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Experimental and numerical studies were performed on the vibrational energy relaxation in shock-heated CO/N2/Ar mixtures. A laser absorption technique was applied to the time-dependent rovibrational temperature time-history measurements. The vibrational relaxation data of reflected-shock-heated CO were summarized at 1720–3230 K. In shock-tube experiments, the rotational temperature of CO quickly reached equilibrium, whereas a relaxation process was found in the time-dependent vibrational temperature. For the mixture with 1.0% CO and 10.0% N2, the vibrational excitation caused a decrease in the macroscopic thermodynamic temperature of the test gas. In the simulations, the state-to-state (StS) approach was employed, where the vibrational energy levels of CO and N2 are treated as pseudo-species. The vibrational state-specific inelastic rate coefficients of N2–Ar collisions were calculated using the mixed quantum–classical method based on a newly developed three-dimensional potential energy surface. The StS predictions agreed well with the measurements, whereas deviations were found between the Schwartz–Slawsky–Herzfeld formula predictions and the measurements. The Millikan–White vibrational relaxation data of the N2–Ar system were found to have the most significant impact on the model predictions via sensitivity analysis. The vibrational relaxation data of the N2–Ar system were then modified according to the experimental data and StS results, providing an indirect way to optimize the vibrational relaxation data of a specific system. Moreover, the vibrational distribution functions of CO and N2 and the effects of the vibration–vibration–translation energy transfer path on the thermal nonequilibrium behaviors were highlighted. [ABSTRACT FROM AUTHOR]

The time-dependent rotational and vibrational temperatures were measured to study the shock-heated thermal nonequilibrium behaviors of CO with Ar, He, and H2 as collision partners. Three interference-free transition lines in the fundamental vibrational band of CO were applied to the fast, in situ, and state-specific measurements. Vibrational relaxation times of CO were summarized over a temperature range of 1110–2820 K behind reflected shocks. The measured rotational temperature instantaneously reached an equilibrium state behind shock waves. The measured vibrational temperature experienced a relaxation process before reaching the equilibrium state. The measured vibrational temperature time histories were compared with predictions based on the Landau–Teller model and the state-to-state approach. The state-to-state approach treats the vibrational energy levels of CO as pseudo-species and accurately describes the detailed thermal nonequilibrium processes behind shock waves. The datasets of state-specific inelastic rate coefficients of CO–Ar, CO–He, CO–CO, and CO–H2 collisions were calculated in this study using the mixed quantum-classical method and the semiclassical forced harmonic oscillator model. The predictions based on the state-to-state approach agreed well with the measured data and nonequilibrium (non-Boltzmann) vibrational distributions were found in the post-shock regions, while the Landau–Teller model predicted slower vibrational temperature time histories than the measured data. Modifications were applied to the Millikan–White vibrational relaxation data of the CO–Ar and CO–H2 systems to improve the performance of the Landau–Teller model. In addition, the thermal nonequilibrium processes behind incident shocks, the acceleration effects of H2O on the relaxation process of CO, and the characterization of vibrational temperature were highlighted. [ABSTRACT FROM AUTHOR]

Accurate rotation of microparticles is of great significance in micro-rotors, multi-angle microscopic observation, microbial three-dimensional phenotyping, and microsystem assembly. However, most methods can only rotate a single object, thus limiting the throughput. In this study, we realized the simultaneous rotation of many trapped and aligned subwavelength glass cylinders inside an evanescent wave field excited by a resonant phononic crystal plate. The unique feature of the rotation lies in its periodic distribution as well as the rotation axis being perpendicular to the acoustic axis. The rotary power originates from viscous torque generated by the evanescent wave-induced near-boundary acoustic streaming's asymmetry distribution on the trapped cylinder. Furthermore, the three-dimensional topographies of rotated cylinders can be reconstructed from the microscopic images under different rotating angles. Our findings can pave the way toward developing simple, disposable, and scalable microfluidic devices for massive subwavelength acoustic rotation by carefully designing acoustic metamaterials. [ABSTRACT FROM AUTHOR]

Accurate calibration of the milling force coefficients is essential for predicting the milling forces and characterizing the milling state. Cutter run-out is an unavoidable phenomenon in end milling process, which affects the working state of the cutter and the machining accuracy of the work-piece. This paper proposes an optimized method based on the average force method to calibrate milling force coefficients and cutter run-out parameters in the end milling process. The entire calibration procedure is divided into three steps. First, the milling force coefficients are initially calibrated through the utilization of the average force method. Then, further optimization is carried out based on the coefficients calibrated by the average force method; average milling force equations are used, and a calibration procedure is presented by defining an objective function which is utilized to limit the average force error ratios between the calculated results and the measured results. Finally, the milling force coefficients obtained in the second step are used to calibrate the cutter run-out parameters; the instantaneous milling force equations are used, and a calibration procedure is also presented by defining a new objective function with the minimum sum of squared errors between the instantaneous prediction results and the instantaneous measurement results. In comparison to the experimentally measured average milling forces and instantaneous milling force curves, the proposed method exhibits significantly smaller mean force error ratios than those of the average force method, while demonstrating improved agreement with the simulated milling force curves. [ABSTRACT FROM AUTHOR]

Tensegrity continuum robots (TCRs) are an emerging class of flexible continuum robots that employ the tensegrity concept to achieve a natural balance of compliance and strength. The dynamics of a TCR with slack cables is a high-dimensional non-smooth nonlinear system. Motion control of such a system is challenging, especially when the TCR is placed horizontally. In this work, a differential–algebraic equations (DAEs) model-based instantaneous optimal control (IOC) approach for the tip's position and orientation collaborative tracking of a horizontal TCR with slack stiffening cables is proposed. Based on the complementarity theory and the Fischer–Burmeister function, the non-smooth problem of cable relaxation can be described as a continuous differentiable algebraic equation. Then, by combining the dynamic differential equations, a DAEs model of the TCR with slack cables can be obtained. Subsequently, the original continuous tip tracking problem is approximated to a series of IOC problems at each discrete time slot. Finally, considering the control input saturation constraints, a suboptimal control law can be obtained just by solving a small-scale optimization problem. The proposed IOC approach provides a novel and unified control framework to deal with the tip tracking problem of the horizontal TCRs, and the non-smooth property of cable relaxation is naturally involved in the IOC controller. Numerical experiments on the tip tracking of a horizontal TCR are conducted to demonstrate the effectiveness and advantages of the proposed IOC method. [ABSTRACT FROM AUTHOR]

