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Laser wireless energy transmission is a widely utilized method, yet its efficiency is constrained by a variety of factors. In order to improve the conversion efficiency of the receivers of the laser wireless power transmission (LWPT) system, the square elliptic hyperboloid (SEH) concentrating module designed for LWPT system receivers is developed. By analysing the I–V characteristic curves from the results of the experiments and employing non‐linear parameter regression, a corrected battery characteristic curve was derived within a specific laser irradiation range. On this basis, an optical–thermal–electric multi‐field coupling characteristic model was developed. The finite element method is used to simulate the multi‐field coupling characteristics and conversion efficiency of the receiving end under diverse working conditions (including different rotation angles and different divergence angles) of the concentrating photovoltaic module. Research shows: First, the larger the divergence half‐angle β of the laser beam, the more obvious the improvement of the effective optical efficiency of the system by the SEH concentrator. Second, the short‐circuit current and the maximum output power of the PV cell at the receiving end are significantly improved by the SEH concentrator, and the improvement effect is more obvious with the increase of the divergence angle and the rotation angle. Third, SEH concentrators did not significantly affect the fill factor of PV cells. [ABSTRACT FROM AUTHOR]

Background: The role of focal amplifications and extrachromosomal circular DNA (eccDNA) is still uncertain in prostate adenocarcinoma (PRAD). Here, we first mapped the global characterizations of eccDNA and then investigate the characterization of eccDNA-amplified key differentially expressed encoded genes (eKDEGs) in the progression, immune response and immunotherapy of PRAD. Methods: Circular_seq was used in conjunction with the TCGA-PRAD transcriptome dataset to sequence, annotate, and filter for eccDNA-amplified differentially expressed coding genes (eDEGs) in PRAD and para-cancerous normal prostate tissues. Afterwards, risk models were created and eKDEGs linked to the PRAD prognosis were identified using Cox and Lasso regression analysis. The immune microenvironment of the risk model was quantified using a variety of immunological algorithms, which also identified its characteristics with regard to immunotherapy, immune response, and immune infiltration. Results: In this research, there was no significant difference in the size, type, and chromosomal distribution of eccDNA in PRAD and para-cancerous normal prostate tissues. However, 4,290 differentially expressed eccDNAs were identified and 1,981 coding genes were amplified. Following that, 499 eDEGs were tested in conjunction with the transcriptome dataset from TCGA-PRAD. By using Cox and Lasso regression techniques, ZNF330 and PITPNM3 were identified as eKDEGs of PRAD, and a new PRAD risk model was conducted based on this. Survival analysis showed that the high-risk group of this model was associated with poor prognosis and validated in external data. Immune infiltration analysis showed that the model risks affected immune cell infiltration in PRAD, not only mediating changes in immune cell function, but also correlating with immunophenotyping. Furthermore, the high-risk group was negatively associated with anti-CTLA-4/anti-PD-1 response and mutational burden. In addition, Tumor Immune Dysfunction and Exclusion analyses showed that high-risk group was more prone to immune escape. Drug sensitivity analyses identified 10 drugs, which were instructive for PRAD treatment. Conclusion: ZNF330 and PITPNM are the eKDEGs for PRAD, which can be used as potential new prognostic markers. The two-factor combined risk model can effectively assess the survival and prognosis of PRAD patients, but also can predict the different responses of immunotherapy to PRAD patients, which may provide new ideas for PRAD immunotherapy. [ABSTRACT FROM AUTHOR]

Most existing hydrogels, even recently developed injectable hydrogels that undergo a reversible sol-gel phase transition in response to external stimuli, are designed to gel immediately before or after implantation/injection to prevent the free diffusion of materials and drugs; however, the property of immediate gelation leads to a very weak tumour-targeting ability, limiting their application in anticancer therapy. Therefore, the development of tumour-specific responsive hydrogels for anticancer therapy is imperative because tumour-specific responses improve their tumour-targeting efficacy, increase therapeutic effects, and decrease toxicity and side effects. In this review, we introduce the following three types of tumour-responsive hydrogels: (1) hydrogels that gel specifically at the tumour site; (2) hydrogels that decompose specifically at the tumour site; and (3) hydrogels that react specifically with tumours. For each type, their compositions, the mechanisms of tumour-specific responsiveness and their applications in anticancer treatment are comprehensively discussed. [ABSTRACT FROM AUTHOR]

Background: Kidney cancer is a prevalent malignancy with an increasing incidence worldwide. Blood cell indices and inflammation-related markers have shown huge potential as biomarkers for predicting cancer incidences, but that is not clear in kidney cancer. Our study aims to investigate the correlations of blood cell indices and inflammation-related markers with kidney cancer risk. Methods: We performed a population-based cohort prospective analysis using data from the UK Biobank. A total of 466,994 participants, free of kidney cancer at baseline, were included in the analysis. The hazard ratios (HRs) and 95% confidence intervals (CIs) for kidney cancer risk were calculated using Cox proportional hazards regression models. Restricted cubic spline models were used to investigate nonlinear longitudinal associations. Stratified analyses were used to identify high-risk populations. The results were validated through sensitivity analyses. Results: During a mean follow-up of 12.4 years, 1,710 of 466,994 participants developed kidney cancer. The Cox regression models showed that 13 blood cell indices and four inflammation-related markers were associated with kidney cancer incidence. The restricted cubic spline models showed non-linear relationships with kidney cancer. Finally, combined with stratified and sensitivity analyses, we found that the mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet distribution width (PDW), systemic immune-inflammation index (SII), and product of platelet count and neutrophil count (PPN) were related to enhanced kidney cancer risk with stable results. Conclusion: Our findings identified that three blood cell indices (MCHC, RDW, and PDW) and two inflammation-related markers (SII and PPN) were independent risk factors for the incidence of kidney cancer. These indexes may serve as potential predictors for kidney cancer and aid in the development of targeted screening strategies for at-risk individuals. [ABSTRACT FROM AUTHOR]

