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Semi-supervised classification has gained widespread popularity because of their superior ability to handle unlabeled samples in practical problems. This paper has presented a novel estimation error-ranked LSSVM method with double Mahalanobis-kernel which is used for semi-supervised classification. The main point is to construct two Mahalanobis distances in Hilbert space to form double Mahalanobis-kernel by considering the relationship between the characteristics of two sorts of samples, so as to reduce the influence of non-informational dimensions. Furthermore, the implementation of the proposed method is required to solve the label security problem of unlabeled samples. The unlabeled sample with the minimum evaluated error is selected for labeling, which effectively ensures the accuracy of the unlabeled sample labeling. This method not only considers the similarity of sample features, but also focuses on the security of unlabeled samples. And based on the experimental results of four artificial data sets and several UCI data sets, it verifies the effectiveness of the semi-supervised method with double Mahalanobis-kernel. Especially considering the experimental results of five disease diagnosis data sets, it demonstrates the potential of the proposed semi-supervised classification method in medical diagnosis. [ABSTRACT FROM AUTHOR]

This study evaluated the feasibility of using polypropylene fiber (PF) as reinforcement in improving tensile strength behavior of cement-stabilized dredged sediment (CDS). The effects of cement content, water content, PF content and length on the tensile strength and stress–strain behavioral evolutions were evaluated by conducting splitting tensile strength tests. Furthermore, the micro-mechanisms characterizing the tensile strength behavior inside PF-reinforced CDS (CPFDS) were clarified via analyzing macro failure and microstructure images. The results indicate that the highest tensile strengths of 7, 28, 60, and 90 d CPFDS were reached at PF contents of 0.6%, 1.0%, 1.0%, and 1.0%, exhibiting values 5.96%, 65.16%, 34.10%, and 35.83% higher than those of CDS, respectively. Short, 3 mm, PF of showed the best reinforcement efficiency. The CPFDS exhibited obvious tensile strain-hardening characteristic, and also had better ductility than CDS. The mix factor (CCa/Cwb) and time parameter (qt0(t)) of CDS, and the reinforcement index (kt-PF) of CPFDS were used to establish the tensile strength prediction models of CDS and CPFDS, considering multiple factors. The PF "bridge effect" and associated cementation-reinforcement coupling actions inside CPFDS were mainly responsible for tensile strength behavior improvement. The key findings contribute to the use of CPFDS as recycled engineering soils. [ABSTRACT FROM AUTHOR]

Ground granulated blast-furnace slag (GGBS) is a common substitute for ordinary Portland cement (OPC). However, GGBS–OPC lacks early strength when OPC content is low (<50%). A new cementitious material called GGBS–OPC–EMR (GOE) was developed by adding electrolytic manganese residue (EMR) to address this issue. Tests were conducted using XRD, SEM, and TG to analyze the micro-structural mechanisms of strength development in GOE. Environmental and economic evaluations were conducted, including CO2-eq (carbon dioxide equivalent) analysis, leaching tests, and economic analysis. Results showed that mixture of GGBS, OPC, and EMR in a 4:2:1 ratio increased the unconfined compressive strength by 25% after 28 days compared to OPC while reducing cement consumption by 70%. Major hydration products in GOE were C–S–H and ettringite (AFt), with approximately 14% EMR promoting AFt production. GOE reduced CO2-eq emissions by 35.9% and saved $46.6/ton compared to OPC. Leaching tests demonstrated GOE's ability to stabilize heavy metals, sulfate, and ammonia nitrogen. [ABSTRACT FROM AUTHOR]

Objective To analyze the prevalence of varicocele (VC) and its relationship with body mass index (BMI) in men undergoing military examination, and provide relevant data support for the subsequent prevention of varicocele. Methods A total of 2017 healthy males aged between 18 and 23 years old, college students at Chenggong District of Kunming, who participated in military examination, were enrolled in the study. The prevalence of varicocele in these male college students was analyzed and the grades of varicocele were evaluated. Height and weight data of patients were collected and the body mass index was calculated. The varicocele grading and BMI of the patients were statistically analyzed. Results Among all the participants, 58.75% were diagnosed with varicocele, including 40. 30% mild varicocele, 12.94% moderate varicocele, 5.00% severe varicocele and 0.50% bilateral varicocele. The average age of participants was (20 ± 1. 5) years, and their median BMI was (22.8 ±1.2) kg/m². Conclusion The prevalence of varicocele in college students of the university town of Chenggong District, Kunming City, Yunnan Province, was 58.75%, which was much higher than that provided by the 2022 edition of urology guidelines. This finding may be related to multiplex factors such as "growth and development are rapid, testicular volume increases rapidly, and local blood flow accelerates". The statistical data revealed that the prevalence of varicocele in those with high BMI was lower than that in those with low BMI. The prevalence of varicocele was negatively correlated with BMI. [ABSTRACT FROM AUTHOR]