Large‐scale hydrogen production through water splitting represents an optimal approach for storing sustainable but intermittent energy sources. However, water oxidation, a complex and sluggish reaction, poses a significant bottleneck for water splitting efficiency. The impact of outer chemical environments on the reaction kinetics of water oxidation catalytic centers remains unexplored. Herein, chemical environment impacts were integrated by featuring methylpyridinium cation group (Py+) around the classic Ru(bpy)(tpy) (bpy=2,2'‐bipyridine, tpy=2,2′ : 6′,2′′‐terpyridine) water oxidation catalyst on the electrode surface via electrochemical co‐polymerization. The presence of Py+ groups could significantly enhance the turnover frequencies of Ru(bpy)(tpy), surpassing the performance of typical proton acceptors such as pyridine and benzoic acid anchored around the catalyst. Mechanistic investigations reveal that the flexible internal proton acceptor anions induced by Py+ around Ru(bpy)(tpy) are more effective than conventionally anchored proton acceptors, which promoted the rate‐determining proton transfer process and enhanced the rate of water nucleophilic attack during O−O bond formation. This study may provide a novel perspective on achieving efficient water oxidation systems by integrating cations into the outer chemical environments of catalytic centers. [ABSTRACT FROM AUTHOR]

Multidrug-resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective treatment strategy, it is critical to better understand how an A. baumannii MDR bacterium interacts with its mammalian host. Pattern-recognition receptors sense microbes, and activate the inflammasome pathway, leading to pro-inflammatory cytokine production and programmed cell death. Here, we examined the effects of a systemic MDR A. baumannii infection and found that MDR A. baumannii activate the NLRP3 inflammasome complex predominantly via the non-canonical caspase-11-dependent pathway. We show that caspase-1 and caspase-11-deficient mice are protected from a virulent MDR A. baumannii strain by maintaining a balance between protective and deleterious inflammation. Caspase-11-deficient mice also compromise between effector cell recruitment, phagocytosis, and programmed cell death in the lung during infection. Importantly, we found that cytosolic immunity - mediated by guanylate-binding protein 1 (GBP1) and type I interferon signalling - orchestrates caspase-11-dependent inflammasome activation. Together, our results suggest that non-canonical inflammasome activation via the (Interferon) IFN pathway plays a critical role in the host response against MDR A. baumannii infection. Genetic and Immunological analysis reveal that non-canonical inflammasome activation via type I Interferon pathway plays a critical role in the host response against a multidrug-resistant Acinetobacter baumannii infection in mice. [ABSTRACT FROM AUTHOR]

Chimeric antigen receptor (CAR) T-cell therapy represents a highly efficacious treatment modality demonstrated to enhance outcomes in patients afflicted with malignancies, particularly those enduring relapsed or refractory hematological malignancies. However, the escalating adoption of CAR T-cell therapy has unveiled several life-threatening toxicities, notably cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), infections, and hematological toxicities (HTs), thereby hindering the broad implementation of CAR T-cell therapy. HTs encompass a spectrum of adverse effects, including cytopenias, hemophagocytic lymphohistiocytosis (HLH), coagulopathies, and B-cell aplasia. While our comprehension of the underlying mechanisms governing CRS and ICANS is advancing, the intricate pathophysiology of HTs remains inadequately elucidated. Such knowledge gaps may precipitate suboptimal therapeutic decisions, potentially culminating in substantial medical resource depletion and detriment to patients' quality of life. In this comprehensive review, based on recent updated findings, we delineate various mechanisms contributing to HTs subsequent to CAR T-cell therapy, explicate manifestations of HTs, and proffer strategic interventions to mitigate this relevant clinical challenge. [ABSTRACT FROM AUTHOR]

The construction of poly‐dioxolane (PDOL) solid‐state electrolytes by in situ polymerization is an effective way to achieve high performance lithium‐metal batteries. However, the poor electrochemical stability and safety issues of linear PDOL limit their further application. In this work, a multifunctional crosslinker has been introduced to construct a flame retardant crosslinked quasi solid‐state electrolyte (FCDOL). Due to the synergistic effect of the crosslinked network, the prepared FCDOL achieves excellent room temperature ionic conductivity (0.72 mS cm−1), high Li+ transference number (0.655), wide electrochemical stabilization window (4.8 V vs Li/Li+), and impressive performance when matched with lithium metal anodes (>4000 h plating/stripping) and high‐voltage cathodes, and the corresponding pouch cells can withstand abusive tests such as bending and cutting, encouraging that in situ polymerization of SPEs provides new insights into high‐energy density and high‐safety solid‐state batteries. [ABSTRACT FROM AUTHOR]

Objective: Cardiovascular complications associated with COVID‐19 are being increasingly recognized. They include potential long‐term effects on the heart, although how these complications manifest in patients with stroke who are already vulnerable to cardiovascular issues is lacking. This study addressed this gap by investigating the influence of SARS‐CoV‐2 infection on cardiac hemodynamic changes in inpatients with stroke, thereby providing valuable insights into the management of cardiac complications in this population. Methods: This retrospective cohort study enrolled inpatients with stroke who did or did not experience SARS‐CoV‐2 infection in Shenzhen Second People's Hospital. Clinical information, hemodynamics data, serum myocardial enzyme levels, functional levels, including Barthel index, and Longshi scale assessment (bedridden, domestic, and community) were extracted from clinical records. An independent sample t‐test and the Mann–Whitney U test were used for comparison between groups. Multiple logistic regression analysis was used to identify indicators associated with decline in cardiac function in patients with stroke post‐COVID‐19. Results: Eighty‐three patients with stroke (average age of 66.0 ± 15.5 years) were recruited (42 patients in the study group and 41 in the control group). No significant difference in general characteristics was observed between the groups. The ejection fraction (EF, 56.45 ± 12.46 vs. 47.64 ± 14.76, p = 0.04) was decreased, and the end‐diastolic volume (EDV, 142.74 ± 80.00 vs. 193.34 ± 140.17, p = 0.001) was increased significantly in patients infected with SARS‐CoV‐2 compared with the noninfected participants. SARS‐CoV‐2 infection was an independent risk factor for EF (−10%) decrease (OR: 5.205, 95% CI: 1.621–16.720, p = 0.006). The risk of cardiac function decline among bedridden infected patients was 15.43 times higher than that of uninfected nonbedridden patients (OR: 15.430, 95% CI: 1.402–169.805, p = 0.025). Conclusion: Patients who are bedridden after stroke face a higher potential risk of cardiac hemodynamic impairment following SARS‐CoV‐2 infection, emphasizing the need for meticulous hemodynamic monitoring during treatment and rehabilitation of these patients to prevent any potential cardiovascular complications. Trial Registration: ClinicalTrials.gov identifier: ChiCTR2300071376. [ABSTRACT FROM AUTHOR]

