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Objective: To investigate the impact of biologic disease‐modifying antirheumatic drug (bDMARD) treatment on the prevalence, seroconversion rate, and longevity of the humoral immune response against SARS–CoV‐2 in patients with immune‐mediated inflammatory diseases (IMIDs). Methods: Anti–SARS–CoV‐2 IgG antibodies were measured in a prospective cohort of health care professional controls and non–health care controls and IMID patients receiving no treatment or receiving treatment with conventional or biologic DMARDs during the first and second COVID‐19 waves. Regression models adjusting for age, sex, sampling time, and exposure risk behavior were used to calculate relative risks (RRs) of seropositivity. Seroconversion rates were assessed in participants with polymerase chain reaction (PCR)–positive SARS–CoV‐2 infection. Antibody response longevity was evaluated by reassessing participants who tested positive during the first wave. Results: In this study, 4,508 participants (2,869 IMID patients and 1,639 controls) were analyzed. The unadjusted RR (0.44 [95% confidence interval (95% CI) 0.31–0.62]) and adjusted RR (0.50 [95% CI 0.34–0.73]) for SARS–CoV‐2 IgG antibodies were significantly lower in IMID patients treated with bDMARDs compared to non–health care controls (P < 0.001), primarily driven by treatment with tumor necrosis factor inhibitors, interleukin‐17 (IL‐17) inhibitors, and IL‐23 inhibitors. Adjusted RRs for untreated IMID patients (1.12 [95% CI 0.75–1.67]) and IMID patients receiving conventional synthetic DMARDs (0.70 [95% CI 0.45–1.08]) were not significantly different from non–health care controls. Lack of seroconversion in PCR‐positive participants was more common among bDMARD‐treated patients (38.7%) than in non–health care controls (16%). Overall, 44% of positive participants lost SARS–CoV‐2 antibodies by follow‐up, with higher rates in IMID patients treated with bDMARDs (RR 2.86 [95% CI 1.43–5.74]). Conclusion: IMID patients treated with bDMARDs have a lower prevalence of SARS–CoV‐2 antibodies, seroconvert less frequently after SARS–CoV‐2 infection, and may exhibit a reduced longevity of their humoral immune response. [ABSTRACT FROM AUTHOR]

Immune-mediated inflammatory diseases (IMIDs) of the joints, gut and skin are treated with inhibitors of inflammatory cytokines. These cytokines are involved in the pathogenesis of coronavirus disease 2019 (COVID-19). Investigating anti-SARS-CoV-2 antibody responses in IMIDs we observe a reduced incidence of SARS-CoV-2 seroconversion in IMID patients treated with cytokine inhibitors compared to patients receiving no such inhibitors and two healthy control populations, despite similar social exposure. Hence, cytokine inhibitors seem to at least partially protect from SARS-CoV-2 infection. Cytokine storm seems to be a common feature of severe COVID-19 pathology. Here, the authors show a reduced rate of SARS-CoV2 positivity in a large population of patients with immune-mediated inflammatory diseases if they are already being treated with cytokine or JAK inhibitors, indicating these treatments are safe to continue and are possibly protective against COVID19. [ABSTRACT FROM AUTHOR]