Introduction: Sjögren's syndrome (SS) and rheumatoid arthritis (RA) are two chronic autoimmune diseases. To date, there have been few reports on the overlap between SS and RA in China, especially regarding correlated acute renal failure cases. Methods: To provide a reference for our clinical peers, this article presents the case report of an elderly female patient who was diagnosed with acute renal failure caused by SS and RA overlap syndrome. Results: We also provide a relevant analysis of SS and RA overlap syndrome treatment. Conclusions: We also provide a relevant analysis of SS and RA overlap syndrome treatment. [ABSTRACT FROM AUTHOR]

In this paper, a novel box-type scheme with convergence order O(τ3-a + h²) is constructed for the fractional sub-diffusion equation with spatially variable coefficient under Neumann boundary conditions. Using L2 formula and the energy method, stability of the scheme are proved. A numerical example is carried out and the result meets with the theoretical analysis. [ABSTRACT FROM AUTHOR]

The global energy landscape faces significant challenges in meeting the demands of modern industries for stable and efficient energy supply. Laser wireless power transmission (LWPT) systems, which utilize the photovoltaic effect to convert laser beam energy, hold great promise due to their long-range transmission capability and high precision. However, the current energy conversion efficiency of these systems requires further improvement to achieve optimal performance. To enhance concentrated photovoltaic (CPV) system performance, the study examines different nonimaging concentrators such as reverse truncated pyramid, cross-compound parabolic concentrator, and square elliptical hyperboloid. Numerical simulations using the finite element method analyze the multifield coupling mechanism of PV modules with various concentration lenses. Three CPV systems with RTP concentrators of different heights were studied to understand the impact of geometry on CPV performance. And the main impact of rotation angle was discussed. The research findings provide essential insights into CPV system performance and the influence of different concentration lenses, contributing valuable knowledge towards improving LWPT technologies. [ABSTRACT FROM AUTHOR]

Grouting defects are an inherent challenge in construction practices, exerting a considerable impact on the operational structural integrity of connections. This investigation employed the impact-echo technique for the detection of grouting anomalies within connections, enhancing its precision through the integration of wavelet packet energy principles for damage identification purposes. A series of grouting completeness assessments were meticulously conducted, taking into account variables such as the divergent material properties of the sleeves and the configuration of adjacent reinforcement. The findings revealed that: (i) the energy distribution for the highstrength concrete cohort predominantly occupied the frequency bands 42, 44, 45, and 47, whereas for other groups, it was concentrated within the 37 to 40 frequency band; (ii) the delineation of empty sleeves was effectively discernible by examining the wavelet packet energy ratios across the spectrum of frequencies, albeit distinguishing between sleeves with 50% and full grouting density proved challenging; and (iii) the wavelet packet energy analysis yielded variable detection outcomes contingent on the material attributes of the sleeves, demonstrating heightened sensitivity when applied to ultrahigh-performance concrete matrices and GFRP-reinforced steel bars. [ABSTRACT FROM AUTHOR]

A novel, efficient and pragmatic method to prepare gem-diboron products with vicinal tertiary/quaternary stereocenters using LiTMP-mediated 1,6-conjugate addition of gem-diborylalkanes to para-quinone methides was described for the first time. The results showed that various gem-diboron products with vicinal tertiary and quaternary stereocenters could be formed within 15 min at ambient temperature. This simple protocol has also been applied for the efficient synthesis of the analogue of Bedaquiline. [ABSTRACT FROM AUTHOR]

Fiber-reinforced polymer (FRP) bars are gaining popularity as an alternative to steel reinforcement due to their advantages such as corrosion resistance and high strength-to-weight ratio. However, FRP has a lower modulus of elasticity compared to steel. Therefore, special attention is required in structural design to address deflection related issues and ensure ductile failure. This research explores the use of machine learning algorithms such as gene expression programming (GEP) to develop a simple and effective equation for predicting the elastic modulus of hybrid fiber-reinforced polymer (HFPR) bars. A comprehensive database of 125 experimental results of HFPR bars was used for training and validation. Statistical parameters such as R2, MAE, RRSE, and RMSE are used to judge the accuracy of the developed model. Also, parametric analysis and SHAP analysis have been carried out to reveal the most influential factors in the predictive model. Finally, the proposed model was compared to the available equations for elastic modulus. The results demonstrate that the developed GEP model performance is better than that of the traditional formula. Statistical parameters and K-fold cross-validation ensured the accuracy and reliability of the predictive model. Finally, the study recommends the optimal GEP model for predicting the elastic modulus of HFRP bars and improving the structural design of HFRP. [ABSTRACT FROM AUTHOR]

Atypical lobular endocervical glandular hyperplasia (ALEGH) is considered a precancerous lesion of gastric-type adenocarcinoma (GAS)/minimal deviation adenocarcinoma (MDA) characterized by an insidious onset, atypical symptoms, and often negative human papillomavirus (HPV) screening. Early screening for this disease is challenging, leading to a high rate of missed clinical diagnoses and the development of malignant tumors at the onset. Increased vaginal discharge and the presence of imaging cystic masses at the internal cervical ostium are often observed in patients with ALEGH. Therefore, we reviewed the clinical data of two cases of ALEGH that were identified and diagnosed in the early stages at our hospital. Through a comprehensive analysis of the medical history and diagnosis plan, combined with a review of relevant literature, to improve the early recognition and diagnosis of ALEGH, as well as strengthen the management of cervical precancerous lesions. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study is to investigate the value of ultrasound combined with computed tomography (CT) in identifying early low-grade appendiceal mucinous neoplasm and appendicitis. Methods: Patients with early low-grade appendiceal mucinous neoplasm and appendicitis from September 2017 to September 2021, including 40 patients with low-grade appendiceal mucinous neoplasm and 40 patients with appendicitis, were collected in this study. Clinical data as well as ultrasound and CT findings of all patients were retrospectively analyzed. Univariate and multivariate logistic regression analyses were applied to establish the ultrasound model, the CT model, and the combined model. Results: The nomogram showed that specific characteristics of CT were dilated appendiceal diameter and clear surrounding fat space in the low-grade appendiceal mucinous neoplasm and that specific characteristics of ultrasound were thin or clear layer appendix wall and flocculent echo in the appendix cavity. These four features were used to construct a nomogram for predicting early low-grade appendiceal mucinous neoplasm, and the area under the curve value was 0.839. Conclusion: Ultrasound combined with CT for diagnosis of early low-grade appendiceal mucinous neoplasm has a significant value; when found significantly dilated appendix in the lower right abdomen, with thin wall, wall calcification, clear surrounding fat space, and progressive enhancement, especially nonspecific symptoms similar to appendicitis, the physician should timely consider the possibility of low-grade appendiceal mucinous neoplasm. [ABSTRACT FROM AUTHOR]

