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Background: Dietary and oral hygiene habits among integrated migrant cultural minorities can vary and could impact susceptibility to caries. Aim: This study aimed to assess and compare the oral health status of Tibetan schoolchildren living in the Tibetan settlement of Bylakuppe, India, stratified by type of residence. Design: A descriptive cross‐sectional study was conducted among Tibetan schoolchildren attending nine schools in the Bylakuppe region. Results: The study population consisted of 916 children aged 5–17: 702 (76.6%) living in secular houses (LSH) and 214 (23.4%) living in monasteries (LM). The prevalence of dental caries was 70.9%, and the mean value of decayed, missing, filled teeth for mixed and primary dentition (DMFT*; dmft) of LSH children (1.56 ± 2.34/1.74 ± 2.66) was higher than of LM ones (1.14 ± 2.34/0.83 ± 2.80; p <.001). DMFT for LM children (1.46 ± 2.04) was slightly higher than for LSH children (1.38 ± 1.96; p >.05). Among the sample, 99.1% had a good simplified Oral Hygiene Index (OHI) and LM children showed higher rates of good values (99.5% vs. 98.2% in LSH children). Most children needed preventive/routine dental treatment, whereas 16.6% needed urgent dental treatment. In 4.5% of children, oral mucosal lesions were present. Conclusion: This study confirms the high need for dental treatment in the children of the Tibetan settlement investigated. [ABSTRACT FROM AUTHOR]

Vibration measurements pose specific experimental challenges to be faced. In particular, optical methods can be used to obtain full-field vibration information. In this scenario, stereo-camera systems can be developed to obtain 3D displacement measurements. As vibration frequency increases, the common approach is to reduce camera exposure time to avoid blurred images, which can lead to under-exposed images and data loss, as well as issues with the synchronization of the stereo pair. Both of these problems can be solved by using high-intensity light pulses, which can produce high-quality images and guarantee camera synchronization since data is saved by both cameras only during the short-time light pulse. To this extent, high-power Light-Emitting Diodes (LEDs) can be used, but even if the LED itself can have a fast response time, specific electronic drivers are needed to ensure the desired timing of the light pulse. In this paper, a circuit is specifically designed to achieve high-intensity short-time light pulses in the range of 1 µs. A prototype of the designed board was assembled and tested to check its capability to respect the specification. Three different measurement methods are proposed and validated to achieve short-time light pulse measurements: shunt voltage measurement, direct photodiode measurement with a low-cost sensor, and indirect pulse measurement through a low-frame-rate digital camera. [ABSTRACT FROM AUTHOR]

The positive effects of meditation on human wellbeing are indisputable, ranging from emotion regulation improvement to stress reduction and present-moment awareness enhancement. Changes in brain activity regulate and support these phenomena. However, the heterogeneity of meditation practices and their cultural background, as well as their poor categorization limit the generalization of results to all types of meditation. Here, we took advantage of a collaboration with the very singular and precious community of the Monks and Geshes of the Tibetan University of Sera-Jey in India to study the neural correlates of the two main types of meditation recognized in Tibetan Buddhism, namely concentrative and analytical meditation. Twenty-three meditators with different levels of expertise underwent to an ecological (i.e., within the monastery) EEG acquisition consisting of an analytical and/or concentrative meditation session at "their best," and with the only constraint of performing a 5-min-long baseline at the beginning of the session. Time-varying power-spectral-density estimates of each session were compared against the baseline (i.e., within session) and between conditions (i.e., analytical vs. concentrative). Our results showed that concentrative meditation elicited more numerous and marked changes in the EEG power compared to analytical meditation, and mainly in the form of an increase in the theta, alpha and beta frequency ranges. Moreover, the full immersion in the Monastery life allowed to share the results and discuss their interpretation with the best scholars of the Monastic University, ensuring the identification of the most expert meditators, as well as to highlight better the differences between the different types of meditation practiced by each of them. [ABSTRACT FROM AUTHOR]

