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We present the results of an investigation of a highly variable C iv broad absorption line (BAL) feature in spectra of the quasar SBS 1408+544 (z = 2.337) that shows a significant shift in velocity over time. This source was observed as a part of the Sloan Digital Sky Survey (SDSS) Reverberation Mapping project and the SDSS-V Black Hole Mapper Reverberation Mapping project, and has been included in two previous studies, both of which identified significant variability in a high-velocity C iv BAL on timescales of just a few days in the quasar rest frame. Using ∼130 spectra acquired over 8 yr of spectroscopic monitoring with SDSS, we have determined that this BAL is not only varying in strength, but is also systematically shifting to higher velocities. Using cross-correlation methods, we measure the velocity shifts (and corresponding acceleration) of the BAL over a wide range of timescales, measuring an overall velocity shift of Δ v = − 683 − 84 + 89 km s−1 over the 8 yr monitoring period. This corresponds to an average rest-frame acceleration of a = 1.04 − 0.13 + 0.14 cm s−2, though the magnitude of the acceleration on shorter timescales is not constant throughout. We place our measurements in the context of BAL-acceleration models and examine various possible causes of the observed velocity shift. [ABSTRACT FROM AUTHOR]

The development of advanced targets capable of achieving ignition with improved energy gain at lower driver energies is one of four key technical challenges to be solved in order to realize economical inertial fusion energy. We report the minimum energy necessary for a small hemispherical mass of fast-ignited high-density deuterium–tritium fuel to explosively ignite a significantly larger hemispherical mass of assembled cold fuel with much lower mass density, both with and without a flux-compressed magnetic field connecting the two regions. With the magnetic field, the burn rate improves, and lower energy states become more effective. The imploded fuel reservoir available in the lower-density, larger-mass region of the steep density gradient determines whether the fusion yield is several hundred MJ or up to a few GJ. We report a case wherein the cold reservoir ignited and produced high gain with the assistance of only ∼700 kJ of hotspot yield, an amount that has already been demonstrated as feasible in laboratory experiments using indirect-drive targets. [ABSTRACT FROM AUTHOR]

Although greater parent-child attachment security is linked with children's lower levels of depressive symptoms, little research has evaluated potential explanatory mechanisms. We investigated whether dispositional gratitude and interpersonal forgiveness explain the relation between attachment security with parents and early adolescents' depressive symptoms. Early adolescents (N = 105; M age = 12.3 years; 51% girls) completed questionnaires assessing their attachment security to mother and father figures, depressive symptoms, and dispositional gratitude, and an interview assessing interpersonal forgiveness. Results revealed that greater attachment security to mothers and fathers was associated with fewer depressive symptoms and greater levels of dispositional gratitude and interpersonal forgiveness. Further, dispositional gratitude and interpersonal forgiveness were negatively associated with depressive symptoms. Dispositional gratitude emerged as a mediator between attachment security with each parent and depressive symptoms. Our findings suggest that greater parent-child security may promote early adolescents' appreciation of positive events, which in turn may relate to fewer depressive symptoms. [ABSTRACT FROM AUTHOR]

Large herbivores can exert pronounced top-down effects on plant communities in grassland ecosystems. Previous studies highlighted the importance of the composition and traits of living plants in regulating the impact of herbivores on plant community. However, there has been little consideration of whether and how plant litter, a ubiquitous "after-life" plant component, affects the outcome of herbivore grazing on grasslands. Here, we conducted a large-scale field experiment in temperate grasslands of northeastern China to investigate how standing plant litter influenced top-down effects of large herbivores (sheep; Ovis aries) on plant species richness, evenness, community composition, and productivity. We found that, in the presence of standing litter, sheep grazing significantly reduced living biomass of forbs by 56%, but have no effects on biomass of the dominant grass, Leymus chinensis. However, in the absence of standing litter, sheep shifted their diet preference from forbs to the grass L. chinensis, leading to a 36% decrease in the biomass of L. chinensis and a 21% decrease in total biomass. Such changes in foraging pressure on plant species led to competitive release that in turn significantly altered plant community composition and increased species evenness. Synthesis and applications. Our results demonstrate that standing litter can alter foraging behaviors of large herbivores and modifying the outcome of their top-down effects on plant community properties in grasslands. These cryptic but perhaps ubiquitous interactions between litter and herbivores may help us better understand the organization and dynamics of plant communities in the grazed grasslands, with important implications for developing effective management and conservation plans. [ABSTRACT FROM AUTHOR]

This systematic review examined how anxiety symptoms and anxiety disorders relate to academic achievement, school dropout, and academic self-concept. Studies with children or adult samples were included in seven meta-analyses (ks for number of samples ranged from 5 to 156; N's for participants ranged from 780 to 37, 203). Results revealed significant but very small effect sizes for the relations between anxiety and overall academic achievement (r = −.06), language achievement (r = −.07), and math achievement (r = −.09), and a nonsignificant effect size for science achievement (r = −.01). Participants with greater anxiety were also significantly more likely to not complete high school (r =.11). They also had a poorer overall academic self-concept (r = −.25) and mathematics self-concept (r = −.30). Few methodological moderators (e.g., study design, age) were significant. Results show that anxiety does not strongly hinder academic achievement, but it is an important correlate of dropout and academic self-concept, which in turn could contribute to poorer life outcomes. Interventions and preventive programs need to consider ways to ameliorate the relations of anxiety with academic outcomes, especially school continuation and academic self-concept. Future studies should identify risk factors that may amplify these relations. [ABSTRACT FROM AUTHOR]

Copyright of Contemporary Accounting Research is the property of Canadian Academic Accounting Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Secure attachments to parents have been linked to social competence, but few studies address how attachment is related to character strengths. This study examined how attachment security is associated with a broad set of character strengths in early adolescence. In a mixed methods study with a sample of 10- to 14-year-olds (N = 92), we assessed attachment with the Friends and Family Interview, which was scored for markers of secure attachment. Children completed the Values in Action Inventory questionnaire of character strengths. More securely attached children more strongly endorsed Interpersonal Strengths (fairness, forgiveness, humor, and kindness), Temperance Strengths (honesty, persistence, and prudence), and the Transcendent Strength of spirituality. By contrast, secure attachment did not predict Intellectual Strengths (creativity, love of learning, appreciation of beauty). The findings show that secure attachments are associated with several character strengths, and future work could consider the foundational processes that account for these associations. Highlights: Parent–child relationships are an important context in which school-age children develop their personal characteristics. We tested whether secure attachments to mothers and fathers are both associated with character development in early adolescence. More securely attached children were more fair, forgiving, humorous in social interaction, kind, honest, persistent, thoughtful in decision making, and spiritual compared to less securely attached children. Many of the study findings are novel, and they point to areas where parents might be especially likely to influence children's character development. [ABSTRACT FROM AUTHOR]

