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Ferroptosis is a cell death process caused by redox imbalance in the cell environment. However, the cell death pathway proves beneficial in anticancer therapy, so compounds inducing ferroptosis are sought. The paper presents a newly synthesized iron complex named FeT, composed of ferricyanide and tartrate, which seems to meet these expectations. It is relatively stable, easily soluble in water and capable of peroxidating unsaturated fatty acids. T24 bladder cells were used as model cells. Preliminary studies demonstrated a strong inhibitory effect of this compound on cell proliferation. The cytotoxicity of FeT was assessed. Independently, it initiates caspase activity, indicating the complex cellular impact of this compound. This effect is compellingly the result of FeT penetration into the cell's interior with possible direct damage to mitochondria, thus explaining the involvement of apoptosis in cell death. At the same time, after penetrating into the cell, it causes an increase in reactive oxygen species (ROS), lipid peroxidation and a decrease in reduced glutathione, which is interpreted as to cause ferroptosis. In turn, reducing mitochondrial potential may indicate both ferroptosis and an internal pathway to apoptosis. [ABSTRACT FROM AUTHOR]

In collaborative wayfinding, partners jointly search the environment for task-relevant information. Studies on collaborative search suggest that it is most efficient to divide the search space so that each partner monitors only the space in front of herself. Cooperation, in contrast, requires the establishment of a perceptual common ground to coordinate actions. This is achieved by tracking the partner's perspective. To investigate these conflicting demands, we used mobile eye tracking and compared gaze behavior during individual and collaborative wayfinding. We introduce gaze angle analysis, a way of analyzing eye tracking data with respect to gaze direction. Our results show that partners, compared to individuals, shift their gazes towards their partner's side. This supports perspective tracking and contradicts spatial division-of-labor. [ABSTRACT FROM AUTHOR]

Sodium thiosulphate injected i.v. into mice causes a marked increase in concentration of several serum proteins, particularly immunoglobulins. When given together with antigen, it significantly potentiates the T-dependent humoral responses. [ABSTRACT FROM AUTHOR]