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This paper demonstrates the use of "big data" to target behavioural interventions that aim to reduce environmental pollution. The data relate to ongoing noncompliance with the EU Nitrates Directive among farmers in Ireland. We compiled more than 1.2 million records from disparate administrative data, then employed multi-level statistical analysis to model regulatory breaches. The novel statistical associations generated shed light on possible reasons for noncompliance and allow us to predict violations more accurately than a regulatory rule of thumb previously used to target a behavioural 'nudge'. By quantifying variation in likely rates of false positives and false negatives, the models can be used to improve the efficiency of the behavioural intervention. The work illustrates how big data can combine with behavioural interventions to support better environmental enforcement. [ABSTRACT FROM AUTHOR]

Flash‐level comparisons between the Geostationary Lightning Mapper (GLM; primarily from GOES‐16), the U.S. National Lightning Detection Network (NLDN), and the Global Lightning Dataset GLD360 have been done at quasi‐climatological scale and in smaller samples of both severe and nonsevere thunderstorms. A small sample of data from GOES‐17 has also been analyzed. These comparisons show that the total lightning detection efficiencies of the GLM instruments drop off within about 2,000 km of the edges of their fields of view, particularly over terrestrial areas. In severe storms, low detection efficiency by GLM is clearly associated with very high midaltitude reflectivity, consistent with the idea that large multiple scattering path lengths, together with absorption of the near‐infrared signals by water (in all of its phases), depresses the GLM detection efficiency. This effect appears to be coupled with additional factors, including time of day, flash energetics, and the incident angle at the GLM sensor. The "lightning jump," the sought‐after signature of severe storms in lightning observations, tends to be poorly correlated between NLDN and GLM unless the storms are fairly isolated, not close to the edge of the GLM field of view, and have moderate midaltitude reflectivity. Key Points: Geostationary Lightning Mapper detection efficiency decreases within 2,000 km of edge of field of view over the western United StatesFlash rates often do not correlate well between Geostationary Lightning Mapper and National Lightning Detection NetworkLow Geostationary Lightning Mapper detection efficiency appears to correlate with a combination of various factors [ABSTRACT FROM AUTHOR]

Abstract: Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for cancer. Due to the mechanism of action of ICIs, inflammatory reactions against normal tissue were an anticipated side effect of these agents; these immune‐related adverse events have been documented and are typically low grade and manageable. Myocarditis has emerged as an uncommon but potentially life‐threatening adverse reaction in patients treated with ICIs. Assessment and characterization of ICI‐associated myocarditis is challenging because of its low incidence and protean manifestations. Nevertheless, the seriousness of ICI‐associated myocarditis justifies a coordinated effort to increase awareness of this syndrome, identify patients who may be at risk, and enable early diagnosis and appropriate treatment. The “Checkpoint Inhibitor Safety Working Group,” a multidisciplinary committee of academic, industry, and regulatory partners, convened at a workshop hosted by Project Data Sphere, LLC, on December 15, 2017. This meeting aimed to evaluate the current information on ICI‐associated myocarditis, determine methods to collect and share data on this adverse reaction, and establish task forces to close the identified knowledge gaps. In this report, we summarize the workshop findings and proposed steps to address the impact of ICI‐associated myocarditis in patients with cancer. [ABSTRACT FROM AUTHOR]

It is the policy of the Chinese Communist Party that the country should become a great maritime power. In this article, Martin N Murphy and Peter Roberts provide an overview of what this means militarily, where China is laying down a challenge to the US and its regional neighbours, where it is falling short, and what this has to do with Europe. [ABSTRACT FROM AUTHOR]

Air traffic controllers guiding planes, insurance adjusters validating claims, meteorologists forecasting weather, and more want to know where lightning strikes. Modern location systems provide them with the information they need. [ABSTRACT FROM AUTHOR]

Lightning stroke density measured by the Global Lightning Dataset (GLD360) has shown several strong maxima around the globe. Several of these extremes are located over large tropical water bodies surrounded by terrain features. Four prominent maxima are examined and compared in this study: Lake Maracaibo in South America, the Strait of Malacca in equatorial Asia, Lake Victoria in East Africa, and Lake Titicaca in South America. Specifically, the authors observe that all four water bodies exhibit sustained maxima in lightning occurrence all night, the peak lightning frequency occurs very late at night or the following morning at three of the four sites, and the nocturnal maxima are out of phase at the four locations even though the afternoon maxima over the surrounding terrain all occur between 1500 and 1700 local solar time. The meteorological factors affecting the diurnal cycle of lightning occurrence over these four water bodies, which are all adjacent to mountains, are explored in this study. [ABSTRACT FROM AUTHOR]

