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Although information systems (IS) are increasingly used to provide sustainable solutions for tourism, our understanding of the social mechanisms whereby IS contribute to a sustainable visitor economy is limited. This paper fills the gap by investigating how organisations enact the affordances of IS in preserving intangible cultural heritage (ICH) to contribute to a sustainable visitor economy. Using an organisational aesthetics perspective, we explore the mechanisms through an in‐depth case study of an ICH‐based company in Jingdezhen, a famous historical porcelain city in China. Through the effective use of IS tools, the case organisation has successfully transformed from a ceramic manufacturing plant to a popular tourist attraction. Our study unveils six sustainable affordances of IS in three dimensions, wherein ICH aesthetics act as direct stimuli, knowledge tools and experiences. Affordances emerge from the processes of both creating and managing aesthetics. By enacting these affordances, the case organisation builds a more profound engagement with online audiences, attracts more ICH visitors and transfers ICH knowledge to potential inheritors of the tradition, creating a sustainable visitor economy. Our findings, summarised into a sustainable affordances model, contribute to the IS for sustainable tourism literature by shedding light on the black box of the social mechanisms of IS‐enabled ICH preservation. The sustainable affordances model can also help ICH‐based organisations reflect on how to build a sustainable visitor economy using IS. [ABSTRACT FROM AUTHOR]

While many organizations have successfully leveraged big data analytics capabilities to improve their performance, our understanding is limited on whether and how big data analytics capabilities affect social innovation in organizations. Based on the organizational information processing theory and the organizational learning theory, this study aims to investigate how big data analytics capabilities support social innovation, and how knowledge ambidexterity mediates this relationship. A total of 354 high-tech companies in China, this study shows that big data analytics management, big data analytics technology, and big data analytics personnel capabilities all have positive effects on social innovation. In addition, both knowledge exploration and knowledge exploitation play a mediating role in this process. Furthermore, a polynomial regression and response surface analysis shows that social innovation increases when knowledge exploration and knowledge exploitation are highly consistent but declines when knowledge exploration and knowledge exploitation are inconsistent. This study not only provides new perspectives for understanding how big data analytics capabilities contribute to social innovation, complementing the existing literature on big data analytics capabilities and social innovation, but also provides important practical guidance on how organizations can develop big data analytics capabilities to improve social innovation and solve social problems in the digital age. [ABSTRACT FROM AUTHOR]

Information systems (IS) play an important role in helping organisations attain environmental sustainability targets, and how to use IS for sustainability transformation is attracting research attention. However, extant studies have mainly focused on such transformation of business enterprises, overlooking it of communities. Our study intends to fill this gap by conducting an in‐depth case study at Feldheim, a small village in Germany that has successfully built a renewable energy system using IS and achieved energy self‐sufficiency. Guided by the belief‐action‐outcome (BAO) framework, our study unveiled a process model of antecedents, belief and action formation, and outcomes specific to community‐based sustainability transformation. The model also reveals three roles that IS assume in such transformation: participation objects, connectivity enablement, and fluctuation mitigation. Our study contributes to the literature on IS‐enabled sustainability transformation by extending it from the business enterprise context to the community context. It also provides communities with guidelines for conducting IS‐enabled sustainability transformation. [ABSTRACT FROM AUTHOR]

Vendor capabilities development has been an important research stream in the information systems (IS) sourcing literature. The existing research, which was based on the context of implementing centralized enterprise systems, focused on the adoption of deliberate learning and implicit learning, with the assumption that effective selection between these two learning approaches is sufficient for service providers to acquire vendor capabilities. However, this assumption may not hold in implementing a decentralized system based on enterprise blockchain. Because an enterprise blockchain system affords a new way of governing transactions and demands a new governance mode, it creates an uncertain and complex landscape in which the mere selection between deliberate learning and implicit learning becomes insufficient. Addressing this gap is crucial because many enterprise blockchain projects fail due to the incompetence of service providers. By conducting an in-depth case study of a successful blockchain service provider, our study reveals a new mechanism for developing vendor capabilities: parallel play. As with parallel play by preschoolers, the service provider combines a set of learning approaches featuring borrowing from peers and learning through experimentation. Our study extends the IS sourcing literature on vendor capabilities development from the context of implementing centralized enterprise systems to the context of implementing decentralized enterprise blockchain systems. Our findings also provide guidelines for blockchain service providers to follow when acquiring vendor capabilities and for clients to use when selecting service providers. [ABSTRACT FROM AUTHOR]

Timely and accurate agricultural drought monitoring and drought-driven mechanism analysis in karst basins in the context of global warming are highly important for drought disaster monitoring and sustainable ecological development in a basin. In this study, based on MODIS data, meteorological and topographic data and land use data from 2001 to 2020, we used the Sen slope, the Mann–Kendall test and a geographic detector to explore the driving mechanisms of agricultural drought caused by climate change and human activities in the karst basin of southern China from 2001 to 2020. The results showed that (1) the spatial distribution of the TVDI in the karst basin in southern China has obvious regional characteristics, showing a decreasing trend from west to east. (2) According to the interannual trend of drought, the degree of drought in the South China karst basin exhibited a weakening trend over the last 20 years, with the most severe drought occurring in 2003. Regarding the seasonal change in the TVDI, drought in spring, summer and autumn exhibited a decreasing trend, while that in winter exhibited an increasing trend, and the drought intensity decreased in the following order: spring (0.58) > autumn (0.53) > summer (0.5) > winter (0.48). (3) Single-factor detection the results showed that rainfall, temperature and elevation were the main factors driving aridification in the study area; multifactor coupling (mean) drove drought in descending order: rainfall (q = 0.424) > temperature (q = 0.340) > elevation (q = 0.219) > land use (q = 0.188) > population density (q = 0.061) > slope (q = 0.057). Therefore, revealing the mechanism of agricultural drought in karst basins through the study of this paper has important theoretical significance and provides technical guidance for drought relief in karst areas. [ABSTRACT FROM AUTHOR]

