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In situ zircon U-Pb geochronological and Lu-Hf isotope studies of detrital zircons from Late Mesoproterozoic to Early Neoproterozoic sedimentary units on the southwestern margin of the Yangtze Block have important implications for the tectonic evolution of the Yangtze Block. The Huili Group contains zircons whose ages are mainly Late Archean to Mesoproterozoic (2 650–2 450, 2 100–1 800, and 1 350–1 150 Ma). The Dengxiangying Group has one major age population of 1 900–1 600 Ma, and two subordinate age populations of 1 350–1 100 and 2 300–2 000 Ma. Yanbian Group sedimentary rocks have a zircon age population mainly in the range of 970–850 Ma, contemporaneous with the ages of widespread arc-related magmatism in the western Yangtze Block. Combining these results with previous work, the Huili and Dengxiangying groups were most likely deposited during ca. 1 160 to 1 000 Ma in an intra-continental rift basin setting, while the Yanbian Group accumulated during >920 to 782 Ma in a back-arc basin setting at the southwestern margin of the Yangtze Block. In addition, all these results further suggest a tectonic transition from a continental rift basin to a convergent environment at the southwestern margin of the Yangtze Block at 1 000–970 Ma. [ABSTRACT FROM AUTHOR]

Aims: Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare subset of alpha‐fetoprotein (AFP)‐producing carcinomas with poor prognosis. However, the molecular features associated with the malignant potential of GEAD remain partially elucidated. Methods and results: In this study, the relationship between clinicopathological parameters and aggressive biological behaviour was analysed in 37 patients with GAED. The results showed that GAED tended to infiltrate the deep layer of the gastric wall and possessed more frequent vascular invasion than conventional gastric adenocarcinoma (CGA) (P < 0.001). All distant metastases were observed in the GAED group, not the CGA group (P < 0.001). High HER2 expression was found in nearly 24.32% of the informative cases, and none showed EBV‐encoded RNA positivity or deficient mismatch repair. The most frequently mutated gene in GAED was p53. Programmed cell death‐ligand 1 (PD‐L1) immunostaining revealed 13 patients with a combined positive score (CPS) ≥ 5 (65%, 13 of 20). Thus, based on these molecular markers (immunostaining, in situ hybridisation and mutation analysis), GAED may be classified as a unique subgroup of the chromosomal instability subtype with HER2+/EBV−/MSS/TP53+/PD‐L1+. Next‐generation sequencing analyses showed that mutations in the TOPI, ELOA and NOTCH3 genes were found only in GAED, and abnormally expressed genes in GAED were significantly enriched in hepatocellular carcinoma‐, gland development‐, and gastric cancer‐related pathways. Conclusion: The HER2+/EBV−/MSS/TP53+/PD‐L1+ profile and hepatocellular carcinoma‐related pathways may be significant in the malignant potential of GAED. In addition to anti‐HER2 therapy, immune check‐point inhibitors may be an effective treatment option for patients with GAED. [ABSTRACT FROM AUTHOR]

Measuring evapotranspiration (ET) components in cotton fields under mulched drip irrigation is needed to improve water use efficiency and promote the development of water-saving agriculture. In this study, an Eddy Covariance (EC) system was used to observe the water-carbon fluxes of cotton fields under mulched drip irrigation in an arid region during two years (2021–2022). The Underlying Water Use Efficiency (uWUE) method was used to partition the ET into transpiration (T) and evaporation (E) in order to reveal the changing characteristics of ET and its components in cotton fields under mulched drip irrigation and analyze the effects of environmental factors on each component. The results showed that the diurnal variation of ET was the same as gross primary productivity (GPP), and their course of change showed a bimodal curve at budding, blooming, and boll stages. The relationship of T at different growth stages was the same as ET, which is blooming and boll stage > budding stage > boll opening stage > seedling stage. ET and its components were mainly affected by temperature (Tair) and net radiation (Rn). This study can provide a theoretical and practical basis for the application of uWUE in cotton fields under mulched drip irrigation and a scientific basis for the rational allocation of water resources and the formulation of a scientific water-saving irrigation system for farmland in an arid region. [ABSTRACT FROM AUTHOR]

Under a specific tectonic background, the change in paleoclimate can show different facies associations and depositional architecture. The Jurassic China continent was an important region for transforming the Paleotethys tectonic domain to the circum-Pacific tectonic domain, and its paleoclimate information was entirely preserved in the continental sedimentary successions. The Middle Jurassic Zhiluo Formation, in the Ordos Basin, was at just the critical period of paleostructure and paleoclimate transition, preserving considerable sedimentological evidence; however, little sedimentological research has been conducted under the transition. This study reconstructed the sedimentary filling characteristics of the Zhiluo Formation under paleoclimate transition based on field outcrop survey, thin section observation, geochemical indices, stratigraphic correlation, and depositional environment analysis. The results showed that with the paleoclimate change from warm and humid to hot and arid, the sedimentary facies of the Zhiluo Formation were characterised by the change from the braided river/braided river delta in the J2z1-1 sedimentary period to the meandering river/meandering river delta in the J2z1-2 sedimentary period, and finally the change to the meandering river, meandering river delta, and lacustrine in the J2z2 sedimentary period. The combined action of the southern super monsoon effect, the increasing global CO2 concentrations, the moving southward of the East Asian block, and the terrain elevation difference, changed the basin's climate from warm and humid to hot and semi-arid/arid. This study provides a crucial basis for reconstructing the interplay between paleoclimate and paleotectonics, and guiding sedimentology and paleoenvironment research on East Asia during the Middle Jurassic period. [ABSTRACT FROM AUTHOR]