We examined accuracy and bias in people's perceptions of their romantic partner's daily social control attempts of daily health behaviours and how misperceptions of partner daily social control are related to both partners' daily experiences. 106 cohabiting couples from the community reported on their own and their partner's daily social control attempts (i.e., persuasion, pressure) and their daily experiences (i.e., positive and negative affect, autonomy, relationship satisfaction) across 14 consecutive days (N = 2377 reports). Multilevel path models examined tracking accuracy, projection, and mean-level bias in perceptions of partner health social control attempts, and associations between mean-level bias and daily experiences. Perceptions of provider influence contained significant tracking accuracy, projection, and mean-level accuracy in provider use of social control. Underperceptions of persuasion were associated with negative outcomes for the perceiver and no outcomes for the provider. Overperceptions of persuasion were associated with negative outcomes for providers and marginally higher positive affect for perceivers. Misperceptions of pressure were associated with negative outcomes for both perceivers and providers. Results suggest that social control may have the most benefit and least harm to both partners when people accurately perceive the mean-levels of such influence attempts on their health behaviours. [ABSTRACT FROM AUTHOR]

Objective: Dysregulated APRIL/BAFF signaling is implicated in the pathogenesis of multiple autoimmune diseases, including systemic lupus erythematosus and lupus nephritis. We undertook this study to develop and evaluate a high‐affinity APRIL/BAFF antagonist to overcome the clinical limitations of existing B cell inhibitors. Methods: A variant of TACI‐Fc generated by directed evolution showed enhanced binding for both APRIL and BAFF and was designated povetacicept (ALPN‐303). Povetacicept was compared to wild‐type (WT) TACI‐Fc and related molecules in vitro and in vivo. Results: Povetacicept inhibited APRIL and BAFF more effectively than all evaluated forms of WT TACI‐Fc and selective APRIL and BAFF inhibitors in cell‐based reporter assays and primary human B cell assays, mediating potent suppression of B cell proliferation, differentiation, and immunoglobulin (Ig) secretion. In mouse immunization models, povetacicept significantly reduced serum immunoglobulin titers and antibody‐secreting cells more effectively than anti‐CD20 monoclonal antibodies, WT TACI‐Fc, or APRIL and BAFF inhibitors. In the NZB × NZW mouse lupus nephritis model, povetacicept significantly enhanced survival and suppressed proteinuria, anti–double‐stranded DNA antibody titers, blood urea nitrogen, glomerulonephritis, and renal immunoglobulin deposition. In the bm12 mouse lupus model, povetacicept significantly reduced splenic plasmablasts, follicular helper T cells, and germinal center B cells. In non‐human primates, povetacicept was well tolerated, exhibited high serum exposure, and significantly decreased serum IgM, IgA, and IgG levels after a single dose. Conclusion: Enhanced APRIL and BAFF inhibition by povetacicept led to greater inhibition of B cell populations critical for autoantibody production compared to WT TACI‐Fc and CD20‐, APRIL‐, or BAFF‐selective inhibitors. Potent, dual inhibition by povetacicept has the potential to significantly improve clinical outcomes in autoantibody‐related autoimmune diseases. [ABSTRACT FROM AUTHOR]

Background: An increasing number of older people are living with chronic kidney disease (CKD). Many have complex healthcare needs and are at risk of deteriorating health and functional status, which can adversely affect their quality of life. Comprehensive geriatric assessment (CGA) is an effective intervention to improve survival and independence of older people, but its clinical utility and cost-effectiveness in frail older people living with CKD is unknown. Methods: The GOAL Trial is a pragmatic, multi-centre, open-label, superiority, cluster randomised controlled trial developed by consumers, clinicians, and researchers. It has a two-arm design, CGA compared with standard care, with 1:1 allocation of a total of 16 clusters. Within each cluster, study participants ≥ 65 years of age (or ≥ 55 years if Aboriginal or Torres Strait Islander (First Nations Australians)) with CKD stage 3–5/5D who are frail, measured by a Frailty Index (FI) of > 0.25, are recruited. Participants in intervention clusters receive a CGA by a geriatrician to identify medical, social, and functional needs, optimise medication prescribing, and arrange multidisciplinary referral if required. Those in standard care clusters receive usual care. The primary outcome is attainment of self-identified goals assessed by standardised Goal Attainment Scaling (GAS) at 3 months. Secondary outcomes include GAS at 6 and 12 months, quality of life (EQ-5D-5L), frailty (Frailty Index – Short Form), transfer to residential aged care facilities, cost-effectiveness, and safety (cause-specific hospitalisations, mortality). A process evaluation will be conducted in parallel with the trial including whether the intervention was delivered as intended, any issue or local barriers to intervention delivery, and perceptions of the intervention by participants. The trial has 90% power to detect a clinically meaningful mean difference in GAS of 10 units. Discussion: This trial addresses patient-prioritised outcomes. It will be conducted, disseminated and implemented by clinicians and researchers in partnership with consumers. If CGA is found to have clinical and cost-effectiveness for frail older people with CKD, the intervention framework could be embedded into routine clinical practice. The implementation of the trial's findings will be supported by presentations at conferences and forums with clinicians and consumers at specifically convened workshops, to enable rapid adoption into practice and policy for both nephrology and geriatric disciplines. It has potential to materially advance patient-centred care and improve clinical and patient-reported outcomes (including quality of life) for frail older people living with CKD. Trial registration: ClinicalTrials.gov NCT04538157. Registered on 3 September 2020. [ABSTRACT FROM AUTHOR]