The emergence of Fintech platforms has revolutionized the way financial services are provided. And yet, in spite of their growing prominence in the global financial sector, there remains a lack of understanding of the competitive strategies that are appropriate for these platform‐based businesses, and the implications of those strategies for their performance. Examining four case studies of some of the most successful Fintech platforms in China from the theoretical perspective of the core logics of strategy, we develop a theoretical framework that suggests that the nature of the competitive strategies deployed by a Fintech platform should be contingent on (1) the extent to which their services can be differentiated, as well as (2) the tangibility and physical presence of the platform's service offerings. More specifically, our framework presents four different combinations of competitive strategies that Fintech platforms can adopt contingent on the nature of their services along these two dimensions. In addition, beyond the two dimensions, our framework suggests that all Fintech platforms should be underpinned by a common strategic core consisting of strategies that align the platform with social pressures. These pressures include those exerted by the government, the market, and society in general. With its findings, it is hoped that our study will provide specific guidance for Fintech practitioners on the appropriate competitive strategies to adopt in order to set their platforms on the path of commercial success. [ABSTRACT FROM AUTHOR]

Achieving three-dimensional (3D) omnidirectional wireless power transfer (OWPT) without any active control is challenging. This paper proposes a square polyhedron transmitter (SPTx) based on the reverse current of parallel coil, which can create a 3D omnidirectional magnetic field. To minimize the counteracting of the reverse magnetic field, each coil is equipped with magnetic shielding material. The coils of SPTx are connected in series and excited by a single power supply without any current amplitude or phase control circuits. The performance of SPTx system is validated with different receivers (Rx) by experiments. In the experiment with dual Rxs, the maximum transmission efficiency is 79.6% with an efficiency stability rate of 49%. In addition, the output power does not affect the efficiency, and more Rxs will increase transmission efficiency. [ABSTRACT FROM AUTHOR]

The occurrence of drought indicates that there is no rainfall or little rainfall within a certain period. Nevertheless, no or little rainfall within a certain time implies that drought may not happen. The drought occurrence in different regions or seasons shows a certain lag to some extent. The lag time and intensity (i.e., the contribution rate of rainfall in previous period to runoff in current period) are deeply affected by watershed water storage capacity. Subsequently, rainfall deficit is a necessary and insufficient for the droughts. To reveal the mechanism of watershed lagged effects and the impact of human activities on droughts, the characteristics of lagged effects and human activities in Central Guizhou of China are analyzed by the Lagged index and Landscape index based on land use data, rainfall and runoff data during the period 1971–2016. The results demonstrate that the impact of the same land use type in different ages (1970s–2010s) on watershed lagged intensity has a significant difference (P < 0.001). Especially for the influence of the woodland and grassland on lagged intensity is increasing with the increase of time scales and the impact difference gradually decreases in cultivated land, water body and construction land. The impact (R-value) of land use type transfer on watershed lagged effect is particularly significant (p < 0.001), and the influence (R-value) of land use type transfer on lagged frequency is shown with a W-shaped pattern in cultivated land and grassland with the ages changing, a single peak character in woodland and a peak valley alternation in water body. The impact of principal component factors (Zs) of land use morphological characteristics on watershed lagged effect has a particularly significant difference (p < 0.001) in different lag periods (Xt−0–Xt−3), different ages (1970s–2010s) and different time scales (1–12 months). Among them, the impact (F-value) of the Zs in the Xt−0–Xt−3 on lagged intensity/frequency is the largest in grassland, followed by in water body and woodland, and the smallest in cultivated land and construction land. The F-value in the 1970s–2010s is larger in construction than in cultivated land and woodland, and it is the smaller in water body and grassland. The F-value in the 1–12 month scales is grassland > water body > cultivated land > construction land > woodland. As a subsequence, this study enriches the research content of landscape ecology, and it provides a theoretical basis for revealing the mechanism of agricultural and hydrological droughts in Karst drainage basins. [ABSTRACT FROM AUTHOR]

Purpose. To assess the differences in accommodation and binocular vision in children with myopic anisometropia and determine the correlation with anisometropia. Method. A total of 110 patients with myopia aged 8–15 years were recruited from June 2021 to February 2022 from the Affiliated Hospital of Xuzhou Medical University. Based on the interocular differences of spherical equivalent refraction, patients were divided into the isometropia (35 children), low anisometropia (LA group, 42 children), and high anisometropia (HA group, 33 children). The variables assessed were refraction, heterophoria, amplitude of accommodation (AMP), accommodative response (AR), gradient AC/A, positive and negative relative accommodation (PRA/NRA), and near stereopsis in the three groups. Pearson's correlation coefficient tests were used to investigate the possible association between each parameter and interocular differences (IODs). Results. Among 110 subjects, there were 49 males and 61 females with a mean age of 11.39 ± 2.28 years. Compared with those in the isometropia group, AMP was lower and near stereopsis was higher in the LA group, and the distance and near heterophoria, PRA, AR, and near stereopsis were higher, and PRA, AMP, and gradient AC/A were lower in the HA group (all P < 0.05). Compared with those in the LA group, the near stereopsis, AR, and the near stereopsis were higher in the HA group, and the gradient AC/A was lower (all P < 0.05). However, no significant differences existed in the negative relative accommodation (P > 0.05). The distance and near heterophoria, AR, AMP, and near stereopsis were observed to be correlated with IODs, respectively (r = −0.259, p = 0.006 ; r = −0.201, p = 0.036 ; r = 0.306, p = 0.001 ; r = −0.315, p = 0.001 ; r = 0.535, p < 0.001). Conclusion. Our results suggested that with the increase of anisometropia, distance and near heterophoria, AR, AMP, and near stereopsis had a tendency to get worse in children with myopic anisometropia. [ABSTRACT FROM AUTHOR]

