1. MicroRNA-29: A Crucial Player in Fibrotic Disease.
- Author
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Deng, Zhenjun, He, Yongjing, Yang, Xujuan, Shi, Hang, Shi, Ao, Lu, Lechun, and He, Li
- Subjects
MICRORNA ,FIBROSIS ,EXTRACELLULAR matrix ,GENE expression ,KELOIDS - Abstract
Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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