1. Integrated multi-omics characterization of SMAD4 mutant colorectal cancer.
- Author
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Zhao, Danyi, Qu, Yanjun, Gao, Na, and Wu, Tao
- Subjects
COLON cancer ,SMAD proteins ,IMMUNOLOGIC memory ,CELLULAR signal transduction ,MISSENSE mutation - Abstract
Colorectal cancer is one of the most common cancers around the world, which is a severe threat to people's health. SMAD4 belongs to the dwarfin/SMAD family, which plays a crucial role in TGF-β and BMP signal pathways. As the molecular characterization of colon cancer patients following SMAD4 mutations remains unclear, we integrated multi-omics data of SMAD4 mutant patients to reveal the profile of molecular characterization of SMAD4 mutation. A missense mutation is the most common mutant type of SMAD4. Patients with SMAD4 mutation had worse survival. Tumor tissues from patients carrying the SMAD4 mutation showed a reduction in various immune cells, such as CD4 + memory T cells and memory B cells. Many differential genes were identified compared to the SMAD4 mutation-free group and could be significantly enriched for tumor- and immune-related signaling pathways. In addition, the mutant group had different drug sensitivities than the non-mutant group. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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