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This article introduces a uniform theory of diffraction–physical optics (UTD–PO) formulation for analyzing radiowave multiple diffraction emanating from trees and buildings in green urban areas, considering illumination from a low transmitter and assuming spherical-wave incidence. Based on Babinet's principle, this solution models buildings as rectangular sections and accounts for the influence of tree crowns (assuming these rise above the average rooftop height) by incorporating appropriate attenuation factors/phasors into the diffraction phenomena of buildings. The validation of the formulation is achieved through measurements made at the 39 GHz 6G mmWave frequency on a scale model of a green urban environment comprising bonsai trees and bricks. The main advantage of the proposed solution is that the calculations only include single diffractions due to recursion, circumventing the need to use higher-order diffraction terms in the diffraction coefficients, thus reducing the computation time and power. Our results may be beneficial for the design of mobile communication systems, including 6G networks, situated in green urban areas and with transmission source positioned lower than the surrounding infrastructure. [ABSTRACT FROM AUTHOR]

This paper presents two uniform theories of diffraction–physical optics (UTD-PO) formulations to undertake analysis of radiowave multiple diffraction resulting from the presence of both buildings and trees in vegetated urban areas, with the assumption of spherical-wave incidence. The solutions presented consider buildings modeled as knife-edges and rectangular sections (the latter being more complex and realistic) and the effect of the tree canopy (the assumption is that this exceeds the height of the average rooftop) is taken into account by adding proper attenuation factors/phasors to building diffraction phenomena. The validation of these formulations has been undertaken by comparing with other methods and measurements performed at 39 GHz on a scaled-model of the environment under analysis, consisting of an array of bricks and bonsai trees. The chief advantage of the solutions put forward is that because of recursion, the calculations only include single diffractions. This avoids any requirement for higher-order diffraction terms in the diffraction coefficients, which means less computer time/power is demanded. The results of this work may be useful when planning future mobile communication systems, including 6G networks and beyond. [ABSTRACT FROM AUTHOR]

Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the biopharmaceutical industry. In previous studies, we observed strong correlations between the performance of CHO cells and expression of two transcription factors (TFs), MYC and XBP1s. Here, we have evaluated the effective of overexpression of these two TFs on CHO cell productivity. To address this goal, we generated an EPO-producing cell line (CHOEPO) using a targeted integration approach, and subsequently engineered it to co-overexpress MYC and XBP1s (a cell line referred to as CHOCXEPO). Cells overexpressing MYC and XBP1s increased simultaneously viable cell densities and EPO production, leading to an enhanced overall performance in cultures. These improvements resulted from the individual effect of each TF in the cell behaviour (i.e., MYC-growth and XBP1s-productivity). An evaluation of the CHOCXEPO cells under different environmental conditions (temperature and media glucose concentration) indicated that CHOCXEPO cells increased cell productivity in high glucose concentration. This study showed the potential of combining TF-based cell engineering and process optimisation for increasing CHO cell productivity. [ABSTRACT FROM AUTHOR]

Copyright of Archivos de Prevención de Riesgos Laborales is the property of Societat Catalana de Salut Laboral-Fundacio Academia & Asociacion de Medicina del Trabajo de la Coma and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Científica Intellectus is the property of Intellectus Revista Academica Digital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Científica Intellectus is the property of Intellectus Revista Academica Digital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)