We present a high-cadence multiepoch analysis of dramatic variability of three broad emission lines (Mg ii, H β, and H α) in the spectra of the luminous quasar (λ L λ (5100 Å) = 4.7 × 1044 erg s−1) SDSS J141041.25+531849.0 at z = 0.359 with 127 spectroscopic epochs over nine years of monitoring (2013–2022). We observe anticorrelations between the broad emission-line widths and flux in all three emission lines, indicating that all three broad emission lines "breathe" in response to stochastic continuum variations. We also observe dramatic radial velocity shifts in all three broad emission lines, ranging from Δ v ∼ 400 km s−1 to ∼800 km s−1, that vary over the course of the monitoring period. Our preferred explanation for the broad-line variability is complex kinematics in the gas in the broad-line region. We suggest a model for the broad-line variability that includes a combination of gas inflow with a radial gradient, an azimuthal asymmetry (e.g., a hot spot), superimposed on the stochastic flux-driven changes to the optimal emission region ("line breathing"). Similar instances of line-profile variability due to complex gas kinematics around quasars are likely to represent an important source of false positives in radial velocity searches for binary black holes, which typically lack the kind of high-cadence data we analyze here. The long-duration, wide-field, and many-epoch spectroscopic monitoring of SDSS-V BHM-RM provides an excellent opportunity for identifying and characterizing broad emission-line variability, and the inferred nature of the inner gas environment, of luminous quasars. [ABSTRACT FROM AUTHOR]

Emotion modulation is achieved through various strategies. We further validated a measure of emotion regulation (ER), the Negative Emotion Regulation Inventory (NERI), designed by Zimmermann and Iwanski (2014) to assess emotions and ER strategies in situations intended to induce sadness, fear, or anger. U.S. children 9–14 years old (n = 105) completed an adapted version of the NERI and measures of anxiety symptoms and attachment security. We replicated Zimmermann and Iwanski's (2014) finding that ER strategies (adaptive regulation, social support seeking, dysfunctional rumination, expressive suppression) varied by emotion situation. We extended their study by showing that specific ER strategies were related to both anxiety symptoms and secure parent-child attachment. This cross-cultural replication and extension study provided some evidence for the reliability and validity of the adapted NERI in U.S. preadolescents. [ABSTRACT FROM AUTHOR]

Relationships with pet dogs are thought to provide substantial benefits for children, but the study of these relationships has been hindered by a lack of validated measures. Approaches to assessing the quality of children's pet dog relationships have tended to focus on positive relationship qualities and to rely on self‐report questionnaires. The aim of this study was to develop and test multiple measures that could be used to assess both positive and negative features of children's relationships with pet dogs. In a sample of 115 children ages 9–14 years who were pet dog owners, we assessed six qualities of pet dog relationships: Affection, Nurturance of Pet, Emotional Support from Pet, Companionship, Friction with Pet, and Pets as Substitutes for People. All qualities were assessed with child questionnaires, parent questionnaires, and child daily reports of interactions with pets. We found substantial convergence in reports from different observers and across different measurement approaches. Principal components analyses and correlations suggested overlap for many of the positive qualities, which tended to be distinct from negative relationship qualities. The study provides new tools which could be used to test further how relationships with pets contribute to children's development. [ABSTRACT FROM AUTHOR]

The use of blood flow restriction is becoming more common and requires the use of individualized pressures in order to remain a safe and effective rehabilitation modality. Measuring limb occlusion pressure (LOP) allows the practitioner to set the restriction pressure so that full occlusion does not occur. Objective: Compare a research-grade clinical vascular doppler and a consumer-grade vascular doppler in the measurement of LOP. Design: A randomized crossover design measuring LOP in the upper and lower body. Methods: 20 participants (men=10) visited the laboratory on one occasion. Limb circumference in the arm and thigh was measured. Following 10 min of supine rest, LOP was measured either in the arm, using a 5 cm wide inelastic cuff, or in the leg, using a 10 cm wide inelastic cuff. Measurements were repeated at 5 min intervals until LOP had been measured in both limbs with both dopplers. Results: Bland-Altman analysis showed agreement between the two dopplers in both the upper body (mean bias: 0.6 (-1.3 - 2.4) mmHg) and lower body (mean bias: -1.5 (-4.4 - 1.4) mmHg). Two one-sided tests of equivalence determined that both dopplers measured a statistically equivalent LOP in the upper body (p = .547) and lower body (p = .288). Conclusions: In a healthy, young population, the consumer-grade vascular doppler measured LOP equally as well as the research-grade clinical doppler. [ABSTRACT FROM AUTHOR]

We evaluate the optimal producer-selected coverage options comprised of coverage length and level for each marketing month for feeder cattle steers (600-900lbs.) insured with Livestock Risk Protection insurance. The optimal contracts are identified as those which have historically provided the highest probability of a positive net return and the highest average net return. We find that, regardless of marketing month, the optimal contracts consist of relatively high coverage levels whereas the optimal length of the contracts varies across months. The results are compared against actual policies purchased to evaluate whether producer decision patterns align with the current findings. [ABSTRACT FROM AUTHOR]

This paper investigates the impact of an applied magnetic field on the yield and hot-spot temperature of inertial confinement fusion implosions. A scaling of temperature amplification due to magnetization is shown to be in agreement with unperturbed two-dimensional (2D) extended-magnetohydrodynamic simulations. A perfectly spherical hot-spot with an axial magnetic field is predicted to have a maximum temperature amplification of 37%. However, elongation of the hot-spot along field lines raises this value by decreasing the hot-spot surface area along magnetic field lines. A scaling for yield amplification predicts that a magnetic field has the greatest benefit for low-temperature implosions; this is in agreement with simplified 1D simulations, but not 2D simulations where the hot-spot pressure can be significantly reduced by heat-flow anisotropy. Simulations including a P2 drive asymmetry then show that the magnetized yield is a maximum when the capsule drive corrects the hot-spot shape to be round at neutron bang time. An applied magnetic field is also found to be most beneficial for implosions that are more highly perturbed, exceeding the theoretical yield enhancement for symmetric hot-spots. Increasing the magnetic field strength past the value required to magnetize the electrons is beneficial due to the additional suppression of perturbations by magnetic tension. [ABSTRACT FROM AUTHOR]