Arctic sea ice plays a crucial role in studies of regional and global climate change. Satellite observations have shown that the extent of Arctic sea ice has been declining over the last four decades. However, long-term variations in Arctic sea ice thickness (SIT) have received less attention because SIT cannot be measured directly by satellite-based instruments. Here, we present a monthly Arctic SIT product based on multiple radar altimetry observations from ERS-2, Envisat, and CryoSat-2. To ensure the accuracy of the SIT retrievals, a novel data processing method is proposed, including leads detection, freeboard conversion to thickness, and inter-mission bias correction. Finally, the monthly SIT estimates for the Arctic Ocean from October 1995 to December 2023 are generated. The thickness estimates are posted on a 5 km resolution polar stereographic grid. The variations in Arctic SIT are analyzed in terms of spatial and temporal distributions. Furthermore, the SIT estimates are compared with observations from upward-looking sonars and airborne laser altimetry from Operation IceBridge, as well as seven publicly released Arctic SIT products. The validation results demonstrate that our SIT product has accuracy equivalent to existing products. The accuracy of our products varies from 0.2 m to 0.4 m according to the input satellite altimetry data. The SIT datasets are available on the Zenodo at https://doi.org/10.5281/zenodo.13699698 (Xiao et al., 2024). [ABSTRACT FROM AUTHOR]

Under the condition of weak grid, the phase‐locked loop (PLL) is one of the main reasons for the sub‐synchronous oscillation of the grid‐connected inverter. Therefore, it is necessary to identify the PLL parameters of the grid‐connected inverter for the analysis of the inverter operating performance. This paper uses the sequence impedance model and measured impedance data of grid‐connected inverter to construct the identification function for parameter identification of PLL, and the function is calculated by particle swarm optimization algorithm to overcome the nonlinear problem of sequence impedance model. In addition, the identification frequency band is selected based on PLL parameter sensitivity to improve the parameter identification accuracy under the same impedance measurement error. At different frequencies, the positive correlation between the sensitivity of the PLL parameters and the identification accuracy is proven to determine the definite frequency band for PLL parameter identification of grid‐connected inverter. Finally, the feasibility and effectiveness of the above research are verified by simulation and semi‐physical experiments. [ABSTRACT FROM AUTHOR]

Purpose: Point-of-interest (POI) recommendation techniques play a crucial role in mitigating information overload and delivering tailored services. To address limitations in conventional POI recommendation systems, constrained by sparse user-POI interactions and incomplete consideration of temporal dynamics, POI recommendation based on the spatial-temporal graph (STG-POI) is proposed. Design/methodology/approach: Spatial-temporal sequence graphs from geographical locations and user interaction history data are constructed, which are used to mine spatial-temporal sequence information. Using the data filtered by the band-pass filter, graph neural networks with distance-awareness and sequence-awareness are applied to capture high-order spatial-temporal connections within diverse graph topologies. The model leverages contrastive learning for self-supervised disentanglement of graph representations, providing self-supervised signals for sequential and geographical intent perception, thereby achieving more precise POI personalization. Findings: Compared to the baseline model GSTN, experiments on the Foursquare and Gowalla data sets reveal that STG-POI improves testing AUC by 2.0%, 2.1%, 2.0% and decreases logloss by 1.9%, 3.3%, 0.3%, respectively. These results indicate the model's effectiveness in capturing spatial-temporal information, surpassing mainstream POI recommendation baseline models. Originality/value: This approach constructs a dual graph from user interaction data, harnessing sequential and geographical information as self-supervised signals. It yields decoupled representations of these influences, offering a comprehensive insight into user behaviors and preferences within location-based social networks, thus enhancing recommendation accuracy and interpretability. This approach addresses the challenge in graph convolutional network where only rough and smooth features are conducive to recommendation by using band-pass filters to significantly reduce computational complexity, thereby enhancing recommendation speed by filtering out noise data that does not contribute to recommendation performance. Experimental results indicate that this model surpasses current mainstream approaches in POI recommendation tasks, effectively integrating both geographical and temporal features. [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA), a chronic joint disease characterized by primary or secondary degeneration of articular cartilage and bone dysplasia, is associated with various risk factors and is the leading cause of musculoskeletal pain and disability, severely impacting the quality of life. Growth hormone (GH), secreted by the anterior pituitary gland, is essential in mediating the growth and development of bone and cartilage. Reportedly, osteoarthritis increases, and the growth hormone decreases with age. A negative correlation between GH and OA suggests that GH may be related to the occurrence and development of OA. Considering that abnormal growth hormone levels can lead to many diseases related to bone growth, we focus on the relationship between GH and OA. In this review, we will explain the effects of GH on the growth and deficiency of bone and cartilage based on the local pathological changes of osteoarthritis. In addition, the potential feasibility of treating OA with GH will be further explored and summarized. [ABSTRACT FROM AUTHOR]

Featured Application: Using a calibration sphere with a known diameter allows for calibration of a robot that includes both geometric errors and end-effector deformation errors. A self-calibration method utilizing spherical constraints is proposed for calibration of robot end-effectors. The method establishes a mathematical model to account for both the geometric errors of the robot and the deformation errors of the end-effector. A nonlinear least-squares parameter identification technique based on spherical constraints is employed to achieve autonomous calibration of the end-effector. Contrasted with methodologies relying on point plane or distance constraints, this novel technique delivers superior positioning accuracy, streamlined operational procedures and enhanced efficiency. Both simulation and experimental validation confirm that the self-calibration method using spherical constraints improves the positioning accuracy of the robot end-effector from 3 mm to 0.3 mm, showing the effectiveness of the method. [ABSTRACT FROM AUTHOR]

Hamartomas, as non-true tumors, are commonly found in the lungs, digestive tract, and kidneys, and there are few clinical reports on nasal cases. Nasal histiocytosis accompanied by lymphatic lesions is a common feature of nasal hamartoma. Three patients with nasal cavity hamartoma were treated in our department, including 1 male and 2 females, with nasal obstruction or epistaxis. The imaging (computed tomography, magnetic resonance imaging) of 2 patients showed a soft tissue mass in the nasal cavity and no erosion of bone, while in 1 patient, the imaging was inconclusive. The excised material in all patients was found to be a soft mass. The 3 cases showed the same pattern under histological examination, and all 3 patients were diagnosed with nasal cavity respiratory epithelial adenomatoid hamartoma (REAH). Nasal hamartoma is a rare disease with nonspecific clinical manifestations and imaging features and is often misdiagnosed. Only by a better understanding of this disease can the rate of correct clinical diagnosis be improved. [ABSTRACT FROM AUTHOR]

This study aims to examine the variation in corrosion characteristics and tensile properties of WE43 magnesium alloy in an actual marine atmospheric environment by means of outdoor exposure tests. The macroscopic corrosion morphology, microstructure, and tensile properties were analyzed. The results indicated that WE43 alloy will corrode rapidly during exposure under marine atmospheric environmental conditions, resulting in a loose and porous Mg(OH)2 layer on the surface. The Mg matrix was mainly consumed as an anode, leading to the occurrence of corrosion pits. With the increase in exposure time, both the tensile strength and plasticity of WE43 alloy gradually deteriorated. After exposure for six months, the elongation and area reduction were significantly reduced, with a reduction ratio of more than 50%. After 18 months of exposure, the ultimate strength of the alloy decreased from 359 MPa to 300 MPa. According to an analysis of fractures in the alloy, the corrosion pits on the sample surface were the main reason for the decrease in tensile properties. [ABSTRACT FROM AUTHOR]