Background: Effective control of tick infestations on dogs is important to reduce the risk of transmission of bacterial, viral, and protozoal pathogens. Laboratory studies were initiated to determine the efficacy of lotilaner against common ticks infesting dogs in the United States. Methods: Eight studies investigated the efficacy of lotilaner against ticks. In two studies dogs were infested with both Dermacentor variabilis and Rhipicephalus sanguineus: one additional study was completed for each of these species. Two studies assessed infestations with Amblyomma americanum and two with Ixodes scapularis. In all studies, dogs were ranked and blocked by counts from pre-treatment infestations and randomly allocated, at least eight per group, to be treated orally with lotilaner (minimum dose rate 20 mg/kg), or to be untreated controls. Treatments were administered on Day 0, within 30 min after dogs were fed. In all studies, infestations were performed with 50 adult ticks on Days -2, 7, 14, 21 and 28, and also on Day 35 for R. sanguineus, D. variabilis and I. scapularis. Tick counts were completed 48 h after treatment or after each subsequent challenge. An adequate infestation was defined as at least 25% of the infestation dose recovered from each of at least six control animals at each evaluation. Efficacy calculations for the primary objective were based on geometric means. Results: In all studies, lotilaner was 100% effective against existing infestations. For post-treatment assessments, on only two occasions did efficacy fall below 99%: in one D. variabilis study efficacy was 98.0% on Day 35 and in one I. scapularis study efficacy on Day 16 was 98.4%. Only mild and transient adverse events were observed, and none were considered to be related to treatment. Conclusion: Lotilaner was completely effective against existing infestations with four common species of ticks, D. variabilis, R. sanguineus, A. americanum and I. scapularis, that affect dogs in North America, with at least 4 weeks efficacy of 98.0% or more against subsequent challenge infestations. These results show that lotilaner is a highly effective isoxazoline that offers sustained efficacy against ticks through and beyond the one-month end-of-dose treatment interval. [ABSTRACT FROM AUTHOR]

Background: Lotilaner is a novel isoxazoline developed for oral administration to dogs. In laboratory studies, lotilaner was shown to be safe and to produce a rapid flea and tick knockdown, with a sustained speed of kill for at least a month post-treatment. A study was undertaken to demonstrate the efficacy, safety and palatability of three monthly doses of lotilaner flavoured chewable tablets (Credelio™, Elanco) in controlling fleas under field conditions in Europe. Methods: Dogs were enrolled at 17 veterinary clinics across Germany, Hungary and Portugal. Qualifying households having no more than three dogs and one primary dog with at least five fleas was randomised 2:1 to a lotilaner (minimum dose rate 20 mg/kg) or a topical fipronil group (administered per label). There were 128 and 64 households allocated to the lotilaner and fipronil groups, respectively. Treatments were dispensed to owners on Days 0, 28 and 56; supplementary household dogs received the same treatment as the primary dog. Post-enrollment flea counts and flea allergy dermatitis (FAD) assessments were made on primary dogs on Days 14, 28, 56 and 84. Efficacy calculations were based on geometric mean percent reductions of live flea counts versus pre-treatment counts on Day 0. The safety and palatability of lotilaner tablets were also assessed. Results: Lotilaner efficacy was 99.1, 99.5, 99.9 and 99.8% on Days 14, 28, 56 and 84, respectively. Corresponding reductions for fipronil were 93.4, 91.2, 94.4 and 97.0%. Lotilaner was superior to fipronil at all post-Day 0 assessments (t(186) ≥ 3.43, P ≤ 0.0007). At every post-treatment assessment, at least 90% of lotilaner-treated dogs were flea-free (98. 4% on Day 84); fewer than 90% of fipronil group dogs were flea-free on the same time points. Lotilaner flavoured chewable tablets were palatable, and both products were well tolerated. Lotilaner alleviated or eliminated clinical signs of FAD, including pruritus. Conclusions: Under field conditions in Europe, lotilaner flavoured chewable tablets were greater than 99% effective in eliminating fleas from dogs at the first post-treatment assessment (Day 14). Efficacy was maintained through Day 84, with corresponding improvements in FAD. Lotilaner tablets were palatable and safe and provided superior flea control to fipronil. [ABSTRACT FROM AUTHOR]

