Search

Background: Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. Results: We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release of IL-1β, IL-6, IL-8, and Vascular Endothelial Growth Factor (VEGF). Transcription and release of these proteins are inhibited in vitro using Anakinra, an IL-1 receptor antagonist that reduces these cytokines in a human peritoneal MM mouse xenograft model. Conclusions: These novel data show that asbestos-induced priming and activation of the NLRP3 inflammasome triggers an autocrine feedback loop modulated via the IL-1 receptor in mesothelial cell type targeted in pleural infection, fibrosis, and carcinogenesis. [ABSTRACT FROM AUTHOR]

The article discusses R. Karush and A. Schmukler's dreams from their patients that connect the analytic process, transference and insight and how they worked with them. It cites the example of 7 year old Tanya which shows how dream can illuminate the transference and Schmulker's description of how the dream of monsters of 7 year old Jim prompted him to wonder about his role in injuries and accidents. It notes how they demonstrate in their articles how dreams facilitate the process of knowing.

A five-year evaluative research project regarding an innovation in psychoanalytic training within institutes of the American Psychoanalytic Association (APsaA) was conducted through the Committee on Child and Adolescent Analysis (COCAA) of its Board on Professional Standards, which led to significant policy changes within APsaA's Principles and Standards of Education. Eleven candidates at four different institutes (Columbia, Denver, Houston-Galveston, and St. Louis) entered a pilot training program for child and adolescent analysis without the requirement of adult training. Satisfaction with training and supervision in these programs was rated high by candidates, faculty, and program directors, with additional flexibility for child analytic training seen as an advantage. The limitations and implications of this implementation study are discussed, including its encouragement of educational evaluation and further research. [ABSTRACT FROM AUTHOR]

The article presents an introduction to the paper "Children in Conflict: Anna Freud and the War Nurseries, by Hansi Kennedy which is comprised by the works of psychoanalyst Anna Freud. It states that the complete researches of Freud were detailed in several books including "Infants Without Families: The Case for and Against Residential Nurseries," "Infants Without Families: Reports on Hampstead Nurseries 1939-1945," and "War and Children." It also mentions that Kennedy developed an interest for different fields in child psychology such as the impacts of trauma, conflict-based psychopathology and psychoanalysis. Moreover, it tells that the work of Kennedy reveals the discoveries of Freud which are concerned with the impacts of war to children.

Examines the concept of insight from the point of view that insight is about knowing. Definition of insight as a process and as a construct; Use of clinical material from the analysis of a young girl; Multifaceted analytic relationship; Dimensions of change; Questions on how the young girl went about knowing; Provision of an analytic environment to the young girl.

Traces the development of Anna Freud's theory and technique of child psychoanalysis. Application of psychoanalytic principles to education; Creation of the Jackson Nursery day care center in 1937 in Vienna, Austria; Creation of the Hampstead War Nurseries in London, England; Attention given to concentration-camp survivors.