The rapid pace of urbanization and industrialization has reshaped land use patterns globally, particularly within the interconnected domains of 'production, living, and ecological spaces' (PLES). Understanding the spatiotemporal evolution of these spaces is crucial for guiding sustainable development. Although a number of previous studies have explored aspects of their dynamics and driving factors, further investigation is needed to fully understand their long-term spatiotemporal evolution and the broader influences of socio-economic and environmental forces. This study aims to fill that important gap by leveraging advanced remote sensing techniques to analyze PLES transformations over a 30-year period. Using Henan Province, China, as a testbed, this study applies high-resolution Landsat data, land use transition matrices, dynamic degree analysis, Principal Component Analysis (PCA), and multiple linear regressions to uncover trends and underlying drivers. The results reveal a substantial reduction in production spaces by 3394.62 km² steady growth in living spaces by 4459.41 km² and complex, non-linear changes in ecological spaces, which decreased by 1067.43 km². Key driving forces, such as economic growth, urbanization, and fiscal policies are identified and discussed. These insights provide a robust framework for sustainable land use planning, with broader implications for rapidly urbanizing regions worldwide. [ABSTRACT FROM AUTHOR]

Achieving comprehensive improvement in both piezoelectric coefficient (d33) and mechanical quality factor (Qm) has become a key issue in the research of high‐power piezoelectric ceramics. Here, we focused on Mn‐doped Pb(In1/2Nb1/2)O3‐Pb(Sc1/2Nb1/2)O3‐PbTiO3 (PIN‐PSN‐PT) relaxor ferroelectric ceramics, where Mn‐doping is employed to enhance Qm. The effects of doping concentration and PT content on phase structure, ferroelectric, dielectric, and electromechanical properties were systematically studied. The well radius matching between Mn ions and B‐site ions facilitates the ion substitution and significantly increases the concentration of oxygen vacancies, thereby enhancing the domain wall pinning effect. A significantly weakened mutual constraint relationship between d33 and Qm is observed in the 2 mol% Mn‐doped PIN‐PSN‐PT ceramics with tetragonal phase, which exhibits Qm exceeding 3000 while maintaining d33 higher than 320 pC/N and Curie temperature higher than 300°C, leading to the vibration velocity over 1.15 m/s. Rayleigh analysis reveals the higher intrinsic piezoelectric response in high PT components compared to that in low PT components, which was thought to be the origin for the weakened mutual constraint relationship between d33 and Qm in tetragonal Mn‐doped PIN‐PSN‐PT ceramics. [ABSTRACT FROM AUTHOR]

Si3N4 ceramics with improved thermal conductivity and mechanical properties were prepared by carbothermal reduction and two‐step sintering. The addition of 2 wt% C led to the development of an intergranular phase YNSiO2 with reduced oxygen content. Notably, setting the pre‐sintering temperature at 1450°C promoted the formation of a rough bimodal morphology within the Si3N4 ceramics. Furthermore, an extended holding period at 1850°C resulted in additional grain growth and the elimination of intergranular phases. The Si3N4 specimens produced at 1450°C for 3 h followed by 1850°C for 8 h, incorporating 2 wt% C, exhibited a notable continuity between Si3N4 grains. The thickness of the grain boundary layer was only about 1 nm, and the N/O atomic ratio of the intergranular phase was measured to be 0.42. Consequently, the resulting thermal conductivity, flexural strength, and fracture toughness of Si3N4 specimens were found to be 101 W·m−1·K−1, 712 ± 29 MPa, and 7.7 ± 0.2 MPa·m1/2, respectively. Compared with samples without C additive and directly sintered at 1850°C for 8 h, the Si3N4 specimens produced in this work showed a significant increase of more than 50% in thermal conductivity and about 17% in fracture toughness. [ABSTRACT FROM AUTHOR]

Molnupiravir (MO) is a pyrimidine nucleoside anti‐SARS‐CoV‐2 drug. MO treatment could cause mild liver injury. However, the underlying mechanism of MO‐induced liver injury and the metabolic pathway of MO in vivo are unclear. In this study, metabolomics analysis and molecular biology methods were used to explore these issues. Through metabolomics analysis, it was found that the homeostasis of pyrimidine, purine, lysophosphatidylcholine (LPC), and amino acids in mice was destroyed after MO treatment. A total of 80 changed metabolites were detected. Among these changed metabolites, 4‐ethylphenyl sulfate, dihydrouracil, and LPC 20:0 was related to the elevation of alkaline phosphatase (ALP), interleukin‐6 (IL6), and nuclear factor kappa‐B (NF‐κB). The levels of 4‐ethylphenyl sulfate, dihydrouracil, and LPC 20:0 in plasma were positively correlated with their levels in the liver, suggesting that these metabolites were associated with MO‐induced liver injury. MO treatment could increase NHC and cytidine levels, activate cytidine deaminase (CDA), and increase LPC levels. CDA and LPC could increase the mRNA expression level of toll‐like receptor (TLR). The current study indicated that the elevation of hepatic TLR may be an important reason for MO leading to the liver injury. [ABSTRACT FROM AUTHOR]