The Ordos Basin's southern part is a composite zone made up of numerous continental blocks and has long been influenced by surrounding tectonism. However, only a few studies have investigated the existence of southern provenance supply and the basin's southern boundary in the Middle Jurassic Zhiluo Formation. Based on sandstone detrital zircon U-Pb dating and zircon rare earth element analyses, net-sand ratio maps, paleocurrent direction and the field outcrop survey, this study establishes the source area and boundary of the Zhiluo Formation in the southern basin, and discusses the tectonic events. The study shows that the four main age peaks in the detrital spectra occurs at 2283 Ma, 1788 Ma, 432.5 Ma and 218.7 Ma, with a few of the zircons dated at 794.5–1235.2 Ma. The North Qilian orogenic belt (N-QLOB), the western part of the North Qinling orogenic belt (NQOB), and the southern margin of the North China Block (SNCB) contributed to the provenance. According to an integrated analysis of the provenance and tectonic background of continental blocks in the basin's southern margin, the boundary of the basin in the depositional period of the Zhiluo Formation should reach the N-QLOB in the southwest, the NQOB in the south, and the Sanmenxia–Lushan fault belt in the southeast. On the basis of the aforementioned findings, the tectonic evolution of the continental blocks at the southern periphery of the Ordos Basin was restored. [ABSTRACT FROM AUTHOR]

Junggar Basin is an important exploration zone for sandstone‐hosted uranium deposits in north‐west China. However, neither the provenance of the host sandstone nor the uranium supply capacity of the potential source rocks have been well evaluated. To determine the provenances of the Mesozoic to Cenozoic sandstone grains and to evaluate relationships between the uranium source and the detritus provenances, a field investigation was performed at the Honggou section in the southern Junggar Basin. U–Pb geochronology and Hf isotopes were obtained from populations of detrital zircons from Jurassic through Palaeogene sandstones. The detrital zircon U–Pb ages display three main groups: 145–190 Ma, 250–360 Ma, and 360–460 Ma. The detrital zircon age distributions and the Hf isotopic characteristics of the sandstones correspond to different igneous rock units within the North and Central Tianshan Mountains. Therefore, the changes in the relative proportions of the zircon age populations indicate that there were major shifts of the provenance areas for the sandstones throughout the Early Jurassic to Palaeogene interval. The majority (92%) of Hf isotope εHf(t) values are positive and in the range of +0.7 to +15.5, which indicates that the majority of the zircons had crystallized in igneous rocks that were mainly derived from juvenile crust or depleted mantle. The majority (93%) of the two‐stage model ages (TDM2) are less than 1.8 Ga, thereby indicating the source of the majority of the igneous rocks was from the melting of ancient Meso‐Proterozoic juvenile crust. Carboniferous–Permian intermediate‐felsic igneous rocks in the Tianshan Mountains may be the primary source of released mobilized uranium and uranium‐enriched siliciclastics into the southern Junggar Basin. This study will assist in future uranium prospecting in this region. [ABSTRACT FROM AUTHOR]

Flood disaster is one of the natural disasters which cause the most serious economic losses, the most casualties, and the greatest social impact. Flood frequency analysis is very important for reducing flood disaster. In this paper, based on the flood data of Manas River and tools of Box–Cox and Johnson normal transformation, the nonparametric statistical method for flood frequency analysis is studied in order to analyze the adaptability between it and the rivers in arid region of north-western China. The calculation result of the fitness index is divided into two parts: high flood discharge and low flood discharge. One of the two evaluation indexes has an advantage in fitting, and the number of advantages of the three methods in each part has been counted. After analysis, for the flood peak discharge frequency of rivers in arid region of north-western China, the frequency curve of Johnson transformation fits best with empirical data. The high flood discharge advantage is 6, and the low flood discharge is 4. For the flood volume frequency of rivers in arid region of north-western China, Box–Cox transform fits well with empirical data at the high flood discharge frequency curve, and its advantage is 12; Johnson transformation has a better fit between the low flood discharge frequency curve and empirical data, and its advantage is 12. Therefore, it is the way of improving the precision of flood frequency analysis to use the method of P-III distribution and normal transformation comprehensively. [ABSTRACT FROM AUTHOR]

Aiming at the problems that need to be solved urgently in the current operation of a multireservoir in Kuitun River Basin, such as the uneven distribution of water resources in time and space, the large workload of manual operation calculation, and low coordination level, the paper takes the optimal operation of water resources in the basin as the main goal and carries out the research on the optimal operation model of the multireservoir in combination with the complex characteristics of local water resources system. Firstly, based on the generalization of hydraulic engineering in Kuitun River Basin, a water resources optimal operation model of the multireservoir is established and is solved by the graph theory. Then, the actual data of typical years were selected to test the model. The test results show that, compared with the actual water distribution, the water shortage rate of 2015 and 2016 in high flow years decreased by 98.57% and 100%, respectively; the water shortage rate of 2013 and 2014 in normal flow years decreased by 92.65% and 96.38%, respectively; and the water shortage rate of 2009 in a low flow year decreased by 87.78%. The model can provide the optimal operation scheme for the optimal operation of the multireservoir in the basin. And it can solve the problems such as the uneven distribution of water resources and the large workload of manual operation calculation and can provide technical support for the optimal operation of water resources of the multireservoir in Kuitun River Basin in the future. [ABSTRACT FROM AUTHOR]