There are few studies on two-dimensional (2D) piezoelectric materials with polyatomic thickness at the present stage. The 2D materials with a thickness of 5 atoms were investigated on the piezoelectric effect of Sb2Se2Te, Sb2Te2Se, and three structures of SbAsSe2Te monolayers. The calculated piezoelectric coefficient d31 of Sb2Te2Se is 1.72 pm/V and is higher than that of the other four 2D piezoelectric materials. Compared with other 2D piezoelectric materials, the out-of-plane piezoelectric properties of 2D Janus Sb2Te2Se show great advantages. Density functional perturbation theory was employed to calculate the piezoelectric tensors. The charge density distribution was calculated to explain the polarization and chemical bonds. The electrostatic potential energy was calculated to reveal the polarization phenomenon. Our works imply that 2D Janus Sb2Te2Se monolayer have potential applications in flexible electronics and piezoelectric devices. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the value of single or combined detection of procalcitonin (PCT), interleukin-6 (IL-6), serum amyloid A (SAA) and c-reactive protein (CRP) in the differential diagnosis of simple and strangulated intestinal obstruction. Methods: This retrospectively study collected 61 patients with intestinal obstruction. The patients were classified into the group of simple or strangulated intestinal obstruction according to operation. The age, sex, basic diseases, lesion sites and inflammatory indicators such as PCT, IL-6, SAA and CRP in two groups were collected and analyzed. The Students' T-test and the Mann-Whitney U test were used to analyze normally and non-normally distributed data, respectively. The categorical variable was analyzed by the chi-square test. The receiver-operating characteristic (ROC) curve and the area under the curve (AUC) were used to predict the differential diagnostic value of single and combined detection of the above clinical inflammatory indicators. Results: The serum levels of PCT, IL-6, SAA and CRP of the strangulated group were significantly higher than those of the simple group (p <.05). The areas under the ROC curve (AUC) were 0.907 for PCT, 0.712 for IL-6, 0.723 for SAA and 0.681 for CRP. With the cutoff values of PCT (0.24 ng/L), IL-6 (19.55 pg/L), SAA (282.50 mg/L) and CRP (63.00 mg/L), the sensitivity and specificity were 86.40% and 87.20% for PCT, 68.20% and 76.90% for IL-6, 59.10% and 87.20% for SAA, 63.60% and 87.20% for CRP, respectively. And the sensitivity and specificity were 86.40% and 89.70% for combined model. The differences between PCT and the combined model are tiny and neither clinically nor statistically significant. Conclusions: For discriminating strangulated intestinal obstruction from simple intestinal obstruction, PCT alone may be the preferred approach due to its simplicity. [ABSTRACT FROM AUTHOR]

Autogenous self-healing is the innate and fundamental repair capability of cement-based materials for healing cracks. Many researchers have investigated factors that influence autogenous healing. However, systematic research on the autogenous healing mechanism of cement-based materials is lacking. The healing process mainly involves a chemical process, including further hydration of unhydrated cement and carbonation of calcium oxide and calcium hydroxide. Hence, the autogenous healing process is influenced by the material constituents of the cement composite and the ambient environment. In this study, different factors influencing the healing process of cement-based materials were investigated. Scanning electron microscopy and optical microscopy were used to examine the autogenous healing mechanism, and the maximum healing capacity was assessed. Furthermore, detailed theoretical analysis and quantitative detection of autogenous healing were conducted. This study provides a valuable reference for developing an improved healing technique for cement-based composites. [ABSTRACT FROM AUTHOR]

Recycling of phosphate tailings (PT) in cement production can reduce the amount of this solid waste and its consequent pollution. This paper used high content of calcined PT as an alternative to light-burned magnesia to prepare magnesium oxysulfate (MOS) cement. Thermal decomposition properties of PT at calcination temperature of 600°C–900°C were studied with X-ray diffraction (XRD) and scanning electron microscopy (SEM). Compressive strength, XRD, Fourier-transform infrared spectroscopy (FT-IR), and SEM were conducted to study the effects of the calcination temperature of PT (600°C–800°C) and the dosage of calcined PT (50%–100%) on the strength development and hydration mechanism of MOS cement. Results showed that the main component of PT, dolomite, partially decomposed into magnesium calcite, periclase, and calcite at 700°C; decomposed further into calcite, periclase, and lime at 800°C; and finally decomposed into lime and periclase at 900°C. The periclase sourced from calcined PT reacted with the MOS system to form brucite and 5Mg(OH)2·MgSO4·7 H2O (517 phase). Gypsum also was formed in the reaction. Brucite, 517 phase, and gypsum worked with the unreacted PT to build the structure and provide the source of strength. MOS paste prepared with 60% PT calcined at 700°C had the highest compressive strength, 63 MPa, at 28 days of all the mixtures. The paste prepared with 50% PT calcined at 700°C had the highest strength retention value, about 68%, after 56 days of water immersion. This study provides a method for the efficient use of PT by incorporating it into MOS cement after calcination. [ABSTRACT FROM AUTHOR]

In this article, we address the problem of asymptotic output tracking control with prescribed transient performance for a class of nonlinear systems in the presence of unknown dynamics. By fusing the funnel control approach and the tool of barrier Lyapunov function, a smooth adaptive tracking control strategy is developed in a recursive manner. In the proposed design, a new barrier Lyapunov function is adopted to eliminate the effects of unknown nonlinear dynamics, ensuring the prescribed transient behavior of the output tracking. The distinctive characteristic of the proposed method is that the designed control algorithm can guarantee not only prescribed output tracking performance but also global asymptotic stability without incorporating any prior knowledge of nonlinear dynamics or even corresponding bounding functions. Three illustrative examples are provided to testify the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

Cement solidification was a widely used method to broaden the resource utilization of dredged sludge. However, the organic matter in sludge limit the application of cement solidification. The fulic acid (FA) was used to simulate the natural organic matter in sludge. With the increase in FA content, the sludge gradually changed from low-liquid-limit clay to high-liquid-limit clay. The unconfined compression test showed that the strength of cement-solidified dredged sludge (CDS) decreased with FA content. The influence mechanism of the FA on cement solidification was revealed by a water content test, a hydration heat test, scanning electron microscopy, and thermogravimetric analysis. FA hindered the conversion of pore water to combined water and reduced the hydration heat inside CDS. The FA in sludge weakened the internal bond within CDS by hindering the development of C-S-H gel from spheroidal to flake. At the same time, the final amount of hydrates such as C-S-H, C-A-H and AFt also decreased in the CDS containing FA. The weakening mechanism of FA on the strength of CDS can be attributed to three aspects: (1) FA adsorbed on the surface of cement minerals and hindered the contact between cement minerals and pore water; (2) acidic FA reduced the pH of the pore liquid in CDS; (3) the carboxyl and hydroxyl functional groups of FA adsorbed calcium ions in pore liquid through ion coordination. [ABSTRACT FROM AUTHOR]