Background: Oral administration of lotilaner flavoured chewable tablets (Credelio™, Elanco) to dogs has been shown to provide a rapid onset of killing activity of infesting ticks, with sustained efficacy for at least 35 days. A study was undertaken in Europe to confirm lotilaner's safety and anti-tick efficacy in client-owned dogs. Methods: In this assessor-blinded study, dogs were enrolled at 19 clinics in Germany, Hungary and Portugal. Qualifying households with no more than three dogs were randomized in an approximate 2:1 ratio to a lotilaner or fipronil/(S)-methoprene (FSM) (Frontline® Combo Spot-on, Merial) treatment group. One household dog with at least three live attached ticks was the primary dog. Treatments were dispensed Days 0, 28 (± 2) and 56 (± 2) for owner administration to all household dogs. Tick counts were performed on primary dogs Days 7 (± 1), and ±2 days on Days 14, 21, 28, 42, 56, 70 and 84; supplementary dogs were assessed for safety ± 2 days on Days 28, 56 and 84. Efficacy was assessed by comparing mean Day 0 live attached tick counts with subsequent counts. Results: The most frequently retrieved ticks were Ixodes ricinus, Dermacentor reticulatus and Rhipicephalus sanguineus (sensu lato), with Ixodes hexagonus also present. In the lotilaner group (n = 127) geometric mean tick count reductions were at least 98% from the first post-treatment visit (Day 7) through Day 56, when efficacy was 100%. For FSM (n = 68), efficacy remained at least 96% through Day 84, but at no point were all dogs free of live attached ticks. Mean counts in lotilaner-treated dogs were significantly lower than FSM-treated dogs on Days 7, 42, 70 and 84 (P < 0.05). Percent efficacy over all post-enrolment visits was 99.3 and 98.3% for lotilaner and FSM groups, respectively (t(190) = 2.23, P = 0.0268). Owners successfully administered all treatments, and both products were well-tolerated. Conclusion: Under European field conditions, lotilaner flavoured chewable tablets administered monthly, were > 98% effective in eliminating live ticks from the first post-treatment assessment (Day 7) through Day 56 and maintained 100% of dogs tick-free on Days 70 and 84. Lotilaner was safe, providing superior tick control to FSM administered according to the same schedule. [ABSTRACT FROM AUTHOR]

Background: There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelio™), an isoxazoline with a rapid onset of action, to provide sustained efficacy against ticks. Two studies were undertaken to confirm lotilaner's efficacy, at the minimum dose rate of 20 mg/kg, against the three most common tick species in Europe. Methods: In each of two studies, 16 Beagle dogs, at least 6 months old, were ranked and blocked by tick counts from infestations placed approximately 1 week before treatment. Within blocks, dogs were randomized to receive either lotilaner flavoured chewable tablets at as close as possible to, but not less than the minimum dose rate of 20 mg/kg, or to be sham-treated controls. Study 1 assessed lotilaner efficacy against concurrent infestations with 50 (± 6) Rhipicephalus sanguineus and 70 (± 6) Ixodes ricinus; Study 2 infestations were with 50 (± 2) Dermacentor reticulatus. Infestations were performed on Day -2 with counts on Day 2, 48 (± 2) hours post-treatment. Post-treatment infestations were performed on Days 7, 14, 21, 28 and 35, and ticks were counted 48 (±2) hours post-infestations. Efficacy was determined by the percent reduction in mean live tick counts. Results: Control group infestations for each tick species were adequate for assessing lotilaner efficacy at all assessment times. On Day 2 no live ticks were found on any lotilaner-treated dog. For subsequent counts, in Study 1 lotilaner was 100% effective in eliminating live I. ricinus and R. sanguineus on all but two occasions for each tick; on each of those occasions efficacy was sustained at greater than 98.0%. In Study 2, except for a single unattached live tick found on Day 16, efficacy against D. reticulatus was 100% at every post-treatment assessment. Conclusion: The high and sustained efficacy against the three common species of ticks in Europe, R. sanguineus, I. ricinus and D. reticulatus, demonstrates that lotilaner can be a valuable tool in the treatment of canine tick infestations. Lotilaner flavoured chewable tablets were well tolerated and effectiveness was sustained through at least 35 days. [ABSTRACT FROM AUTHOR]