Pine wilt disease is a devastating forest disaster caused by Bursaphelenchus xylophilus, which has brought inestimable economic losses to the world's forestry due to lack of effective prevention and control measures. In this paper, a porous structure CuBTC was designed to deliver avermectin (AM) and a control vector insect Japanese pine sawyer (JPS) of B. xylophilus, which can improve the biocompatibility, anti-photolysis and delivery efficacy of AM. The results illustrated the cumulative release of pH-dependent AM@CuBTC was up to 12 days (91.9%), and also effectively avoided photodegradation (pH 9.0, 120 h, retention 69.4%). From the traceable monitoring experiment, the AM@CuBTC easily penetrated the body wall of the JPS larvae and was transmitted to tissue cells though contact and diffusion. Furthermore, AM@CuBTC can effectively enhance the cytotoxicity and utilization of AM, which provides valuable research value for the application of typical plant-derived nerve agents in the prevention and control of forestry pests. AM@CuBTC as an environmentally friendly nanopesticide can efficiently deliver AM to the larval intestines where it is absorbed by the larvae. AM@CuBTC can be transmitted to the epidemic wood and dead wood at a low concentration (10 mg/L). [ABSTRACT FROM AUTHOR]

Background: Pine wilt disease as a devastating forest disaster result from Bursaphelenchus xylophilus that spread by stem-borers Monochamus alternatus feeding on pine leaves, which has brought inestimable economic losses to the world's forestry due to lack of effective prevention and control measures. In this paper, we put forward a proposal for utilizing nanoHKUST-1 to encapusulate the Pyrethrins II that a nerve agent extracted from plant to control M. alternatus, including toxicity mechanism research, traceable biopesticide monitoring, and environment assessment for the first time. The highly biocompatible nanoHKUST-1 can solve the problems of poor water solubility, easy degradation and low control efficiency of Pyrethrins II. Results: The results illustrated the biopesticide loading efficiency of PthII@HKUST-1 reached 85% and the cumulative release of pH-dependent PthII@HKUST-1 was up to 15 days (90%), and also effectively avoid photodegradation (pH 7.0, retention 60.9%). 50 nm PthII@HKUST-1 made it easily penetrate the body wall of MA larvae and transmit to tissue cells through contact and diffusion. Moreover, PthII@HKUST-1 can effectively enhance the cytotoxicity and utilization of Pyrethrins II, which will provide valuable research value for the application of typical plant-derived nerve agents in the prevention and control of forestry pests. PthII@HKUST-1 as an environmentally friendly nano-pesticide can efficiently deliver Pyrethrins II to the larval intestines and absorbed by the larvae. PthII@HKUST-1 could also be transmitted to the epidemic wood and dead wood at a low concentration (10 mg/L). Conclusion: Here we speculate that nanoHKUST-1 will bring new opportunity to research biopesticide inhibition mechanism of different agricultural and forestry pests, which will break through the existing research limitations on development, utilization and traceable monitoring of biopesticide, especially for the study of targeting specific proteins. [ABSTRACT FROM AUTHOR]

Avian leukosis virus (ALV) causes tumor diseases in poultry and is circulating all over the world, leading to significant economic losses. In addition, mixed infection of ALV with other viruses is very common and is often reported to contaminate live vaccines. At present, there is no effective method to suppress the replication of ALV in vitro , so it is very difficult to remove it in mixed infection. As a retrovirus, the replication of ALV can be limited by reverse transcriptase (RT) inhibitors like zidovudine (AZT), but it also causes nontargeted cytotoxicity. To find the optimal solution in cytotoxicity and inhibition efficiency in vitro culture system, we firstly designed a combination therapy of AZT and short hairpin RNA (shRNA) targeting ALV and then verified its efficiency by multiple biological methods. Results showed that shRNA can effectively inhibit the expression of RT and then limit the replication of ALV. The combination of AZT and shRNA can significantly improve the antiviral efficiency in viral replication, shedding, and provirus assembly under the condition of low cytotoxicity. Overall, in this study, the combination therapy of AZT and shRNA targeting ALV showed excellent antiviral performance against ALV in vitro culture system. This method can be applied to multiple scenarios, such as the removal of ALV in mixed infection or the purification of contaminated vaccine strains. [ABSTRACT FROM AUTHOR]

