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Using brain activity directly as input for assistive tool control can circumventmuscular dysfunction and increase functional independence for physically impaired people. The motor cortex is commonly targeted for recordings, while growing evidence shows that there exists decodable movement-related neural activity outside of the motor cortex. Several decoding studies demonstrated significant decoding from distributed areas separately. Here, we combine information from all recorded non-motor brain areas and decode executed and imagined movements using a Riemannian decoder. We recorded neural activity from 8 epilepsy patients implanted with stereotactic-electroencephalographic electrodes (sEEG), while they performed an executed and imagined grasping tasks. Before decoding, we excluded all contacts in or adjacent to the central sulcus. The decoder extracts a low-dimensional representation of varying number of components, and classified move/no-move using a minimum-distance-to-geometric-mean Riemannian classifier. We show that executed and imagined movements can be decoded from distributed non-motor brain areas using a Riemannian decoder, reaching an area under the receiver operator characteristic of 0.83 ± 0.11. Furthermore, we highlight the distributedness of the movement-related neural activity, as no single brain area is the main driver of performance. Our decoding results demonstrate a first application of a Riemannian decoder on sEEG data and show that it is able to decode from distributed brain-wide recordings outside of the motor cortex. This brief report highlights the perspective to explore motor-related neural activity beyond the motor cortex, as many areas contain decodable information. [ABSTRACT FROM AUTHOR]

Patterns in expression data conserved across multiple independent disease studies are likely to represent important molecular events underlying the disease. We present the INSPIRE method to infer modules of co-expressed genes and the dependencies among the modules from multiple expression datasets that may contain different sets of genes. We show that INSPIRE infers more accurate models than existing methods to extract low-dimensional representation of expression data. We demonstrate that applying INSPIRE to nine ovarian cancer datasets leads to a new marker and potential driver of tumor-associated stroma, HOPX, followed by experimental validation. The implementation of INSPIRE is available at http://inspire.cs.washington.edu. [ABSTRACT FROM AUTHOR]

The detection of multiple changes (i.e., different kinds of change) in multitemporal remote sensing images is a complex problem. When multispectral images having B spectral bands are considered, an effective solution to this problem is to exploit all available spectral channels in the framework of supervised or partially supervised approaches. However, in many real applications, it is difficult/impossible to collect ground truth information for either multitemporal or single-date images. On the opposite, unsupervised methods available in the literature are not effective in handling the full information present in multispectral and multitemporal images. They usually consider a simplified subspace of the original feature space having small dimensionality and, thus, characterized by a possible loss of change information. In this paper, we present a framework for the detection of multiple changes in bitemporal and multispectral remote sensing images that allows one to overcome the limits of standard unsupervised methods. The framework is based on the following: 1) a compressed yet efficient 2-D representation of the change information and 2) a two-step automatic decision strategy. The effectiveness of the proposed approach has been tested on two bitemporal and multispectral data sets having different properties. Results obtained on both data sets confirm the effectiveness of the proposed approach. [ABSTRACT FROM AUTHOR]

In the past few decades, the number and variety of genomic and proteomic data available have increased dramatically. Molecular or functional interaction networks are usually constructed according to high-throughput data and the topological structure of these interaction networks provide a wealth of information for inferring the function of genes or proteins. It is a widely used way to mine functional information of genes or proteins by analyzing the association networks. However, it remains still an urgent but unresolved challenge how to combine multiple heterogeneous networks to achieve more accurate predictions. In this paper, we present a method named ReprsentConcat to improve function inference by integrating multiple interaction networks. The low-dimensional representation of each node in each network is extracted, then these representations from multiple networks are concatenated and fed to gcForest, which augment feature vectors by cascading and automatically determines the number of cascade levels. We experimentally compare ReprsentConcat with a state-of-the-art method, showing that it achieves competitive results on the datasets of yeast and human. Moreover, it is robust to the hyperparameters including the number of dimensions. [ABSTRACT FROM AUTHOR]