Background: Dogs worldwide are at risk of Babesia spp. infections. Preventive efficacy of lotilaner tablets (Credelio™, Elanco) against Babesia canis was evaluated in two studies. Methods: Sixteen dogs in Study 1 and 12 dogs in Study 2, all seronegative and polymerase chain reaction (PCR) negative for B. canis, were randomized to a sham-treated control group or a lotilaner (20-43 mg/kg) treatment group, administered on Day 0 (Study 1: n = 8/group; Study 2: n = 6/group). Dogs were each infested with 50 Dermacentor reticulatus, a percentage of which (Study 1: 8.0-30.0%; Study 2: 12.2%) were infected with B. canis, in Study 1 on Days 2, 7, 14, 21 and 28, and in Study 2 on Day 28. Ticks were removed and counted on Day 30 in Study 1, and Day 34 in Study 2. Blood was collected for Babesia detection via smear, PCR and immunofluorescence assay (IFA) in Study 1 on Day 2, then approximately weekly through Day 56, and in Study 2 at weekly intervals between Days 28 to 49, and on Days 63 and 91. Additional samples were collected from dogs with body temperature > 39.4 °C (measured three times weekly, from Days 7 to 56 in Study 1 and from Days 35 to 56 in Study 2) and positive for B. canis on blood smear. Dogs with confirmed infections were rescue-treated, removed from the study and, in Study 1, replaced. Results: Across both studies B. canis infection of ticks ranged between 8.0-30.0%. In Study 1, all control dogs were positive for B. canis on blood smear and PCR on Day 10 and IFA on Day 21; on Day 21 seven of eight replacement control dogs were B. canis-positive; no replacement dogs were B. canis-positive following tick removal on Day 30. In Study 2, all control dogs were B. canis-positive on Day 56. All lotilaner-treated dogs remained B. canis-negative at all assessments in both studies. Conclusion: Lotilaner efficacy was 100% in preventing establishment of B. canis infection, despite post-treatment challenge with infected ticks on Days 2, 7, 14, 21 and 28. [ABSTRACT FROM AUTHOR]

Background: Lotilaner (Credelio™) is the newest member of the novel isoxazoline chemical class to be developed to treat canine ectoparasitism. Administered orally, lotilaner is rapidly absorbed with peak blood levels occurring within 2 h post-treatment. A study was undertaken to determine the earliest onset of lotilaner's efficacy against existing flea infestations. Methods: From 72 Beagles, 64 qualifying dogs were ranked in descending order of flea counts from a Day -8 infestation and placed into eight blocks. Within blocks, eight dogs were randomly allocated among eight groups: Groups 1 to 4 were treated orally with lotilaner, at as close as possible to the minimum dose rate of 20 mg/kg within 30 (± 5) minutes after feeding; Groups 5 to 8 were untreated controls. All dogs were infested with 100 ± 5 fleas on Day -2, and whole-body flea counts were completed at 30 min and one, two and 8 h after treatment. Efficacy calculations were based on arithmetic and geometric means if an adequate infestation (at least six of eight untreated dogs with a flea retention of ≥ 50%) was demonstrated in the equivalent control group. Results: Adequate infestations were established in all control groups. At 30 min and 1 h post-treatment, relative to the matching untreated control group, there were no significant reductions in mean flea counts in lotilaner-treated dogs, although moribund fleas were evident at 1 h post-treatment. At 2 h after treatment, compared with the equivalent control group, the geometric mean flea count reduction in the lotilaner group was 64.0% (t(7) = 2.86, P = 0.0242). At 8 h after treatment, lotilaner efficacy was 99.6%. There were no treatment-related adverse events. Conclusion: This study demonstrates that lotilaner flavored chewable tablets are well tolerated and begin to kill fleas within 2 h of treatment, achieving 99.6% efficacy within 8 h. Lotilaner can therefore be used to quickly alleviate the flea irritation that arises from existing infestations. [ABSTRACT FROM AUTHOR]

Background: With the geographical expansion of tick species and increased recognition of pathogens they transmit, there is a requirement for safe and rapidly effective control measures for dogs. Lotilaner, a novel isoxazoline, is rapidly absorbed following administration of a flavored chewable tablet formulation (Credelio™), providing at least 98% efficacy for at least 1 month following assessments at 48 h post-treatment, and following subsequent challenges. A study was conducted to determine the speed with which lotilaner kills ticks. Methods: From 38 dogs, the 32 with the highest Ixodes ricinus counts from a Day -4 infestation were randomized among four groups: two groups were untreated controls, two received lotilaner tablets at a minimum dose rate of 20 mg/kg. Infestations with I. ricinus were performed on Days -2, 7, 14, 21, 28 and 35. Counts were completed 4 and 8 h post-treatment (Day 0), and 8 and 12 h following subsequent infestations. All live ticks were incubated for 24 h following removal from study dogs. Results: At 4 h post-treatment, there was a 69.8% reduction in geometric mean live tick counts in treated dogs compared to controls. After incubation, the reduction increased to 97.2%. At 8 h after treatment, pre-and post-incubation reductions were 99.2 and 100%, respectively. Following post-treatment challenges, post-incubation efficacy through Day 28 at 8 and 12 h was at least 94.3 and 98.0%, respectively, and was 85.7 and 94.2% at 8 and 12 h after the Day 35 challenge. Mean live tick counts in the lotilaner groups were significantly lower than in the control groups at all assessments through Day 35 at 8 (t(7) ≥ 9, P < 0.0001, Days 0 to 28; (t(7) = 3.54, P ≤ 0.0095, Day 35) and 12 h post-treatment and after subsequent infestations (t(7) ≥ 10, P < 0.0001, all days). There were no treatment-related adverse events. Conclusion: Lotilaner at a minimum dose rate of 20 mg/kg began to kill ticks on dogs within 4 h of treatment and efficacy was 100% within 8 h. Lotilaner sustained a rapid kill of newly infesting I. ricinus through 35 days. By quickly killing ticks that infest dogs, lotilaner has potential to help limit the transmission of tick-borne pathogens. [ABSTRACT FROM AUTHOR]