The tectonic evolution of the southwestern Yangtze Block during the Early Neoproterozoic period is still controversial because of the limited quantities of 1 000–860 Ma magmatic rocks. In this study, our new LA-ICP-MS zircon U-Pb dating results demonstrate that the Yanbian granodiorites in the southwest Yangtze Block were emplaced at 894.6±7.4 Ma, representing the product of an 894 Ma magmatism. The Yanbian granodiorites are metaluminous to weak peraluminous with A/CNK values of 0.8–1.1, resembling I-type granitoids. They are characterized by right-inclined REE patterns with moderate to insignificant negative Eu anomalies (δEu=0.6–0.9). Their primitive mantle-normalized trace element patterns are characterized by depletion of Nb, Ta and Ti and weakly enrichment of Th. Considering the positive whole-rock εNd(t) (+5.8 to +6.8), we propose that these granodiorites originated from the partial melting of juvenile mafic lower crust. The Yanbian I-type granitoids have low Y and Nb contents similar to volcanic arc igneous rocks in the Y-Nb plot for tectonic discrimination. In conclusion, Early Neoproterozoic Yanbian granodiorites have generated in a compression setting in an active continental margin. Together with previous studies from the southwestern Yangtze Block, we suggest that the 894 Ma subduction-related Yanbian granodiorites represent the early stage of subduction at the southwestern margin of the Yangtze Block. [ABSTRACT FROM AUTHOR]

Caledonian orogeny is another important tectonic event in South China Block after the breakup of the Rodinia supercontinent. With a view to constrain the tectonic evolution and proto–basin in South China, this paper reports the geochemical and zircon U‐Pb dating data of the Ordovician strata in central Hunan, South China. Geochemical features and paleocurrent directions suggest that the lower Ordovician deposited in a passive continental margin basin with a provenance of quartzose components and showing an affinity with the Yangtze Block. U‐Pb age data for 260 detrital zircons from upper Ordovician identify three major age populations as: 900–1200 Ma, 1400–1800 Ma and 2400–2700 Ma. The detrital zircon age spectrum as well as the paleocurrent directions suggest that upper Ordovician deposited in a foreland basin and showing a close affinity with the Cathaysia Block. It is also suggest that the lower Ordovician continuously accepted the mineral from the Yangtze Block, whereas the provenance of the upper Ordovician sedimentary basin changed from the Yangtze Block to the Cathaysia Block. This change implies a tectonic movement, which caused the transformation of the proto–basin in the Hunan area in SCB from passive continental margin basin to foreland basin probably took place during late Ordovician. This fact also demonstrate that the Caledonian orogeny in South China Block began no later than 453 Ma, and a new crustal evolution model is proposed. [ABSTRACT FROM AUTHOR]

This paper presents age and geochemical data of a recently identified Late Paleozoic volcanic sequence in central Jilin Province, with aims to discuss the petrogenesis and to constrain the tectonic evolution of the Central Asian Orogenic Belt in this area. Firstly, the volcanic rocks have zircon U‐Pb ages of 290–270 Ma. Secondly, they are characterized by (a) ranging in composition from the low‐K tholeiite series to high‐K calc‐alkaline series; (b) enrichment in light rare earth elements and depletion of heavy rare earth elements, with negative Eu anomalies; and (c) negative Nb, Ta, and Ti anomalies. Finally, the volcanic rocks yield ∊Hf(t) values of +7.1 to +17. These data suggest that the central Jilin volcanic rocks were possibly derived from predominant partial melting of a depleted lithospheric mantle that might have been modified by subducted slab–derived fluids. Combined with previous studies, the Late Paleozoic–Early Mesozoic magmatism in Central Jilin can be divided into two stages: (a) a volcanic arc stage (290–270 Ma) represented by low‐K to high–K, tholeiite to calc–alkaline plutons and (b) a syn–collisional stage (260–240 Ma) represented by high‐K calc–alkaline I‐type granites. Furthermore, the timing and the tectonic setting of the above magmatic rocks show that the arc was probably produced by the northward subduction of the Paleo‐Asian Ocean and that the final closure of the Paleo‐Asian Ocean occurred prior to the Early Triassic. [ABSTRACT FROM AUTHOR]