Cervical cancer (CC) is a common cancer in women and a serious threat to women's lives. TRIM11 has been confirmed as a carcinogen in multiple cancers. Here, we will excavate the detailed mechanism of TRIM11 in CC. CC cell lines and nude mice were experimental subjects in this study. The abundance of genes and proteins was detected using qRT-PCR, western blot, and IHC. Cell proliferation, migration, and invasion were determined by CCK-8 assay, wound healing assay, and Transwell, respectively. The interactions among METTL14, TRIM11, and PHLPP1 were confirmed using RIP and co-IP, respectively. The stability of TRIM11 mRNA was examined by qRT-PCR with actinomycin D treatment. The m6A level of TRIM11 was detected by MeRIP assay. Results showed that TRIM11 levels were elevated in CC cells. TRIM11 depletion attenuated the proliferation, migration, and invasion of Hela and SiHa cells. Additionally, TRIM11 was modified with m6A, which was mediated by METTL14, and the stability of TRIM11 mRNA was enhanced by IGF2BP1 depending on the level of m6A modification. TRIM11 ubiquitinated PHLPP1 and led to reduced PHLPP1 expression at the protein level. PHLPP1 could further result in the dephosphorylation of AKT and inhibit AKT signaling. PHLPP1 knockdown neutralized TRIM11 silencing-mediated repression of malignant phenotypes of CC cells. TRIM11 mediated by the METTL14-IGF2BP1 axis promotes the AKT pathway to accelerate CC progression by mediating the ubiquitination of PHLPP, which might provide novel therapeutic targets for CC treatment. [ABSTRACT FROM AUTHOR]

Lithium-sulfur (Li-S) batteries with high energy density and low cost are promising for next-generation energy storage. However, their cycling stability is plagued by the high solubility of lithium polysulfide (LiPS) intermediates, causing fast capacity decay and severe self-discharge. Exploring electrolytes with low LiPS solubility has shown promising results toward addressing these challenges. However, here, we report that electrolytes with moderate LiPS solubility are more effective for simultaneously limiting the shuttling effect and achieving good Li-S reaction kinetics. We explored a range of solubility from 37 to 1,100 mM (based on S atom, [S]) and found that a moderate solubility from 50 to 200 mM [S] performed the best. Using a series of electrolyte solvents with various degrees of fluorination, we formulated the Single-Solvent, Single-Salt, Standard Salt concentration with Moderate LiPSs solubility Electrolytes (termed S6MILE) for Li-S batteries. Among the designed electrolytes, Li-S cells using fluorinated-1,2-diethoxyethane S6MILE (F4DEE-S6MILE) showed the highest capacity of 1,160 mAh g-1 at 0.05 C at room temperature. At 60 °C, fluorinated-1,4-dimethoxybutane S6MILE (F4DMB-S6MILE) gave the highest capacity of 1,526 mAh g-1 at 0.05 C and an average CE of 99.89% for 150 cycles at 0.2 C under lean electrolyte conditions. This is a fivefold increase in cycle life compared with other conventional ether-based electrolytes. Moreover, we observed a long calendar aging life, with a capacity increase/recovery of 4.3% after resting for 30 d using F4DMB-S6MILE. Furthermore, the correlation between LiPS solubility, degree of fluorination of the electrolyte solvent, and battery performance was systematically investigated. [ABSTRACT FROM AUTHOR]

Objective: To investigate the mechanism of Ge-Gen-Qin-Lian-Wan (GGQLW) for the treatment of Novel coronavirus pneumonia (COVID-19) by network pharmacology and molecular docking methods. Methods: The active compounds and targets of GGQLW were retrieved from the TCMSP database; the targets of COVID-19 were obtained from the OMIM database; the molecular target network of GGQLW for COVID-19 was constructed by Cytoscape software; GO and KEGG analysis were obtained from DAVID database; molecular docking was performed by AutoDock 4.2 and PyMol. Results: A total of 146 active components of GGQLW were obtained; 49 therapeutic targets; 156 GO enrichment information were involved, including 122 BP, 14 CC, and 20 MF; GO results analysis revealed that GGQLW anti-COVID-19 might be mainly through apoptosis, inflammation, immune modulation, and other BP; 121 KEGG pathways, and GGQLW anti-COVID-19. The highly relevant signaling pathways were: TNF signaling pathway, Pathways in cancer, HIF-1 signaling pathway; molecular docking results showed that baicalein, berberine, quercetin and formononetin, the core components of GGQLW for COVID-19 treatment, were better bound to SARS-CoV-2 3CL hydrolases were better bound. Conclusion: The molecular targets and mechanisms of GGQLW for the treatment of COVID-19 were explored through network pharmacology and molecular docking, providing a theoretical basis for the treatment of COVID-19 by GGQLW. [ABSTRACT FROM AUTHOR]