Public health surveillance based on data analytics plays a crucial role in detecting and responding to public health crises, such as infectious disease outbreaks. Previous information science research on the topic has focused on developing analytical algorithms and visualization tools. This study seeks to extend the research by investigating information practices in data analytics for public health surveillance. Through a case study of how data analytics was conducted for surveilling Influenza A and COVID‐19 outbreaks, both exploration information practices (i.e., probing, synthesizing, exchanging) and exploitation information practices (i.e., scavenging, adapting, outreaching) were identified and detailed. These findings enrich our empirical understanding of how data analytics can be implemented to support public health surveillance. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The oncogenic role of Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document the biological function of MATR3 in HCC based on integrated bioinformatics analysis and functional studies. According to the TCGA database, MATR3 expression was found to be positively correlated with clinicopathological characteristics in HCC. The receiver operating characteristic (ROC) curve and Kaplan-Meier (KM) curve displayed the diagnostic and prognostic potentials of MATR3 in HCC patients, respectively. Pathway enrichment analysis represented the enrichment of MATR3 in various molecular pathways, including the regulation of the cell cycle. Functional assays in HCC cell lines showed reduced proliferation of cells with stable silencing of MATR3. At the same time, the suppressive effects of MATR3 depletion on HCC development were verified by xenograft tumor experiments. Moreover, MATR3 repression also resulted in cell cycle arrest by modulating the expression of cell cycle-associated genes. In addition, the interaction of MATR3 with cell cycle-regulating factors in HCC cells was further corroborated with co-immunoprecipitation and mass spectrometry (Co-IP/MS). Furthermore, CIBERSORT and TIMER analyses showed an association between MATR3 and immune infiltration in HCC. In general, this study highlights the novel oncogenic function of MATR3 in HCC, which could comprehensively address how aberrant changes in the cell cycle promote HCC development. MATR3 might serve as a prognostic predictor and therapeutic target for HCC patients. [ABSTRACT FROM AUTHOR]

Pharmacokinetic pharmacodynamic modeling is an important tool which uses statistical methodology to provide a better understanding of the relationship between concentration and effect of drugs such as analgesics and sedatives. Pharmacokinetic pharmacodynamic models also describe between‐subject variability that allows identification of subgroups and dose adjustment for optimal pain management in individual patients. This approach is particularly useful in the pediatric population, where most drugs have received limited evaluation and dosing is extrapolated from adult practice. In children, the covariates of weight and age are used to describe size‐ and maturation‐related changes in pharmacokinetics. It is important to consider both size and maturation in order to develop an accurate model and determine the optimal dose for different age groups. An adequate assessment of analgesic and sedative effect using pain scales or brain activity measures is essential to build reliable pharmacokinetic pharmacodynamic models. This is often challenging in children due to the multidimensional nature of pain and the limited sensitivity and specificity of some measurement tools. This review provides a summary of the pharmacokinetic and pharmacodynamic methodology used to describe the dose–concentration–effect relationship of analgesics and sedation in children, with a focus on the different pharmacodynamic endpoints and the challenges of pharmacodynamic modeling. [ABSTRACT FROM AUTHOR]

Exercise preconditioning (EP) is a line of scientific inquiry into the short-term biochemical mediators of cardioprotection in the heart. This study examined the involvement of autophagy induced by energy metabolism in myocardial remodelling by EP and myocardial protection. A total of 120 healthy male Sprague Dawley (SD) rats were randomly divided into six groups. Plasma cTnI, HBFP staining and electrocardiographic indicators were examined in the context of myocardial ischemic/hypoxic injury and protection. Western blotting and fluorescence double labelling were used to investigate the relationship between energy metabolism and autophagy in EP-resistant myocardial injury caused by exhaustive exercise. Compared with those in the C group, the levels of myocardial ischemic/hypoxic injury were significantly increased in the EE group. Compared with those in the EE group, the levels of myocardial ischemic/hypoxic injury were significantly decreased in the EEP + EE and LEP + EE groups. Compared with that in the EE group, the level of GLUT4 in the sarcolemma was significantly increased, and the colocalization of GLUT4 with the sarcolemma was significantly increased in the EEP + EE and LEP + EE groups (P < 0.05). LC3-II and LC3-II/LC3-I levels of the EEP + EE group were significantly elevated compared with those in the EE group (P < 0.05). The levels of p62 were significantly decreased in the EEP + EE and LEP + EE groups compared with the EE group (P < 0.05). EP promotes GLUT4 translocation and induced autophagy to alleviate exhaustive exercise-induced myocardial ischemic/hypoxic injury. [ABSTRACT FROM AUTHOR]

Aim: Climate and land use changes are two major pervasive and growing global causes of rapid changes in the distribution patterns of biodiversity, challenging the future effectiveness of protected areas (PAs), which were mainly designed based on a static view of biodiversity. Therefore, evaluating the effectiveness of protected areas for protecting the species threatened by climate and land use change is critical for future biodiversity conservation. Location: China. Methods: Here, using distributions of 200 Chinese Theaceae species and ensemble species distribution models, we identified species threatened by future climate and land use change (i.e. species with predicted loss of suitable habitat ≥30%) under scenarios incorporating climate change, land use change and dispersal. We then estimate the richness distribution patterns of threatened species and identify priority conservation areas and conservation gaps of the current PA network. Results: Our results suggest that 36.30%–51.85% of Theaceae species will be threatened by future climate and land use conditions and that although the threatened species are mainly distributed at low latitudes in China under both current and future periods, the mean richness of the threatened species per grid cell will decline by 0.826–3.188 species by the 2070s. Moreover, we found that these priority conservation areas are highly fragmented and that the current PA network only covers 14.21%–20.87% of the 'areas worth exploring' and 6.91%–7.91% of the 'areas worth attention'. Main Conclusions: Our findings highlight the necessity of establishing new protected areas and ecological corridors in priority conservation areas to protect the threatened species. Moreover, our findings also highlight the importance of taking into consideration the potential threatened species under future climate and land use conditions when designating priority areas for biodiversity conservation. [ABSTRACT FROM AUTHOR]