Asian elephant is large herbivorous animal with elongated hindgut. To explore fecal microbial community composition with various ages, sex and diets, and their role in plant biomass degrading and nutrition conversation. We generated 119 Gb by metagenome sequencing from 10 different individual feces and identified 5.3 million non-redundant genes. The comprehensive analysis established that the Bacteroidetes, Firmicutes and Proteobacteria constituted the most dominant phyla in overall fecal samples. In different individuals, the alpha diversity of the fecal microbiota in female was lower than male, and the alpha diversity of the fecal microbiota in older was higher than younger, and the fecal microbial diversity was the most complex in wild elephant. But the predominant population compositions were similar to each other. Moreover, the newborn infant elephant feces assembled and maintained a diverse but host-specific fecal microbial population. The discovery speculated that Asian elephant maybe have start to building microbial populations before birth. Meanwhile, these results illustrated that host phylogeny, diets, ages and sex are significant factors for fecal microbial community composition. Therefore, we put forward the process of Asian elephant fecal microbial community composition that the dominant populations were built first under the guidance of phylogeny, and then shaped gradually a unique and flexible gut microbial community structure under the influences of diet, age and sex. This study found also that the Bacteroidetes were presumably the main drivers of plant fiber-degradation. A large of secondary metabolite biosynthetic gene clusters, and genes related to enediyne biosynthesis were found and showed that the Asian elephant fecal microbiome harbored a diverse and abundant genetic resource. A picture of antibiotic resistance genes (ARGs) reservoirs of fecal microbiota in Asian elephants was provided. Surprisingly, there was such wide range of ARGs in newborn infant elephant. Further strengthening our speculation that the fetus of Asian elephant has colonized prototypical fecal microbiota before birth. However, it is necessary to point out that the data give a first inside into the gut microbiota of Asian elephants but too few individuals were studied to draw general conclusions for differences among wild and captured elephants, female and male or different ages. Further studies are required. Additionally, the cultured actinomycetes from Asian elephant feces also were investigated, which the feces of Asian elephants could be an important source of actinomycetes. [ABSTRACT FROM AUTHOR]

Chemical solidification based on cement is one of the most widely used methods to treat marine dredged silt (DS) with very poor engineering properties. This study investigated the strength and microstructure of cement-solidified salt-rich dredged silt (CSDS) modified by nanoparticles. The unconfined compressive strength (UCS) test showed that the UCS of CSDS containing 9% NaCl was obviously lower than that without NaCl. Furthermore, the detrimental effect of chloride salt on the UCS increased with its content significantly. The nano-SiO2 (NS) used as cement additives can significantly improve the UCS of CSDS and adding 8% NS can reduce cement usage by at least 40%. Compared with NS, the nano-MgO (NM) mainly improved the early UCS of CSDS within 7 days. The needle-like Friedel's salt (the reaction product of chloridion with cement) and lamellar brucite (expansive mineral) were clearly detected by the X-ray diffraction test. The calcium silicate hydrate and magnesium silicate hydrate mainly contributed to construct the skeleton, which was confirmed by the scanning electron microscopy images. The NS and NM with high reactivity can be used as effective cement additives to overcome the negative effect of chloride salt, so as to increase the strength of CSDS. [ABSTRACT FROM AUTHOR]

This study investigates the mechanical behavior of cement-stabilized dredged sediment (CDS) improved by nano-MgO (NM) and polypropylene fiber (PF). The effects of NM content, PF content and PF length on the mechanical behavior of NM-modified and PF-reinforced CDS (CNPDS) were evaluated by conducting unconfined compressive strength (UCS, qu) and splitting tensile strength (STS, qt) tests. Furthermore, optical microscope scans were conducted to detect the interface friction evolution. The results indicated that adding NM can significantly improve UCS and STS of CDS, and the optimum NM content was 1.2%. The optimum PF content tended to increase with increasing curing age, and the 3 mm-length PF was the most effective in improving UCS and STS. Increasing NM content mainly increased the strength, but had little influence on ductility. The inclusion of PF can effectively improve the ductility of CNPDS, and contributed to its tensile strain-hardening characteristic. The relation of q t = 0.23 q u was obtained regardless of other influence factors. The combination of NM-modification and PF induced "bridging" effect provided a coupling effect inside CNPDS, and a concept model representing this process was established. The key findings in this study can be used as an effective method for dredged sediment stabilization in practical engineering. [ABSTRACT FROM AUTHOR]

The strength, durability and swelling behavior of cement-solidified dredged sludge (CDS) has been attracted more and more attention in recent years. This study performed a series of laboratory tests including unconfined compressive strength (UCS), water absorption, swelling tests and pH to investigate the effectiveness of using fly ash (FA) and nano-SiO2 (NS) blended with Portland cement (PC) for DS solidification. Microstructural properties were also analyzed by conducting scanning electron microscopy (SEM) and X-ray diffraction (XRD) tests. The results showed that the addition of FA and NS can significantly improve the UCS of CDS. Using FA and NS together as PC admixture can effectively improve the water resistance. Compared with FA, NS was more effective to reduce the water absorption and swelling of CDS. Adding 0.9% NS to CDS notably reduced the 7-day water absorption and swelling value by up to 40% and 67.5%, respectively. Furthermore, the addition of NS is beneficial to control the pH level of CDS. The SEM and XRD results showed that CSH and CAH gels were the major cementitious products inside solidified DS. The addition of NS contributed to the formation of additional CSH gels in CDS. [ABSTRACT FROM AUTHOR]

Cement-stabilized dredged sediment (CDS) when used as a new road construction material cannot only solve the problem of abandoned sediment disposal, but also effectively save natural soil resources. This study aimed to evaluate the strength and permeability of CDS and establish corresponding prediction models from the perspective of a stabilization mechanism. The soil–water composition and pore size distribution were investigated by the nuclear magnetic resonance (NMR) technique. The results demonstrated that more liquid pore water inside the CDS specimen transformed into combined water with cement hydration. The amount of combined water, which essentially characterized the hydration process of cement, presented a linear relationship with log (t). The cementation and filling action of hydrates resulted in the transformation of large pores into smaller ones, hence the optimal pore size decreased with an increasing curing period and cement content. The stress–strain curves and hydraulic conductivity were determined based on unconfined compression and flexible wall penetration tests, respectively. The unconfined compressive strength increased exponentially with the amount of combined water, and the functional correlations of hydraulic conductivity and micropore parameters were established. The reliability of the NMR technique as a new method to study the microscopic evolution mechanism of the strength and permeability of CDS was further verified by scanning electron microscopy and mercury intrusion porosimetry tests. [ABSTRACT FROM AUTHOR]