Background: A series of novel inflammation-related indexes has been confirmed to be efficient indicators of human immune and inflammatory status, with great potential as predictors for a variety of diseases. However, the association between inflammation-related indexes and sex hormones in the general population remained uncertain. Methods: We incorporated data from the NHANES 2013-2016 survey of American adults. On the basis of distribution and comparison analysis, we chose to undertake separate analyses of men and women (including premenopausal and postmenopausal groups). Multivariable weighted linear regression models, eXtreme Gradient Boosting (XGBoost) models, generalized linear analysis, stratified models, logistic regression models and sensitivity analysis were utilized to assess the relationships between inflammation-related indexes and sex hormones. Results: Total 9372 participants out of 20146 were fitted into our research. We conducted separate gender analysis due to different distribution. Multivariable weighted linear regression indicated every component of the inflammationrelated index was negatively correlated with at least one component of the male hormone indexes. However, SII, NLR, PPN, and NC were associated positively with female estradiol. XGBoost identify SII, PLR and NLR were the critical indexes on sex hormones. Inflammation-related indexes was associated with Testosterone deficiency in male and postmenstrual group and associated with Excessive Estradiol in premenstrual group. Finally, the subgroup analysis revealed that the association between sex hormones and inflammatory indicators was prominent in American adults over the age of 60 or those with BMI (>28 kg/m²). Conclusion: In all, inflammation-related indexes act as independent risks associated with sex hormone alterations and metabolic disorder in both genders. Using multiple models, we revealed the relative importance of inflammation-related indexes. Subgroup analysis also identified the high-risk population. More prospective and experimental research should be conducted to validate the results. [ABSTRACT FROM AUTHOR]

Background: The fruit of Terminalia chebula has been widely used for a thousand years for treating diarrhea, ulcers, and arthritic diseases in Asian countries. However, the active components of this Traditional Chinese medicine and their mechanisms remain unclear, necessitating further investigation. Objectives: To perform simultaneous quantitative analysis of five polyphenols in T. chebula and evaluate their anti-arthritic effects including antioxidant and anti inflammatory activity in vitro. Materials and methods: Water, 50% water-ethanol, and pure ethanol were used as extract solvents. Quantitative analysis of gallic acid, corilagin, chebulanin, chebulagic acid, and ellagic acid in the three extracts was performed using high-performance liquid chromatography (HPLC). Antioxidant activity was assessed by the 2,2-diphenylpicrylhydrazyl (DPPH) radical-scavenging assay, and anti-inflammatory activity was evaluated by detecting interleukin (IL)-6 and IL-8 expression in IL-1β-stimulated MH7A cells. Results: The 50%water-ethanol solvent was the optimal solvent yielding the highest total polyphenol content, and the concentrations of chebulanin and chebulagic acid were much higher than those of gallic acid, corilagin, and ellagic acid in the extracts. The DPPH radical-scavenging assay showed that gallic acid and ellagic acid were the strongest antioxidative components, while the other three components showed comparable antioxidative activity. As for the anti-inflammatory effect, chebulanin and chebulagic acid significantly inhibited IL-6 and IL-8 expression at all three concentrations; corilagin and ellagic acid significantly inhibited IL-6 and IL-8 expression at high concentration; and gallic acid couldnot inhibitIL-8 expression and showedweakinhibitionofIL-6expression in IL-1β-stimulated MH7A cells. Principal component analysis indicated that chebulanin and chebulagic acid were the main components responsible for the anti-arthritic effects of T. chebula. Conclusion: Our findings highlight the potential anti-arthritic role of chebulanin and chebulagic acid from T. chebula. [ABSTRACT FROM AUTHOR]

Background: Some VOCs are identified as endocrine-disrupting chemicals (EDCs), interfering with the effect of sex hormones. However, no studies focused on the common spectrum of environmental VOCs exposure affecting sex hormones in the average male population. Objectives: We aimed to explore the association between VOCs and sex hormones in American adult males using multiple statistical models. Methods: The generalized linear (GLM), eXtreme Gradient Boosting (XGBoost), weighted quantile sum (WQS), Bayesian kernel machine regression (BKMR) and stratified models were used to evaluate the associations between Specific Volatile Organic Compounds and sex hormones in American adult male from NHANES 2013-2016. Results: Pearson correlation model revealed the potential co-exposure pattern among VOCs. XGBoost algorithm models and the WQS model suggested the relative importance of VOCs. BKMR models reveal that co-exposure to the VOCs was associated with increased Testosterone (TT), Estradiol (E2), SHBG and decreased TT/E2. GLM models revealed specific VOC exposure as an independent risk factor causing male sex hormones disorders. Stratified analysis identified the high-risk group on the VOCs exposures. We found Blood 2,5-Dimethylfuran in VOCs was the most significant effect on sex hormones in male. Testosterone increased by 213.594 (ng/dL) (124.552, 302.636) and estradiol increased by 7.229 (pg/mL) for each additional unit of blood 2,5-Dimethylfuran (ng/mL). Conclusion: This study is an academic illustration of the association between VOCs exposure and sex hormones, suggesting that exposure to VOCs might be associated with sex hormone metabolic disorder in American adult males. [ABSTRACT FROM AUTHOR]

An isolation trench is a simple and effective method to isolate structural vibrations originating from sources of vibration other than earthquakes (machines, traffic, explosions, etc.); however, there is still not a conclusive depth of the isolation trench for frame structures. To investigate the isolation effect of a trench in the frame structure designed for ground vibration, both a field test and finite element analysis were conducted to analyze the reduced effect of the vibration. The vibration reduction analysis was based on the dynamic equation and wave theory. Considering the vibration control of an industrial plant frame, a soil-trench-building finite element model was built to analyze the vibration characteristics of the floor before and after the open isolation trench structure was used. According to the model, a dynamic test was carried out on the frame structure to assess the effect of the vibration reduction by introducing the trench. The results showed that the depth of the trench was the dominating factor in vibration isolation. When the depth of the trench reached 1~1.3 times the wavelength of the Rayleigh wave, the damping effect was the strongest. the width of the trench has little effect on the vibration isolation efficiency, and the trench must be maintained at a certain distance from the building to ensure the vibration damping efficiency. The vibration of each floor was obviously reduced after the trench was built. The vibration damping effect of the trench was significant. [ABSTRACT FROM AUTHOR]

