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: Objective To develop a generic French self-administered instrument for measuring hospitalized patients satisfaction based on the patients point of view: the questionnaire for satisfaction of hospitalized (QSH) patients. : Design The development was supervised by a steering committee and undertaken through three standard steps. Item generation was derived from 95 face-to-face interviews, performed in hospitalized patients and in patients scheduled to be admitted. The item reduction led to a 69-item questionnaire. The validation process was based on validity, reliability and some aspects of external validity. : Setting Medical, surgical and obstetrical departments (n = 187) of public hospitals (n = 11) from different French regions (n = 3). : Participants Eligible patients were adult subjects hospitalized for at least 24 h. : Main outcome measures QSH, sociodemographic data, hospitalization department, visual analogue scales of satisfaction. : Results The final version of QSH contained 45 items describing 9 dimensions, leading to 2 composite scores (staff and structure index). The factor structure accounted for 71% of the total variance. Internal consistency was satisfactory (item-internal consistency over 0.40; Cronbachs alpha coefficients ranged from 0.76 to 0.96). The scalability was satisfactory with inlier-sensitive fit (INFIT) statistics inside an acceptable range. Scores of dimensions were strongly positively correlated with visual analogue scale scores (all P < 0.001). External validity showed statistical associations between QSH scores and age or department. Participation rate was 91%. : Conclusions The availability of a reliable and valid French questionnaire concerning hospitalized patients satisfaction, exclusively generated from patients interviews, enables patient feedback to be incorporated in a continuous quality health-care improvement strategy. [ABSTRACT FROM AUTHOR]