Cities are taking the lead on climate change mitigation with ambitious goals to reduce carbon dioxide (CO2) emissions. The implementation of effective mitigation policies will require accurate measurements to guide policy decisions and monitor their efficacy. Here, we present a comprehensive CO2 inventory of an urban temperate forest and unmanaged grassland using field observations. We estimate the annual storage of CO2 by vegetation and soils and place our biogenic flux estimates in the context of local fossil fuel (FF) emissions to determine when, where, and by how much biogenic fluxes alter net CO2 flux dynamics. We compare our hourly estimates of biogenic fluxes in the forest site to modeled estimates using a modified version of Urban‐Vegetation Photosynthesis and Respiration Model (Urban‐VPRM) in Washington DC/Baltimore area presenting the first urban evaluation of this model. We estimate that vegetation results in a net biogenic uptake of −2.62 ± 1.9 Mg C ha−1 yr−1 in the forest site. FF emissions, however, drive patterns in the net flux resulting in the region being a net source of CO2 on daily and annual timescales. In the summer afternoons, however, the net flux is dominated by the uptake of CO2 by vegetation. The Urban‐VPRM closely approximates hourly forest inventory based estimates of gross ecosystem exchange but overestimates ecosystem respiration in the dormant season by 40%. Our study highlights the importance of including seasonal dynamics in biogenic CO2 fluxes when planning and testing the efficacy of CO2 emission reduction polices and development of monitoring programs. Plain Language Summary: The quantification of biogenic carbon dioxide (CO2) fluxes in cities is important to developing, reporting, and testing the efficacy of greenhouse gas emission reduction policies. Yet, to date there is a lack of detailed CO2 flux inventories conducted in urban ecosystems which is hindering our abilities to advance and evaluate urban carbon cycling models. Our study characterizes how unique features of urbanization influence carbon cycling dynamics in a temperate forest and grassland and provides a critical evaluation of a model for estimating biogenic fluxes of CO2. We identify key areas of needed model development and identify the seasonal and temporal significance of biogenic fluxes relative to total CO2 fluxes (biogenic + anthropogenic sources) in our study area. Key Points: In urban landscapes, the biogenic carbon dioxide (CO2) fluxes from forest patches and grassland areas vary at fine temporal and spatial scalesThe Urban‐Vegetation Photosynthesis and Respiration Model closely approximated temporal trends in gross ecosystem exchange but overestimated ecosystem respiration in the wintertimeFossil fuel emissions drive patterns in the net flux of CO2 except in summer afternoons when biogenic fluxes dominate [ABSTRACT FROM AUTHOR]

The impact of clonal heterogeneity on disease behavior or drug response in acute myeloid leukemia remains poorly understood. Using a cohort of 2,829 patients, we identify features of clonality associated with clinical features and drug sensitivities. High variant allele frequency for 7 mutations (including NRAS and TET2) associate with dismal prognosis; elevated GATA2 variant allele frequency correlates with better outcomes. Clinical features such as white blood cell count and blast percentage correlate with the subclonal abundance of mutations such as TP53 and IDH1. Furthermore, patients with cohesin mutations occurring before NPM1, or transcription factor mutations occurring before splicing factor mutations, show shorter survival. Surprisingly, a branched pattern of clonal evolution is associated with superior clinical outcomes. Finally, several mutations (including NRAS and IDH1) predict drug sensitivity based on their subclonal abundance. Together, these results demonstrate the importance of assessing clonal heterogeneity with implications for prognosis and actionable biomarkers for therapy. Individual studies have been underpowered to draw clear associations between clonal heterogeneity and response to therapy in acute myeloid leukemia (AML). Here, the authors aggregate multiple AML cohorts and are able to correlate the clonal abundance of somatic mutations with clinical outcomes and drug sensitivity. [ABSTRACT FROM AUTHOR]

Low temperature in winter depresses rates of photosynthesis, which, in evergreen plants, can exacerbate imbalances between light absorption and photochemical light use. Damage that could result from increased excess light absorption is minimized by the conversion of excitation energy to heat in a process known as energy dissipation, which involves the de-epoxidized carotenoids of the xanthophyll cycle. Overwintering evergreens employ sustained forms of energy dissipation observable even after lengthy periods of dark acclimation. Whereas most studies of photoprotective energy dissipation examine one or a small number of species; here, we measured the levels of sustained thermal energy dissipation of seventy conifer taxa growing outdoors under common-garden conditions at the Red Butte Garden in Salt Lake City, Utah, U.S.A. (forty nine taxa were also sampled for needle pigment content). We observed an extremely wide range of wintertime engagement of sustained energy dissipation; the percentage decrease in dark-acclimated photosystem II quantum efficiency from summer to winter ranged from 6 to 95%. Of the many pigment-based parameters measured, the magnitude of the seasonal decrease in quantum efficiency was most closely associated with the seasonal increase in zeaxanthin content expressed on a total chlorophyll basis, which explained only slightly more than one-third of the variation. We did not find evidence for a consistent wintertime decrease in needle chlorophyll content. Thus, the prevailing mechanism for winter decreases in solar-induced fluorescence emitted by evergreen forests may be decreases in fluorescence quantum yield, and wintertime deployment of sustained energy dissipation likely underlies this effect. [ABSTRACT FROM AUTHOR]

During thyroid surgeries, it is important for surgeons to accurately identify healthy parathyroid glands and assess their vascularity to preserve their function postoperatively, thus preventing hypoparathyroidism and hypocalcemia. Near infrared autofluorescence detection enables parathyroid identification, while laser speckle contrast imaging allows assessment of parathyroid vascularity. Here, we present an imaging system combining the two techniques to perform both functions, simultaneously and label‐free. An algorithm to automate the segmentation of a parathyroid gland in the fluorescence image to determine its average speckle contrast is also presented, reducing a barrier to clinical translation. Results from imaging ex vivo tissue samples show that the algorithm is equivalent to manual segmentation. Intraoperative images from representative procedures are presented showing successful implementation of the device to identify and assess vascularity of healthy and diseased parathyroid glands. [ABSTRACT FROM AUTHOR]

We analyze the impact of video game and social media usage on academic performance in an undergraduate introductory finance course. We implement a multivariate econometric model and find that certain aspects of social media and video gaming have significant relationships with student performance. Among the general sample, students who use YouTube to rewatch class lectures score higher than those who do not, whereas total hours of social media consumed by students negatively correlates with student grades. Among students who play video games, students who use Facebook and Instagram perform significantly worse in course average and in the probability of earning an A. Video game usage has no significant correlation with student grade or earning an A in the general sample. In the gaming sample, we find three significant video game variables based on when and why students play. Our results indicate a nuanced correlation of video gaming and social media aspects and help explain the contradictory findings of previous studies on how video gaming and social media impact grades. [ABSTRACT FROM AUTHOR]