Food supplements should not contain substances considered unsafe or pose a health risk to consumers. In recent years illegal adulterants have been found in various functional foods without notification of their presence or amount in the labelling. In this study, a validated method was developed and applied as a screening method to detect 124 forbidden substances belonging to 13 classes of compounds in food supplements. Liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) and a simple and rapid extraction protocol was applied to 110 food supplements collected from the internet market or during official controls in Italy. The percentage of non-compliant samples was 4.5%, relatively high compared with the official control results for these substances usually obtained on other food matrices. The results suggested the need to strengthen controls in this field to detect food supplement adulteration, which represents a potential health risk for the consumer. [ABSTRACT FROM AUTHOR]

A new, simple and sensitive method for determining and confirming methylene blue and its analogues such as azure A, azure B, azure C, thionine, and new methylene blue in fish muscles have been developed. The method is based on acetonitrile extraction followed by extract purification using dispersive solid-phase extraction (dSPE) with basic aluminium oxide (ALN) and solid-phase extraction (SPE) using primary and secondary amines (PSA) sorbent in matrix adsorption mode. The separation and detection of the dyes in the fish extract are achieved within 5 min by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) using an octadecyl analytical column with a mixture of acetonitrile, methanol and 0.1% formic acid as a mobile phase in gradient elution. The developed method has been in-house validated according to European law. The method recovery for fish muscle was 98.3–103.1%, whereas the decision limit (CCα) was from 0.45 to 0.49 µg kg−1. [ABSTRACT FROM AUTHOR]

This study reports the data of polychlorinated dibenzo-p-dioxins (PCDDs), -furans (PCDFs), and polychlorinated biphenyls dioxin-like (dl PCBs) measured in a total of 260 samples of the dairy supply chain collected over a period of 7 years (2011–2017) in the Latium region (Italy). Levels and average profiles of congeners were reported for each group of the analyzed dairy matrices, and any differences between different sampling strategies were considered (around likely pollutant sources or casual sampling). Of the samples, 95.4% resulted compliant with the regulated levels; only samples belonging to the "sheep bulk milk" matrix were found to be above either the action levels or the maximum levels (tot. 12 samples). Raw milk of the sheep species showed the highest averages (PCDD/F 0.248 and dl PCB 0.966 WHO TEQ pg/g of fat) compared to the milk of other species. The buffalo milk showed a content of dl PCB significantly lower (dl PCB: 0.371 WHO TEQ pg/g of fat) than the sheep milk (p<0.05). Dioxins were found to be superior to furans in almost all dairy products, except in the noncompliant samples where furans were higher. The OCDD was found to be the most abundant congener in almost all dairy products. This study provides a first list of reference values for background contamination of the dairy supply chain in the Latium region. These pre-existing values will be useful in all cases of environmental pollution to identify critical situations. [ABSTRACT FROM AUTHOR]

Ochratoxin A (OTA) is a mycotoxin produced by several species of Aspergillus and Penicillium and commonly detected in a wide range of foodstuffs. The purpose of this work was to monitor the presence of OTA in cheeses and pork meat products. A simple and accurate "dilute and shoot" method with no need of immunoaffinity column and isotopic labeled internal standard, by liquid chromatography–tandem mass spectrometry, was validated in accordance with the criteria set out in Commission Regulation (EC) No. 401/2006. The method showed good linearity in solvent and in matrix (R2 ≥ 0.995), limit of detection was 0.2 µg/kg for cheese and 0.3 µg/kg for pork meat products, limit of quantification was fixed at 1 µg/kg, and recovery was estimated at two different concentration levels (1 and 5 µg/kg) and ranged from 75% to 101%. The interday and intraday laboratory precisions were lower than 7%. The matrix effect, the recovery of the extraction process, and the overall process efficiency were evaluated. No significant ME was observed in the two matrices considered. This method was applied to the analysis of 75 samples, coming from official controls implemented by the Lazio Region (Central Italy). In one sample of dry‐cured ham, the concentration found (69.3 µg/kg) was well above the guidance value recommended by the Italian Ministry of Health (1 µg/kg). These data together with the detection of OTA in three grated cheeses suggest the importance of monitoring these products. Considering the high dietary intake of these matrices, especially among vulnerable populations, further research should be devoted to estimate exposure and risk assessment for OTA. [ABSTRACT FROM AUTHOR]