This paper presents the results of combined studies of geochronology, geochemistry, whole rock Sr‐Nd and zircon Hf‐O isotopes carried out upon the rhyodacite and ignimbrite of Shangshu village, Shangyu town and Shanghupeng village of Jiangshan City in Zhejiang Province, along the northwestern side of the Jiangshan–Shaoxing suture. SHRIMP zircon U‐Pb dating of samples in the three areas yielded weighted mean 206Pb/238U ages of 842.8 ± 6.9 Ma and 850.0 ± 7.3 Ma, 839 ± 9 Ma and 832.2 ± 8.1 Ma, 828.3 ± 8.5 Ma and 836.9 ± 9.9 Ma, respectively. These ages are older than the volcanic rocks of the Shangshu Formation dated at around 780 Ma distributed in Fuyang City, Hangzhou City, Kaihua County, etc. The volcanic rocks generally have high SiO2 (54.08–76.80 wt%) and Al2O3 (12.40–21.31 wt%), low Fe2O3 (0.68–8.92 wt%), MgO (0.29–2.49 wt%), CaO (0.12–2.86 wt%), TiO2 (0.10–1.59 wt%) and P2O5 (0.01–0.39 wt%), with variable total alkalis (K2O + Na2O =5.42–8.29 wt%). There exists a clear negative correlation between SiO2 and P2O5. The volcanic rocks have A/CNK ratios of 1.03–2.77 and thus are peraluminous. They are characterized by enrichment in LREE, Rb, Ba, Zr, Hf, K, Th, La, U and depletion in Nb, Sr, P, Ti, with distinct LREE and HREE fractionation of (La/Yb)N values of 5.68–11.67, and with a moderate negative Eu anomaly (&Eu=0.58–0.89). Whole‐rock geochemical data shows that the Jiangshan volcanic rocks are possibly I‐type granitic rocks, even though they have some characteristics of A&S‐type granites due to the magma fractional crystallization and water‐rock interaction. Zircon δ18O values are 3.97‰–5.49‰ (average 4.50‰), 2.90‰–5.21‰ (average 4.32‰) for ignimbrite from Shangshu village section, and Shanghupeng village section, respectively. They are slightly lower than the average δ18O values of igneous zircons in equilibrium with mantle magmas (5.3 ± 0.6‰ (2σ)), the lower δ18O value also demonstrating the presence of high temperature water‐rock interactions. The ignimbrite rocks have positive ∊Nd(t) (4.02, 3.37, 3.91, 4.74, 2.85, 4.39, totals from the three areas) and ∊Nd(t) (in‐situ zircon) (4.3–14.6, a weighted mean of 8.4; 6.6–12.7, a weighted mean of 9.0; 8.1–12.0, a weighted mean of 9.5, respectively, from the three areas). In conjunction with the trace element studies, they indicate that the source region of the Jiangshan volcanic rocks was mainly composed of juvenile lower crustal material, mixed with some mantle‐sourced magma. Detailed elemental and isotopic data suggest that the Jiangshan volcanic rocks were formed in a continental arc setting. There is a series of ca. 860–830 Ma volcanic rocks formed in a back‐arc extensional setting in the southern margin of the eastern Jiangnan Orogen, along the northwest side of the Jiangshan–Shaoxing suture. The first stage rift‐related anorogenic magmatism may have occurred as early as ca. 860 Ma in the eastern Jiangnan Orogen. [ABSTRACT FROM AUTHOR]

This paper reports in situ U–Pb ages and Hf isotopic data on detrital zircons from Palaeozoic strata in central‐eastern Jilin Province, NE China, with the aim of constraining the timing of final closure of the Paleo‐Asian Ocean and the tectonic evolution of the eastern segment of the Central Asian Orogenic Belt (CAOB). Zircons from Middle to Late Permian Fanjiatun and Yangjiagou formations in central Jilin Province are characterized by four major groups of age populations (2.5–2.3 Ga, 1.9–1.7 Ga, 1.3–1.0 Ga, and Late Palaeozoic ages). The Paleo‐Mesoproterozoic and Cambrian zircons have positive εHf(t) values, suggesting that the source was mainly locally derived from the CAOB, whereas a lesser amount of Archean zircons with positive εHf(t) values, indicating that source from the North China Craton (NCC). The Phanerozoic zircons have both positive and negative εHf(t) values indicates that material from bidirectional provenances in the CAOB and the NCC. However, Late Permian Kaishantun Formation in eastern Jilin Province contain a single group of Phanerozoic zircons with positive εHf(t) values, distinct from known igneous zircons in the NCC, suggesting a local source. These observations, along with the results of previous studies on Middle–Late Permian igneous rocks in Jilin Province, indicate that the eastern segment of the Paleo‐Asian Ocean underwent the initial closure in central Jilin Province during the Middle Permian and the final closure in eastern Jilin Province in the Late Permian–Early Triassic. The detrital zircon geochronological data clearly record two stages of tectonic evolution and the scissor‐like closure model of the Paleo‐Asian Ocean in the eastern segment of the CAOB. [ABSTRACT FROM AUTHOR]

We undertook U-Pb-Hf isotope testing of detrital zircons from Late Paleozoic sedimentary rocks in the Jilin Province, NE China, with the aim of constraining the tectonic evolution of eastern Central Asian Orogenic Belt. The age populations of the detrital zircons from the sandstone of the Jiefangcun Formation in the Songliao Block are ~2234, ~1782, ~1030–921, ~817, ~540, and ~381–254 Ma, whereas those of the zircons from the greywacke of the Permian Kedao Formation in the Songliao Block yield are ~2436, ~1905, ~1692, 1146–1170, ~554–498, and ~342–255 Ma. Combined Hf isotope characteristics, these ages reveal that: (1) rocks from the Jiefangcun and Kedao formations were deposited after 254 and 255 Ma, respectively; (2) these formations were sourced mainly from the Songliao Block and the Jiamus Terrane in the eastern CAOB and to a lesser amount, from the northern margin of the NCC; and (3) it appears that several remnants of ancient Precambrian basement occur adjacent to these Late Paleozoic strata that occur within the microcontinental blocks. Detrital zircons from the silty sandstone of the Miaoling Formation in the western margin of the Khanka Terrane yield peak age populations of 508–476, 463–396, and 348–258 Ma, having similar εHf(t) values to those obtained from zircons within the Jiamusi Terrane. These data indicate that (1) deposition of the Miaoling Formation in the western margin of the Khanka Terrane had started by 258 Ma, and (2) these sediments were sourced mainly from the Jiamusi Terrane and local magmatic rocks. The widespread occurrence of detrital zircons with ages of 480–550 Ma and positive εHf(t) values within the Late Paleozoic strata in the Songliao Block and the Jiamusi–Khanka Terrane, indicates that the amalgamation of these blocks took place during the middle stage of the Paleozoic, probably after the Silurian, prior to the Late Permian. [ABSTRACT FROM AUTHOR]

