Search

Background. Sterol-regulatory element-binding protein 1 (SREBP1) is a transcription factor involved in lipid metabolism that is encoded by sterol regulatory element binding transcription factor 1(SREBF1). SREBP1 overexpression is associated with the progression of several human tumors; however, the role of SREBP1 in head and neck squamous cell carcinoma (HNSC) remains unclear. Methods. SREBF1 expression in pan-cancer was analyzed using the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) data, and the association between SREBF1 expression and clinical characteristics of HNSC patients was examined using the UALCAN database. Enrichment analysis of SREBF1-related genes was performed using the Cluster Profiler R package. TCGA database was used to investigate the relationship between immune cell infiltration and SREBF1 expression. CCK-8, flow cytometry, and wound healing assays were performed to investigate the effect of SREBF1 knockdown on the proliferation and migration of HNSC cells. Results. SREBF1 was significantly upregulated in several tumor tissues, including HNSC, and SREBF1 overexpression was positively correlated with sample type, cancer stage, tumor grade, and lymph node stage in HNSC patients. Gene enrichment analysis revealed that SREBF1 is associated with DNA replication and homologous recombination. SREBF1 upregulation was positively correlated with the infiltration of cytotoxic cells, B cells, T cells, T helper cells, and NK CD56 bright cells in HNSC. Knockdown of SREBF1 inhibited the proliferation and migration of HNSC cells (Hep2 and TU212) and induced apoptosis by downregulating the expression of steroidogenic acute regulatory protein-related lipid transfer 4 (STARD4). Conclusions. SREBF1 may promote HNSC proliferation, migration and inhibit apoptosis by upregulating STARD4 and affecting the level of immune cell infiltration. [ABSTRACT FROM AUTHOR]

Creativity and innovation have significantly increased in the past years. Amabile and Pratt were the leading proponents of creativity who integrated a dynamic componential model of creativity and innovation in organizations. The present study discusses the concept of innovative behavior within the scientific and technological environment based on the dynamic componential model of creativity and innovation and the Triadic Reciprocal Determinism Theory. The study investigates the mediating effect of achievement motivation and the moderating effect of the organizational innovative climate between the meaning of work and innovative behavior. Meaning of work has a positive impact on innovative behavior based on the structural equation modeling and the results of data collected from the survey of 4,666 scientific and technological workers in China. In addition, achievement motivation plays a partial intermediary role between the meaning of work and innovative behavior. However, innovation within organizational climate plays a negative regulatory role between achievement motivation and innovative behavior. The study finds some existing weaknesses through the Importance-Performance Map Analysis. Lastly, we examine the critical findings and present hypothetical suggestions. [ABSTRACT FROM AUTHOR]