Polycyclic aromatic hydrocarbons (PAHs) and mercury were investigated in smoked catfish illegally sold and confiscated by Italian authorities in Turin (North-western Italy). The mean benzo(a)pyrene (BaP) concentration was 73 ± 11 μg kg−1 and the total mean PAH concentration (ΣPAH) was 243 ± 38 μg kg−1, both exceeding the EU maximum limits (2.0 and 12 μg/kg) set in muscle of smoked fish and fishery products. Mercury was recovered at 0.59 ± 0.09 mg kg−1 d.w. Poor smoking treatment performed in street food by ethnic minorities can expose these groups of population to serious health risks. PAH food contamination poses particular concern for the populations who traditionally consume these products, such as African communities. There is an urgent need to take appropriate action and raise awareness of risk among exposed population. [ABSTRACT FROM AUTHOR]

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The purpose of the present work is to introduce two-parameter criteria for unconditional instability and for special cases of conditional stability, which can be particularly interesting for the design of two and three port oscillators. The criteria involve the two-port stability factor ${K}$ , as was to be expected, and have analogies with the well-known ones for unconditional stability. The mutual relationships existing between the Input and the Output Stability Area, demonstrated in a previous paper, will be used to construct a complete table in which to each of the possible reciprocal positions between stability areas and unit circle, an algebraic criterion corresponds, consisting in the calculation of two simple parameters. Also, limit cases will be analyzed. [ABSTRACT FROM AUTHOR]

Rationale: Carry‐over is an undesirable contamination from medicated to non‐medicated during the production of feedingstuffs. In 2014 the European Parliament and the Council started working to produce a new regulatory act that will fix tolerable levels of drugs by carry‐over in non‐target feed to have a harmonized practice to evaluate this contamination by veterinary drugs. Methods: We developed a rapid and effective multi‐analyte method coupling ultraperformance liquid chromatography to tandem mass spectrometry (UPLC/MS/MS) for the detection of 37 drugs belonging to different classes of antimicrobials (sulfonamides, tetracyclines, macrolides, quinolones, pleuromutilins and streptogramins) in feeds at carry‐over levels. The method was in‐house validated in the concentration range 0.25–2.0 mg kg−1, according to the Regulation (UE) 2017/625 requirements and the guideline included in the Commission Decision 2002/657/EC for official methods. Results: The UPLC/MS/MS method allows the determination of the antimicrobials in 15 min, by providing results compliant to the criteria established by the European Commission legislation. All the analytes showed a limit of detection (LOD) in the range 2.0–5.0 μg kg−1 and a limit of quantification (LOQ) at 10.0 μg kg−1; oxytetracycline, doxycycline, spiramycin and virginiamycin have a higher LOD and LOQ (15.0 μg kg−1; 30.0 μg kg−1, respectively). Recoveries were satisfactory ranging from 90.4% to 103.1%. Conclusions: The method is characterized by an effective clean‐up of all drugs without the use of large sample size and organic solvent extraction. [ABSTRACT FROM AUTHOR]