Compared to earthquakes and volcanoes, drought is one of the most damaging natural disasters and is mainly affected by rainfall losses, especially by the runoff regulation ability of the underlying watershed surface. Based on monthly rainfall runoff data recorded from 1980 to 2020, in this study, the distributed lag regression model is used to simulate the rainfall-runoff process in the karst distribution region of South China, and a time series of watershed lagged-flow volumes is calculated. The watershed lagged effect is analyzed by four distribution models, and the joint probability between the lagged intensity and frequency is simulated by the copula function family. The results show that (1) the watershed lagged effects simulated by the normal, log-normal, P-III and log-logistic distribution models in the karst drainage basin are particularly significant, with small mean square errors (MSEs) and significant time-scale characteristics. (2) Affected by spatiotemporal distribution differences in rainfall and the impacts of different basin media and structures, the lag response of runoff to rainfall differs significantly among different time scales. Especially at the 1-, 3- and 12-month scales, the coefficient of variation (Cv) of the watershed lagged intensity is greater than 1, while it is less than 1 at the 6- and 9-month scales. (3) The lagged frequencies simulated by the log-normal, P-III and log-logistic distribution models are relatively high (with medium, medium–high and high frequencies, respectively), while that simulated by the normal distribution is relatively low (medium–low and low frequencies). (4) There is a significant negative correlation (R < − 0.8, Sig. < 0.01) between the watershed lagged intensity and frequency. For the joint probability simulation, the fitting effect of the gumbel Copula is the best, followed by the Clayton and Frank-1 copulas, and while that of the Frank-2 copula is relatively weak. Consequently, the propagation mechanism from meteorological drought to agricultural or hydrological drought and the conversion mechanism between agricultural and hydrological drought are effectively revealed in this study, thereby providing a scientific basis for the rational utilization of water resources and drought resistance and disaster relief in karst areas. [ABSTRACT FROM AUTHOR]

Blasthole detection is crucial but challenging in tedious underground mining processes, given the diversity of surrounding rock backgrounds and uneven light intensity. However, existing algorithms have limitations in extracting image features and identifying differently sized objects. This study proposes a cascade-network-based blasthole detection method. The proposed method includes a blasthole feature extract transformation (BFET) module and a blasthole detection (BD) module. Firstly, we constructed the BFET module on the improved Cycle Generative Adversarial Network (CycleGAN) by multi-scale feature fusion. Then, we fused the convolution features of the generators in CycleGAN to obtain the enhanced feature map of the blasthole images. Secondly, the BD module was cascaded with the BFET module to accomplish the task of detecting blastholes. Results indicated that the detection accuracy of the blasthole image was significantly improved by strengthening the contrast of the image and suppressing over-exposure. The experimental results also showed that the proposed method enhanced the contrast of the image and could improve the accuracy of blasthole detection in real time. Compared with the YOLOv7 and CycleGAN+YOLOv7 methods, the detection accuracy of our method was improved by 5.34% and 2.38%, respectively. [ABSTRACT FROM AUTHOR]

MicroRNAs (miRNAs) are recognized as latent diagnostic, prognostic, and therapeutic biomarkers for endometrial carcinoma (EC). We attempted to discuss function and mechanism of miR-125b-5p in EC cell progression. This study manifested a decreased miR-125b-5p level and an increased mitochondrial fission process 1 (MTFP1) level in EC, and there was an inverse correlation between them. Moreover, in vitro assays were performed. The results denoted that miR-125b-5p could target a putative binding site on MTFP1 3'UTR to reduce MTFP1 expression, thereby repressing cell malignant behaviors. Besides, the promoting impact of MTFP1 overexpression on malignant phenotypes of EC cells could be restored by miR-125b-5p up-regulation. Considering, our investigation exhibited that miR-125b-5p curbed EC cell malignant phenotypes through targeting MTFP1. This study generates a fresh functional mechanism for EC occurrence and progression, which also lays the groundwork for clinical therapies. [ABSTRACT FROM AUTHOR]

Droughts are becoming more frequent in the karst region of southwest China due to climate change, and accurate monitoring of karst agricultural droughts is crucial. To this end, in this study, based on random forest (RF) and support vector regression (SVR) algorithms, the monthly precipitation, monthly potential evapotranspiration, monthly normalised difference vegetation Index (NDVI), elevation, and karst development intensity from January to December 2001–2020 were used as independent variables, and the standardised soil moisture index (SSI) calculated by GLDAS soil moisture was used as the dependent variable to construct karst agricultural drought monitoring models at different timescales, using Guizhou Province as an example. The performance of the models constructed by the two algorithms was also evaluated using root mean square error (RMSE), coefficient of determination (R2), and correlation analysis, and the spatial and temporal evolution trends of karst agricultural drought at different timescales were analysed based on the model with better performance. The prediction of karst agricultural drought from January to December 2021–2025 was based on the seasonal difference autoregressive moving average (SARIMA) model and the analysis of change trends was performed using the Bayesian estimator of abrupt change, seasonal change, and trend (RBEAST). The results showed that (1) the drought model constructed by the RF regression algorithm performed better than the SVR algorithm at 1-, 3-, 6-, 9-, and 12-month timescales and was superior for monitoring karst agricultural drought. (2) The model showed that the overall trend of agricultural drought at different timescales was alleviated; 2010, 2011, and 2012 were typical drought years. At the same time, most regions showed a trend of drought mitigation, whereas a few regions (Bijie City, Liupanshui City, and Qianxinan Prefecture) showed a trend of aggravation. (3) The study predicted an overall high west–east distribution of drought intensity by 2021–2025. The 1- and 3-month timescales showed a trend of agricultural drought mitigation, and the 6-, 9-, and 12-month timescales showed a trend of aggravation; in 2021, 2022, and 2024, the abrupt change rates of autumn and winter droughts were higher. The results can provide a reference basis for the monitoring of agricultural drought in karst agriculture and the formulation of drought prevention and anti-drought measures. [ABSTRACT FROM AUTHOR]