We examine whether proprietary costs of disclosure affect the reporting of segment-level tax expense. Current accounting rules for segment-level reporting afford managers significant discretion in what line items to report. We predict and find firms with higher proprietary costs of disclosure (i.e., higher tax avoidance) are less likely to disclose segment-level tax information. These results are stronger for firms that define business segments on a geographic basis, where disclosure could reveal tax expense information about specific tax jurisdictions, consistent with the proprietary cost hypothesis. Overall, our results suggest some managers potentially use discretion in current guidance to avoid segment-level disclosure of taxes when these disclosures have the potential to be detrimental to the firm. JEL Classifications: H20; H25; M41. [ABSTRACT FROM AUTHOR]

Context: Cystic fibrosis (CF) transmembrane conductance (CFTR) dysfunction may play a role in CF-related bone disease (CFBD). Ivacaftor is a CFTR potentiator effective in improving pulmonary and nutritional outcomes in patients with the G551D-CFTR mutation. The effects of ivacaftor on bone health are unknown.Objective: To determine the impact of ivacaftor on bone density and microarchitecture in children and adults with CF.Design: Prospective observational multiple cohort study.Setting: Outpatient clinical research center within a tertiary academic medical center.Patients or Other Participants: Three cohorts of age-, race-, and gender-matched subjects were enrolled: 26 subjects (15 adults and 11 children) with CF and the G551D-CFTR mutation who were planning to start or had started treatment with ivacaftor within 3 months (Ivacaftor cohort), 26 subjects with CF were not treated with ivacaftor (CF Control cohort), and 26 healthy volunteers.Interventions: All treatments, including Ivacaftor, were managed by the subjects' pulmonologists.Main Outcome Measures: Bone microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT), areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) and bone turnover markers at baseline, 1, and 2 years.Results: Cortical volume, area, and porosity at the radius and tibia increased significantly in adults in the Ivacaftor cohort. No significant differences were observed in changes in aBMD, trabecular microarchitecture, or estimated bone strength in adults or in any outcome measures in children.Conclusions: Treatment with ivacaftor was associated with increases in cortical microarchitecture in adults with CF. Further studies are needed to understand the implications of these findings. [ABSTRACT FROM AUTHOR]

Konchitchki and Patatoukas Journal of Accounting and Economics 57 (1-2), 76–88, (2014a) show that aggregate accounting earnings growth predicts future nominal gross domestic product (GDP) growth and that professional macro forecasters do not fully incorporate the information contained in aggregate accounting earnings. Based on results from prior literature, which find that accounting earnings reflect bad economic news in a timelier manner than good news, we condition Konchitchki and Patatoukas's GDP growth forecast model on the sign of earnings changes. We show that negative changes in aggregate earnings predict future GDP growth while positive changes in earnings do not. Furthermore, we show that professional macro forecasters underreact to the information contained in negative changes in aggregate earnings about future GDP growth. Additional tests suggest our findings are a result of conservative accruals in earnings. [ABSTRACT FROM AUTHOR]

Application of a magnetic field to an indirect drive inertial confinement fusion target requires diffusion of the field through the high-Z and electrically conducting Hohlraum. The onset of the external field generates eddy currents in the Hohlraum wall that result in (1) a reduction of the peak field at the capsule, (2) heating of the Hohlraum wall through Ohmic dissipation, and (3) wall movement due to the inward force from the eddy current interacting with the field. Heating of the wall causes an increase in blackbody radiation which can preheat the capsule and frozen deuterium–tritium fuel, while wall motion leads to potential misalignment of the lasers at the Hohlraum wall. Limiting these detrimental effects sets requirements on the tolerable magnitude of each effect. We present a nonlinear model for B-field diffusion through an infinitely long thin-walled cylinder with a temperature dependent resistivity, to show that a 15 lm thick wall of pure gold fails to meet these requirements. A new Hohlraum material made from an alloy of Au and Ta has a measured resistivity of > 60 times that of Au and is shown with the nonlinear model to meet the requirements for magnetization. We compare the nonlinear model to simulations of the actual Hohlraum target using a finite element code which includes temperature-dependent Hohlraum resistivity. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Raptor Research is the property of Raptor Research Foundation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Since 2006, six satellites measuring solar‐induced chlorophyll fluorescence (SIF) have been launched to better constrain terrestrial gross primary productivity (GPP). The promise of the SIF signal as a proxy for photosynthesis with a strong relationship to GPP has been widely cited in carbon cycling studies. However, chlorophyll fluorescence originates from dynamic energy partitioning at the leaf level and does not exhibit a uniformly linear relationship with photosynthesis at finer scales. We induced stomatal closure in deciduous woody tree branches and measured SIF at a proximal scale, alongside leaf‐level gas exchange, pulse amplitude modulated (PAM) fluorescence, and leaf pigment content. We found no change in SIF or steady‐state PAM fluorescence, despite clear reductions in stomatal conductance, carbon assimilation, and light‐use efficiency in treated leaves. These findings suggest that equating SIF and photosynthesis is an oversimplification that may undermine the utility of SIF as a biophysical parameter in GPP models. Plain Language Summary: Earth's vegetation plays a key role in storing carbon that would otherwise reside in the atmosphere. Recently, there has been increasing interest in measuring fluorescent light emitted by the chlorophyll in plant cells in order to track carbon uptake. Satellite fluorescence measurements show a strong, direct relationship with primary productivity. However, leaf‐level chlorophyll fluorescence studies have yielded insights into the origin of this signal as one of several pathways by which plants consume excess absorbed light. At finer scales, fluorescence emission may become inversely related to photosynthetic rate, due to the additional role of heat dissipation as an alternative pathway for plants to partition energy. To investigate the contradiction between measurements across scales, we experimentally manipulated tree branches, inhibiting photosynthesis by closing the stomata through which plants exchange water and carbon dioxide gases. We observed significant reductions in leaf‐level gas exchange in treated branches but found no similar change in fluorescence measured at the leaf level or from a proximal tower. While fluorescence offers physiological insights, we suggest that the close relationship with primary productivity at the satellite scale could result from a shared driver, such as chlorophyll content and that fluorescence data should be interpreted with care. Key Points: Leaf‐level chlorophyll fluorescence does not exhibit a significant relationship with photosynthesis after inducing stomatal closureRemote fluorescence data provide insight into the light reactions of photosynthesis, but do not directly track carbon assimilationThe link between fluorescence and primary productivity may result from shared drivers, such as chlorophyll content or energy partitioning [ABSTRACT FROM AUTHOR]