Background: The psycho-physiological changes in brain-body interaction observed in most of meditative and relaxing practices rely on voluntary slowing down of breath frequency. However, the identification of mechanisms linking breath control to its psychophysiological effects is still under debate. This systematic review is aimed at unveiling psychophysiological mechanisms underlying slow breathing techniques (<10 breaths/minute) and their effects on healthy subjects. Methods: A systematic search of MEDLINE and SCOPUS databases, using keywords related to both breathing techniques and to their psychophysiological outcomes, focusing on cardio-respiratory and central nervous system, has been conducted. From a pool of 2,461 abstracts only 15 articles met eligibility criteria and were included in the review. The present systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: The main effects of slow breathing techniques cover autonomic and central nervous systems activities as well as the psychological status. Slow breathing techniques promote autonomic changes increasing Heart Rate Variability and Respiratory Sinus Arrhythmia paralleled by Central Nervous System (CNS) activity modifications. EEG studies show an increase in alpha and a decrease in theta power. Anatomically, the only available fMRI study highlights increased activity in cortical (e.g., prefrontal, motor, and parietal cortices) and subcortical (e.g., pons, thalamus, sub-parabrachial nucleus, periaqueductal gray, and hypothalamus) structures. Psychological/behavioral outputs related to the abovementioned changes are increased comfort, relaxation, pleasantness, vigor and alertness, and reduced symptoms of arousal, anxiety, depression, anger, and confusion. Conclusions: Slow breathing techniques act enhancing autonomic, cerebral and psychological flexibility in a scenario of mutual interactions: we found evidence of links between parasympathetic activity (increased HRV and LF power), CNS activities (increased EEG alpha power and decreased EEG theta power) related to emotional control and psychological well-being in healthy subjects. Our hypothesis considers two different mechanisms for explaining psychophysiological changes induced by voluntary control of slow breathing: one is related to a voluntary regulation of internal bodily states (enteroception), the other is associated to the role of mechanoceptors within the nasal vault in translating slow breathing in a modulation of olfactory bulb activity, which in turn tunes the activity of the entire cortical mantle. [ABSTRACT FROM AUTHOR]

Abstract: A quick and reproducible screening analytical method for the simultaneous determination of algal toxins, belonging to different chemical classes, was developed to provide a toxin profile in seawater, useful to assess potential risks to environment and human health. The target compounds were: gonyautoxin-1,4, gonyautoxin-2,3, decarbamoylgonyautoxin-2,3, N‐sulfocarbamoyl-gonyautoxin-1,2, neosaxitoxin, decarbamoyl-neosaxitoxin, saxitoxin, decarbamoyl-saxitoxin, domoic acid, 13-desmethyl spirolide C (SPX1), palytoxin and okadaic acid. Extraction and clean-up were carried out with a combination of Bond Elut LRC-C18 and Carbograph4 cartridges connected in series. Analyte separation was performed in gradient elution mode in 12 min with a Gemini C18 column. Compound detection was carried out in multiple reaction monitoring and in positive ionization mode for paralytic shellfish poisoning toxins, domoic acid, SPX1 and palytoxin, and in negative ionization mode for okadaic acid. The toxins were quantified with matrix-matched calibration curves constructed by spiked seawater samples (concentration levels 0.02–2 μg L−1 depending on the compound). The method was reproducible with intra-day and inter-day relative standard deviations ranging from 4 to 9% and from 8 to 16%, respectively. Good recoveries (84–105%) and good accuracy (2–20%) were obtained by spiking experiments. Limits of detection were calculated for each toxin and varied from 0.011 to 0.12 μg L−1 depending on the compound. The developed method was applied to cultured Ostreopsis cf. ovata samples. The proposed procedure may be considered a valuable alternative to existing methods for monitoring toxic microalgae, since it offers a rapid screening of target toxins, reduced organic solvent consumption, and handling of smaller sample volumes while providing good sensitivity and accuracy.Graphical Abstract: [ABSTRACT FROM AUTHOR]

This paper presents a design exploration, at both system and circuit levels, of integrated transceivers for the upcoming fifth generation (5G) of wireless communications. First, a system level model for 5G communications is carried out to derive transceiver design specifications. Being 5G still in pre-standardization phase, a few currently used standards (ECMA-387, IEEE 802.15.3c, and LTE-A) are taken into account as the reference for the signal format. Following a top-down flow, this work presents the design in 65nm CMOS SOI and bulk technologies of the key blocks of a fully integrated transceiver: low noise amplifier (LNA), power amplifier (PA) and on-chip antenna. Different circuit topologies are presented and compared allowing for different trade-offs between gain, power consumption, noise figure, output power, linearity, integration cost and link performance. The best configuration of antenna and LNA co-design results in a peak gain higher than 27dB, a noise figure below 5dB and a power consumption of 35mW. A linear PA design is presented to face the high Peak to Average Power Ratio (PAPR) of multi-carrier transmissions envisaged for 5G, featuring a 1dB compression point output power (OP1dB) of 8.2dBm. The delivered output power in the linear region can be increased up to 13.2dBm by combining four basic PA blocks through a Wilkinson power combiner/divider circuit. The proposed circuits are shown to enable future 5G connections, operating in a mm-wave spectrum range (spanning 9GHz, from 57GHz to 66GHz), with a data-rate of several Gb/s in a short-range scenario, spanning from few centimeters to tens of meters. [ABSTRACT FROM AUTHOR]

