1. Randomized Controlled Trial of Hyaluronic Acid/Carboxymethylcellulose Dressing after Endoscopic Sinus Surgery.
- Author
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Bradford A. Woodworth, Rakesh K. Chandra, Mark J. Hoy, Fu-shing Lee, Rodney J. Schlosser, and M. Boyd Gillespie
- Subjects
RANDOMIZED controlled trials ,HYALURONIC acid ,CELLULOSE ,ENDOSCOPIC surgery ,POSTOPERATIVE pain ,SURGICAL dressings ,SURGICAL complications ,FOLLOW-up studies (Medicine) - Abstract
AbstractObjective:To determine if a hyaluronic acid/carboxymethylcellulose (HA/CMC) sinus dressing reduces the rate of postoperative scarring. Methods:In a randomized, matched-controlled, single-blinded study, following the completion of surgery, an HA/CMC dressing was randomly assigned to one side with the opposite unpacked side serving as a control. Results:Fifty-three patients underwent surgery for chronic rhinosinusitis (CRS; 39 patients) or CRS with nasal polyposis (14 patients). At the 8-week follow-up, there was no difference in synechiae on the HA/CMC side compared to the control (p = 0.09). HA/CMC-treated sinuses, however, demonstrated fewer synechiae in the first 2 weeks postoperatively compared to the control (p = 0.01), and were associated with significantly less nasal congestion at the 4-week (p = 0.02) and 8-week follow-up visits (0.03). Conclusion:There was no long-term difference in the rate of synechiae in the HA/CMC-treated sinus compared to the control. However, less severe nasal congestion and synechiae in the initial postoperative period may reduce the need for aggressive sinus debridement.Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] more...
- Published
- 2010
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