Acute lower respiratory tract infections (ALRTIs) are a leading cause of mortality in young children worldwide due to human respiratory syncytial virus (RSV). The aim of this study was to monitor genetic variations in RSV and provide genomic data support for RSV prevention and control. A total of 105 complete RSV genome sequences were determined during 2017-2020. Phylogenetic analysis showed that all of the RSVA sequences were of genotype ON1, and all of the RSVB sequences were of genotype BA9. Notably, a phylogenetic tree based on the whole genome had more branches than a tree based on the G gene. In comparison to the RSV prototype sequences, 71.43% (50/70) of the ON1 sequences had five amino acid substitutions (T113I, V131N, N178G, H258Q, and H266L) that occurred simultaneously, and 68.57% (24/35) of the BA9 genotype sequences had 12 amino acid substitutions, four of which (A131T, T137I, T288I, and T310I) occurred simultaneously. In the F gene, there were 19 amino acid substitutions, which were mainly located in the antigenic sites Ø, II, V, and VII. Other amino acid substitutions were found in the NS1, NS2, P, SH, and L proteins. No significant evidence of recombination was found in any of the sequences. These findings provide important data that will be useful for prevention, control, and vaccine development against RSV. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this cross-sectional study is to investigate the levels of NLRP3 in the serum and induced sputum of children with asthma and their potential association with lung function and disease severity. Methods: This cross-sectional study included 83 children with bronchial asthma who sought medical care at our hospital from May 2023 to February 2024. Portable spirometry was used to monitor lung function parameters, including forced vital capacity, forced expiratory volume in 1 s, peak expiratory flow. The expression of C-reactive protein (CRP), interleukin (IL)-6, IL-1β, TNF-α, and Nod-like receptor family pyrin domain-containing 3 (NLRP3) in the serum and induced sputum were measured by enzyme-linked immunosorbent assay. Data analysis was performed using SPSS 25.0 and differences with P < 0.05 were considered statistically significant. Results: Children with asthma exhibited significantly elevated levels of serum NLRP3, CRP, IL-6, IL-1β, and TNF-α compared to healthy controls. In addition, children with moderate–severe asthma had significantly higher levels of serum and induced sputum NLRP3 and IL-1β compared to children with mild asthma. Spearman's correlation analysis revealed a positive correlation between induced sputum NLRP3 and IL-6. Moreover, induced sputum NLRP3 was negatively correlated with lung function parameters. The results of receiver operating characteristic curves showed that induced sputum NLRP3 could be used for diagnosing children with moderate–severe asthma, with an AUC was 0.758, cutoff value of 3.33 ng/mL, sensitivity of 66.1%, and specificity of 70.8%. Furthermore, the logistic regression analysis revealed that serum and induced sputum NLRP3, induced sputum IL-6 and IL-1β were risk factors for children with moderate–severe asthma. Conclusions: In this cross-sectional study, we found a significant increase in NLRP3 levels in induced sputum of children with asthma, which further increased in those with moderate–severe disease. The levels of NLRP3 in induced sputum could serve as potential biomarkers for assessing disease severity. [ABSTRACT FROM AUTHOR]

A new cladosporol derivative xylophilum A (1), together with 10 known compounds (2–11), were isolated from the rice fermentation of the fungus Cladosporium xylophilum. Their structures were established by extensive spectroscopic methods and comparison of their NMR data with literatures. The antimicrobial activity of compound 1 against 11 kinds of pathogenic microbial was evaluated, but no significant activity was found (MIC >100 μg/ml). [ABSTRACT FROM AUTHOR]

The prognosis of patients with high-risk acute myeloid leukemia (AML) is dismal even after allogeneic stem cell transplantation (allo-HSCT), with relapse remaining the leading cause of treatment failure. Here, we investigated whether ruxolitinib and decitabine plus modified busulfan-cyclophosphamide (mBu/Cy) conditioning could reduce relapse in high-risk AML after allo-HSCT. This prospective, single-arm, phase II trial enrolled 37 patients who received allo-HSCT between September 2020 and March 2022 at the First Medical Center of Chinese People's Liberation Army (PLA) General Hospital. Eligible patients (10–62 years) had relapsed/refractory, positive measurable residual disease (MRD) prior to conditioning or adverse genetic abnormalities. Ruxolitinib (35 mg twice daily, days − 15 to − 10) and decitabine (20 mg/m2/day, days − 15 to − 10) were administered followed by mBu/Cy conditioning. All patients achieved engraftment. The cumulative incidences (CIs) of acute graft-versus-host disease (GVHD) grades II–IV and III–IV were 35.0% and 10.5%, respectively. The 1-year cumulative incidence of chronic GVHD was 8.1%. The 1-year CI of relapse was 29.7% among all patients, 0% in patients who achieved the first complete remission (CR1) prior to conditioning, and 0% in those with MRD-negative prior to conditioning. The 1-year non-relapse mortality was 5.4%. The 1-year probabilities of overall survival, disease-free survival, and GVHD-free relapse-free survival were 70.3%, 62.2%, and 54.1%, respectively. In conclusion, the novel conditioning showed primary efficacy in terms of a reduction in relapse in high-risk patients with AML after allo-HSCT, especially in those who achieved CR1 and MRD-negative prior to conditioning. Also, the new conditioning regimen may help reduce the incidence of chronic GVHD. ClinicalTrials.govidentifier: NCT04582604. [ABSTRACT FROM AUTHOR]

Most existing studies have focused on the innovation capabilities of organisations within interfirm networks while neglecting to consider the impact of the choice of innovation evolution mechanisms and the degree of internal interaction control on this system. This study addresses this research gap based on the NK model framework to investigate how different innovation evolution mechanisms and the degree of internal interaction control affect interfirm network performance. In addition, we investigate the moderating role played by the frequency of technological change between the innovation evolution mechanism and the degree of internal interaction control of the interfirm network. The results show that to achieve higher performance levels, the interfirm network should be assigned a self-organisational model in the early stage of innovation evolution, while in the later stage of innovation evolution, it should undergo organisational changes and be assigned a federated alliance model to establish an alliance coordination committee with a certain degree of interactive control over the supporting firms. When the frequency of technological change is low, the alliance coordinating committee takes relatively strong control over the supporting firms as the best, and when the frequency is high, the degree of control over the supporting firms should be appropriately weakened. [ABSTRACT FROM AUTHOR]

Background: The effects of physical activity on the development of different types of cancers have not been comprehensively studied. This nationwide, population-based cohort study investigated the effects of leisure-time physical activity (LTPA) on the development of different types of cancer in Taiwanese adults. A total of 67,890 adult participants (≥ 18 y old) from five rounds (2001, 2005, 2009, 2013, and 2017) of the Taiwan National Health Interview Survey were included. LTPA was measured as the metabolic equivalent of task (MET) expenditure per week and was classified as inactive (< 1 MET-h), low (1-7.49 MET-h), or high (≥ 7.5 MET-h). The LTPA and other covariates were collected through in-person interviews at baseline. New-onset cancer was ascertained from histopathological reports. The Fine-Gray sub-distribution method, with death as a competing risk, was used to determine the impact of LTPA on incident cancer risk. Results: During the 844,337 person-years of follow-up, 4,435 individuals developed cancer. Compared to inactive adults, individuals engaging in high levels of LTPA (≥ 7.5 MET-h/week) were significantly associated with a reduced risk of developing cancer (adjusted hazard ratio [aHR] = 0.93; 95% confidence interval [CI] = 0.87–0.99). However, those with low levels of LTPA (1-7.49 MET-h/week) did not exhibit a significant association with a reduced risk of developing cancer (aHR = 1.00; 95% CI = 0.92–1.10). When considering specific types of cancers, participants with high levels of LTPA (≥ 7.5 MET-h/week) had a significantly lower risk of developing bladder cancer (aHR = 0.68; 95% CI = 0.47–0.99), cervical cancer (aHR = 0.48; 95% CI = 0.24–0.95), and thyroid cancer (aHR = 0.64; 95% CI = 0.44–0.93). Conclusions: Our findings suggest that high LTPA (≥ 7.5 MET-h/week) is significantly associated with a low risk of incident bladder, cervical, and thyroid cancers. Key points: This prospective cohort study with a mean follow-up of 12.4 years found that high leisure-time physical activity (≥ 7.5 MET-h/week) was significantly associated with a lower risk of incident cancer, including bladder, cervical, and thyroid cancer. Healthcare professionals should encourage inactive adults to perform leisure-time physical activities to reduce cancer risk. [ABSTRACT FROM AUTHOR]