This study investigated the use of portland cement (PC)–ground-granulated blast-furnace slag (GGBS) binary cement (BC), which was improved by chemical activation and nanomodification, as a potential alternative to PC for stabilization of dredged sediment (DS). The activators of Na2SiO3 (SM), Ca(OH)2 (CH), Na2SO4 (SS), and nanomodifiers of nano-SiO2 (NS) and nano-MgO (NM) were used to improve the strength gaining of BC-stabilized DS (BCDS). A series of unconfined compressive strength (UCS), X-ray diffraction (XRD), and scanning electron microscopy (SEM) tests were conducted to investigate the strength development and associated micromechanisms of nanomodified and activated BCDS. The results indicated that chemical activation can effectively improve the UCS of BCDS, and optimum single activator contents of SM, CH, and SS were respectively 6%, 4%, and 10%. Composite activators SM/SS with mass ratio of 1/9 exhibited more advantages than a single activator. Nanomodification can further improve the UCS of SM/SS-BCDS. The optimum single nanoparticle contents of NS and NM for SM/SS-BCDS were 6% and 8%, respectively. Compared with a single nanoparticle, composite nanoparticles NS/NM with mass ratio of 5/5 were more effective in improving UCS of SM/SS-BCDS. The 15% optimum NS/NM-SM/SS-BC can be used to replace 30% PC for DS stabilization. XRD and SEM results confirmed that the main hydration products of NS/NM-SM/SS-BCDS were calcium silicate hydrate (CSH), calcium aluminate hydrate (CAH), and ettringite, which contributed to the strength enhancing. [ABSTRACT FROM AUTHOR]

Background: Microtubule dynamics plays a crucial role in the spatial arrangement of cell organelles and activation of the NLRP3 inflammasome. Purpose: This study aimed to explore whether microtubule affinity regulating kinase 4 (MARK4) can be a therapeutic target of periodontitis by affecting microtubule dynamics and NLRP3 inflammasome-mediated pyroptosis in macrophages. Materials and Methods: The NLRP3 inflammasome-related genes and MARK4 were measured in the healthy and inflamedhuman gingival tissues. Bone marrow-derived macrophages (BMDMs) were infected with Porphyromonas gingivalis, while the MARK4 inhibitors (OTSSP167 and Compound 50) and small interference RNAwere utilized to restrain MARK4. Apoptosisassociated speck-like protein (ASC)speck was detected by confocal, and levels of interleukin-1ß (IL-1ß), as wellas IL-18, were assessed by ELISA. Results: Increased staining and transcription of MARK4, NLRP3, ASC, and Caspase-1 were observed in the inflamed gingiva. P. gingivalis infection promoted MARK4 expression and the NLRP3 inflammasome in BMDMs. Inhibition of MARK4 decreased LDH release, IL-1ß and IL-18 production, ASC speck formation, and the pyroptosis-related genes transcription. Furthermore, MARK4 inhibition reduced microtubule polymerization and acetylation in P. gingivalis-infected BMDMs. Conclusions: MARK4 promoted NLRP3 inflammasome activation and pyroptosis in P. gingivalis-infected BMDMs by affecting microtubule dynamics. MARK4 inhibition might be a potential target in regulating the NLRP3 inflammasome during periodontitis progress. [ABSTRACT FROM AUTHOR]

A novel Actinobacterium strain YIM 131861 T, was isolated from lichen collected from the South Bank Forest of the Baltic Sea, Germany. It was Gram-stain-positive, strictly aerobic, catalase positive and oxidase negative, yellow pigmented. Cells were motile with a polar flagellum, irregular rod shaped and did not display spore formation. The strain grew at 15 − 30 °C (optimum 25 °C), at pH 6.0 − 10.0 (optimum pH 7.0) and in the presence of 0 − 1.5% (w/v) NaCl (optimum 1%). Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain YIM 131861 T belonged to the genus Glaciibacter, and exhibited a high sequence similarity (96.4%) with Glaciibacter superstes NBRC 104264 T. The genomic DNA G + C content of strain YIM 131861 T was 68.2 mol%. The average nucleotide identity (ANI) and digital DNA–DNA hybridization (dDDH) values between strain YIM 131861 T and Glaciibacter superstes NBRC 104264 T were 73.2 and 19.9% based on the draft genome sequence. The cell-wall peptidoglycan type was B2γ and contained the 2, 4-diaminobutyric acid as the diagnostic amino acid. Whole cell sugars were galactose, rhamnose, ribose and glucose. It contained MK-12 and MK-13 as the predominant menaquinones. The major cellular fatty acids (> 10%) were identified as anteiso-C15:0, iso-C16:0 and anteiso-C17:0. The polar lipids were diphosphatidylglycerol, phosphatidylglycerol and two unknown glycolipids. Based on the results of phenotypic, chemotaxonomic and phylogenetic analyses, strain YIM 131861 T should belong to the genus Glaciibacter and represents a novel species of the genus Glaciibacter, for which the name Glaciibacter flavus sp. nov. is proposed. The type strain is YIM 131861 T (= CGMCC 1.16588 T = NBRC 113572 T). [ABSTRACT FROM AUTHOR]

In order to study the separation characteristics of the aeroengine dynamic pressure oil-air separator, this paper uses the coupling method of PBM and CFD two-fluid model to study the influencing factors such as cylinder diameter, cylinder length, and other factors on the separator performance. The flow field structure, velocity, gas volume distribution, separation efficiency, and gas and liquid holdup rate in the separator under different operating conditions are analyzed. Combined with the analysis results of the cylinder diameter and the cylinder length, the influence law of length-diameter ratio on separation efficiency is summarized. The optimum length-to-diameter ratio that maximizes the separation performance of the separator is obtained in this research, which provides a reference for the design and improvement of the separator. The results show that, as the diameter of the cylinder increases, the separation efficiency increases first and then decreases. When dsep = 16 mm and dsep = 18 mm, the separator reaches its maximum efficiency, which is about 93%. With the increase of the cylinder length, the separation efficiency first increases and reaches the maximum when l2 = 90 mm and then decreases slowly. When the separator cylinder is either too long or too short, it will cause the separation performance to decrease. There is an optimal aspect ratio. There is an optimal aspect ratio, and the separation performance of the separator is the best when the aspect ratio is between 5 and 6. [ABSTRACT FROM AUTHOR]