Our previous studies demonstrated that CCR9 plays an important role in several aspects of T-cell acute lymphoblastic leukemia progression and that CCR9 is a potential therapeutic target. However, the underlying mechanism that regulates CCR9 expression remains incompletely understood. In this study, bioinformatics analysis and validation in clinical samples revealed the lncRNA15691 to be positively correlated with CCR9 mRNA expression and significantly upregulated in T-cell acute lymphoblastic leukemia samples and CCR9high T-cell acute lymphoblastic leukemia cell lines. LncRNA15691, a previously uncharacterized lncRNA, was found to be located in both the cytoplasm and the nucleus via fluorescence in situ hybridization assay. In addition, lncRNA15691 upregulated the expression of CCR9 and was involved in T-cell acute lymphoblastic leukemia cell invasion. In vivo experiments showed that lncRNA15691 promoted leukemia cell homing/infiltration into the bone marrow, blood, and spleen, whereas the CCR9 ligand, CCL25, augmented the extramedullary infiltration of CCR9low leukemia cells overexpressing lncRNA15691 into blood, spleen, and liver. Subsequently, RNA protein pull-down assays, coupled with liquid chromatography–tandem mass spectrometry, were used to uncover potential lncRNA15691-interacting proteins, which were then validated by RNA immunoprecipitation. These mechanistic studies revealed that lncRNA15691 upregulated CCR9 expression via directly binding to and stabilizing MATR3 by inhibiting its nuclear degradation mediated by PKA. Collectively, our study revealed a novel mechanism of regulating CCR9 expression and implicated lncRNA15691 as a potential novel biomarker for T-cell acute lymphoblastic leukemia infiltration. [ABSTRACT FROM AUTHOR]

Exercise preconditioning (EP) has a good myocardial protective effect. This study explored whether EP improves electrocardiographic (ECG) signs of myocardial ischemic/hypoxic injury and the occurrence of malignant arrhythmia after exhaustive exercise. A total of 120 male SD rats were randomly divided into the control group (group C), early exercise preconditioning group (group EEP), late exercise preconditioning group (group LEP), exhaustive exercise group (group EE), early exercise preconditioning + exhaustive exercise group (group EEP + EE) and late exercise preconditioning + exhaustive exercise group (group LEP + EE). Changes in heart rate (HR), ST segment, T wave and QT corrected (QTc) intervals on ECG; hematoxylin-basic fuchsin-picric acid (HBFP) staining; and cTnI levels were used to study myocardial injury and the protective effect of EP. Compared with those in group C, the levels of plasma markers of myocardial injury, HBFP staining and ECG in group EE were significantly increased (P < 0.05). Compared with those in group EE, the levels of plasma markers of myocardial injury, HBFP staining and ECG in group EEP + EE and group LEP + EE were significantly decreased (P < 0.05). The results suggested that EP improved ECG signs of myocardial ischemic/hypoxic injury and malignant arrhythmias that occur after exhaustive exercise. The ST segment and T wave could also serve as indexes for evaluating exhaustive exercise-induced myocardial ischemia/hypoxia. [ABSTRACT FROM AUTHOR]

The architecture, engineering, and construction (AEC) industry globally has a long history of prudently adopting novel technologies to improve products and services. Yet the rapid development of digital technology currently taking place is threatening to produce a more disruptive inflection, or substantial jolt. This paper explores the state of readiness of the AEC industry for such anticipated transformation. We illustrate our conceptual arguments with evidence from an explorative study across a sample of AEC organizations in Australia. At the core of this paper, we offer six provocations that highlight what we consider major challenges for the AEC industry—across multiple levels of analysis—related to the increasing role of digital technology. We then turn to lessons learned from other industries in order to propose a framework consisting of four leadership thinking schemas to enable digital transformation readiness: future thinking, strategic thinking, capability thinking, and experimental thinking. For these four schemas, we present practices and initiatives that may help AEC firms to better adapt—or to proactively create and shape a sustainable future. [ABSTRACT FROM AUTHOR]

Late exercise preconditioning (LEP) is known to have a cardioprotection against myocardial injury induced by high-intensity exercise (HE). B-type natriuretic peptide (BNP) carries out the majority of its effects through interaction with natriuretic peptide receptor A (NPR-A) and natriuretic peptide receptor C (NPR-C) to protect heart health. This study aims to investigate the changes in the expression of BNP, NPR-A and NPR-C, during LEP-induced cardioprotection. Male Sprague–Dawley rats (n = 100) were randomly divided into 4 experimental groups (25/group). Rats of LEP model were subjected to an intermittent exercise consisting of 4 periods, each period including 10 min of running at 30 m/min (approximately 75% VO2max) followed by 10 min of intermittent rest. A model of HE-induced myocardial injury was developed by subjecting rats to one bout of high-intensity treadmill exercise at 35 m/min (approximately 80% VO2max) and 0% grade. Following LEP, the levels of BNP and NPR-A were significantly increased, whereas the protein levels of NPR-C were tended to be lower. A group of rats were subjected to LEP followed by HE, and the levels of BNP and NPR-A were significantly elevated in this group, whereas there was a significant decrease in the protein levels of NPR-C. LEP may increase the synthesis and secretion of BNP to assist the cardioprotection via up-regulating of NPR-A and down-regulating of NPR-C. [ABSTRACT FROM AUTHOR]

Digital social innovation (DSI) involves the use of digital technologies in the development and implementation of innovative products, services, processes and business models that seek to improve the well-being and agency of socially disadvantaged groups or address social problems related to marginality, inequality and social exclusion (Qureshi, Pan, & Zheng, 2017; Shalini et al., 2021). Information Systems Frontiers, 22 (11), 1 - 21. https://doi.org/10.1007/s10796-020-09991-6 153 Parthiban, R., Qureshi, I., Bandyopadhyay, S., & Jaikumar, S. (2021). Social inclusion/exclusion (Diaz Andrade & Doolin, 2016; Iivari et al., 2018; Riaz & Qureshi, 2017); social inequality (Qureshi et al., 2018; Zheng & Walsham, 2008, 2021)Embedded agency of DSIrsHow are DSIrs able to engage with local institutions yet bring change in these very same institutions? 151 Pandey, M., Bhati, M., Shukla, D. M., & Qureshi, I. (2021). 152 Parthiban, R., Qureshi, I., Bandyopadhyay, S., Bhatt, B., & Jaikumar, S. (2020). [Extracted from the article]