The contradiction between high piezoelectricity and uniquely poor temperature stability generated by polymorphic phase boundary is a huge obstacle to high-performance (K, Na)NbO3 -based ceramics entering the application market as Pb-based substitutes. We possess the phase boundary by mimicking Pb(Zr, Ti)O3's morphotropic phase boundary structure via the synergistic optimization of diffusion phase boundary and crystal orientation in 0.94(Na0.56K0.44)NbO3−0.03Bi0.5Na0.5ZrO3−0.03(Bi0.5K0.5)HfO3 textured ceramics. As a result, a prominent comprehensive performance is obtained, including giant d33 of 550 ± 30 pC/N and ultrahigh temperature stability (d33 change rate less than 1.2% within 25-150 °C), representing a significant breakthrough in lead-free piezoceramics, even surpassing the Pb-based piezoelectric ceramics. Within the same temperature range, the d33 change rate of the commercial Pb(Zr, Ti)O3−5 ceramics is only about 10%, and more importantly, its d33 (~ 350 pC/N) is much lower than that of the (K, Na)NbO3-based ceramics in this work. This study demonstrates a strategy for constructing the phase boundary with MPB feature, settling the problem of temperature instability in (K, Na)NbO3-based ceramics. The authors induce a phase boundary similar to Pb(Zr, Ti)O3's morphotropic phase boundary structure in (K, Na)NbO3-based ceramics, which exhibit high residual polarization as well as a significantly improved piezoelectric constant d33. [ABSTRACT FROM AUTHOR]

Dielectric ceramics possess a unique competitive advantage in electronic systems due to their high-power density and excellent reliability. Na1/2Bi1/2TiO3-based ceramics, one type of extensively studied energy storage dielectric, however, often experience A-site element volatilization and Ti4+ reduction during high-temperature sintering. These issues may result in increased energy loss, reduced polarization and low dielectric breakdown electric field, ultimately making it challenging to achieve both high energy storage density and efficiency. To address these issues, we introduce a synergistic optimization strategy that combine polarization engineering and grain alignment engineering. First principles calculations and experimental analyses show that the doping of Mn2+ can suppress the reduction of Ti4+ in Na1/2Bi1/2TiO3-based ceramics and enhance ion off-centering displacements, thereby reducing energy loss and improving polarization. In addition, we prepared multilayer ceramic capacitors with grains oriented along the <111> direction using the template grain growth method. This approach effectively reduces electric-field-induced strain by 37% and markedly enhances breakdown electric field by 42% when compared with nontextured counterpart. As a result of this comprehensive strategy, <111 >-textured Na1/2Bi1/2TiO3-based multilayer ceramic capacitors achieve an ultra-high energy density of 15.7 J·cm−3 and an excellent efficiency beyond 95% at 850 kV·cm−1, exhibiting a superior overall energy storage performance. Grain alignment and polarization engineering were simultaneously utilized to enhance the energy storage performance of Na1/2Bi1/2TiO3-based multilayer ceramic capacitors, leading to an energy density of 15.7 J·cm−3 and energy efficiency over 95%. [ABSTRACT FROM AUTHOR]

Improving the accuracy of parking space recognition is crucial in the fields for Automated Valet Parking (AVP) of autonomous driving. In AVP, accurate free space recognition significantly impacts the safety and comfort of both the vehicles and drivers. To enhance parking space recognition and annotation in unknown environments, this paper proposes an automatic parking space annotation approach with tight coupling of Lidar and Inertial Measurement Unit (IMU). First, the pose of the Lidar frame was tightly coupled with high-frequency IMU data to compensate for vehicle motion, reducing its impact on the pose transformation of the Lidar point cloud. Next, simultaneous localization and mapping (SLAM) were performed using the compensated Lidar frame. By extracting two-dimensional polarized edge features and planar features from the three-dimensional Lidar point cloud, a polarized Lidar odometry was constructed. The polarized Lidar odometry factor and loop closure factor were jointly optimized in the iSAM2. Finally, the pitch angle of the constructed local map was evaluated to filter out ground points, and the regions of interest (ROI) were projected onto a grid map. The free space between adjacent vehicle point clouds was assessed on the grid map using convex hull detection and straight-line fitting. The experiments were conducted on both local and open datasets. The proposed method achieved an average precision and recall of 98.89% and 98.79% on the local dataset, respectively; it also achieved 97.08% and 99.40% on the nuScenes dataset. And it reduced storage usage by 48.38% while ensuring running time. Comparative experiments on open datasets show that the proposed method can adapt to various scenarios and exhibits strong robustness. [ABSTRACT FROM AUTHOR]

A series of copper foam-based monolithic catalysts were prepared by the hydrothermal method, electrophoretic deposition method, and impregnation method using ZIF-67 as a sacrificial template agent. Among them, the Co3O4@CF-H catalyst prepared by the hydrothermal method exhibited excellent toluene catalytic oxidation activity with a T90 (temperature at 90% conversion of toluene) of 218 °C when the weight hour space velocity (WHSV) was 15 000 mL g−1 h−1. The favorable catalytic performance for toluene was maintained even at higher space velocity (WHSV = 60 000 mL g−1 h−1 and T90 = 234 °C) and in an oxygen-poor environment (T90 = 232 °C at 3 vol% O2 content). Particularly, the Co3O4@CF-H catalyst exhibited excellent resistance to CO2 interference and stability. The excellent catalytic performance of the Co3O4@CF-H monolithic catalysts, analyzed in conjunction with a variety of characterization results, was attributed to their strong cobalt–copper interaction, excellent low-temperature reduction and oxygen mobility, as well as the abundance of reactive oxygen and Co3+ species. In situ DRIFTS results revealed that the degradation path of toluene on the Co3O4@CF-H catalyst may be as follows: toluene → benzyl alcohol → benzaldehyde → benzoic acid → maleic anhydride → acetone → CO2 and H2O. DFT calculations illustrated that the loading of Co3O4 and the presence of Cu0 in the copper foam skeleton were both beneficial for improving the catalytic activity. Specifically, it favored the adsorption of oxygen and toluene, and facilitated the dissociation and activation of O2. Overall, this work provides a monolithic catalyst with potential applications for the treatment of VOC exhaust gases. [ABSTRACT FROM AUTHOR]