This study investigated the feasibility of using lime (L) and carbide slag (CS) to activate ground granulated blast-furnace slag (GGBS), as a potential substitute to Portland cement (PC) for stabilizing dredged sludge (DS). A series of unconfined compressive strength (UCS), scanning electron microscopy (SEM) and X-ray diffraction (XRD) tests were performed to evaluate the strength development and micro-mechanisms of stabilized DS. The results showed that the optimum lime content was 20-25% for L-GGBS stabilized DS, which can achieve the highest UCS. The 28-, 60- and 90-day optimum UCS of stabilized DS with 20% L-GGBS were 1.38, 1.14 and 1.06 times that of 15% PC stabilized DS. Similarly, the optimum CS content of 25-30% was recommended for achieving the highest UCS of CS-GGBS stabilized DS. The 28-, 60- and 90-day optimum UCS of 20% CS-GGBS stabilized DS were 1.45, 1.12 and 1.02 times that of 15% PC stabilized DS. It was suggested using 20% L-GGBS or CS-GGBS instead of 15% PC for stabilizing DS. The SEM and XRD results revealed that the CSH and CAH gels were the main hydration products for stabilized DS, and the ettringite was also obviously detected in CS-GGBS stabilized DS. [ABSTRACT FROM AUTHOR]

Acetone is widely used as an organic solvent or as an intermediate in material preparation. However, acetone is fairly volatile and highly toxic. Long-term exposure to acetone may damage the kidney, liver, and nerve. Therefore, the detection of acetone is of great significance to ensure the safety of laboratory personnel and facilities. We systematically explored the adsorption of acetone, methane and formaldehyde on pristine tellurene based on first-principles calculations. The electron localisation function (ELF) and density of states (DOS) for three organic gases adsorption on tellurene indicate that they are all physically adsorbed on the substrate. The results of adsorption energy, charge transfer, work function and charge density difference (CDD) show that the gas sensor made of tellurene can exhibit high sensitivity to acetone. In addition, we demonstrated that doping Cu atom to pristine tellurene can enhance the adsorption strength between tellurene and acetone. In summary, our investigation will provide some guidance for experimentalists to exploit the novel acetone sensors. [ABSTRACT FROM AUTHOR]

Autoclaved aerated concrete (AAC) is an energy-saving and environmentally friendly building material. However, ordinary portland cement (OPC) mortar is prone to cracking and spall when it is used for surface plastering of AAC. To resolve this situation, this research proposes a novel plastering mortar appropriate for AAC based on magnesium phosphate cement (MPC) incorporating fly ash (FA) and cenospheres. Two series of mortar mixtures were formulated with different FA and cenosphere dosages. Firstly, MPC was partially replaced with FA by weight. Then, in the case of fixed FA content, sand was replaced with an equal volume of cenospheres at different percentages. The mechanical strength, water retention, drying shrinkage, and thermal conductivity of the MPC mortar was investigated. The hydration products and microscopic properties of the MPC mortar were examined by scanning electron microscope (SEM) and X-ray diffraction (XRD). The results show that FA greatly improves the water retention of MPC mortar. The water retention of MPC mortar is 97.5% at FA replacement of 40%. Although cenospheres replacing sand slightly reduced mechanical strength of MPC mortar, they can significantly decrease the thermal conductivity and drying shrinkage of mortar. When sand was completely replaced with cenospheres, the bond strength, drying shrinkage rate, and thermal conductivity were 0.6 MPa, 0.08 mm/m , and 0.26 W/m·K , respectively. Finally, XRD and SEM tests of MPC mortar also indicated that cenospheres inhibited the hydration of MPC and reduced the strength of MPC mortar. In conclusion, the developed MPC mortar has excellent bond strength as well as low drying shrinkage rate and thermal conductivity, which can effectively deal with the problem of cracking and spall in traditional plaster mortar and is also an eco-friendly building material. [ABSTRACT FROM AUTHOR]

Based on the aeroengine lubricating oil system test bench, this paper used a dimensional analysis method to establish a mathematical model for predicting the separation efficiency and resistance of a dynamic pressure oil-air separator suitable for engineering. The analysis of the multivariate nonlinear fitting error and the experimental data showed that the established separation efficiency and resistance model could accurately predict the separation and resistance performance of the dynamic pressure oil-air separator within a certain range; the average error of the four separation characteristic prediction models was 3.5%, and the maximum error was less than 16%. The model that was established by the least square method had the highest accuracy; the average error of the multivariate nonlinear fitting of the four resistance characteristic prediction models was less than 4%, and the maximum error was less than 15%, which could be used to predict the resistance performance of the separator. The applicable working condition of the model is lubricating oil flow rate 4.3~8.5 L/min and oil-air ratio 0.5~3. [ABSTRACT FROM AUTHOR]