The design and test of a radio detection and ranging (Radar) sensor signal acquisition and processing platform is presented in this paper. The Radar sensor operates in real time and is suited for surveillance applications in transport systems. It includes a front-end with a continuous-wave frequency-modulated transceiver operating in X-band, with a single transmitter and multiple receivers, and a multichannel high-speed A/D converter. Sensor signal processing and data communication tasks with external hosts are managed by a field-programmable gate array. The signal processing chain includes region of interest selection, multidimensional fast Fourier transform, peak detection, alarm decision logic, data calibration, and diagnostic. By configuring the Radar sensing platform in low-power mode (7-dBm transmitted power), it is possible to detect still and moving targets with a covered range up to 300-m and 30-cm resolution. The measuring range can be increased up to 2 km by adding an extra 34.5-dBm power amplifier. The Radar sensing platform can be configured for a maximum detected speed of 200 km/h, with a resolution of 1.56 km/h, or a speed up to 50 km/h with a resolution of 0.4 km/h. The cross-range resolution depends on the number of receiving channels; a tradeoff can be found between cross-range resolution of the Radar sensor and its complexity and power consumption. With respect to the state of the art of surveillance Radar sensors and light detection and ranging, the proposed solution stands for its high configurability and for the better tradeoff that can be found in terms of covered distance and power consumption. [ABSTRACT FROM AUTHOR]

Hens’ eggs collected in home-producing farms located in different areas of the Campania region of southern Italy were analysed for six NDL-polychlorobiphenyls (PCB indicators), 17 polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs), and 12 congeners of dioxin-like PCBs (DL-PCBs). In the investigated area, waste from civil, industrial and hospital activities was illegally dumped and in many cases burned, so the area is called the ‘Land of fire’. This illicit practice has been considered the main source of pollution in this territory and the cause of the persistent organic pollutants’ (POPs) contamination in the neighbouring lands intended for agricultural use and livestock. The results, which were obtained from the analysis of 56 samples of eggs, showed levels of contamination by dioxins and PCBs that have often exceeded the action levels set by European Union Recommendation 711/2013 and sometimes even exceeded the maximum levels set by Commission Regulation (EU) 1259/2011. The median PCDD/Fs was 0.41 pg TEQ g−1fat (range = 0.01–6.18 pg TEQ g−1fat) and the median concentration of DL-PCBs was 0.70 pg TEQ g−1fat (range = 0.01–14.60 pg TEQ g−1fat), whereas NDL-PCBs median was 7.35 ng g−1fat (range = 0.48–67.55 ng g−1fat). Nevertheless, the estimated weekly intake (EWI) calculated for consumers of eggs home produced in Campania is lower than the tolerable weekly intake (TWI) established by the European Union Scientific Committee on Food (SCF). [ABSTRACT FROM PUBLISHER]

Emerging application scenarios for Cyber Physical Systems often require the networking of sensing and actuation nodes at high data rate and through wireless links. Lot of surveillance and control systems adopt as input sensors distributed video cameras operating at different spectral ranges and covering different fields of view. Arrays of radio/light detection and ranging (Radar/Lidar) sensors are often used to detect the presence of targets, of their speeds, distance and direction. The relevant bandwidth requirement amounts to some Gbps. The wireless connection is essential for easy and flexible deployment of the sensing/actuation nodes. A key technology to keep low the size and weight of the nodes is the fully integration at mm-waves of wireless transceivers sustaining Gbps data rate. To this aim, this paper presents the design of 60 GHz transceiver key blocks (Low Noise Amplifier, Power Amplifier, Antenna) to ensure connection distances up to 10 m and data rate of several Gbps. Around 60 GHz there are freely-available (unlicensed) worldwide several GHz of bandwidth. By using a CMOS Silicon-on-Insulator technology RF, analog and digital baseband circuitry can be integrated single-chip minimizing noise coupling. At mm-wave the wavelength is few mm and hence even the antenna is integrated on chip reducing cost and size vs. off-chip antenna solutions. The proposed transceiver enables at physical layer the implementation in compact nodes of links with data rates of several Gbps and up to 10 m distance; this is suited for home/office scenarios, or on-board vehicles (cars, trains, ships, airplanes) or body area networks for healthcare and wellness. [ABSTRACT FROM AUTHOR]