Ammonium dinitramide (ADN) is considered as a potential substitute for ammonium perchlorate in energetic materials due to its high density, positive oxygen balance, and halogen-free characteristics. However, its application has been severely limited because of its strong hygroscopicity, difficult storage, and incompatibility with isocyanate curing agents. In order to better bloom the advantages of the highly energetic and environment-friendly ADN in the fields of energetic materials, an in-depth analysis of the current situation and discussion of key research points are particularly important. In this paper, a detailed overview on the synthesis, thermal decomposition, hygroscopic mechanism, and anti-hygroscopicity of ADN has been discussed, its application in powdes and explosives are also presented, and its future research directions are proposed. [ABSTRACT FROM AUTHOR]

Background: The incidence of diabetes mellitus (DM) in China is increasing yearly and has become a major problem plaguing national public health. The diagnosis of diabetic kidney disease (DKD) is based primarily on clinical criteria, and most patients do not receive a formal evaluation by renal biopsy; thus, misdiagnosis and underdiagnosis are common. The incidence of non-diabetic kidney disease (NDKD) is also higher in those with DM. To date, many cases of IgA nephropathy (IgAN) among those with DKD have been reported, while cases of IgAN in patients with long-duration DM who did not develop DKD are less commonly reported. Case description: A 70-year-old male patient with a diabetes duration of 26 years had proteinuria for one year. The clinical manifestations of nephrotic syndrome and IgAN were confirmed by renal biopsy. The patient received targeted treatment for three years with partial alleviation of proteinuria. Conclusion: Renal biopsy might aid in the definitive diagnosis of DKD, NDKD, and NDKD combined with DKD. Precise therapy based on renal pathology might help to improve outcomes in the kidney. [ABSTRACT FROM AUTHOR]

In this study, CuO-Cr2O3-PbO ternary nanocomposites (TNCs) with different atomic ratios of Cu:Cr:Pb (5:2:8, 5:4:6, 5:6:4, 5:8:2) were synthesized by means of efficient mechanical milling. As confirmed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM), uniform and impurity-free CuO-Cr2O3-PbO TNCs with an average grain size of 30 nm were successfully obtained. The catalytic properties of CuO-Cr2O3-PbO TNCs favorable for the pyrolysis of ammonium perchlorate (AP) were studied through thermogravimetric (TG) analysis and differential scanning calorimetry (DSC). The results show that TNC-8, which has an atomic ratio of 5:8:2 (Cu:Cr:Pb), exhibited the highest catalytic activity for the pyrolysis of AP when the pyrolytic temperature of AP decreased from 441.3 °C to 360.2 °C and the Gibbs free energy (ΔG≠) decreased from 199.8 kJ·mol-1 to 175.2 kJ·mol-1, as compared to CuO-Cr2O3-PbO nanocomposites with other atomic ratios. [ABSTRACT FROM AUTHOR]

Cancer has long been a hot research topic, and recent years have witnessed the incidence of cancer trending toward younger individuals with great socioeconomic burden. Even with surgery, therapeutic agents serve as the mainstay to combat cancer in the clinic. Intensive research on nanomaterials can overcome the shortcomings of conventional drug delivery approaches, such as the lack of selectivity for targeted regions, poor stability against degradation, and uncontrolled drug release behavior. Over the years, different types of drug carriers have been developed for cancer therapy. One of these is liposome-in-gel (LP-Gel), which has combined the merits of both liposomes and hydrogels, and has emerged as a versatile carrier for cancer therapy. LP-Gel hybrids have addressed the lack of stability of conventional liposomes against pH and ionic strength while displaying higher efficiency of delivery hydrophilic drugs as compared to conventional gels. They can be classified into three types according to their assembled structure, are characterized by their nontoxicity, biodegradability, and flexibility for clinical use, and can be mainly categorized based on their controlled release, transmucosal delivery, and transdermal delivery properties for anticancer therapy. This review covers the recent progress on the applications of LP-Gel hybrids for anticancer therapy. [ABSTRACT FROM AUTHOR]

Background: A new form of cell death, copper-dependent cell death (termed cuproptosis), was illustrated in a recent scientific study. However, the biological function or prognostic value of cuproptosis regulators in bladder cancer (BLCA) remains unknown. Materials and Methods: Sequencing data obtained from BLCA samples in TCGA and GEO databases were preprocessed for analysis. Biological function and immune cell infiltration levels evaluated by gene set variation analysis (GSVA) were employed to calculate enrichment scores. Iteration least absolute shrinkage and selection operator (LASSO) and COX regression model were employed to select feature genes and construct a novel cuproptosis-related (CR) score signature. The genomics of drug sensitivity in cancer (GDSC) and tumor immune dysfunction and exclusion (TIDE) analysis were used to predict the chemotherapy and immunotherapy efficacy for BLCA patients. The relative expression of the genes involved in the signature was also verified by real-time quantitative PCR (qRT-PCR) in cell lines and tissues. Results: Expression abundance and the prognostic value of cuproptosis regulators proved that cuproptosis might play a vital part in the carcinogenesis of BLCA. GSVA revealed that cuproptosis regulators might be associated with metabolism and metastasis-related pathways such as TGF-β, protein secretion, oxidative Phosphorylation, MYC targets, MTORC1, and adipogenesis pathways. CR scores could predict the prognosis and evaluate the chemotherapy and immunotherapy efficacies of BLCA. CR scores were positively correlated with EMT, MYC, MTORC1, HEDGEHOG, and E2F signaling pathways; meanwhile, they were negatively correlated with several immune cell infiltration levels such as CD8+ T cells, γδT cells, and activated dendritic cells. Several GEO datasets were used to validate the power of prognostic prediction, and a nomogram was also established for clinical use. The expressions of DDX10, RBM34, and RPL17 were significantly higher in BLCA cell lines and tissues in comparison with those in the corresponding normal controls. Conclusion: Cuproptosis might play an essential role in the progression of BLCA. CR scores could be helpful in the investigation of prognostic prediction and therapeutic efficacy and could make contributions to further studies in BLCA. [ABSTRACT FROM AUTHOR]