Strain YIM 132242T, isolated from lichen collected from Pu'er, Yunnan Province, China, was short-rod-shaped, Gram-reaction-negative, aerobic, catalase- and oxidase-positive. Growth of the strain was occurred at 10–39 °C (optimum, 28–35 °C), at pH 4.0–10.0 (optimum, pH 7.0–8.0) and at salinities of 0–8% (w/v) NaCl (optimum, 0–2%). Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain YIM 132242T belonged to the genus Paracoccus and had the highest levels of sequence similarity to Paracoccus aerius KCTC 42845T (97.0% similarity), Paracoccus sediminis CMB17T (96.8% similarity), and Paracoccus fontiphilus MVW-1T (96.4% similarity). The major fatty acid was identified as C18:1ω7c (77.6%). The predominant respiratory quinone was ubiquinone-10 (Q-10). Polar lipid analysis indicated the presence of phosphatidylglycerol (PG), phosphatidylethanolamine (PE), phosphatidylcholine (PC), diphosphatidylglycerol (DPG), an unidentified lipid (L), and three unidentified phospholipids (PL1-PL3). Based on the draft genome sequence, the DNA G + C content of the strain was 67.1 mol%, and the values of average nucleotide identity (ANI) and digital DNA–DNA hybridization (dDDH) of strain YIM 132242T with Paracoccus aerius KCTC 42845T were 85.4% and 29.1%, respectively. On the basis of the data from this polyphasic characterization, strain YIM 132242T represents a novel species of the genus Paracoccus, for which the name Paracoccus lichenicola sp. nov. is proposed. The type strain is YIM 132242T (= KCTC 72463T = CGMCC1.17191T). [ABSTRACT FROM AUTHOR]

In this study, the adsorption of gas molecules, such as O2, NH3, CO, CO2, H2O, NOx (x = 1, 2) and SO2, on Janus Te2Se monolayer has been investigated by means of density functional theory (DFT) calculations. We show that Janus Te2Se monolayer is preferable for SO2 and NOx molecules with suitable adsorption strength and apparent charge transfers. We further calculated the current–voltage (I–V) curves using the nonequilibrium Green's function (NEGF) method. The transport feature exhibits distinct responses with a dramatic change of I–V curves before and after NOx (SO2) adsorption on Janus Te2Se. Thus, we predict that Janus Te2Se could be a promising candidate for SO2 and NOx sensors with high selectivity and sensitivity. Moreover, the effect of strain on the gas/substrate adsorption systems was also studied, implying that the strained Janus Te2Se monolayer could enhance the sensitivity and selectivity to SO2 and NO2. The adsorbed SO2 and NO2 on Janus Te2Se could escape by releasing the applied strain, which indicates that the capture process is reversible. Our study widens the application of Janus Te2Se not only as piezoelectric materials, but also as a potential gas sensor or capturer of SO2 and NOx with high sensitivity and selectivity. [ABSTRACT FROM AUTHOR]

Agricultural by-products are increasingly used in the production of bio-based concrete. Compaction forming technology was used in this study to develop a sustainable biocomposite made from corn stalk (CS) and magnesium phosphate cement (MPC). The goal was to experimentally evaluate the effect of forming pressure (FP), CS content, and fly ash (FA) content on the apparent density, compressive strength, and thermal conductivity of CS-MPC biocomposite (CMB). Furthermore, the microstructure changes of typical CMB samples were analyzed by conducting scanning electron microscopy (SEM) tests. The results indicated that the apparent density and thermal conductivity of CMB were less influenced by the FP, while the compressive strength can be effectively improved by increasing FP. The increase of CS content from 25% to 45% led to a 47% reduction in thermal conductivity and a significant decrease of compressive strength. The inclusion of FA had little influence on the apparent density, but resulted in 9.48% reduction in thermal conductivity by adding 20% FA. The optimum FA content of 10% was recommended as MPC admixture, which can increase compressive strength of CMB by 4.17%. The linear empirical model for predicting thermal conductivity by apparent density was established. The microstructure changes inside CMB showed the bonding properties between MPC and CS, and the corresponding micromechanisms were analyzed. The findings provide a basic theory for using CMB as thermal insulation material in buildings. [ABSTRACT FROM AUTHOR]

Strain YIM 102744-1T was isolated from Rhinopithecus roxellanae fecal sample collected at Yunnan Wild Animal Park, Yunnan province, PR China. Cells were Gram-stain-negative, aerobic, non-motile and irregular rods. Optimal growth occurred in the presence of 0–1.0% (w/v) NaCl, at pH 7.0–8.0, and at 30 °C. The predominant ubiquinone was Q-10. The major cellular fatty acids (> 10.0%) were C18:1ω7c and C16:1ω7c/C16:1ω6c. The dominant polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and phosphatidylcholine. The DNA G + C content was 62.4 mol%. Phylogenetic analysis based on 16S rRNA gene sequences revealed that YIM 102744-1T belonged to the family Rhodobacteraceae and shared the highest similarity with the type strain Gemmobacter intermedius 119/4T (96.6%). In addition, phylogenetic trees indicated that strain YIM 102744-1T formed a distinct clade together with the closest relative G. intermedius 119/4T. Based on the results of polyphasic taxonomic analysis, strain YIM 102744-1T is considered to represent a novel species within a new genus Falsigemmobacter, for which the name Falsigemmobacter faecalis gen. nov., sp. nov. is proposed. The type strain of Falsigemmobacter faecalis is YIM 102744-1T(= KCTC 52106T = CCTCC AB 2016031T). Because Gemmobacter intermedius 119/4T formed a branch with YIM 102744-1 in the phylogenetic trees and was clearly separated from the other members within the genus Gemmobacter, it is also proposed to transfer into the genus Falsigemmobacter as Falsigemmobacter intermedius comb. nov. (type strain 119/4T = CIP 110795T = LMG 28215T = CCM 8510T). The type species of the genus Falsigemmobacter is Falsigemmobacter intermedius gen. nov., comb. nov. [ABSTRACT FROM AUTHOR]