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extra-nodal lymphoma. The high relapse rate of PCNSL remains a major challenge to the hematologists, even though patients exhibit high sensitivity to the methotrexate-based chemotherapeutic regimens. Recently, the advent of Bruton's tyrosine kinase inhibitor (BTKi) and CAR T treatment has made more treatment options available to a proportion of patients. However, whether BTKi monotherapy should be given alone or in combination with conventional chemotherapy is still a clinical question. The status of CAR T therapy for PCNSLs also needs to be elucidated. In this review, we summarized the latest progress on the epidemiology, pathology, clinical manifestation, diagnosis, and treatment options for PCNSLs. [ABSTRACT FROM AUTHOR]

Wildlife management is becoming increasingly critical to improving the sustainability of biodiversity and the welfare of human beings. This paper uses affordance as a lens to explore the design of information systems that can assist in managing wildlife in protected areas. Through an action design research (ADR) study with a forest department, we develop and test design principles for a class of wildlife management analytics system (WMAS). We identify the initial design principles, including elements of the action potential, materiality, and boundary condition, and iteratively refine them based on an instantiation of WMAS through two iterations of design and implementation cycles. Through our work, we contribute to design knowledge by abstracting the artefacts, design principles in particular, and the ADR approach by generalising two new activities and corresponding principles when designing analytical models. Our findings can also be used to address a class of similar problems and systems in practice. [ABSTRACT FROM AUTHOR]

The cardioprotection of exercise preconditioning (EP) has been well documented. EP can be divided into two phases that are the induction of exercise preconditioning (IEP) and the protection of exercise preconditioning (PEP). PEP is characterized by biphasic protection, including early exercise preconditioning (EEP) and late exercise preconditioning (LEP). LC3 lipidation-mediated autophagy plays a pivotal role in cardioprotection. This study aimed to investigate the alterations of LC3 lipidation-associated proteins during EP-induced cardioprotection against myocardial injury induced by exhaustive exercise (EE) was used in a rat model of EP. These rats were subjected to an intermittent exercise consisting of four periods, with each period including 10 min of running at 30 m/min and 0% grade (approximately 75% VO2max) followed by 10 min of intermittent rest. A model of EE-induced myocardial injury was developed by subjecting rats to a consecutive running (30 m/min, 0% grade) till exhaustion. Following EEP, the colocalization of LC3 with Atg7 was significantly increased, and LC3-I, LC3-II, LC3-II/LC3-I, Atg7, Atg4B, and Atg3 levels were significantly increased. Atg7, Atg4B, and Atg3 mRNAs were all significantly upregulated, and LC3 mRNAs tended to be higher. Following LEP, Atg4B, and Atg3 levels were significantly increased. Atg7, Atg4B, and Atg3 mRNAs were all significantly upregulated, and LC3 mRNAs tended to be higher. A group of rats were subjected to EEP followed by EE, and the co-localization of LC3 with Atg7 was significantly increased, while LC3-I, LC3-II, LC3-II/LC3-I, Atg7, Atg4B, and Atg3 levels were also significantly increased. Moreover, there was a significant increase in the co-localization of LC3 with Atg7, LC3-I, LC3-II, Atg7, and Atg4B levels during LEP followed by EE. The formation of autophagosome during LEP followed by EE may have been weaker than that during EEP followed by EE due to the lower lipidation of LC3. EP may promote autophagy to maintain cell homeostasis and survival, which cooperates for cardioprotection of alleviating exhaustive exercise-induced myocardial injury by increasing LC3 lipidation-associated proteins. There is a difference between EEP and LEP in terms of the mechanisms of cardioprotection afforded by these respective conditions. The positive regulation of transcription and translation level of LC3 lipidation-associated proteins may all be involved in the mechanism of EEP and LEP, while compared with LEP, the regulation of translation level of EEP is more positively to promote autophagy. [ABSTRACT FROM AUTHOR]

Exercise preconditioning (EP) can alleviate myocardial ischemic/hypoxic injury by inducing endogenous cardioprotection. Hematoxylin–eosin (HE), hematoxylin-basic fuchsin-picric acid (HBFP), and chromotrope-2R brilliant green (C-2R BG) staining have been used to visualize myocardial ischemic/hypoxic changes in previous EP studies, but comprehensive evaluation and comparisons of these methods are lacking. This study evaluated ischemic/hypoxic changes in adjacent myocardial sections by HE, HBFP, and C-2R BG and compared the characteristics of sections stained by these three methods to show changes associated with exercise-induced myocardial ischemic/hypoxic injury. Rats were randomly divided into four groups: control (C), exercise preconditioning (EP), exhaustive exercise (EE), and exercise preconditioning + exhaustive exercise (EP + EE). Adjacent myocardial sections were stained as described above and compared to evaluate the effects of exercise-induced myocardial ischemic/hypoxic injury. The three staining methods revealed consistent localization patterns of myocardial ischemic/hypoxic injury in all groups. Results suggest that EP can alleviate exhaustive exercise-induced myocardial ischemic/hypoxic injury, and the three staining methods are suitable for the histological study of exercise-induced myocardial ischemic/hypoxic injury and protection. HE staining is a simple procedure but is not specific for myocardial ischemic/hypoxic injury. HBFP and C-2R BG staining can be used to specifically visualize myocardial ischemic/hypoxic injury. [ABSTRACT FROM AUTHOR]

The recent pandemic has painfully reminded us of the need for IS design to be informed by possible futures and conscious of undesirable futures – Within months, many of the nice-to-have IS functionalities have become must-haves; Technology solutions in response to the pandemic have raised privacy and equality concerns. Although design science research fundamentally focuses on shaping artefacts and events to create a more desirable future, there has been limited guidance on how futures should be accounted for. This article addresses the gap by integrating insights from future-oriented IS research and futures research to develop guidelines for engaging with futures throughout the design science research process. The future-ready design research (FRDR) process prompts researchers to be more aware of futures, to foster the innovative foresight for actively pursuing the preferred future, and to espouse the responsible foresight for consciously avoiding undesirable futures. The guidelines are illustrated with a design science research project on outbreak analytics and the instantiated system's subsequent adaptation and utilisation in COVID-19. [ABSTRACT FROM AUTHOR]