This study used spectrometry to determine the spectral absorption of five types of mafic-ultramafic rocks from the Kaishantun ophiolite suite in Northeast China. Absorption peak wavelengths were determined for peridotite, diabase, basalt, pyroxenite, and gabbro. Glaucophane, actinolite, zoisite, and epidote absorption peaks were also measured, and these were used to distinguish such minerals from other associated minerals in ophiolite suite samples. Combined with their chemical compositions, the blueschist facies (glaucophane + epidote + chlorite) and greenschist facies (actinolite + epidote + chlorite) mineral assemblage was distinct based on its spectral signature. Based on the regional tectonic setting, the Kaishantun ophiolite suite probably experienced the blueschist facies metamorphic peak during subduction and greenschist facies retrograde metamorphism during later slab rollback. [ABSTRACT FROM AUTHOR]

The gene encoding migration and invasion inhibitory protein ( MIIP), located on 1p36.22, is a potential tumour suppressor gene in glioma. In this study, we aimed to explore the role and mechanism of action of MIIP in colorectal cancer ( CRC). MIIP protein expression gradually decreased along the colorectal adenoma-carcinoma sequence and was negatively correlated with lymph node and distant metastasis in 526 colorectal tissue samples ( p < 0.05 for all). Analysis of The Cancer Genome Atlas ( TCGA) data showed that decreased MIIP expression was significantly associated with MIIP hemizygous deletion ( p = 0.0005), which was detected in 27.7% (52/188) of CRC cases, and associated with lymph node and distant metastasis ( p < 0.05 for both). We deleted one copy of the MIIP gene in HCT116 CRC cells using zinc finger nuclease technology and demonstrated that MIIP haploinsufficiency resulted in increased colony formation and cell migration and invasion, which was consistent with the results from siRNA-mediated MIIP knockdown in two CRC cell lines ( p < 0.05 for all). Moreover, MIIP haploinsufficiency promoted CRC progression in vivo ( p < 0.05). Genomic instability and spectral karyotyping assays demonstrated that MIIP haploinsufficiency induced chromosomal instability ( CIN). Besides modulating the downstream proteins of APC/ CCdc20, securin and cyclin B1, MIIP haploinsufficiency inhibited topoisomerase II (Topo II) activity and induced chromosomal missegregation. Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC. Moreover, we characterized the MIIP gene as a novel CIN suppressor gene, through altering the stability of mitotic checkpoint proteins and disturbing Topo II activity. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Molar tooth (briefly called MT) carbonate is one of the Proterozoic carbonates with enigmatic sedimentary structure. According to the morphology of MT, it can be divided into two main genesis-morphology types, i.e., autochthonous and allochthonous, and each type can be further divided into a series of subtypes. The autochthonous MT can be divided into filamentous (MF1), ribbon, nodular and dotted type (MF4), in which the ribbon one can be subdivided into simple vertical (MF2) and complex ribbon (MF3), broken ribbon by storm in situ (MF5) and MT within nodular limestone (MF6). Allochthonous MT includes conglomerate clasts and horizontal detritus. Studying on the links between MT and the host rocks on five stratigraphic sections in the southeastern Jilin and eastern Liaoning indicates that the morphology of MT is closely related to host rocks, and seven genetic types by relationships between MT and the host rocks with facies interpretations are classified and discussed in this paper. The sedimentary environments of MT formation will be diverse if their morphologies are different. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the diagnostic value of SYT-SSX detected by reverse transcriptase–polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma (SS) in known and potential cases. SYT-SSX was analyzed in formalin-fixed, paraffin-embedded tissues of 62 known SS, 60 non-SS and 133 potential SS by RT-PCR and FISH. FISH was mainly performed on a tissue microarray with some modifications. SYT-SSX was detected in 94.7% (54/57) of known SS and 70.5% (86/122) of potential SS by RT-PCR and in 96.7% (58/60) of known SS and 78.1% (100/128) of potential SS by FISH. Moreover, SYT-SSX was negative in 100% (58/58) of non-SS by RT-PCR and in 100% (59/59) of non-SS by FISH. Accordingly, SYT-SSX was detected in 106 potential SS by RT-PCR or FISH, including 80 cases manifested by both methods, 20 specimens verified only by FISH and 6 samples confirmed only by RT-PCR. Clinical findings and immunohistochemistry data were analyzed in potential SS with final molecular diagnosis. The positive ratio of cytokeratin (CK) and epithelial membrane antigen (EMA) in finally diagnosed SS was 51.9% (55/106) and 61.3% (65/106), respectively. Except EMA, clinical parameters (age, sex, tumor size, tumor sites) and other immunohistochemistry indexes (CK, S-100, neurone specific enolase (NSE), CD99, myoglobin, smooth muscle actin (SMA), cluster of differentiation (CD) 68 and mesothelial cell) had no significant difference between finally diagnosed SS and non-SS. It is indicated that the efficiency of FISH is comparable to or even higher than that of RT-PCR for SYT-SSX detection. The detection of SYT-SSX by RT-PCR or FISH is very useful for the final diagnosis of potential synovial sarcomas. ( Cancer Sci 2008; 99: 1355–1361) [ABSTRACT FROM AUTHOR]