Background: The association between malnutrition and outcomes of heart transplantation (HTx) has not been well studied. The purpose of this article was to evaluate the prognostic value of three different nutrition indices in HTx, including CONUT (Controlling Nutritional Status), NRI (Nutritional Risk Index) and GNRI (Geriatric Nutritional Risk Index). Methods: A total of 438 patients who underwent THx from January 2015 to December 2020 were included in this study. The nutritional status of the patients was evaluated by CONUT, NRI and GNRI. Kaplan-Meier (KM) curves were constructed to compare the difference in overall survival (OS) between the normal and malnutrition groups in each index. Cox regression analysis was used to identify the independent risk factors of OS. The predictive power was compared by time-dependent ROC and time-dependent ccurves. Logistic regression model was used to evaluate the relationship between these three nutrition indices and postoperative clinical events. Results: 336 (76.7%), 183 (43.8%), and 190 (43.4%) patients had malnutrition according to CONUT, NRI and GNRI calculations. 102 (23.3%) patients had died at the end of follow-up. After adjustment for confounding variables, multivariate Cox analysis showed that CONUT [HR 1.286 (95%CI 1.166 ~ 1.419); p < 0.001], NRI [HR 0.942 (95%CI 0.923 ~ 0.962); p < 0.001] and GNRI [HR 0.959 (95%CI 0.939 ~ 0.979); p < 0.001] were all independent predictors for OS. The predictive power of CONUT score was higher than that of NRI (p = 0.045) and GNRI (p < 0.001). Regarding the postoperative complications, multivariate logistic regression model showed that malnutrition assessed by CONUT [HR 1.156 (95%CI 1.032 ~ 1.294); p = 0.012] and NRI [HR 1.543 (95%CI 1.008 ~ 2.362); p = 0.046] was independent risk factors for posttransplant infections. Conclusion: Poor nutritional status, as assessed by CONUT, NRI and GNRI, was associated with an increased risk of mortality after HTx. CONUT displayed the highest predictive power compared to the other two indices. CONUT and NRI were also independently associated with posttransplant infections. [ABSTRACT FROM AUTHOR]

Utilizing imaging spectroscopy technology to identify methane super‐emitters plays a vital role in mitigating methane emissions in the Oil & Gas (O&G) sector. While earlier research has uncovered significant point‐source methane emissions from O&G production in the US and Canada, which are key regions with large methane emissions, a comprehensive post‐COVID‐19 survey has been notably absent. Here, we perform a detailed survey of methane super‐emitters across multiple basins of North America (Marcellus Shale, Haynesville/Bossier Shale, Permian Basin and Montney Shale) using the new Chinese Gaofen5‐01A/02 (GF5‐01A/02) satellite measurements during 2022–2023. We detect 139 individual methane plumes emanating from 122 point sources, with flux rates ranging from 519 to 16,071 kg hr−1. These emissions exhibit a highly skewed and heavy‐tailed distribution, constituting approximately 23% of the flux inversion with TROPOMI in the sample region, with a range of 13%–40%. Moreover, we observe a 66.7% reduction in methane emissions in Permian Basin during COVID‐19, followed by fluctuations until spring 2023. By summer 2023, methane emissions rebound to twice their previous magnitude (1.68 ± 0.58 Tg a−1). Using these point‐source surveys, we further quantify a regional methane emission of 2.69 ± 0.86 Tg a−1 in Permian Basin. This estimation closely aligns with top‐down inversions (2.22 ± 0.40 Tg a−1) from TROPOMI. The upscale estimation underscores the effectiveness of high‐resolution remote sensing measurements in improving bottom‐up emissions inventories and refining regional methane emission assessments. Our results highlight the potential climate benefits derived from regular monitoring and specific remediation efforts focused on relatively few strong point‐source emissions. Plain Language Summary: Reducing methane (CH4) leaks from Oil & Gas (O&G) production is crucial for abating climate change. However, detecting these abnormal CH4 emissions globally is challenging as they often occur unexpectedly. Satellite remote sensing with hyperspectral imaging spectrometer provides an effective approach for top‐down monitoring. These instruments produce CH4 plume maps, enabling the quantification of emissions. In this research, we conduct a comprehensive survey in major O&G basins of North America during 2022–2023 using the new Chinese Gaofen5‐01A/02 satellite. Through repeated observations by high‐resolution satellites, we capture CH4 emission dynamics in sample basins and quantify their contribution to regional methane budget. Our results demonstrate the value of high‐resolution satellite observations in reducing uncertainties in quantifying anthropogenic CH4 emission and supporting strategies for emission mitigation. Key Points: The new Chinese Gaofen5‐01A/02 hyperspectral satellite missions have great capability in methane mappingWe find substantial methane point‐source emissions in Permian Basin after COVID‐19 during 2022–2023Satellite‐based survey can effectively improve bottom‐up regional methane emissions inventories [ABSTRACT FROM AUTHOR]

The interaction between ion beams and plasma is a fundamental and important physical process, plasma can effectively neutralize the current and charge of ion beam pulses as an ideal medium for its transmission and focusing. The analytical model of short heavy ion beam pulse in cold background plasma under external magnetic field is established. Combined with the experimental parameters, by 2.5D particle-in-cell numerical simulations, the entire transport process of heavy ion beam application strong magnetic fields in plasma is investigated. Our research results indicate that the interaction between short-pulse heavy ion beams and plasma generates a longitudinally induced magnetic field in the same direction as the external magnetic field. Moreover, the electron cyclotron electromagnetic waves of anti-parallel to local magnetic field are excited, and the excitation mechanism is mainly drift instability of electrons beam caused by the heavy ion beam. Temporal variations of the longitudinal induced magnetic field Bz in plasma and vacuum regions under different external magnetic fields [ABSTRACT FROM AUTHOR]

Current-carrying friction affects electrical contact systems like switches, motors, and slip rings, which determines their performance and lifespan. Researchers have found that current-carrying friction is influenced by various factors, including material type, contact form, and operating environment. This article first reviews commonly used materials, such as graphite, copper, silver, gold, and their composites. Then different contact forms like reciprocating, rotational, sliding, rolling, vibration, and their composite contact form are also summarized. Finally, their environmental conditions are also analyzed, such as air, vacuum, and humidity, on frictional force and contact resistance. Additionally, through experimental testing and theoretical analysis, it is found that factors such as arcing, thermal effects, material properties, contact pressure, and lubrication significantly influence current-carrying friction. The key mechanisms of current-carrying friction are revealed under different current conditions, including no current, low current, and high current, thereby highlighting the roles of frictional force, material migration, and electroerosion. The findings suggest that material selection, surface treatment, and lubrication techniques are effective in enhancing current-carrying friction performance. Future research should focus on developing new materials, intelligent lubrication systems, stronger adaptability in extreme environments, and low friction at the microscale. Moreover, exploring stability and durability in extreme environments and further refining theoretical models are essential to providing a scientific basis for designing efficient and long-lasting current-carrying friction systems. [ABSTRACT FROM AUTHOR]