Background: Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelio™, Elanco) administered orally to dogs, produces rapid flea and tick knockdown and sustained speed of kill for at least a month posttreatment with a wide safety margin. A field study was undertaken to validate pre-clinical results. Methods: Dogs were enrolled at 10 veterinary clinics across the United States. Qualifying households containing up to three dogs and one primary dog with at least 10 fleas were randomized 2:1 to receive lotilaner (Credelio™, Elanco) at the recommended minimum dose of 20 mg/kg, or afoxolaner (Nexgard®, Merial), administered per label, to give a minimum dose of 2.5 mg/kg. Treatments were dispensed on Days 0, 30 and 60 for administration by owners; all household dogs received the same treatment as the primary dog. Post-enrollment flea and tick counts were made on primary dogs on Days 30, 60 and 90, and all dogs were assessed for tablet palatability and safety. Results: For efficacy assessments, data were used from 111 lotilaner-treated dogs and 50 afoxolaner-treated dogs; for safety, 197 and 86 dogs, respectively. Percent reductions from baseline in geometric mean flea counts for the lotilaner group were 99.3, 99.9 and 100% on Days 30, 60 and 90, respectively, and for afoxolaner 98.3, 99.8 and 99.8% (P < 0.001, both groups, all days). On Day 90, 100% of lotilaner-treated dogs and 93% of afoxolaner-treated dogs were flea-free. Too few ticks were present to allow assessment. There were no differences in palatability between products (P = 0.2132), with, respectively, 94% and 96% of lotilaner and afoxolaner treatments accepted when offered by hand, in an empty food bowl or with food. Both treatments were well tolerated, alleviating clinical signs of flea allergy dermatitis (FAD) in dogs affected at enrollment. Conclusion: A single owner-administered lotilaner treatment was greater than 99% effective in reducing mean flea counts within 30 days. Three consecutive monthly lotilaner treatments resulted in a 100% reduction in flea infestations, and a substantial reduction in signs of FAD. Lotilaner flavored tablets were readily accepted under field conditions. The absence of treatment-related adverse events confirms the safety of lotilaner in dogs. [ABSTRACT FROM AUTHOR]

Background: Lotilaner (Credelio™, Elanco), a novel isoxazoline, is a systemic insecticide and acaricide that is rapidly absorbed following oral administration to dogs and has a half-life of 30 days. As part of a development program, studies were undertaken to investigate lotilaner's initial and sustained efficacy and speed of kill against fleas. Methods: Four studies were conducted to evaluate the onset of lotilaner's speed of flea knockdown at the time of treatment, and to determine the sustained speed of flea kill (SOK) up to 35 days post-treatment. Each study assessed one or two specific time points (4, 6, 8 and 12 h) post-treatment and following weekly re-infestations. In each study, dogs were randomised to a lotilaner or an untreated group based on pre-administration flea counts, and before treatment were infested with adult Ctenocephalides felis. Dogs randomised to a lotilaner group received a single treatment on Day 0, at the minimum recommended dose rate of 20 mg/kg, 30 (± 5) minutes after being fed. Efficacy was calculated using geometric, and arithmetic mean flea counts in treated versus untreated groups. Results: On Day 0, lotilaner efficacy was 89.9% at 4 h, 99.2% at 6 h, 99.9% at 8 h, and 100% at 12 h post-treatment. At each weekly assessment, lotilaner efficacy at 4 h remained at > 97%, at 8 h remained at > 99%, and at 12 h remained at 100% through Day 35. Across all studies, there were no treatment-related adverse events. Conclusion: Lotilaner's rapid flea knockdown immediately following treatment and sustained SOK through 35 days post-treatment offers a new solution for helping to eliminate the health risks that accompany flea infestations on dogs. The consistency of the rapid, sustained flea SOK demonstrated in these studies generates confidence that monthly use of lotilaner in dogs can be valuable in disrupting the flea life cycle in a contaminated environment, and that newly acquired fleas will die quickly, thereby reducing the discomfort of flea bites. The sustained lotilaner SOK also provides confidence that there will be no "end-of-dose" resurgence in flea burdens with the potential accompanying consequence of flares in flea-bite hypersensitivity. [ABSTRACT FROM AUTHOR]

