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Background/objective: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. Methods: A real‐life 4‐week prospective, open study on Cal/BD aerosol foam (not compared to vehicle or emollient cream) was performed in adult psoriasis patients attending three Dermatology units located in Campania region, Italy, between March and October 2018. Inclusion criteria were a history of skin pain over the last week and psoriatic involvement of the palmar area. Before (t0) and after a course of once daily application of Cal/BD aerosol foam for 4 weeks (t1), the following items were evaluated: Psoriasis Area and Severity Index (PASI), Physician Global Assessment (PGA) index of target plaque on palmar region, subjective skin pain features through Pain Qualities Assessment Scale questionnaire and skin pain threshold measured by pressure digital algometer at palmar psoriatic plaques. Results: Seventy‐five patients (43 male, mean age of 43.2 years) were enrolled. After 4 weeks of therapy with Cal/BD aerosol foam, a significant improvement in both PASI (mean: 6.5 ± 2.1 at t0 vs. 2.3 ± 1.6 at t1) and palmar plaques PGA (mean: 3.6 at t0 vs. 1.7 at t1) was observed (P < 0.001). The mean intensity score of skin pain decreased from 7.6 to 1.3 (P < 0.001); among skin pain qualities, intense, sensible, aching and unpleasant showed the highest rate of reduction (t0–t1: 6.3, 6.3, 6.1 and 5.8, respectively). Pain threshold of palmar skin lesions increased at t1. Conclusions: Our real‐life study suggested that Cal/BD aerosol foam may represent a valid topical anti‐psoriatic treatment, not only improving skin lesions, but also relieving cutaneous pain, thus contributing to ameliorate patients' quality of life. [ABSTRACT FROM AUTHOR]

The computerization of manufacturing is one of the major challenges of the so-called fourth industrial revolution or Industry 4.0. Virtualization of the smart factory should provide real-time vision, control and monitoring of production through interactive dashboards and synchronization of data coming from different factory functions. The latter characteristics are particularly difficult to implement when the manufacturing core relies on traditional manual labour rather than on automation, as in the case of manual assembly. Monitoring or even controlling the manual work in real-time is extremely difficult to put into practice. Therefore, realizing the principles of Industry 4.0 in manual or semi-automatic labour contexts means developing new production control systems that involve the worker in the monitoring process without negatively affecting the production times or the psychological status of the workers. In particular, the authors propose a computer-aided production control framework based upon multimedia manuals and smart completeness control systems that can be used to implement the principles of Industry 4.0 in manual or semi-automatic work environments. This technology has been successfully tested in laboratory on the basis of a real industrial case study. The response of the testers has been positive and the outcomes in terms of increased product quality are promising. [ABSTRACT FROM AUTHOR]

The water-cooled lithium-lead breeding blanket is a candidate option for the European Demonstration Power Plant (DEMO) nuclear fusion reactor. This breeding blanket concept relies on the liquid lithium-lead as breeder-multiplier, pressurized water as coolant, and EUROFER as structural material. The current design is based on DEMO 2015 specifications and represents the follow-up of the design developed in 2015. The single-module-segment approach is employed. This is constituted by a basic geometry repeated along the poloidal direction. The power is removed by means of radial-toroidal (i.e., horizontal) water cooling tubes in the breeding zone. The lithium-lead flows in a radial-poloidal direction. On the back of the segment, a 100-mm-thick plate is in charge of withstanding the loads due to normal operation and selected postulated initiating events. Water and lithium-lead manifolds are designed and integrated with a consistent primary heat transport system, based on a reliable pressurized water reactor operating experience, and the lithium-lead system. Rationale and features of the single-module-segment water-cooled lithium-lead breeding blanket design are discussed and supported by thermo-mechanic, thermo-hydraulic, and neutronic analyses. Preliminary integration with the primary heat transfer system, the energy storage system, and the balance of plant is briefly discussed. Open issues, areas of research, and development needs are finally pointed out. @EUROfusion Consortium*, 2017. *For more details see http://www.euro-fusionscipub.org/disclaimer-copyright [ABSTRACT FROM AUTHOR]

The remote handling (RH) maintenance of components of International Fusion Materials Irradiation Facility (IFMIF) is one of the most challenging activities to be performed to guarantee the required high level of IFMIF plant availability. Among these components, the maintenance of the target assembly (TA) system appears to be critical, because it is located in the most severe region of neutron irradiation. The present European TA design is based on the so-called replaceable backplate (BP) bayonet concept. It was developed with the objective to reduce the waste material and to simplify the procedures for the target and BP replacement, thus reducing the intervention time for their substitution. The RH maintenance activity for the TA comprises a number of in situ refurbishment tasks, such as the removal of the BP, cleaning of surfaces from lithium solid deposition, inspection of the target body, installation of a new BP, and testing of the assembled system. However, there is also the possibility to replace the entire TA and to perform these refurbishment tasks offline in a dedicated hot cell. To accomplish all the refurbishment operations for the TA within the expected time for maintenance, the annual preventive maintenance period for IFMIF has been fixed in 20 days; several 3-D kinematic simulations in virtual reality environment and experimental activities aimed at developing and validating the implemented maintenance procedures for this component were carried out, in collaboration with the IDEAinVR Laboratory of CREATE/University of Naples Federico II, at the research center at ENEA Brasimone, Italy. The in situ refurbishment processes and the target replacement were simulated and tested and the feasibility of each maintenance operation was proved. In this paper, a description of the simulations and the validation activities carried out together with the main outcomes obtained are given. [ABSTRACT FROM AUTHOR]

The article presents a case of allergic contact dermatitis due to tromatadine hydrochloride. The patient a 18 year-old woman was referred with an eczematous reaction on her left cheek which developed after a 5-day application of a tromantadine-hydrochloride-containing ointment for recurrent herpes. Patch tests were performed with a standard series and tested positive for tromantadine hydrochloride It is a topical antiviral agent derived from amantadine. It is widely used in the treatment of recurrent herpes simplex.