Natural plant-derived compounds with broad-spectrum antimicrobial activity have become an effective strategy against multidrug-resistant bacteria. The present study was designed to compare the antibacterial activity of six chlorogenic acid (CA) isomers extracted from stevia and investigated the underlying antibacterial mechanisms involved. The results indicated that isochlorogenic acid C (ICAC) exhibited the strongest antibacterial activity against the tested bacteria, especially E. coli, at a 2 mg/mL minimum inhibitory concentration (MIC) and 8 mg/mL minimum bactericidal concentration (MBC). At the MBC, ICAC inhibited 72.66% of the clinical multidrug-resistant strains. Scanning electron microscopy (SEM) revealed that ICAC induced considerable morphological alterations in E. coli ATCC25922 and C4E2. The significant increase in the activity of extracellular alkaline phosphatase (AKP) indicated that ICAC damages the permeability of the bacterial cell wall. Additionally, the intracellular membrane (IM) permeability and the content of lipopolysaccharide (LPS), a main component of the outer membrane (OM), were determined. The significant decrease in LPS content and increased leakage of intracellular proteins and K+ from E. coli indicated that ICAC could induce the exfoliation of OM and disrupt IM permeability, resulting in the loss of barrier function. The uptake of propidium iodide (PI), a compromised cell membrane nucleic acid stain, and confocal laser scanning microscopy (CLSM) further demonstrated that ICAC disrupted IM integrity. Moreover, the bactericidal effect and damage to bacterial microstructural function occurred in a dose-dependent manner. These data demonstrate that ICAC has excellent antibacterial activity and is a promising approach for overcoming the antibiotic resistance of pathogenic bacteria. [ABSTRACT FROM AUTHOR]

Usually, the term 'rising damp' refers to capillary water rising from the ground which may damage architectural heritage. In this work, the essence of rising damp in extremely arid regions and its driving force are revealed based on experiments monitoring the relative humidity (RH) and atmospheric pressure (AP) in the Dunhuang Mogao Grottoes. The air in the vadose zone, the unsaturated region between ground level and the top of the water table, is here referred to as 'earth-air'. When the AP rises, the earth-air is compressed, and atmospheric air enters into the soil. Then, when the AP drops, moist earth-air expands and rises into the structure. The RH in the soil is thus negatively correlated with the AP, yielding a correlation coefficient of up to –0.94. Under the action of this long-term dry–wet alternation, the salt present in the building near ground undergoes repeated cycles of crystallization and dissolution, resulting in efflorescence and a deterioration zone. Therefore, the deterioration due to rising damp in extremely arid regions is caused by the rising of moist earth-air rather than capillarity. The height to which it rises is directly proportional to the amplitude of the daily AP fluctuation and thickness of the vadose zone, exhibiting a bimodal fluctuation pattern on a daily scale. The discovery of this mechanism of rising damp provides a scientific basis for preventive conservation interventions. [ABSTRACT FROM AUTHOR]

Aquaporins (AQPs) are highly conserved small transmembrane proteins that facilitate the transport of water and small solutes across cell membranes. Aquaglyceroporin 7 (AQP7), a significant member of the AQP family, is widely distributed throughout the body. For years, AQP7 was predominantly recognized for its role as a small-molecule transporter, facilitating the passage of small molecular substances. However, growing studies have revealed that AQP7 is also involved in the regulation of lipid synthesis, gluconeogenesis, and energy homeostasis, and it is intimately linked to a variety of diseases, such as obesity, type 2 diabetes mellitus, cardiovascular diseases, cancer, and inflammatory bowel disease. This article presents a comprehensive overview of the structure of AQP7, its regulatory mechanisms, its vital roles in both healthy and diseased states, and potential therapeutic advancements. We hope that these studies will serve as a valuable reference for the development of future treatments and diagnostic protocols targeting AQP7. [ABSTRACT FROM AUTHOR]

Influenza A virus (IAV) infection, which leads to millions of new cases annually, affects many tissues and organs of the human body, including the central nervous system (CNS). The incidence of affective disorders has increased after the flu pandemic; however, the potential mechanism has not been elucidated. PB1-F2, a key virulence molecule of various influenza virus strains, has been shown to inhibit cell proliferation and induce host inflammation; however, its role in the CNS has not been studied. In this study, we constructed and injected PB1-F2 into the hippocampal dentate gyrus (DG), a region closely associated with newborn neurons and neural development, to evaluate its influence on negative affective behaviors and learning performance in mice. We observed anxiety- and depression-like behaviors, but not learning impairment, in mice injected with PB1-F2. Furthermore, pull-down and mass spectrometry analyses identified several potential PB1-F2 binding proteins, and enrichment analysis suggested that the most affected function was neural development. Morphological and western blot studies revealed that PB1-F2 inhibited cell proliferation and oligodendrocyte development, impaired myelin formation, and interfered with synaptic plasticity in DG. Taken together, our results demonstrated that PB1-F2 induces affective disorders by inhibiting oligodendrocyte development and regulating synaptic plasticity in the DG after IAV infection, which lays the foundation for developing future cures of affective disorders after IAV infection. [ABSTRACT FROM AUTHOR]

Luteolin is a natural flavonoid, which exists in many plants, including onions, broccoli, carrots, peppers, celery, olive oil, and mint. Luteolin is a dietary flavonoid with potent uric acid‐lowering and antioxidant bioactivities. To date, the mechanism by which luteolin alleviates hyperuricemia nephropathy (HN) still needs to be better defined. This study aims to evaluate the therapeutic efficacy of luteolin in a preclinical mouse model and in vitro. Luteolin was administered in the HN mice induced by the combination of potassium oxonate and hypoxanthine to evaluate the potential renoprotective effects in vivo. The NRK‐52E cells were stimulated with adenosine for in vitro evaluation. Hematoxylin and eosin staining, biochemical analysis, immunoblotting, immunofluorescence, and immunohistochemistry were performed for the histopathologic and mechanistic investigations. The results suggest that luteolin attenuated tubular dilation and epithelial atrophy in the renal tissue of HN mice. Further, luteolin improved biochemical indicators concerning renal functions and oxidative stress in vivo. Mechanistically, luteolin reduced the renal expressions of KIM‐1 and caspase‐3. Luteolin activated renal SIRT1/6 cascade and its downstream Nrf2‐mediated antioxidant pathway. Furthermore, luteolin elevated the renal expressions of ATP‐binding cassette subfamily G isoform 2 protein (ABCG2) and organic anion/cation transporters. In addition, livers of luteolin‐treated HN mice exhibited robust inhibition of xanthine oxidase. Together, our study shows that luteolin alleviates renal injury in the HN mice by activating urate excretion and Nrf2/HO‐1/NQO1 antioxidant pathways and inhibiting liver xanthine oxidase activity. Thus, luteolin may be a potential agent for the treatment of HN. [ABSTRACT FROM AUTHOR]