Russia’s use of hybrid warfare techniques has raised concerns about the security of the Baltic States. Gary Schaub, Jr, Martin Murphy and Frank G Hoffman recommend a series of measures to augment NATO’s Readiness Action Plan in the Baltic region, including increasing the breadth and depth of naval exercises, and improving maritime domain awareness through cooperative programmes. They also suggest unilateral and cooperative measures to develop a sound strategic communications strategy to counter Moscow’s information operations, reduce dependence on Russian energy supplies and build the resilience of critical undersea and maritime infrastructure. Finally, the article proposes that more attention be devoted to resolving unsettled maritime boundaries between Latvia and Lithuania, and between Denmark and Poland, to reduce the chance that these can be exploited to increase regional instability as part of a larger hybrid campaign. [ABSTRACT FROM AUTHOR]

Background/Study Context: This study examined the potential impact of self-reported depressive symptoms on the age-related capacity for inhibition and suppression, utilizing a negative priming paradigm. Methods: One hundred eighty-five community-residing adults varying in age (98 younger adults, Mage = 22; 87 older adults, Mage = 69) completed a nonconscious priming task, the Geriatric Depression Scale (GDS), the White Bear Suppression Inventory (WBSI), the Depression Sensitivity Scale (DSS), a free thought suppression task, as well as several measures indexing overall cognitive ability and psychomotor speed. Hierarchical regressions investigated the interaction of depressive symptoms with age and its effect on both positive and negative priming performance, indexing both facilitation and inhibition effects, respectively. Results: Results support the hypothesis that noncognitive factors affect effortful performance among older adults, although this influence varied with the specific component of the GDS, i.e., Dysphoria, Social Withdrawal, and Cognitive Control, and with the measure of depressive symptoms, i.e., GDS versus DSS. Conclusion: These data suggest that aging's impact on both facilitation and inhibition, e.g., positive and negative priming, are to an extent, a function of individual differences in depressive symptoms that interact with age in influencing the necessity to reallocate one's cognitive resources to deal with depressive thoughts and feelings. [ABSTRACT FROM AUTHOR]

Temporal and spatial distributions of the North American monsoon have been studied previously with rainfall and satellite data. In the current study, the monsoon is examined with lightning data from Vaisala's Global Lightning Dataset (GLD360). GLD360 has been operating for over three years and provides sufficient data to develop an exploratory climatology with minimal spatial variation in detection efficiency and location accuracy across the North American monsoon region. About 80% of strokes detected by GLD360 are cloud to ground. This paper focuses on seasonal, monthly, and diurnal features of lightning occurrence during the monsoon season from Mazatlán north-northwest to northern Arizona and New Mexico. The goal is to describe thunderstorm frequency with a dataset that provides uniform spatial coverage at a resolution of 2-5 km and uniform temporal coverage with individual lightning events resolved to the millisecond, compared with prior studies that used hourly point rainfall or satellite data with a resolution of several kilometers. The monthly lightning stroke density over northwestern Mexico increases between May and June, as thunderstorms begin over the high terrain east of the Gulf of California. The monthly lightning stroke density over the entire region increases dramatically to a maximum in July and August. The highest stroke densities observed in Mexico approach those observed by GLD360 in subtropical and tropical regions in Africa, Central and South America, and Southeast Asia. The diurnal cycle of lightning exhibits a maximum over the highest terrain near noon, associated with daytime solar heating, a maximum near midnight along the southern coast of the Gulf, and a gradual decay toward sunrise. [ABSTRACT FROM AUTHOR]

Historically only shallow basements were included in developments in Cork city owing to the underlying layers of soft alluvium and high-permeability glaciofluvial gravels. In recent times several large schemes, with basements up to 10 m deep, have been completed. In this paper the design and performance of these developments is summarized. Particular emphasis is placed on two schemes at Eglinton St. and Half Moon St. Although dewatering by deep well systems is feasible, flow rates can be substantial. Careful consideration needs to be given to the site-specific properties of the glaciofluvial gravels to permit the level of the cut-off to be efficiently chosen so as to minimize inflows and external groundwater lowering and to mitigate against the possible risk of surface settlements. A 'soft gel' grout blanket was used successfully as an alternative at one site. Lateral wall movements were low and it seems possible that more efficient designs are possible, especially if the small strain stiffness and dilation properties of the material are taken into account. [ABSTRACT FROM AUTHOR]