Smartphone technology has been recently applied for biomedical image acquisition and data analysis due to its high-quality imaging capability, and flexibility to customize multi-purpose apps. In this work, we developed and characterized a smartphone-microfluidic fluorescence imaging system for studying the physiology of pancreatic islets. We further evaluated the system capability by performing real-time fluorescence imaging on mouse islets labeled with either chemical fluorescence dyes or genetically encoded fluorescent protein indicators (GEFPIs). Our results showed that the system was capable of analyzing key beta-cell insulin stimulator-release coupling factors in response to various stimuli with high-resolution dynamics. Furthermore, the integration of a microfluidics allowed high-resolution detection of insulin secretion at single islet level. When compared to conventional fluorescence microscopes and macro islet perifusion apparatus, the system has the advantages of low cost, portable, and easy to operate. With all of these features, we envision that this smartphonemicrofluidic fluorescence imaging system can be applied to study islet physiology and clinical applications. [ABSTRACT FROM AUTHOR]

Accumulating vast amounts of pollutants drives modern civilization toward sustainable development. Construction waste is one of the prominent issues impeding progress toward net-zero. Pollutants must be utilized in constructing civil engineering structures for a green ecosystem. On the other hand, large-scale production of industrial steel fibers (ISFs) causes significant damage to the goal of a sustainable environment. Recycled steel fibers (RSFs) from waste tires have been suggested to replace ISFs. This research critically examines RSF's application in the mechanical properties' improvement of concrete and mortar. A statistical analysis of dimensional parameters of RSFs, their properties, and their use in manufacturing various cement-based composites are given. Furthermore, comparative assessments are carried out among the improvements in compressive, split tensile, and flexural strengths of plain and RSF-incorporated concrete and mortar. In addition, the optimum contents of RSF for each strength property are also discussed. The influence of RSFs parameters on various strength properties of concrete and mortars is discussed. The possible applications of RSF for various civil engineering structures are reviewed. The limitations and errors noticed in previous review papers are also outlined. It is found that the maximum enhancement in compressive strength (CS), split tensile strength (STS), and flexure strength (FS) are 78%, 149%, and 157%, respectively, with the addition of RSF into concrete. RSF increased cement mortars' CS, STS, and FS by 46%, 50.6%, and 69%, respectively. The current study encourages the building sector to use RSFs for sustainable concrete. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between orthotopic U-shaped ileal neobladder volume and bladder function. To investigate the correlation between the volume of the radical cystectomy and the U-shaped ileal neobladder in situ and the function of the bladder. Methods: The clinical data of patients undergoing in orthotopic U-shaped neobladder in our hospital were retrospectively analyzed. They were divided into two groups according to the length of the retained ileum. Group 1: The length of the ileum was 25-35cm (including 35cm), and the second group: the length of the ileum was 35-45cm. The basic information, cushion usage, urodynamic examination and complications of the two groups were obtained. Results: A total of 88 patients were included in the study, including 33 in the first group and 55 in the second group. There was no statistical difference in general data, lymph node collection, lymph node positive rate, positive margin rate, postoperative pathological stage, pathological grade, pathological type, intraoperative blood loss, blood transfusion, postoperative hospital stay, and complications between the two groups of patients. significance. Although the usage of urine pads in group 1 was more than that in group 2 in the short term after operation (P<0.05), it started from the third year after operation. Patients in group 1 used less cushion than group 2 (P<0.05). Urodynamic examination was performed on the patients, and the bladder function of group 1 maintained satisfactory time longer than that of group 2. The total number of deaths in the two groups was 12 and 23, respectively. The 5-year overall survival (OS) rate of group 1 was 53.60%, and the 5-year overall survival rate of group 2 was 52.9%. Conclusions: A new bladder formed by cutting the ileum with a length of 25-35 cm (including 35cm) has a longer time to maintain good bladder function than cutting the ileum with a length of 35-45 cm to produce a new bladder. [ABSTRACT FROM AUTHOR]

In this paper, a notched three-point bending test is used to study the fracture performance of the short basalt fiber bundle reinforced concrete (SBFBRC). To compare and analyze the enhancement effect of different diameters and different content of basalt fiber bundles on the fracture performance of concrete, some groups are set up, and the P-CMOD curves of each group of specimens are measured, and the fracture toughness and fracture energy of each control group are calculated. The fracture toughness and fracture energy are two important fracture performance parameters to study the effect and law of the new basalt fiber bundles on the fracture performance of concrete. The research results show that the diameter and content of the new basalt fiber bundles have a certain effect on the fracture performance of concrete. With the increase of the content of basalt fiber bundles, the peak load, crack initiation toughness, instability toughness and fracture energy of SBFBRC are greatly improved compared with the benchmark group. When the fiber bundle diameter is 0.2 mm, the peak load increases by 69.5% compared with the reference group. The instability toughness reaches its maximum value at 0.2 mm diameter, which is 59.7% higher than the benchmark. [ABSTRACT FROM AUTHOR]