Romantic relationships are one of the most significant interpersonal ties in adolescence, thus understanding factors that may contribute to their formation and quality are important. The current meta‐analysis focuses on links between friendship quality and romantic relationship outcomes for adolescents up to 18 years. In a series of meta‐analyses (k = 28 studies, N's = 946–4,040), friendship qualities were not related to romantic involvement. However, we did find robust evidence of continuity between friendship qualities and romantic relationship qualities. Additionally, adolescents experienced more negative quality in their romantic relationships than in their friendships. These findings suggest that friendships have implications for adolescents' romantic relationships, although more research is needed on specific quality associations, and the mediators of these relations. [ABSTRACT FROM AUTHOR]

Humans are exposed to the antimicrobial agent triclosan (TCS) through use of TCS‐containing products. Exposed tissues contain mast cells, which are involved in numerous biological functions and diseases by secreting various chemical mediators through a process termed degranulation. We previously demonstrated that TCS inhibits both Ca2+ influx into antigen‐stimulated mast cells and subsequent degranulation. To determine the mechanism linking the TCS cytosolic Ca2+ depression to inhibited degranulation, we investigated the effects of TCS on crucial signaling enzymes activated downstream of the Ca2+ rise: protein kinase C (PKC; activated by Ca2+ and reactive oxygen species [ROS]) and phospholipase D (PLD). We found that TCS strongly inhibits PLD activity within 15 minutes post‐antigen, a key mechanism of TCS mast cell inhibition. In addition, experiments using fluorescent constructs and confocal microscopy indicate that TCS delays antigen‐induced translocations of PKCβII, PKCδ and PKC substrate myristoylated alanine‐rich C‐kinase. Surprisingly, TCS does not inhibit PKC activity or overall ability to translocate, and TCS actually increases PKC activity by 45 minutes post‐antigen; these results are explained by the timing of both TCS inhibition of cytosolic Ca2+ (~15+ minutes post‐antigen) and TCS stimulation of ROS (~45 minutes post‐antigen). These findings demonstrate that it is incorrect to assume that all Ca2+‐dependent processes will be synchronously inhibited when cytosolic Ca2+ is inhibited by a toxicant or drug. The results offer molecular predictions of the effects of TCS on other mammalian cell types, which share these crucial signal transduction elements and provide biochemical information that may underlie recent epidemiological findings implicating TCS in human health problems. Mast cells are involved in numerous biological functions and diseases by secreting various chemical mediators through a process termed degranulation. Protein kinase C and phospholipase D are enzymes crucial to this process. Antimicrobial triclosan inhibits mast cell degranulation via phospholipase D inhibition. Triclosan does not affect protein kinase C activity but delays its movement. Ca2+‐dependent biomolecules are not always inhibited when Ca2+ is inhibited by drugs. Triclosan modes of action predict other cellular effects. [ABSTRACT FROM AUTHOR]

We investigate whether characteristics of firms' debt structure, beyond leverage and debt covenants, are associated with predictable variation in conditional conservatism. The contracting theory of conservatism holds that conditional conservatism is an efficient mechanism employed by an organization to address agency conflict arising from contracts with various parties. For firms with contracts that are associated with more agency conflict, the potential benefit of a conservative reporting strategy should increase. We examine the following debt contract characteristics: (1) convertibility, (2) securitization, (3) seniority, and (4) placement. We find that debt types thought to be associated with a downward shift in agency conflict (convertible, secured, senior, and private debt) are associated with less conservative reporting. Our evidence supports contracting theory as being descriptive of the link between debt and conservatism. Also, our evidence corroborates the assertion that debt contract modifications do not fully resolve lenders' demands for conservative reporting. [ABSTRACT FROM AUTHOR]

Traditional methods of carbon monitoring in mountainous regions are challenged by complex terrain. Recently, solar‐induced fluorescence (SIF) has been found to be an indicator of gross primary production (GPP), and the increased availability of remotely sensed SIF provides an opportunity to estimate GPP across the Western United States. Although the empirical linkage between SIF and GPP is strong, the current mechanistic understanding of this linkage is incomplete and depends upon changes in leaf biochemical processes in which absorbed sunlight leads to photochemistry, heat (via nonphotochemical quenching [NPQ]), fluorescence, or tissue damage. An improved mechanistic understanding is necessary to leverage SIF observations to improve representation of ecosystem processes within land surface models. Here we included an improved fluorescence model within the Community Land Model, Version 4.5 (CLM 4.5), to simulate seasonal changes in SIF at a subalpine forest in Colorado. We found that when the model accounted for sustained NPQ, this provided a larger seasonal change in fluorescence yield leading to simulated SIF that more closely resembled the observed seasonal pattern (Global Ozone Monitoring Experiment‐2 [GOME‐2] satellite platform and a tower‐mounted spectrometer system). We found that an acclimation model based on mean air temperature was a useful predictor for sustained NPQ. Although light intensity was not an important factor for this analysis, it should be considered before applying the sustained NPQ and SIF to other cold climate evergreen biomes. More leaf‐level fluorescence measurements are necessary to better understand the seasonal relationship between sustained and reversible components of NPQ and to what extent that influences SIF. Key Points: Sustained nonphotochemical quenching is the major sink for excess light for a high‐elevation conifer forest in winterA temperature‐based acclimation model was able to reproduce seasonal changes in sustained NPQIncluding a representation of sustained NPQ improved the simulation of SIF for cold‐climate evergreens within a land surface model [ABSTRACT FROM AUTHOR]

The role of major mergers in galaxy evolution remains a key open question. Existing empirical merger identification methods use non-parametric and subjective visual classifications that can pose systematic challenges to constraining merger histories. As a first step towards overcoming these challenges, we develop and share publicly a new python -based software tool that identifies and extracts the flux-wise and area-wise significant contiguous regions from the model-subtracted residual images produced by popular parametric light-profile fitting tools (e.g. galfit). Using Hubble Space Telescope (HST) H -band single-Sérsic residual images of 17 CANDELS galaxies, we demonstrate the tools ability to measure the surface brightness and improve the qualitative identification of a variety of common residual features (disc structures, spiral substructures, plausible tidal features, and strong gravitational arcs). We test our method on synthetic HST observations of a z  ∼ 1.5 major merger from the VELA hydrodynamic simulations. We extract H -band residual features corresponding to the birth, growth, and fading of tidal features during different stages and viewing orientations at CANDELS depths and resolution. We find that the extracted features at shallow depths have noisy visual appearance and are susceptible to viewing angle effects. For a VELA z  ∼ 3 major merger, we find that James Webb Space Telescope NIRCam observations can probe high-redshift tidal features with considerable advantage over existing HST capabilities. Further quantitative analysis of plausible tidal features extracted with our new software hold promise for the robust identification of hallmark merger signatures and corresponding improvements to merger rate constraints. [ABSTRACT FROM AUTHOR]