Abstract: Ground‐based and satellite‐based lightning locating systems are the most common ways to detect and geolocate lightning. Depending upon the frequency range of operation, LLSs may report a variety of processes and characteristics associated with lightning flashes including channel formation, leader pulses, cloud‐to‐ground return strokes, M‐components, ICC pulses, cloud lightning pulses, location, duration, peak current, peak radiated power and energy, and full spatial extent of channels. Lightning data from different types of LLSs often provide complementary information about thunderstorms. For all the applications of lightning data, it is critical to understand the information that is provided by various lightning locating systems in order to interpret it correctly and make the best use of it. In this study, we summarize the various methods to geolocate lightning, both ground‐based and satellite‐based, and discuss the characteristics of lightning data available from various sources. The performance characteristics of lightning locating systems are determined by their ability to geolocate lightning events accurately with high detection efficiency and with low false detections and report various features of lightning correctly. Different methods or a combination of methods may be used to validate the performance characteristics of different types of lightning locating systems. We examine these methods and their applicability in validating the performance characteristics of different LLS types. [ABSTRACT FROM AUTHOR]

With the economic rise of powers such as China that wish to reinterpret the global order underpinning trade and international law, there is renewed requirement for Western navies to think about how maritime power can contribute to the protection of commerce in the twenty-first century. In this article, Martin N Murphy explores the intersection that is now evident between economic, financial and maritime warfare, assessing how maritime power can once again be used in the exploitation of economic and financial weakness. [ABSTRACT FROM AUTHOR]

Historically only shallow basements were included in developments in Cork city owing to the underlying layers of soft alluvium and high-permeability glaciofluvial gravels. In recent times several large schemes, with basements up to 10 m deep, have been completed. In this paper the design and performance of these developments is summarized. Particular emphasis is placed on two schemes at Eglinton St. and Half Moon St. Although dewatering by deep well systems is feasible, flow rates can be substantial. Careful consideration needs to be given to the site-specific properties of the glaciofluvial gravels to permit the level of the cut-off to be efficiently chosen so as to minimize inflows and external groundwater lowering and to mitigate against the possible risk of surface settlements. A 'soft gel' grout blanket was used successfully as an alternative at one site. Lateral wall movements were low and it seems possible that more efficient designs are possible, especially if the small strain stiffness and dilation properties of the material are taken into account. [ABSTRACT FROM AUTHOR]

A literary criticism of the book "The Joy of the Gospel: Evangelii Gaudium" by Pope Francis is presented. It outlines the fundamental issues for the future of humanity such as the inclusion of the poor in community and peace and social dialogue. It analyzes the preferential option of the Catholic Church for the poor. An overview of the Church teaching and Scripture, is also given.

To all faithful Christians who shall read the present patent, Hugh, by divine providence Abbot of the monastery of Reading, and its community, eternal salvation in the Lord. Be it known that we the aforesaid abbot and community by unanimous assent and agreement do give grant and confirm to our beloved in Christ Leonard Cox our grammar school of Reading including the little lane adjoining it on the east side. We also grant and give and by these present confirm to the same Leonard an annual salary or annuity of ten pounds sterling to be taken annually from and in our lands and estates in the county of Berkshire every quarter in equal portions, viz. at the feasts of the Lord's Nativity, the Annunciation of the Blessed Virgin Mary, the birthday of Saint John the Baptist, and St Michael the Archangel, together with daily provision of food and drink for the said Leonard at my table and that of my successors as often as he shall come within the monastery itself, unless there is reason to the contrary, and otherwise at the table of the Prior. This our grammar school and adjacent lane and annual salary or annuity of ten pounds together with food and drink to be had held and enjoyed by the same Leonard Cox until the end of his life on condition that the same Leonard should himself personally govern, direct and regulate the said school, and give careful instruction in grammar and poetry to the youths foregathered there and by good example bring them up in devout and orthodox observance of the catholic religion, and take vigilant care to instruct and advance them in the humanities to the best of his ability or knowledge. [ABSTRACT FROM AUTHOR]

The European Cancer Concord is a unique patient‐centered partnership that will act as a catalyst to achieve improved access to an optimal standard of cancer care and research for European citizens. In order to provide tangible benefits for European cancer patients, the partnership proposes the creation of a “European Cancer Patient's Bill of Rights,” a patient charter that will underpin equitable access to an optimal standard of care for Europe's citizens. [ABSTRACT FROM AUTHOR]

An essay is presented which explores the history and development of the North African Barbary Pirates. Topics discussed include the contribution of tribute and ransom from European shipping to the survival of the Barbary Pirates, the condition of Barbary states under the Ottomans, and the collapse of the system. Also mentioned is information on the impact of Arab nationalism on the stabilization of North Africa.