A novel bacterial strain, designated YIM 132548 T, was isolated from Lepraria sp. lichen collected from Yunnan province, south-west PR China. The organism was Gram-stain negative, aerobic and methylotrophic. The cell was catalase positive and oxidase negative, asporogenous, rod-shaped and motile with three polar flagella. The strain could grow at 15–30 °C (optimum, 20 °C), at pH 6.0–9.0 (optimum, pH 7.0) and does not grow in the presence of NaCl. According to the 16S rRNA gene sequence analysis, strain YIM 132548 T showed high levels of 16S rRNA gene sequence similarity with Methylobacterium soli YIM 48816 T (97.6%) and Methylobacterium durans NBRC 112876 T (97.3%), less than 97.0% with other validly named type strains of the genus Methylobacterium. Ubiquinone Q-10 was the predominant respiratory ubiquinone. The predominant cellular fatty acid was identified as summed feature 8 (C18:1ω7c). The major polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol and phosphatidylcholine. The DNA G + C content of the draft genome sequence is 70.2 mol%. The average nucleotide identity and digital DNA–DNA hybridizations values of strain YIM 132548 T with M. soli YIM 48816 T and M. durans NBRC 112876 T were 87.0% and 82.0%, 40.6% and 27.2% based on draft genome sequences, respectively. On the basis of phylogenetic, chemotaxonomic, phenotypic and genomic data, strain YIM 132548 T is concluded to represent a novel species of the genus Methylobacterium, for which the name Methylobacterium planium sp. nov. is proposed. The type strain is YIM 132548 T (= CGMCC 1.17323 T = NBRC 114056 T). [ABSTRACT FROM AUTHOR]

A novel actinobacterium, YIM 132087T, isolated from Lepraria sp. lichen collected from Yunnan province, south-west PR China. Cells are Gram-stain-positive, catalase-positive and oxidase-negative, aerobic, non-motile and short rod-shaped. Colonies are asporogenous, circular and white brown in colour. Optimal growth occured at 15−35 °C (optimum 28 °C), at pH 5.0−9.0 (optimum pH 6.0), and in the presence of 3% NaCl (w/v). The DNA G+C content of strain YIM 132087T based on the draft genome sequence was 71.3 mol%. Phylogenetic analysis based on 16S rRNA gene sequences suggested that strain YIM 132087T belonged to the genus Nakamurella and exhibited high levels of 16S rRNA gene sequence similarity with Nakamurella endophytica CGMCC 4.7038T (97.9%) and Nakamurella intestinalis NBRC 111844T (97.2%). The DNA–DNA hybridization values between strain YIM 132087T and its closest relatives are lower than 26%. Strain YIM 132087T had meso-diaminopimelic acid as the diagnostic cell-wall diamino acid, and MK-8(H4) as the predominant menaquinone. Predominant cellular fatty acids (> 10%) were iso-C16:0, iso-C15:0, C16:0 and anteiso-C15:0. The polar lipid profile were found to be diphosphatidylglycerol, phosphatidylmethylethanolamine, phosphatidylethanolamine, phosphatidylinositol, three unknown phospholipids, one unknown aminophospholipid and one unknown lipid. Based on phenotypic, phylogenetic and chemotaxonomic analysis, strain YIM 132087T belongs to the genus Nakamurella and represents a novel species of the genus Nakamurella, for which the name Nakamurella albus sp. nov., with type strain YIM 132087T (=CGMCC 4.7629T =NBRC 114017T), is proposed. [ABSTRACT FROM AUTHOR]

A Gram-negative, motile, aerobic and coccoid rod-shaped bacterium, designated strain YIM132180T, was isolated from a Lepraria sp. lichen collected from Pu'er, Yunnan Province, China. The strain grew at 15–35 °C (optimum, 25–28 °C), at 0–2% (w/v) NaCl (optimum, 0–1%) and at pH 6.0–9.0 (optimum, pH 7.0). The 16S rRNA gene sequence showed that strain YIM132180T had highest similarity (96.4%) with Aureimonas endophytica 2T4P-2-4T, followed by Aureimonas ureilytica NBRC 106430T (95.7%) and Aureimonas rubiginis CC-CFT034T (95.6%). Phylogenetic analysis showed that the strain grouped with species of the genus Aureimonas. The genomic sequence was 4,779,519 bp and contained 4584 coding sequences (CDSs), 54 RNA genes, 3 complete rRNA genes and 47 tRNA genes. The major fatty acids (>10%) of strain YIM132180T were C18:1ω7c, C-16:0 and C19:0 cyclo ω8c. The predominant menaquinone was ubiquinone 10 (Q-10). The polar lipid profile comprised diphosphatidylglycerol, phosphatidylcholine, phosphatidylmethylethanolamine, phosphatidylethanolamine, phosphatidylglycerol, unidentified phospholipid, amino lipid, lipid and most importantly sulfoquinovosyldiacylglycerol (SQDG). Based on the draft genome sequence, the G +C content of strain YIM132180T was 68.4 mol%. The results of the polyphasic taxonomic study, including phenotypic, chemotaxonomic, and phylogenetic analyses, showed that strain YIM132180T represents a novel species of the genus Aureimonas, for which the name Aureimonas leprariae sp. nov. is proposed. The type strain is YIM 132180T (=KCTC 72462T = CGMCC 1.17389T). [ABSTRACT FROM AUTHOR]

A novel strain, YIM 131921T, was isolated from a Physcia sp. lichen collected from the South Bank Forest of the Baltic Sea. The strain is Gram-negative, catalase positive and oxidase negative, strictly aerobic, asporogenous, non-motile and reddish brown in colour. The temperature and pH for growth were found to be 20–30 °C (optimum 28 °C) and pH 6.5–12.0 (optimum pH 7.0 ± 0.5). No growth was observed in the presence of NaCl. Based on 16S rRNA gene sequence similarity, strain YIM 131921T shares high similarities with Rubellimicrobium roseum YIM 48858T (98.3%), followed by Rubellimicrobium mesophilum MSL-20T (96.8%), Rubellimicrobium aerolatum 5715S-9T (96.1%) and Rubellimicrobium thermophilum DSM 16684T (96.0%). Phylogenetic trees showed YIM 131921T forms a cluster with type strains of the genus Rubellimicrobium. The predominant cellular fatty acids (> 20%) were identified as summed feature 8 (C18:1ω7c) and C16:0. Q-10 was found to be the predominant respiratory ubiquinone. The polar lipids were identified as diphosphatidylglycerol, phosphatidylglycerol, phosphatidylcholine, glycolipid, phospholipids and an unidentified aminolipid. The DNA G + C content of the draft genome sequence is 66.6 mol%. Strain YIM 131921T showed an average nucleotide identity value of 80.3% and a digital DNA–DNA hybridizations value of 26.1% with the reference strain R. roseum YIM 48858T based on draft genome sequences. Based on comparative analyses of phenotypic, molecular, chemotaxonomic data and genomic comparisons, strain YIM 131921T is concluded to represent a novel species of the genus Rubellimicrobium, for which the name Rubellimicrobium rubrum sp. nov. is proposed. The type strain is YIM 131921T (= CGMCC 1.13958T = NBRC 114054T = KCTC 72461T). [ABSTRACT FROM AUTHOR]

