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The serum levels of lipids, apolipoproteins and lipoprotein ratios in 19 healthy persons and 20 patients with uraemia not dialyzed were determined. Based on creatinine level the patients were divided into two groups: L (serum creatinine 2–5 mg/dl) and H (serum creatinine 5–10 mg/dl). Dyslipoproteinaemia in uraemic patients is already manifested in the early stages of the disease through its abnormal apolipoproteins rather than lipid profile and it suggests a high risk of atherosclerosis. [ABSTRACT FROM AUTHOR]

We have investigated the effect of intraperitoneal gentamicin on dialysis efficiency in 10 intermittent peritoneal dialysis (IPD) patients. The following parameters were measured: net ultrafiltration (UF); concentration ratios (D/P) of urea, creatinine, potassium; peritoneal clearances (ml/min) of urea, creatinine, potassium; mass transfer of sodium (MT); sodium sieving index (SC). It has been found that gentamicin significantly decreased D/P urea (p<0.056) and D/P creatinine (p<0.05). We found also a significant decrease of mean clearances of urea (p<0.05) and creatinine (p<0.05). The mean clearance of potassium did not significantly change. There was no significant change in UF, MT and SC. Our preliminary data suggest that gentamicin decreases the permeability of the peritoneum for certain low molecules in IPD patients, which may have a negative impact on dialysis efficiency. [ABSTRACT FROM AUTHOR]