1. Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C.
- Author
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Kaulitz, D., Mihica, D., Plesker, R., Geissler, A., Tönjes, R., and Denner, J.
- Subjects
SWINE infections ,RETROVIRUSES ,LABORATORY swine ,XENOTRANSPLANTATION ,RECOMBINANT viruses ,ANIMAL vaccination ,BLOOD cells - Abstract
Porcine endogenous retroviruses (PERVs) represent a risk for xenotransplantation using pig cells or organs since they are integrated in the genome of all pigs and infect human cells in vitro. Recombinants between PERV-A and PERV-C have been described in pigs in vivo and found de novo integrated in the genome of somatic cells, but not in the germ line. To study whether PERV-A/C can infect and have a pathogenic effect in normal pigs, German landrace pigs were inoculated with high-titre PERV-A/C. No provirus integration was found in blood cells or in various tissues, and no antibody production was observed, indicating the absence of infection. [ABSTRACT FROM AUTHOR] more...
- Published
- 2011
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