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In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when biliary tract pressure was increased. It was found that both the blood pressure and cardiac output evidently decreased ( P<0.05) parallelly, and the systolic pressure decreased more markedly than diastolic pressure. At the same time there was fluctuation in heart rate and in central venous pressure; but there was no significant difference between them ( P>0.05), suggesting that in the absence of infective agents, the increased biliary tract pressure can bring about a decrease in cardiac output, which is an important factor contributing to an early blood pressure decrease in acute cholangitis of severe type (ACST). [ABSTRACT FROM AUTHOR]

An experimental study of the effect of acute biliary hypertension on hemodynamics and activity of the major splanchnic nerve was conducted in Japanese big ear white rabbits. A catheter with an inflatable rubber bag fixed to its anterior end Was inserted into the extrahepatic biliary duct via the duodenum, and a biliary high pressure of 20 kPa (150 mmHg) was created and maintained for 2 h by inflating the bag with water. The right major splanchnic nerve was isolated and the impulse frequencies of the nerve were recorded during the study. Arterial blood pressure was also dynamically monitored. A significant fall of the arterial blood pressure (P< 0.0l) and an increase in impulse frequency of the nerve (P< 0.01) were found in this 'simple type' acute biliary high pressure without infection. Biliary decompression immediately eliminated these abnormalities (P< 0.0l). The drop in blood pressure Was much less prominent if the right splanchnic nerve Was blocked prior to biliary high pressure. [ABSTRACT FROM AUTHOR]