The well-developed root system enables plant survival under various environmental stresses. WUSCHEL-RELATED HOMEOBOX GENE 11 (WOX11) plays a critical role in adventitious root formation and development in rice, Arabidopsis, and easy-to-root tree poplar. However, in difficult-toroot trees, the knowledge of WOX11 during adventitious root formation and development remains scarce. In this study, the JrWOX11 gene was isolated from a difficult-to-root tree walnut and heterologously expressed in the "84K" poplar. The results showed that JrWOX11 contained a similar structure and sequence to the homologous genes in rice, Arabidopsis, and poplar, but had different numbers and types of motifs and cis-elements. JrWOX11 lacked the motif GGAIQY compared to that in easy-to-root trees. In addition, JrWOX11 expression was induced by ABA, PEG, and NaCl treatments. Overexpression of JrWOX11 in poplar promoted root initiation and significantly increased adventitious root (ARs) number, lateral roots (LRs) number, and root hair (RH) length. Furthermore, the aboveground biomass was notably increased under NaCl and PEG treatments in transgenic plants. When NaCl and PEG were removed, the survival rate, aerial shoot development, and de novo root organogenesis were also markedly enhanced in transgenic shoot cuttings. The study provides valuable information on the differences between JrWOX11 and the homologous genes in rice, Arabidopsis, and poplar, and supports the critical role of JrWOX11 in the formation of AR and tolerance to salt and osmotic stresses. [ABSTRACT FROM AUTHOR]

Cracks in concrete structures have always been the main reason to allow the aggressive and harmful agents to infringe the concrete resulting in its deterioration and decreasing lifespan. In the present study, the water permeability of the cracked concrete has been investigated. The consequences of cracking on the durability and endurance of concrete were also studied. A state-of-the-art permeability setup was designed to measure the water flow in normal and fiber-reinforced concrete under direct tensile loading. The setup was convenient for determining the average stress applied to the concrete specimens and simultaneously the maximum crack opening. Furthermore, the effect of fiber content on the cracking geometry (tortuosity and roughness) was evaluated by incorporating the coordinate data of the cracked surface using a 3D sensor-based laser scanning data acquisition system. To understand the effect of fiber content on the cracking geometry (tortuosity and roughness), the acquired data were then analyzed. Test results show that the designed setup is suitable to measure the water permeability under direct tensile loading. Water permeability decreased upon increasing the steel fiber dosage. Besides, the results show that tortuosity decreased while surface roughness increased with the fiber dosage increment. Promising preliminary results indicated that there is an inverse relationship between surface roughness and water permeability. The crack sensing setup successfully monitored the crack. [ABSTRACT FROM AUTHOR]

Objectives: Wuhan is the city where coronavirus disease (COVID-19) was first reported and developed into a pandemic. However, the impact of the prolonged COVID-19 pandemic on medical staff burnout remains limited. We aimed to identify the prevalence and major determinants of burnout among medical staff 1 year after the beginning of the COVID-19 pandemic in Wuhan, China. Materials and Methods: A total of 1,602 medical staff from three hospitals in Wuhan, China, were included from November 1-28, 2021. Chi-square tests were conducted to compare the prevalence of burnout across groups based on sociodemographic and professional characteristics. A multivariate analysis was performed using a forward stepwise logistic regression model. Results: Approximately 37.39% of the medical staff experienced burnout 1 year after COVID-19 pandemic. Emotional exhaustion (EE) was the most common symptom of burnout, with 1,422 (88.76%) participants reporting a severe EE. Burnout was associated with insufficient social support and "neutral" or "dissatisfied" patientphysician relationships. Respondents who participated in the care of COVID-19 patients had a higher risk of burnout symptoms than those who did not participate. In particular, mental resilience was negatively associated with burnout among the medical staff. Conclusion: Nearly two-fifths of the participants had symptoms of burnout, with reduced personal accomplishment being the predominant symptom 1 year after COVID-19. Healthcare organizations should regularly measure and monitor burnout among the medical staff. In addition, creating positive work environments and improving the mental resilience of medical staff may be effective ways to reduce burnout. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease, commonly occurs in the elderly population, causing a significant medical and economic burden to the aging society worldwide. At present, there are few effective methods that achieve satisfactory clinical results in the treatment of PD. Platelet-derived growth factors (PDGFs) and platelet-derived growth factor receptors (PDGFRs) are important neurotrophic factors that are expressed in various cell types. Their unique structures allow for specific binding that can effectively regulate vital functions in the nervous system. In this review, we summarized the possible mechanisms by which PDGFs/PDGFRs regulate the occurrence and development of PD by affecting oxidative stress, mitochondrial function, protein folding and aggregation, Ca2+ homeostasis, and cell neuroinflammation. These modes of action mainly depend on the type and distribution of PDGFs in different nerve cells. We also summarized the possible clinical applications and prospects for PDGF in the treatment of PD, especially in genetic treatment. Recent advances have shown that PDGFs have contradictory roles within the central nervous system (CNS). Although they exert neuroprotective effects through multiple pathways, they are also associated with the disruption of the blood--brain barrier (BBB). Our recommendations based on our findings include further investigation of the contradictory neurotrophic and neurotoxic effects of the PDGFs acting on the CNS. [ABSTRACT FROM AUTHOR]

Recently, geopolymer concrete (GPC) has gained substantial consideration and commercial interest in the construction industry owing to the superior mechanical and chemical properties in comparison with the ordinary Portland cement (OPC) that it brings through the use of waste material and reduction in the CO2 emission. Previous research Studies revealed that different ratios of chemical oxide combination of the raw material (fly ash, rice husk ash, meta kaolin, sugarcane bagasse ash, GGBS etc.) strongly affect the mechanical and durability properties of GPC. Nevertheless, findings concerning different ratios of Si/Al, alkaline solution to binder, NaOH to Na2SiO3, combined percentage of Fe2O3 + CaO and molar concentration of NaOH are controversial regarding the compressive strength of GPC. Therefore, in the light of literature, this study presents the investigation of the compressive strength behavior against the different ratios of oxides and alkaline solution (i.e. Si/Al, alkaline solution/binder, NaOH/Na2SiO3, Fe2O3 + CaO and NaOH molar concentration) present in the raw material used for the production of GPC. An extensive data from previous research publications has been collected and trend of compressive strength for 7 and 28 days was developed against different ratios of Si/Al, alkaline solution/binder, NaOH/Na2SiO3, in order to conclude a typical range for the above mention parameters. It was concluded that compressive strength of GPC greatly depends on the variation in ratios of Si/Al, alkaline solution/binder, NaOH/Na2SiO3, Fe2O3 + CaO and NaOH molar concentration. It was also concluded that the compressive strength of GPC has been primarily affected by the ratio of Si/Al, alkaline solution/binder, NaOH/Na2SiO3 and molar concentration of NaOH. Besides, the oxides like CaO and Fe2O3 although smaller in quantity in comparison with the alumina and silicate oxides, have indicated a distinct influence on the compressive strength development. [ABSTRACT FROM AUTHOR]