An effective analytical method for the screening of mycotoxins, in indoor/outdoor airborne particulate matter, was developed and method performance data are presented. Mycotoxins are natural compounds produced, in particular conditions, as secondary metabolites by filamentous fungi and moulds, and, after their production, they can be transported far from their source. To simulate real samples, an urban dust (reference material 1649a) free from mycotoxins was used as matrix and spiked by the most common mycotoxins, chosen on the basis of studies carried out previously in other real matrices: deoxynivalenol, aflatoxin B1, ochratoxin A, T-2 toxin, zearalenone and sterigmatocystin. The analytical method was optimised and structured in four successive steps: (1) accelerated solvent extraction of the (spiked) analytes from matrix, (2) solid-phase purification (SPE) of the previous extract, (3) pre-concentration of the eluates from SPE and (4) analysis of the concentrated eluates by high performance liquid chromatography tandem mass spectrometry in multiple reaction monitoring mode. After a proper sampling campaign, the method was applied to real indoor and outdoor particulate matter samples, where the clean-up step showed to be very effective and fundamental to avoid misleading analytical results. [ABSTRACT FROM AUTHOR]

Simple Summary: The restriction of the use of bisphenol A (BPA) in industrial production has led manufacturers to employ several BPA analogues. The endocrine-disrupting activity of these substitutes has been proven, and some of them are already widespread in the environment. The intake of these endocrine-disrupting chemicals through diet represents a public concern, and food contamination data are still scarce in scientific literature. To investigate the levels of BPA and its analogues in the production chain of buffalo milk, we developed and validated two analytical methods based on UHPLC–MS/MS and HPLC–FLD. The methods were used to analyse feed and feed additives, raw milk, drinking water, and blood serum samples from buffalo farms in the Campania region, Southern Italy. BPA was found to be the most abundant contaminant, proving that the presence of this compound is still significant and should be monitored. Bisphenol A (BPA) and some of its analogues are well known as endocrine-disrupting chemicals (EDCs), i.e., compounds that can affect the physiological hormonal pathways in both animals and humans, causing adverse health effects. The intake of these substances through diet represents a public concern, compounded by the scarce data in the literature about contamination levels in food. In the framework of a research project, funded by the Italian Ministry of Health, we determined the contamination levels of BPA and 19 EDCs in the production chain of buffalo milk, analysing feed, drinking water, buffalo milk, and blood sera. Overall, 201 feed, 9 feed additive, 62 drinking water, 46 milk, and 190 blood serum samples were collected from 10 buffalo farms in the Campania region, Southern Italy, between 2019 and 2020, and analysed. Moreover, 15 retail bovine milk samples packaged both in Tetra Pak and in PET were analysed to further evaluate consumers' exposure to EDCs. The results of our work showed no contamination by EDCs in drinking water samples, whereas in 43% of all of the other samples from the farms at least one bisphenol was detected. The most abundant bisphenol detected was BPA (32% of the samples from the farms and 80% of the retail milk samples), thus proving that this compound is still widely used for plastic production. [ABSTRACT FROM AUTHOR]