New Findings: What is the central question of this study?Is chemerin, an adipokine implicated in obesity, increased in neonates following in utero cigarette smoke exposure.What is the main finding and its importance?Chemerin mRNA expression was increased and chemerin DNA methylation was decreased in babies born to mothers who smoked during pregnancy. These data provide a potential mechanism that may be mediating the increased obesity risk in individuals that are born to mothers who smoked during pregnancy. It has been shown that in utero tobacco exposure increases offspring risk for obesity, but the mechanisms responsible for this increased risk are not well understood. Chemerin is an adipokine that regulates adipocyte differentiation. This chemokine is elevated in obese individuals and with smoke exposure, but its levels have not been measured in neonates exposed to cigarette smoke in utero. We examined chemerin gene expression [n = 31 non‐smoker (NS) and 15 smoker (S)] and DNA methylation (n = 28 NS and n = 11 S) in skin collected from babies born to mothers who smoked during pregnancy as compared to non‐smoking controls. Quality RNA and DNA were isolated from foreskin tissue following circumcision, and chemerin gene expression and DNA methylation were assessed. Further, in a second cohort, we utilized primary dermal foreskin fibroblasts as a functional measure of adipogenesis in living cells (n = 11 NS and n = 8 S). Cells were stimulated with an adipogenic cocktail, mRNA was isolated from cells after 14 days, and chemerin gene expression assessed via real‐time PCR. Chemerin mRNA was elevated in both whole tissue (NS: 2409.20 ± 555.28 counts and S: 2966.72 ± 636.84 counts; P < 0.01) and primary fibroblasts (NS: 1.12 ± 0.552ΔΔCT and S: 2.13 ± 1.342ΔΔCT; P = 0.04) collected from infants born to smoking mothers. Chemerin DNA methylation was reduced in whole tissue of offspring born to smokers (NS: 4.18 ± 1.28 and S: 3.07 ± 1.31%; P = 0.02), which may contribute to the increased gene expression. Neonates born to mothers who smoke during pregnancy exhibit distinct changes in chemerin gene expression in response to in utero tobacco smoke exposure which are regulated in part by epigenetic alterations. [ABSTRACT FROM AUTHOR]

Early during their maturation, adult-born dentate granule cells (aDGCs) are particularly excitable, but eventually develop the electrophysiologically quiet properties of mature cells. However, the stability versus plasticity of this quiet state across time and experience remains unresolved. By birthdating two populations of aDGCs across different animal ages, we found for 10-month-old rats the expected reduction in excitability across cells aged 4-12 weeks, as determined by Egr1 immunoreactivity. Unexpectedly, cells 35 weeks old (after genesis at an animal age of 2 months) were as excitable as 4-week-old cells, in the dorsal hippocampus. This high level of excitability at maturity was specific for cells born in animals 2 months of age, as cells born later in life did not show this effect. Importantly, excitability states were not fixed once maturity was gained, but were enhanced by enriched environment exposure or LTP induction, indicating that any maturational decrease in excitability can be compensated by experience. These data reveal the importance of the animal’s age for aDGC excitability, and emphasize their prolonged capability for plasticity during adulthood. [ABSTRACT FROM AUTHOR]

In a sample of U.S. multiple-segment firms, we document a negative association between aggregation via segment reporting and timely loss recognition. A higher level of aggregation, as reflected in a firm’s reported organizational structure (the definition and characteristics of its segments), causes a multiple-segment firm to exhibit less cross-segment variation in profitability than a matched control portfolio of single-segment firms. We find that firms that engage in more aggregation report accounting numbers that provide less timely information about economic losses. We also observe that firms that provide more disaggregated segment data subsequent to adopting SFAS 131 experienced an increase in timely loss recognition. This result implies that higher quality segment reporting leads to an increase in timely loss recognition, which, per extant research, is associated with better governance. Our results complement results in Berger and Hann [2003. The impact of SFAS No. 131 on information and monitoring. Journal of Accounting Research, 41, 163-223] that show a decline in inefficient internal-capital-market transfers subsequent to the adoption of SFAS 131. Overall, we provide evidence supporting Beyer, Cohen, Lys, and Walther’s [2010. The financial reporting environment: Review of the recent literature. Journal of Accounting and Economics, 50, 296-343] contention that accounting conservatism is, in part, a function of managers’ aggregation choices. [ABSTRACT FROM AUTHOR]

We examine the potential that imposed magnetic fields of tens of Tesla that increase to greater than 10 kT (100 MGauss) under implosion compression may relax the conditions required for ignition and propagating burn in indirect-drive inertial confinement fusion (ICF) targets. This may allow the attainment of ignition, or at least significant fusion energy yields, in presently performing ICF targets on the National Ignition Facility (NIF) that today are sub-marginal for thermonuclear burn through adverse hydrodynamic conditions at stagnation [Doeppner et al., Phys. Rev. Lett. 115, 055001 (2015)]. Results of detailed two-dimensional radiation-hydrodynamic-burn simulations applied to NIF capsule implosions with low-mode shape perturbations and residual kinetic energy loss indicate that such compressed fields may increase the probability for ignition through range reduction of fusion alpha particles, suppression of electron heat conduction, and potential stabilization of higher-mode Rayleigh-Taylor instabilities. Optimum initial applied fields are found to be around 50 T. Given that the full plasma structure at capsule stagnation may be governed by threedimensional resistive magneto-hydrodynamics, the formation of closed magnetic field lines might further augment ignition prospects. Experiments are now required to further assess the potential of applied magnetic fields to ICF ignition and burn on NIF. [ABSTRACT FROM AUTHOR]

We examine whether estimated taxable income provides incremental information about firms' operating risk. We develop taxable income-based measures that should be useful in assessing risk in a simple earnings predictability model. In our empirical tests these taxable income-based measures explain cross-sectional variation in the predictability and variability of future pre-tax financial performance. Further, these measures are associated with predictable variation in market-based measures of firm risk. Our findings shed light on how accounting information--specifically, book income and tax income--impacts investors' assessment of firm risk as well as improving our understanding of the extent and nature of information contained in estimated taxable income. [ABSTRACT FROM AUTHOR]

