cooperation ,COMPARATIVE studies ,INSULIN pumps ,EXERCISE ,CROSSOVER trials ,PSYCHOTHERAPY ,LACTIC acid - Abstract
Objective: To evaluate exercise-related glucose and counterregulatory responses (CRR) in adults with type 1 diabetes with impaired awareness of hypoglycemia (IAH) using hybrid closed-loop (HCL) insulin delivery to maintain glucose homeostasis.Research Design and Methods: Twelve participants undertook 45-min high-intensity intermittent exercise (HIIE) and moderate-intensity exercise (MIE) in random order. The primary outcome was continuous glucose monitoring (CGM) time in range (70-180 mg/dL) for 24-h post-exercise commencement.Results: CGM time in range was similar for HIIE and MIE (median 79.5% [interquartile range 73.2, 87.6] vs. 76.1% [70.3, 83.9], P = 0.37), and time with levels <54mg/dL post-exercise commencement was 0%. HIIE induced greater increases in cortisol (P = 0.002), noradrenaline (P = 0.005), and lactate (P = 0.002), with no differences in adrenaline, dopamine, growth hormone, or glucagon responses.Conclusions: IAH adults using HCL undertaking HIIE and MIE exhibit heterogeneity in CRR. Novel findings were a preserved cortisol response and variable catecholamine responses to HIIE. [ABSTRACT FROM AUTHOR]- Published
- 2020
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