Along with the progress in research on the Precambrian, Molar-tooth carbonates (simplified as MT, or microsparite carbonates or MT structure) which were formed in the Middle-Late Proterozoic have become a hot subject recently. The Proterozoic Molar-tooth (MT) carbonate rocks refer to those Meso-to Neoproterozoic (1600–650 Ma) carbonates with MT structure, i.e., a series of peculiar, ptygmatically folded and spar-filled cracks in fine-grained carbonates of Precambrian age, located in the environment of mid-to inner ramp and shallow platform. MTS, like a bridge connecting the inorganic world with the organic one, are closely related to the evolution of paleo-oceans, atmosphere and biosphere. Their development and/or recession are/is related to the origin of life and the abruption of sedimentary geochemistry events of marine carbonates. By using modern instruments and testing methods adequately, the contents of oxides in sandstones were measured and the REE distribution pattern curves were established; an accurate value of isotopic ratio of 87Sr/86Sr was obtained, that is, the age of MT formation is about 750–900 Ma; C and O isotopes of some fresh micrite limestone samples were analyzed; the energy spectrum analysis revealed that the MT consists mainly of microspar calcite, while as for its chemical composition, the matrix shows outstanding peaks of Ca, Mg, Al, Si, and K. The geochemical indicators proved that Neoproterozoic MT carbonates in the Jilin-Liaoning region were developed at the margin of a stable continent, in the torrid zone where the paleo-temperature was about 50°C, the seawater had normal salinity when MT was formed during the Wanlong period in southern Jilin and during the Yingchengzi and Xingmincun periods in eastern Liaoning. The sedimentary environment was located in the inner ramp. In summary, it is of great importance to understand the origin of MT, ascertain the paleo-climate and paleo-environment characteristics, constrain the age and the stratigraphic division and comparison of the Proterozoic so as to study the geochemical characteristics of MT carbonates and their formation environment. [ABSTRACT FROM AUTHOR]

SHRIMP U-Pb zircon dating was carried out for the Daohugou Biota near Ningcheng of Inner Mongolia and for lavas overlying or underlying salamander-bearing strata at Reshuitang in Lingyuan of West Liaoning. The results suggest that the Daohugou Biota occurred at an interval from 168 Ma to 164 – 152 Ma. Both the Daohugou Biota and the salamander-bearing fossil assemblage are the same biota and thus developed from 168 to 152 Ma, i.e. from late Middle Jurassic to the early Late Jurassic. The Daohugou Biota-bearing rocks, resting on the Jiulongshan Formation in disconformity and being overlain in unconformity by Late Jurassic Tuchengzi Formation and Early Cretaceous rocks containing the Jehol Biota, are mainly composed of volcanic-sedimentary rocks in a normal sequence. It is recommended that the Daohugou Biota and the related stratigraphy should be correlated with the Tiaojishan Formation (Lanqi Formation in West Liaoning) or its synchronous rocks. It is suggested that the Daohugou Biota and the Jehol Biota would be neither taken into one biota nor considered as the earliest elements of the Jehol Biota. The Daohugou Biota and the related rocks and the Yixian Formation were respectively formed in different periods of volcanic-sedimentary tectonics. [ABSTRACT FROM AUTHOR]

Huge diabase occurs within the Proterozoic strata in the southern margin of the North China Block, geographically in the northern parts of Anhui and Jiangsu provinces, where no strata younger than Neoproterozoic have been found. Zircons from the diabase show three different structures from cathodoluminesecence imaging, but they are all of magmatic origin. SHRIMP U-Pb dating yields a range of 206Pb/238U ages from 2600 to 124 Ma, but two geological events can clearly be identified from both concordant and discordant ages. One gives two weighted mean 207Pb/206Pb ages of 976 ± 24 and 1038 ± 26 Ma which are interpreted as timing of diabase crystallization, and the other has a weighted mean 207Pb/206Pb age of 2523 ± 52 Ma that represents formation time of inherited zircon from the old crust. The dating results indicate that the mafic magmatic event occurred in a transition period from the latest Mesoproterozoic to the earliest Neoproterozoic, consistent with global subduction of Grenvill ocean crust to result in the assembly of supercontinent Rodinia. Therefore, the North China Block needs to be taken into account when reconstructing the position of China continents within the framework of Rodinia supercontinent. [ABSTRACT FROM AUTHOR]