Maritime violence perpetrated by non-state actors is a feature of the Indian Ocean. This includes the piracy, which has occurred most prominently off Somalia but also in the waters of Bangladesh, India and Indonesia, and terrorism perpetrated by al-Qaeda, the Tamil separatist movement in Sri Lanka, the Liberation Tigers of Tamil Eelam (LTTE), and the Pakistani Islamist group Lashkar-e-Taiba (LeT) against the Indian city of Mumbai. This paper aims to chart why opportunities for non-state actors to use violence to advance their interests may continue across the region. [ABSTRACT FROM PUBLISHER]

The extended Kalman filter (EKF) can be used for the purpose of training nonlinear neural networks to perform desired input–output mappings. To improve the computational requirements of the EKF, Puskorius proposed the decoupled EKF (DEKF) as a practical remedy for the proper management of computational resources. This approach, however, sacrifices computational accuracy of estimates because it ignores the interactions between the estimates of mutually exclusive weights. To overcome such a limitation, therefore, we proposed hybrid implementation based on EKF (HEKF) for respiratory motion estimation, which uses the channel number for the mutually exclusive groups and the coupling technique to compensate the computational accuracy. Moreover, the authors restricted to a DEKF algorithm in which the weights connecting the inputs to a node are grouped together. If there are multiple input training sequences with respect to the time stamp, the complexity can increase by the power of the input channel number. To improve the computational complexity, we split the complicated neural network into a couple of simple neural networks to adjust separate input channels. The experimental results validated that the prediction overshoot of the proposed HEKF was improved by 62.95% in the average prediction overshoot values. The proposed HEKF showed a better performance of 52.40% improvement in the average of the prediction time horizon. We have evaluated that the proposed HEKF can outperform DEKF by comparing the prediction overshoot values, the performance of the tracking estimation value, and the normalized root-mean-squared error. [ABSTRACT FROM PUBLISHER]

This article identifies the salient lessons from three specific periods--the Graeco-Roman, Atlantic piracy and its extension into the Indian Ocean during the early Seventeenth Century, and piracy off China during the Ch' ing dynasty--that can most usefully inform the counter-piracy effort off Somalia. It makes the point that piracy's sinuous character has always given rise to conceptual and definitional difficulties; but that while law has had an important voice in piracy matters since Roman times it has never been the only voice. It suggests that modern pirate hunters, by treating piracy as akin to a domestic criminal activity, have shackled the effectiveness of violent suppression which their historical predecessors found so useful, while at the same time undervaluing the fundamental roles of politics and economics in piracy formation and the continuous struggle to make the seas safe for legitimate commerce. [ABSTRACT FROM AUTHOR]

While there are some non-contentious issues about which states can cooperate, most must be molded around the demands of national interest. Piracy is a case where suppression would appear to be in the interest of all states; after all, pirates have been regarded as the enemies of all since Roman times. Despite this, states have often been more ambivalent as they have found piracy to be a useful cloak behind which to hide their wider geo-strategic ambitions. This paper notes that Somali piracy has attracted the interest of China whose citizens have been attacked and hijacked. It asks if this deployment demonstrates that China is committed to the protection of shipping in the context of the existing maritime order or if it has a wider purpose to advance Chinese interests in the Indian Ocean region. [ABSTRACT FROM AUTHOR]

Purpose: To develop a statistical sampling procedure for spatially-correlated uncertainties in deformable image registration and then use it to demonstrate their effect on daily dose mapping. Methods: Sequential daily CT studies are acquired to map anatomical variations prior to fractionated external beam radiotherapy. The CTs are deformably registered to the planning CT to obtain displacement vector fields (DVFs). The DVFs are used to accumulate the dose delivered each day onto the planning CT. Each DVF has spatially-correlated uncertainties associated with it. Principal components analysis (PCA) is applied to measured DVF error maps to produce decorrelated principal component modes of the errors. The modes are sampled independently and reconstructed to produce synthetic registration error maps. The synthetic error maps are convolved with dose mapped via deformable registration to model the resulting uncertainty in the dose mapping. The results are compared to the dose mapping uncertainty that would result from uncorrelated DVF errors that vary randomly from voxel to voxel. Results: The error sampling method is shown to produce synthetic DVF error maps that are statistically indistinguishable from the observed error maps. Spatially-correlated DVF uncertainties modeled by our procedure produce patterns of dose mapping error that are different from that due to randomly distributed uncertainties. Conclusions: Deformable image registration uncertainties have complex spatial distributions. The authors have developed and tested a method to decorrelate the spatial uncertainties and make statistical samples of highly correlated error maps. The sample error maps can be used to investigate the effect of DVF uncertainties on daily dose mapping via deformable image registration. An initial demonstration of this methodology shows that dose mapping uncertainties can be sensitive to spatial patterns in the DVF uncertainties. [ABSTRACT FROM AUTHOR]