Synthetic cannabinoids, which began proliferating in the United States in 2009, have gone through numerous iterations of modification to their chemical structures. More recent generations of compounds have been associated with significant adverse outcomes following use, including cognitive and psychomotor impairment, seizures, psychosis, tissue injury and death. These effects increase the urgency for forensic and public health laboratories to develop methods for the detection and identification of novel substances, and apply these to the determination of their metabolism and disposition in biological samples. This comprehensive review describes the history of the appearance of the drugs in the United States, discusses the naming conventions emerging to designate new structures, and describes the most prominent new compounds linked to the adverse effects now associated with their use. We review in depth the metabolic pathways that have been elucidated for the major members of each of the prevalent synthetic cannabinoid drug subclasses, the enzyme systems responsible for their metabolism, and the use of in silico approaches to assist in predicting and identifying the metabolites of novel compounds and drug subclasses that will continue to appear. Finally, we review and critique analytical methods applied to the detection of the drugs and their metabolites, including immunoassay screening, and liquid chromatography mass spectrometry confirmatory techniques applied to urine, serum, whole blood, oral fl uid, hair, and tissues. [ABSTRACT FROM AUTHOR]

Clinical outcomes after primary graft failure (PGF) remain poor. Here we present a large retrospective analysis (n=23 272) which investigates means to prevent PGF and early detection of patients at high risk. In patients with hematologic malignancies, who underwent their first myeloablative allogeneic hematopoietic cell transplantation, PGF was reported in 1278 (5.5%), and there was a marked difference in PGFs using peripheral blood stem cell compared with bone marrow grafts (2.5 vs 7.3%; P<0.001). A fourfold increase of PGF was observed in myeloproliferative disorders compared with acute leukemia (P<0.001). Other risk factors for PGF included recipient age <30, HLA mismatch, male recipients of female donor grafts, ABO incompatibility, busulfan/cyclophosphamide conditioning and cryopreservation. In bone marrow transplants, total nucleated cell doses ⩽2.4 × 108 per kg were associated with PGF (odds ratio 1.39; P<0.001). The use of tacrolimus-based immunosuppression and granulocyte colony-stimulating factor were associated with decreased PGF risk. These data, allow clinicians to do more informed choices with respect to graft source, donor selection, conditioning and immunosuppressive regimens to reduce the risk of PGF. Moreover, a novel risk score determined on day 21 post transplant may provide the rationale for an early request for additional hematopoietic stem cells. [ABSTRACT FROM AUTHOR]

Objective Determine the relative stiffness of 3 bandage/splint constructs intended for emergency fracture stabilization. Design Experimental model. A single plane free end deflection model was developed to simulate the forces placed on a bandage/splint construct during stabilization of a complete mid-metacarpal bone fracture. The total deflection of the model in one plane was measured following application of 3 different bandage/splint combinations including a classic, 3 layered Robert Jones Bandage (RJB) with a splint placed on the outside of the bandage (RJB-3), an RJB with splint placed after the first of 3 bandage layers (RJB-1), and a single layer full limb bandage with external splint (SS). Comparisons were made between the deflections of the model with each bandage/splint combinations in an effort to determine the most effective method for field fracture stabilization. Setting Laboratory. Animals No animals were utilized in data collection for this study. Two live horses were utilized during the pilot study. Interventions Application of bandage and splint to a model intended to simulate the bending force on a lower forelimb fracture in a horse Measurements and Main Results Deflection was determined by the difference between the height of the model's supported free end before application of a 4.5 kg weight and at the conclusion of the deflection test. There was no significant difference in the amount of deflection between bandage/splint combinations (78 ± 32 mm (RJB-1), 94 ± 44 mm (RJB-3), and 93 ± 33 mm (SS)) Conclusions The one-layer bandage with splint was equivalent to either RJB configuration in the mean amount of deflection in the simple model of a fracture. [ABSTRACT FROM AUTHOR]

Hematopoietic cell transplantation (HCT) with non-myeloablative (NMA) conditioning for lymphoproliferative diseases (LD) includes fludarabine with and without low-dose TBI. Transplant outcomes were compared among patients aged ⩾40 years with LD who received a HCT with TBI (N=382) or no-TBI (N=515) NMA from 2001 to 2011. The groups were comparable except for donor, graft, prophylaxis for GVHD, disease status and year of HCT. Cumulative incidences of grades II-IV GVHD at 100 days were 29% and 20% (P=0.001) and of chronic GVHD at 1 year were 54% and 44% (P=0.004) for TBI and no-TBI, respectively. Multivariate analysis of progression/relapse, treatment failure and mortality showed no outcome differences by conditioning. Full donor chimerism at day 100 was observed in 82% vs 64% in the TBI and no-TBI groups, respectively (P=0.006). Subsets of the four most common conditioning/GVHD prophylaxis combinations demonstrated higher rates of grades II-IV acute (P<0.001) and chronic GVHD (P<0.001) among recipients of TBI-mycophenolate mofetil (MMF) compared with other combinations. TBI-based NMA conditioning induces faster full donor chimerism, but overall survival outcomes are comparable to no-TBI regimens. Combinations of TBI and MMF are associated with higher rates of GVHD without impact on survival outcomes in patients with LD. [ABSTRACT FROM AUTHOR]

Intravenous morphine infusions have been administered to 12 critically-ill patients during controlled ventilation. Acute oliguric renal failure was present in 4 patients, who were treated with a combination of haemofiltration and haemodialysis. Severity of physiological disturbance was assessed using a modified APACHE Score, level of sedation by a linear-analogue scale, and blood morphine levels by high-pressure liquid chromatography. Morphine clearance was impaired in renal failure, and was dependent on haemofiltration volumes; accumulation of morphine did not occur during this form of treatment. Conscious level was clearly more closely related to the degree of physiological disturbance than blood morphine levels; and for a given blood morphine level, depression of consciousness was more pronounced the greater the degree of physiological disturbance. Use of a physiological sickness score may help to clarify some of the factors influencing cerebral function during critical illness. Careful clinical monitoring of level of sedation is important in patients with oliguric renal failure receiving morphine, and haemofiltration appears to reduce the risk of morphine accumulation in these patients. [ABSTRACT FROM AUTHOR]