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Chromosome 15q11q13 is among the least stable regions in the genome due to its highly complex genomic architecture. Low copy repeat elements at 15q13.3 facilitate recurrent copy number variants (CNVs), with deletions established as pathogenic and CHRNA7 implicated as a candidate gene. However, the pathogenicity of duplications of CHRNA7 is unclear, as they are found in affected probands as well as in reportedly healthy parents and unaffected control individuals. We evaluated 18 children with microduplications involving CHRNA7, identified by clinical chromosome microarray analysis (CMA). Comprehensive phenotyping revealed high prevalence of developmental delay/intellectual disability, autism spectrum disorder, and attention deficit/hyperactivity disorder. As CHRNA7 duplications are the most common CNVs identified by clinical CMA, this study provides anticipatory guidance for those involved with care of affected individuals. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of the paper is to provide a theoretical reflection on existing and emerging literature on social entrepreneurship as it applies to the developing country experience, and specifically to the informal economy in Senegal, West Africa. Design/methodology/approach – The paper adopts an exploratory, multi-disciplinary approach grounded in economic and social theory, including open-ended interviews and focus groups. The data are complemented by field observations and analysis. Findings – Socio-religious networks in West Africa like Mouridism, with its strong emphasis on work and giving of one's personal financial gains back to the Muslim brotherhood, has actually created a non-capitalist spirit of commerce, and to some degree entrepreneurialism, among Senegalese Mourids who are majority Wolof. Research limitations/implications – As an initial exploration into this topic, the paper lacks sufficient empirical data and therefore the research results may lack generalizability. Practical implications – The paper helps draw comparisons between what we know and what we do not know about social entrepreneurship in the informal economy, moving beyond the conventional neo-liberal notions of competitive markets to explore entrepreneurial activities at the "Bottom of the pyramid" that establish economic exchange value which is socially embedded. Originality/value – The paper seeks to address a perceived gap in the theoretical and empirical literature on the emerging phenomenon of social entrepreneurship. By analytically framing the debate on the role of markets in the social sector through a developing country lens, we are looking at social entrepreneurship as the intersection of embedded social and economic realities of the majority of workers who operate in the informal economy in Senegal. [ABSTRACT FROM AUTHOR]

A correction to the article "The Cognitive and Behavioral Phenotypesof Individuals with CHRNA7 Duplications" that was published in the March 2017 issue is presented.