Objectives Sunitinib is the standard care for first-line treatment of metastatic renal cell carcinoma. The aim of this study was to determine whether a sunitinib regimen of 50 mg/day 2-weeks on/1-week off could maintain the same dose-intensity as the standard 4-weeks on/2-weeks off schedule, and provide the same efficacy in terms of objective response, progression-free survival and overall survival, while reducing drug-related toxicity. Methods A total of 31 patients with metastatic renal cell carcinoma received sunitinib orally at the dose of 50 mg/day in a 2-weeks on/1-week off regimen until disease progression or intolerable toxicities occurred. Results All enrolled patients were assessable in terms of toxicity and response. They received treatment for a median of 16 months (range 2.0-36.0+ months). A total of 13 patients (42%) obtained an objective response; disease stabilization was achieved in 10 patients (32%), whereas eight patients (26%) experienced disease progression. The most important toxicities were anemia, gastrointestinal effects, fatigue and hypertension, but they were all controlled. Conclusions Sunitinib 50 mg given orally in a 2-weeks on/1-week off regimen can provide a high response rate and avoid drug-related toxicities, achieving the same dose intensity as the standard schedule, and probably longer disease control. [ABSTRACT FROM AUTHOR]

This paper presents wireless sensing systems to increase safety and robustness in industrial process control, particularly in industrial machines for marble slab working. The process is performed by abrasive or cutting heads activated independently by the machine controller when the slab, transported on a conveyer belt, is under them. Current slab detection systems are based on electromechanical or optical devices at the machine entrance stage, suffering from deterioration and from the harsh environment. Slab displacement or break inside the machine due to the working stress may result in safety issues and damages to the conveyer belt due to incorrect driving of the working tools. The experimented contactless sensing techniques are based on four RFID and two capacitive sensing technologies and on customized hardware/so?ware. The proposed solutions aim at overcoming some limitations of current state-of-the-art detection systems, allowing for reliable slab detection, outside and/or inside the machine, while maintaining low complexity and at the same time robustness to industrial harsh conditions. The proposed sensing devices may implement a wireless or wired sensor network feeding detection data to the machine controller. Data integrity check and process control algorithms have to be implemented for the safety and reliability of the overall industrial process. [ABSTRACT FROM AUTHOR]

With reference to an architecture for the full integration of a 60 GHz receiver in embedded systems with wireless gigabit connectivity, the paper presents the design of key building blocks such as: on-chip antenna, low noise amplifier (LNA) and a time-interleaved fast A/D converter (ADC) with AMBA AXI interface towards the digital baseband part. With respect to the state of the art the co-design of the on-chip antenna with the LNA, and the fast ADC architecture realized as a time-interleaved array of threshold-configuring SAR channels, represent new solutions optimized in terms of power consumption. Complexity and performance results in a 65-nm CMOS SOI technology, suitable also for digital systems integration, are presented. The performance and complexity results of the designed antenna, LNA and ADC are integrated in a system level simulator with those obtained by adopting known solutions for other receiver blocks (mixer, IF and baseband amplifiers and filters, frequency synthesizer) thus estimating the performance achievable with a whole 60 GHz receiver and digitization sub-system macrocell. The system-level estimated performances confirm the feasibility of a full-integrated receiver supporting short-range High Definition (HD) connectivity of several Gb/s with a Signal-to-Noise-Ratio compliant with WiGig and Wireless HD new standardization initiatives. [ABSTRACT FROM AUTHOR]

A new system-on-a-chip radar sensor for next-generation wearable wireless interface applied to the human health care and safeguard is presented. The system overview is provided and the feasibility study of the radar sensor is presented. In detail, the overall system consists of a radar sensor for detecting the heart and breath rates and a low-power IEEE 802.15.4 ZigBee radio interface, which provides a wireless data link with remote data acquisition and control units. In particular, the pulse radar exploits 3.1-10.6GHz ultra-wideband signals which allow a significant reduction of the transceiver complexity and then of its power consumption. The operating principle of the radar for the cardiopulmonary monitoring is highlighted and the results of the system analysis are reported. Moreover, the results obtained from the building-blocks design, the channel measurement, and the ultrawideband antenna realization are reported. [ABSTRACT FROM AUTHOR]