In this study, the incorporation of glass fibers in concrete bridge decks has been studied for improving its mechanical properties as well as energy absorption capacity and toughness indices. The mix proportion of 1:3:2 (cement:sand:aggregate) was selected having water-cement ratio of 0.71. For the manufacturing of glass fiber reinforced concrete (GFRC), the glass fibers (2-inch) were incorporated at a percentage level of 1 %, 2 %, 3 % and 4 % by weight of cement in concrete mixes. The findings reveal that the split-tensile and flexural strength of GFRC increases at all the percentage levels, however, the compressive strength of the blended mixes get reduced by increasing the dosage of glass fibers in the concrete. Besides, the energy absorption and toughness indices are also studied for different types of loadings (i.e. compressive, splitting-tensile and flexural loadings) up to a percentage level of 4 %. The findings reveal that the split-tensile and flexural energy absorption was increased with the increase in the dosage of glass fibers in comparison with the conventional concrete mixes, however, the compressive energy absorption of the blended mixes get reduced by increasing the dosage of glass fibers in the concrete. Whereas, the toughness indices for compressive, spilt-tensile and flexure was increased while increasing the percentage of glass fibers as compared to the conventional concrete. Among the different percentages of glass fibers, its 4 % addition gives better results as compared to 1 %, 2 % and 3 %. Hence, the 4 % of GF can be suggested to be the optimum percentage of the fibers for the selected mix-design in controlling the resistance of concrete in the bridge decks. Although, the energy absorption of GFRC is lesser in comparison with the toughness indices, GFRC are appropriate for enhancing ductility and resistance against loadings in concrete bridge decks. [ABSTRACT FROM AUTHOR]

Beam-column joints (BCJs) constructed until the 1970s carry a low shear capability due to the absence of shear reinforcement. Fiber-reinforced polymers (FRP) are more reliable than other materials to strengthen a weak BCJ. To date, plenty of analytical models have been developed to analyze the actual contribution of the FRP to the shear strength of RC BCJs. However, the models developed are either too complex in computational efforts or based on empirical coefficients that result in compromised results. The models that formulate the contribution of FRP to the shear strength of the FRP-strengthened deficient interior BCJ are very limited, and such models are too complex. An adequate BCJs' FRP strain equation must still be developed to address these issues. Therefore, the FRP effective strain equation and contribution of FRP to RC BCJs are derived in this research work using an updated database of the appropriate BCJs. The initial analytical model of Bousselham, which Del Vecchio later improved, is further extended to FRP-strengthened deficient interior BCJs. For this purpose, an updated database of the 32 tests around the world of FRP-strengthened interior BCJs deficient in seismic reinforcement is prepared. Firstly, the experimental effective FRP strain is derived using the experimental database. Then, a power-type equation is derived for the effective FRP strain by considering the crucial parameters of the FRP-strengthened interior BCJs. Finally, the experimental shear strengths and those determined with the proposed equation of the FRP-strengthened joints are compared. The average ratio between the experimental and analytical (proposed model) joint shear strengths of the considered specimens ensured the accuracy of the suggested model. The suggested approach makes computing the FRP enhancements required to avoid shear failure in interior joints easy and reliable for researchers and field engineers interested in seismically reinforcing existing structures. [ABSTRACT FROM AUTHOR]

Neutral temperature Tg in capacitively coupled argon plasmas was measured by using a fiber Bragg grating sensor. The measurement of Tg is based on the thermal equilibrium process between the sensor and neutral gases, which is found to become fast upon increasing pressure, due to enhanced heat conduction. Additionally, Tg was found to increase with increasing high frequency power due to enhancive collisions with charged particles. It is also observed that Tg exhibits a significant gradient in space, ranging from 10 to 120 °C higher than room temperature for the conditions investigated. In addition, the spatial profiles of Tg at different pressures generally resemble those of the Ar+ density ni, measured with a floating double probe. The neutral gas is mainly heated via elastic collisions with ions in the sheath region followed by heat conduction among neutrals. [ABSTRACT FROM AUTHOR]

The frequent occurrence of safety accidents during the calendering process is caused by the flammable and explosive properties of composite modified double-base (CMDB) propellant. Optimization of process parameters with the aid of fluid simulation technology could effectively ensure the safety of the calendering process. To improve the accuracy of the simulation results, material parameters and model structure were corrected based on actual conditions, and adaptive grid technology was applied in the local mesh refinement. In addition, the rheological behavior, motion trajectories and heat transfer mechanisms of CMDB propellant slurry were studied with different gaps, rotational rates and temperatures of two rollers. The results indicated that the refined mesh could significantly improve the contour clarity of boundaries and simulate the characteristics of CMDB propellant slurry reflux movement caused by the convergent flow near the outlet. Compared with the gap, the increased rotational rate of roller could promote the reflux movement and intensify the shear flow of slurry inside the flow region by viscous shear dragging. Meanwhile, under the synergistic effect of contact heat transfer as well as convective heat exchange, heat accumulated near the outlet and diffused along the reflux movement, which led to the countercurrent heat dissipation behavior of CMDB propellant slurry. The plasticizing mechanism of slurry and the safety of calendering under different conditions were explored, which provided theoretical guidance and reference data for the optimization of calendering process conditions. Based on the simulation results, the safety of the CMDB propellant calendering process could be significantly improved with a few tests conducted during a short research and development cycle. [ABSTRACT FROM AUTHOR]