To investigate the relationship between vascular epithelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in melanomas and the expressive difference of VEGF and COX-2 between melanomas with and without vasculogenic mimicry(VM). Sixty cases of malignant melanomas embedded in paraffin were studied. The tumors were divided into a high-grade malignant group and a low-grade malignant group based on their tumor type, atypia and survival time of the patient. Then tissue microarrays were produced from these paraffin-embedded tumor tissues which were stained for VEGF, COX-2 and PAS. The difference in expression between VEGF and COX-2 in the malignant melanomas was compared using a grid-count. In addition, the tumors were also divided into mimicry and non-mimicry groups based on their PAS staining. Then the differences between the PAS positive and negative areas of the 2 groups were compared. In malignant melanomas with VM, VEGF and COX-2 expression was less in tumors in which VM was absent, but VEGF, COX-2 expression in high-grade malignant melanomas was higher than that in low-grade grade malignant melanomas. Expression of VEGF was correlated with COX-2 expression. VM exists in some high-grade malignant melanomas. The differences and relations between VEGF and COX-2 showed that some high-grade malignant melanomas possess a unique molecular-mechanism of tumor metastasis and blood supply. [ABSTRACT FROM AUTHOR]

The article discusses the research on the discovery of crystalline basement rocks at Yangtze Block in Southern China and mentions its geological significance in China. Topics include the use of uranium-lead dating to analyse isotopic composition of zircons from the granitic gneiss, the geochronology data provides tectonic activities in Yunnan Province, China, and the cathodoluminescence images of the rocks.

Background: Trunk-boring pests (TBPs) are an important type of forest pest, TBPs not only feed on the branches and trunks of trees, but also spread quarantine diseases in forests. However, because the larvae of TBPs live inside the trunk and are well concealed, prevention and control are difficult. The lack of effective control methods leads to the death of many trees in forests. In this study, a novel nanopesticide featuring high bioactivity and slow-release properties was developed to control TBPs. Thiacloprid (THI), which is commonly used to control Coleoptera species, was used as a model pesticide. Results: The oleophobic properties of bovine serum albumin (BSA) were exploited to encapsulate the hydrophobic pesticide THI by self-assembly, and the size of the obtained nanoparticles, THI@BSA·NPs, was approximately 23 nm. The loading efficiency reached 70.4%, and THI@BSA·NPs could be released continuously for over 15 days, with the cumulative release reaching 93.5%. The fluorescein isothiocyanate (FITC)-labeled nanoparticles were evenly distributed in the digestive tract and body surface of a typical TBPs, M. alternatus, and the stomach and contact toxicities increased by 33.7% and 25.9%, respectively, compared with those of free THI. Furthermore, the results showed that the transport efficiency of THI@BSA·NPs was highest at a concentration of 50 μg/mL, and the THI@BSA·NPs content in the trunk, from to lower to higher layers, was 8.8, 8.2, 7.6, and 5.8 μg/g. At the same time, THI@BSA·NPs also exhibited high transport efficiency in dead trees. Conclusion: The transport efficiency and toxicity of the active ingredients are the key factors for the control of TBPs. This work provided idea for the application of biological delivery system encapsulated hydrophobic pesticides. The novel self-assembled THI@BSA·NPs have promising potential for sustainable control of TBPs. [ABSTRACT FROM AUTHOR]

The article focuses on findings of a study on discovery of Molar Tooth Structures in the Kangjia Formation at Benxi, Liaoning, citing its Significance. It states stratigraphic and sedimentary research about the Neoproterozoic strata in the Benxi area, and mentions that Kangjia Formation has a conformable contact with the underlying Neoproterozoic Qiaotou Formation. It notes molar tooth structures in the micrites of Neoproterozoic Kangjia Formation.

Background: Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression. However, its relevance to the progression of human breast cancer is yet to be established. Furthermore, it is not clear whether MMP-13 can be used as an independent breast cancer biomarker. This study was conducted to assess the expression profile of MMP-13 protein in invasive breast carcinomas to determine its diagnostic and prognostic significance, as well as its correlation with other biomarkers including estrogen receptor (ER), progesterone receptor (PR), Her-2/neu, MMP-2, MMP-9, tissue inhibitor of MMP-1 and -2 (TIMP-1 and TIMP-2).Methods: Immunohistochemistry (IHC) was performed on paraffin-embedded tissue microarray containing specimens from 263 breast carcinomas. The intensity and the extent of IHC were scored by pathologists in blind fashion. The correlation of the gene expression profiles with patients' clinicopathological features and clinical outcomes were analyzed for statistical significance.Results: MMP-13 protein was detected in the cytoplasm of the malignant cells and the peritumoral stromal cells. MMP-13 expression by tumor cells (p < 0.001) and stromal fibroblasts (p <0.001) both correlated with carcinoma infiltration of lymph nodes. MMP-13 also correlated with the expression of Her-2/neu (p = 0.015) and TIMP-1 (p < 0.010), respectively in tumor cells. Tumor-derived, but not stromal fibroblast-derived, MMP-13 correlated with aggressive tumor phenotypes. Moreover, high levels of MMP-13 expression were associated with decreased overall survival. In parallel, the prognostic value of MMP-13 expressed by peritumoral fibroblasts seems less significant. Our data suggest that lymph node status, tumor size, Her-2/neu expression, TIMP-1 and MMP-13 expression in cancer cells are independent prognostic factors.Conclusion: Tumor-derived, but not stromal fibroblast-derived, MMP-13 correlated with aggressive tumor phenotypes, and inversely correlated with the overall survival of breast cancer patients. MMP-13 may serve as an independent prognostic factor for invasive breast cancer patients. MMP-13 may be particularly useful as a prognostic marker when evaluated along with Her-2/neu and lymph node status. [ABSTRACT FROM AUTHOR]