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Heart disease is a very common high-incidence disease. Due to the wide variety of pathology of heart disease, how to improve the medical diagnosis of heart disease and carry out earlier intervention and treatment is a problem that needs to be solved urgently. The paper adds the decision tree algorithm and its comparison and proposes an optimized classification algorithm Co-SVM. Based on the establishment of a heart disease diagnosis classifier based on data mining algorithms, it is aimed at exploring which of these four algorithms is more suitable for heart disease diagnosis problems and optimizing them. A brief description of the cause, influencing factors, and acquired data of heart disease can be seen from the accuracy and scientificity of the data, which further enhances the authenticity and reliability of the clinical diagnosis model of heart disease. At the same time, the ultrasound diagnosis technology of heart disease is introduced, and the important role of ultrasound diagnosis technology in the medical diagnosis of heart disease is discussed. This thesis uses the heart disease clinical data set to establish a heart disease diagnosis classifier based on the decision tree algorithm, neural network algorithm, support vector machine algorithm, and Co-SVM algorithm. Through experimental comparison and analysis, the optimal classification is selected according to the obtained results. The algorithm is Co-SVM algorithm. The experimental results show that the proposed Co-SVM algorithm has a higher accuracy rate than the other three classic algorithms, and the effectiveness of the Co-SVM algorithm is verified by the evaluation results of multiple algorithms. By applying the Co-SVM algorithm in the medical diagnosis system, it is helpful to assist doctors in making more accurate and precise diagnosis of the condition. [ABSTRACT FROM AUTHOR]