Aim: Autoimmune diabetes mellitus (defined as ADM) comprises classical type 1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA). In this study, microRNAs (miRNAs) expression profiles and functions in peripheral blood mononuclear cells (PBMCs) of ADM patients were mapped and used to explore epigenetic regulation of the pathogenesis of ADM. Methods: PBMCs samples from T1DM patients, LADA patients, and type 2 diabetes mellitus (T2DM) patients, as well as age- and sex-matched healthy controls for T1DM and T2DM, respectively, were collected and were sequenced to screen the miRNAs expression profiles. The target genes were verified by dual-luciferase reporter assay. Silencing or overexpressing of the differentially expressed miRNAs, or simultaneously silencing the miRNAs and it's target gene, and then levels of the mRNAs, protein and cytokines were detected. Results: miR-143-3p expression was upregulated in ADM patients. The target gene of miR-143-3p was identified as Fos-related antigen 2 (FOSL2). Transfection of a miR-143-3p inhibitor into PBMCs upregulated FOSL2 expression, resulting in a downregulated expression of the IL-2, TNF-α, and IFN-γ, and an upregulated expression of IL-6. Transfection of a miR-143-3p mimic into PBMCs downregulated FOSL2 expression, leading to an upregulation of IL-2 and TNF-α expression and a downregulation of IL-6 expression. When silencing FOSL2 while inhibiting miR-143-3p in PBMCs, there was no significant change in expression of the FOSL2 mRNA, protein and cytokines. Conclusion: The expression of miR-143-3p in PBMCs from ADM patients is upregulated. miR-143-3p could function in the pathogenesis of ADM by modulating the inflammatory reaction through FOSL2. [ABSTRACT FROM AUTHOR]

With the rapid development of the Internet of things (IoT) technology, the application of IoT has been expanded greatly, and the disadvantages of the traditional battery power supply have become increasingly prominent. The power supply mode limits the development of the concrete structural health monitoring network. And the application of magnetic resonance coupled wireless power transfer technology can solve the problem of power supply to sensors embedded in concrete. The corrected transmission efficiency considering the concrete conductivity is proposed which establishes the relationship between the electromagnetic field and the circuit model. And the field-circuit coupled model of asymmetric wireless power transfer system in concrete is developed. The effects of radial offset and axial dislocation on the transmission efficiency at different concrete conductivity are further analyzed. The relationship between the resonant frequency and the transmission efficiency in different concrete conductivity is analyzed, and an optimization scheme is proposed to improve the transmission efficiency. Finally, the experimental setups are established, and the theoretical analysis is verified. The conclusions cannot only break through the bottleneck of the scale of the concrete structural health monitoring network but also further releases the application potential of IoT. [ABSTRACT FROM AUTHOR]

With the rapid development of the Internet of things (IoT) technology, the application of IoT has been expanded greatly, and the disadvantages of the traditional battery power supply have become increasingly prominent. The power supply mode limits the development of the concrete structural health monitoring network. And the application of magnetic resonance coupled wireless power transfer technology can solve the problem of power supply to sensors embedded in concrete. The corrected transmission efficiency considering the concrete conductivity is proposed which establishes the relationship between the electromagnetic field and the circuit model. And the field-circuit coupled model of asymmetric wireless power transfer system in concrete is developed. The effects of radial offset and axial dislocation on the transmission efficiency at different concrete conductivity are further analyzed. The relationship between the resonant frequency and the transmission efficiency in different concrete conductivity is analyzed, and an optimization scheme is proposed to improve the transmission efficiency. Finally, the experimental setups are established, and the theoretical analysis is verified. The conclusions cannot only break through the bottleneck of the scale of the concrete structural health monitoring network but also further releases the application potential of IoT. [ABSTRACT FROM AUTHOR]

The perennial issue of information value creation needs to be understood in the contemporary era of a more networked user environment enabled by information technology (IT). This mixed‐methods study investigates information value cocreation from the social informatics perspective to surface sociotechnical implications for IT design and use, since cocreation is inherently social and technology‐mediated. Specifically, the cocreation of software as an information‐intensive product is examined. Data on the cocreation of Xiaomi's MIUI firmware were collected from two sources: 49 interviews of staff and user participants and web crawling of the cocreation platform. They were analyzed with interpretive analysis, topic modeling, and social network analysis for triangulation. Findings indicate three sociotechnical information practices co‐constituted by information, IT, people, and their activities. Each practice is instrumental in rapidly and continuously converting external information into cocreated information value. The adsorption information practice attracts new and diverse external information; the absorption practice integrates external and internal information rapidly by involving users; the desorption practice allows rapid adoption of the cocreated product so that information value can be realized and demonstrated for further cocreation. Critically analyzing these practices reveals unanticipated or paradoxical issues affecting the design and use of common cocreation technology such as discussion forums. [ABSTRACT FROM AUTHOR]

In addition to innate curiosity, many of us also see scientific research as a way of making the world a better place. There has been a drive to better understand and observe the practical and societal impact of research, led by researchers seeking to find meaning and purpose in their work, as well as government agencies responsible for allocating research funding to maximum effect. Despite a wealth of guidance from researchers discussing impact and agencies evaluating impact, making practice impact visible and demonstrable remains arduous to researchers because it appears to be possible only at the end of a long and winding pathway to impact. This article presents a framework for demonstrating practice impact as it is being realized progressively, rather than only at the end of the pathway. It identifies usable, in‐use, and useful research outputs, with each having cumulative and demonstrable practice impact. Our analyses of existing impact evaluation guidelines and top‐ranked impact cases submitted to the Research Excellence Framework 2014 showed that all three forms of impact can be demonstrated and are recognized as practice impact. Framing impact in terms of "use" inherently connects the perspectives of researchers and beneficiary users and positions users as co‐producers of impact rather than passive objects and recipients of research. The 3U framework is descriptive as well as prescriptive. It identifies impact indicators for each form of impact. It also indicates the necessary actions for strengthening impact. When applied iteratively, the 3U framework facilitates the identification and pursuit of new research questions that will further solidify a research endeavour's practice impact. [ABSTRACT FROM AUTHOR]

Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real‐world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first‐line therapeutic antibody ustekinumab. The impact of differing dosing strategies on response was explored. Data were collected from a UK prospective multicenter observational cohort (491 patients on ustekinumab monotherapy, drug levels, and anti‐drug antibody measurements on 797 serum samples, 1,590 measurements of Psoriasis Area Severity Index (PASI)). Ustekinumab PKs were described with a linear one‐compartment model. A maximum effect (Emax) model inhibited progression of psoriatic skin lesions in the turnover PD mechanism describing PASI evolution while on treatment. A mixture model on half‐maximal effective concentration identified a potential nonresponder group, with simulations suggesting that, in future, the model could be incorporated into a Bayesian therapeutic drug monitoring "dashboard" to individualize dosing and improve treatment outcomes. [ABSTRACT FROM AUTHOR]

Background: Gastric cancer (GC) is among the most common forms of cancer affecting the digestive system. This study sought to identify hub genes regulating early GC (EGC) in order to explore their potential for early diagnosis and prognosis of patients. Methods: We utilized a publically available dataset from the Gene Expression Omnibus database (GSE55696). Differences between EGC and LGIN with respect to gene expression were compared using the limma software. Identified differentially expressed genes (DEGs) were subjected to gene ontology (GO) and pathway enrichment analyses with the DAVID application, and the STRING website and Cytoscape software were used to construct a protein-protein interaction (PPI) network incorporating these DEGs. This network was in turn used to identify hub genes among selected DEGs, which were analyzed with the Kaplan-Meier Plotter database. In addition, Western blotting, qRT-PCR, immunohistochemistry, and UALCAN were all employed to validate the relationship between the expression of these genes and GC patient prognosis. Results: A total of 482 DEGs were identified, with GO analyses indicating an increase in the expression of genes linked with the development of cancer. Pathway analyses also indicated that these genes play a role in certain cancer-related pathways. The PPI network highlighted four potential hub genes, of which only ICAM1 was linked to a poor GC patient prognosis. This link between ICAM1 and GC patient outcomes was confirmed via UALCAN, Western blotting, immunohistochemistry, and qRT-PCR. Conclusion: ICAM1 may therefore modulate tumor progression in GC, thus potentially representing a valuable prognostic and diagnostic biomarker of EGC. [ABSTRACT FROM AUTHOR]

Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia–hypoxia, allowing the heart to be protected for subsequent high-intensity exercise (HE). We applied approaches, chromotrope-2R brilliant green (C-2R BG) staining and plasma cTnI levels measuring, to characterize two periods of cardioprotection after EP: early EP (EEP) and late EP (LEP). Further addressing the relationship between ischemia–hypoxia and autophagy, key proteins, Beclin1, LC3, Cathepsin D, and p62, were determined by immunohistochemical staining, western blotting, and by their adjacent slices with C-2R BG. Results indicated that exercise-induced ischemia–hypoxia is a key factor in Beclin1-dependent autophagy. High-intensity exercise was associated with the impairment of autophagy due to high levels of LC3II and unchanged levels of p62, intermittent ischemia–hypoxia by EP itself plays a key role in autophagy, which resulted in more favorable cellular effects during EEP-cardioprotection compared to LEP. [ABSTRACT FROM AUTHOR]

Accumulating evidence shows that the AMPK-mTOR pathway modulates autophagy via coordinated phosphorylation of ULK1. The aim of the present study was to investigate the relationship between AMPK, mTOR, and ULK1 during late exercise preconditioning (LEP), and to explore whether LEP-induced myocardial protection is related to the autophagy. The exercise preconditioning (EP) protocol was as follows: rats were instructed to for run four repeated in duration of 10 minutes (including 10 minutes rest between each period) on a treadmill. Exhaustive exercise (EE) after LEP pretreatment and administration of wortmannin (an autophagy inhibitor that suppresses Class III PI3K-kinase (PI3KC3) activity) were added to test the protective effect. Cardiac troponin I (cTnI), and transmission electron microscopy (TEM), along with hematoxylin-basic fuchsin-picric acid (HBFP) staining, were used to evaluate the myocardial ischemic-hypoxic injury and protection. Western blot was used to analyze the relationship of autophagy-associated proteins. Exhaustive exercise caused severe myocardial ischemic-hypoxic injury, which led to an increase in cTnI levels, changes of ischemia–hypoxia, and cells ultrastructure. Compared with the EE group, LEP significantly suppressed exhaustive exercise-induced myocardial injury. However, wortmannin attenuated LEP-induced myocardial protection by inhibiting autophagy. Compared with the C group, AMPK was increased in the LEP, EE, and LEP+EE groups, but phosphorylation of AMPK at Thr712 was not significantly changed. Exercise did not have any effect on mTOR expression. Compared with the C group, ULK1 was increased and the ULK1ser757/ULK1 ratio was decreased in the LEP and LEP+EE groups. ULK1 was not significantly affected in the EE group, however, phosphorylation of ULK1 at Ser757 was remarkably decreased. To sum up, our results suggested that LEP promoted autophagy through the activation of AMPK-mTOR-ULK1 pathway, and that activated autophagy was partially involved in myocardial protection against EE-induced myocardial ischemic-hypoxic injury. [ABSTRACT FROM AUTHOR]

Acute myeloid leukemia (AML) is a myeloid malignancy characterized by the proliferation of abnormal and immature myeloid blasts in the bone marrow. Circular RNA (circRNA) is a novel class of long non-coding RNA with a stable circular conformation that regulates various biological processes. The aberrant expression of circRNA and its impact on AML progression has been reported by a number of studies. Despite recent advances in circRNA research, our understanding of the leukemogenic mechanism of circRNA remains very limited, and translating the current circRNA-related research into clinical practice is challenging. This review provides an update on the functional roles of and research progress on circRNAs in AML with an emphasis on mechanistic insights. The challenges and opportunities associated with circRNA-based diagonostic and therapeutic development in AML are also outlined. [ABSTRACT FROM AUTHOR]