Background/Aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor. Although evidence shows that a DNA damage-independent ATM (oxidized ATM) may be involved in cancer progression, the underlying mechanism is still unclear. Methods: Immunohistochemistry, immunofluorescence and western blotting were applied to detect the levels of oxidized ATM. Transwell assay was used to detect the cell migration and invasion abilities in different treatments. Quantitative phosphoproteome analysis was performed using hypoxic BT549 cells, in the presence or absence of Ku60019, a specific inhibitor of ATM kinase. The phosphorylated cortactin, the target protein of oxidized ATM, was confirmed by immunoprecipitation-western blots and in vitro kinase assay. The functions of phosphorylated cortactin were studied by specific short hairpin RNA, site-directed mutation, transwell assay, and actin polymerization assay. Results: Enhanced oxidized ATM proteins were present not only in the advanced and invasive breast tumor tissues but also malignant hypoxic breast cancer cells, in the absence of DNA damage. Loss of ATM expression or inhibiting oxidized ATM kinase activity reduced breast cancer cell migration and invasion. Using quantitative phosphoproteomics approach, 333 oxidized ATM target proteins were identified, some of these proteins govern key signaling associated with gap junction, focal adhesion, actin cytoskeleton rearrangement. Cortactin, one of the biggest changed phospho-protein, is a novel oxidized ATM-dependent target in response to hypoxia. Mechanically, we reveal that hypoxia-activated ATM can enhance the binding affinity of cortactin with Arp2/3 complex by phosphorylating cortactin at serine 113, and as a result, in favor of breast cancer cell migration and invasion. Conclusion: Oxidized ATM can phosphorylate cortactin at serine 113, playing a critical role in promoting breast tumor cell mobility and invasion via actin polymerization. [ABSTRACT FROM AUTHOR]

The combination of chemical stabilization and fiber reinforcement can simultaneously improve the strength and ductility of dredged sediment. The polypropylene fiber (PF) and straw fiber (SF) were respectively used as artificial and natural reinforcements of cement-stabilized dredged sediment (CDS). A series of unconfined compressive strength (UCS) tests were conducted to investigate the effects of cement content, fiber content, fiber length and water content on the mechanical properties of PF-reinforced CDS (CPFDS) and SF-reinforced CDS (CSFDS). Furthermore, the cementation-reinforcement mechanism was explored and analyzed via macro failure characteristics and micro interfacial morphologies inside typical CPFDS and CSFDS samples. The results showed that increasing cement content or decreasing water content significantly improved the UCS and aggravated the brittleness of CPFDS and CSFDS. The suitable addition of PF can effectively improve the UCS of CDS, while incorporating SF exhibited the opposite role. The maximum 7d-, 28d-, 60d- and 90d-UCS of CPFDS were respectively 17.7%, 43.6%, 10.7% and 9.7% higher than that of CDS. The optimum length of PF inside CPFDS and SF inside CSFDS was 3 mm and 5–10 mm, respectively. Both incorporating PF or SF can effectively improve the ductility of CDS. Based on the proposed parameters of total-water/cement ratio and fiber cementation factor, the effective strength development models of CPFDS and CSFDS considering cement content, fiber content, water content and curing time were empirically established. The fiber "bridge" effect and interfacial friction between fiber and cemented soil particles were mainly responsible for the strength evolution and ductility improvement of CPFDS and CSFDS. [ABSTRACT FROM AUTHOR]

Combining interval-valued hesitant fuzzy soft sets (IVHFSSs) and a new comparative law, we propose a new method, which can effectively solve multiattribute decision-making (MADM) problems. Firstly, a characteristic function of two interval values and a new comparative law of interval-valued hesitant fuzzy elements (IVHFEs) based on the possibility degree are proposed. Then, we define two important definitions of IVHFSSs including the interval-valued hesitant fuzzy soft quasi subset and soft quasi equal based on the new comparative law. Finally, an algorithm is presented to solve MADM problems. We also use the method proposed in this paper to evaluate the importance of major components of the well drilling mud pump. [ABSTRACT FROM AUTHOR]

Background: The nuclear localization of Drosha is critical for its function as a microRNA maturation regulator. Dephosphorylation of Drosha at serine 300 and serine 302 disrupts its nuclear localization, and aberrant distribution of Drosha has been detected in some tumors.Aims: The purpose of the present study was to assess cytoplasmic/nuclear Drosha expression in gastric cancer carcinogenesis and progression.Methods: Drosha expression and its subcellular location was investigated by immunohistochemical staining of a set of tissue microarrays composed of normal adjacent tissues (374), chronic gastritis (137), precancerous lesions (94), and gastric adenocarcinoma (829) samples, and in gastric cancer cell lines with varying differentiation by immunofluorescence and western blot assay.Results: Gradual loss of cytoplasmic Drosha was accompanied by tumor progression in both gastric cancer tissues and cell lines, and was inversely associated with tumor volume (P = 0.002), tumor grade (P < 0.001), tumor stage (P = 0.018), and distant metastasis (P = 0.026). Aberrant high levels of cytoplasmic Drosha were apparent in intestinal metaplasia and dysplasia tissues. The levels of nuclear Drosha were sharply decreased in chronic gastritis and maintained through precancerous lesions to gastric cancer. High levels of cytoplasmic Drosha predicted longer survival (LR = 7.088, P = 0.008) in gastric cancer patients.Conclusions: Our data provide novel insights into gastric cancer that cytoplasmic Drosha potentially plays a role in preventing carcinogenesis and tumor progression, and may be an independent predictor of patient outcome. [ABSTRACT FROM AUTHOR]