Melatonin is endowed with a growth inhibitory effect in MCF-7 breast cancer cells whose mechanism has been related to an antiestrogenic activity exerted by inhibition of binding of the estradiol–estrogen receptor complex to its DNA responsive element. Looking for downstream gene determinants of this effect, we performed a transcriptome profiling by high-density microarrays of estrogen-treated MCF-7 cells exposed or not to melatonin. We found that cyclin D1 was one of the main downregulated genes by melatonin. Validation experiments clearly confirm that in MCF-7 cells the estrogen-induced growth inhibitory activity of melatonin is consistently associated with inhibition of estrogen-elicited cyclin D1 induction. This effect is almost purely transcriptional. Reporter gene assays indicate that the same portion of the cyclin D1 promoter which confers estrogen sensitivity, encompassing a potential cAMP responsive element binding site, is repressed by melatonin. Transcriptional downregulation of cyclin D1 is the key molecular event for melatonin's antiproliferative activity, as this activity can be completely and selectively rescued by transient cyclin D1 overexpression. Finally, we provide indirect evidence that the effect of melatonin on the cyclin D1 promoter is mediated by the c- jun and ATF-2 proteins, known to bind the minimal estrogen-sensitive cyclin D1 promoter element. These findings establish for the first time a molecular link between melatonin and its effects on the cell cycle, providing at the same time a rationale for its use in adjuvant chemotherapy. [ABSTRACT FROM AUTHOR]

A super-junction lateral double diffused MOST (SJ-LDMOST) in silicon-on-sapphire technology, targeting power integrated circuits (PICs), is proposed, implemented and characterized. The proposed structure eliminates "substrate-assisted-depletion" effects in lateral SJ devices thus achieving charge compensation between the n and p SJ-pillars as well as a uniform electric field distribution in the drift region in the off-state. Three-dimensional (3-D) simulations of the device, using realistic aspect ratios for the SJ-pillars, indicate that a significant reduction in specific on-resistance for a given breakdown voltage can be achieved as compared to conventional reduced surface field (RESURF) devices. Experimental devices were implemented using a seven mask CMOS compatible process. Fabricated SJ-LDMOSTs with a drift region length of 66 µm and a pillar aspect ratio of 1.2 µm/0.7 µm (width/height) exhibit a specific on-resistance of 0.82 Ω.cm² and a breakdown voltage (BV) ranging between 500 and 600 V corresponding to less than 8.5% charge imbalance in the pillars. [ABSTRACT FROM AUTHOR]

(Poly)phosphates are approved as water-preserving and emulsifying agents that improve the appearance and consistency of many food products. The labelling of added (poly)phosphates is essential for protecting vulnerable population groups and to prevent unfair trade practices resulting in economic fraud. The problems with (poly)phosphates' utilisation concerns both analytical and legislative issues, such as: (1) their straightforward detection; (2) excessive addition altering freshness perception and misleading consumers; (3) uncontrolled usage increasing foodstuff weight; (4) application in products where they are not permitted; and (5) no indication on the label. Bearing all these issues in mind, the main purpose of this study was the quantification and screening of the (poly)phosphates profile in meat, marine and dairy products (160 samples), of which 43 were without declared (poly)phosphate treatment. Analysis was completed by high-performance ion-exchange chromatography either with conductometric detection or coupled to Q-Exactive Orbitrap high-resolution mass spectrometry. Although the (poly)phosphates profiles varied greatly according to species and processing type, the following criteria for detection of illicit treatment were established: high orthophosphate level, quantified short-chain (poly)phosphate anions and the presence of long-chain forms. In conclusion, the instrumental platforms used in this study can be recommended to inspection bodies as reliable methods for the detection of food adulteration with (poly)phosphates. [ABSTRACT FROM AUTHOR]

Derives several criteria for the evaluation of unconditional stability for active microwave two-port networks. Equivalence among the different stability criteria; Demonstration of a proof of the unconditional stability criterion; Relation of the proof to the concept of stability circles and geometrical conditions on the Smith chart.

Summarizes the noise and flunctuation in submicrometric Al-Si interconnect lines. Characteristics of low-frequency noise (LFN) in metals; Sample description and experiments; Analysis of the experimental data; Discussion on LFN in metal lines; Conclusion.